Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation

AIDS

Volumn 17, Issue 11, 2003, Pages 1597-1604

  Di Fabio, Simonetta ^a   Van Roey, Jens ^b   Giannini, Giacomo ^a   Van Den Mooter, Guy ^c   Spada, Massimo ^a   Binelli, Andrea ^a   Pirillo, Maria F ^a   Germinario, Elena ^a   Belardelli, Filippo ^a   De Bethune, Marie Pierre ^b   Vella, Stefano ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b Virco BVBA   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cell associated HIV; huSCID mice; Microbicides; Sexual transmission

Indexed keywords

ALCOHOL; ANTIGEN P24; CARBOMER; DAPIVIRINE; EDETATE SODIUM; GLYCEROL; HYDROXYETHYLCELLULOSE; PROPYLENE GLYCOL; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIETHANOLAMINE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENZYME; WATER;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL MONITORING; CELL CULTURE; CELL ISOLATION; CELL LABELING; COCULTURE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; DNA EXTRACTION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; FLUORESCENCE; GEL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; INFECTION PREVENTION; INHIBITION KINETICS; LYMPH NODE; LYMPHOCYTE; LYMPHOCYTE MIGRATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SEXUAL TRANSMISSION; SPLEEN CELL; SUPERNATANT; TREATMENT OUTCOME; VAGINA; VIRUS DETECTION; VIRUS TRANSMISSION;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-INFECTIVE AGENTS; CELLULOSE; FEMALE; GELS; HIV INFECTIONS; HIV-1; LYMPHOCYTES; MICE; MICE, SCID; POLYVINYLS; REVERSE TRANSCRIPTASE INHIBITORS; VAGINA; VISCOSITY;

EID: 0042128299     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200307250-00003     Document Type: Article

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