Progesterone implants enhance SIV vaginal transmission and early virus load

Nature Medicine

Volumn 2, Issue 10, 1996, Pages 1084-1089

  Marx, Preston A ^a,b   Spira, Alexander I ^a,b   Gettie, Agegnehu ^a   Dailey, Peter J ^c   Veazey, Ronald S ^d   Lackner, Andrew A ^d   Mahoney, C James ^e   Miller, Christopher J ^f   Claypool, Lee E ^g   Ho, David D ^a   Alexander, Nancy J ^h  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d HARVARD MEDICAL SCHOOL   (United States)

^e NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^h EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROGESTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; MACACA; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VAGINITIS; VIRUS INFECTION;

ANIMALS; ANTIBODIES, VIRAL; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; DNA, VIRAL; DRUG IMPLANTS; EPITHELIUM; FEMALE; FOLLICULAR PHASE; LEUKOCYTES, MONONUCLEAR; MACACA MULATTA; MUCOUS MEMBRANE; PROGESTERONE; PROVIRUSES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VAGINA; VIREMIA;

ANIMALIA; MACACA; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0345360806     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1096-1084     Document Type: Article

References (21)

1. Stratton, P. & Alexander, N.J. Heterosexual spread of HIV infection. Reprod. Med. Rev. 3, 113-136 (1994).
2. Plourde, P.J. & Plummer, F.A. Oral contraceptives and the risk of HIV among heterosexual women in Nairobi. in HIV Epidemiology: Models and Methods (ed. Nicolosi, A.) 107-116 (Raven, New York, 1994).
3. Plummer, F.A. et al. Cofactors in male-female sexual transmission of human immunodeficiency virus type 1. J. Infect. Dis. 163, 233-239 (1991).
4. Daly, C.C., Helling-Giese, G.E., Mati, J.K. & Hunter, D.J. Contraceptive methods and the transmission of HIV: Implications for family planning. Genitourin. Med. 70, 110-117 (1994).
5. Miller, C.J. et al. Genital mucosal transmission of simian immunodeficiency virus: Animal model for heterosexual transmission of human immunodeficiency virus. J. Virol. 63, 4277-4284 (1989).
6. Marx, P.A. et al. Protection against vaginal transmission with microencapsulated vaccine. Science 260, 1323-1327 (1993).
7. Miller, C.J. et al. Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J. Virol. 68, 6391 (1994).
8. + depletion and AIDS. J. Med. Primatol. 23, 397-409 (1994).
9. Miller, C.J., Alexander, N.J., Vogel, P., Anderson, J. & Marx, P.A. Mechanism of genital transmission of SIV: A hypothesis based on transmission studies and location of SIV in the genital tract of chronically infected female rhesus macaques. J. Med. Primatol. 21, 64-68 (1992).
10. Kell, P.D., Barton, S.E., Edmonds, D.K. & Boag, F.C. HIV Infection in a patient with Meyer-Rokitansky-Kuster-Hauser syndrome. J. R. Soc. Med. 85, 706-707 (1992).
11. Spira, A.I. et al. Cellular targets of infection and route of viral dissemination following an intravaginal inoculation of SIV into Rhesus macaques. J. Exp. Med. 183, 215-225 (1996).
12. Fawcett, D.W. Female reproductive system. in A Textbook of Histology, 12th edn. (eds. Bloom, W. & Fawcett, D.W.) 857-858 (Chapman & Hall, New York, London, 1994).
13. Parakkal, P.F. & Gregoire, A.T. Differentiation of vaginal epithelium in the normal and hormone-treated rhesus monkey. Biol. Reprod. 6, 117-130 (1972).
14. Overpeck, J.G., Colson, S.H., Hohmann, J.R., Applestine, M.S. & Reilly, J.F. Concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters: A literature survey. J. Toxicol. Environ. Health 4, 785-803 (1978).
15. Ellinwood, W.E., Norman, R.L. & Spies, H.G. Changing frequency of pulsatile luteinizing hormone and progesterone secretion during the luteal phase of the menstrual cycle of rhesus monkeys. Biol. Reprod. 31, 714-722 (1984).
16. Frankel, S.S. et al. Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 272, 115-117 (1996).
17. Teepe, A.G., Allen, L.B., Wordinger, R.J. & Harris, E.F. Effect of the estrous cycle on susceptibility of female mice to intravaginal inoculation of herpes simplex virus type 2 (HSV-2). Antiviral Res. 14, 227-236 (1990).
18. Parr, M.B. et al. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab. Invest. 70, 369-380 (1994).
19. Rasheed, S., Li, Z. & Xu, D. Human immunodeficiency virus load: Quantitative assessment in semen from seropositive individuals and in spiked seminal plasma. J. Reprod. Med. 40, 747-757 (1995).
20. Pachl, C. et al. Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J. Acquir. Immun. Defic. Syndr. Hum. Retrovir. 8, 446-454 (1995)
21. Collins, M.L. et al. Preparation and characterization of RNA standards for use in quantitative branched DNA hybridization assays. Anal. Biochem. 226, 120-129 (1995).