Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2R-/- (NSG) BLT mice

Virology

Volumn 417, Issue 1, 2011, Pages 154-160

  Stoddart, Cheryl A ^a   Maidji, Ekaterina ^b   Galkina, Sofiya A ^a   Kosikova, Galina ^a   Rivera, Jose M ^a   Moreno, Mary E ^a   Sloan, Barbara ^a   Joshi, Pheroze ^a   Long, Brian R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BLT mice; Hematopoietic stem cells; HIV animal models; HIV vaginal transmission; HIV AIDS pathogenesis; Humanized mice; NOD scid IL 2R mice; NOD scid mice

Indexed keywords

CD34 ANTIGEN; INTERLEUKIN 2 RECEPTOR GAMMA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LEUKOCYTE; LIVER; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE; THYMUS; VAGINAL TRANSMISSION; VIRUS TRANSMISSION;

ANIMALS; ANTIGENS, CD34; DISEASE SUSCEPTIBILITY; FEMALE; HIV; HIV INFECTIONS; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; LEUKOCYTES; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; TRANSPLANTATION, HETEROLOGOUS; VAGINA;

ANIMALIA; MUS;

EID: 79961003836     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.05.013     Document Type: Article

References (31)

1. Berges B.K., Akkina S.R., Folkvord J.M., Connick E., Akkina R. Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice. Virology 2008, 373:342-351.
2. Berkowitz R.D., Alexander S., McCune J.M. Causal relationships between HIV-1 coreceptor utilization, tropism, and pathogenesis in human thymus. AIDS Res. Hum. Retroviruses 2000, 16:1039-1045.
3. Brainard D.M., Seung E., Frahm N., Cariappa A., Bailey C.C., Hart W.K., Shin H.S., Brooks S.F., Knight H.L., Eichbaum Q., Yang Y.G., Sykes M., Walker B.D., Freeman G.J., Pillai S., Westmoreland S.V., Brander C., Luster A.D., Tager A.M. Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J. Virol. 2009, 83:7305-7321.
4. Brehm M.A., Cuthbert A., Yang C., Miller D.M., DiIorio P., Laning J., Burzenski L., Gott B., Foreman O., Kavirayani A., Herlihy M., Rossini A.A., Shultz L.D., Greiner D.L. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin. Immunol. 2010, 135:84-98.
5. Cann A.J., Zack J.A., Go A.S., Arrigo S.J., Koyanagi Y., Green P.L., Pang S., Chen I.S. Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formation. J. Virol. 1990, 64:4735-4742.
6. Cao X., Shores E.W., Hu-Li J., Anver M.R., Kelsall B.L., Russell S.M., Drago J., Noguchi M., Grinberg A., Bloom E.T., Paul W.E., Katz S.I., Love P.E., Leonard W.J. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995, 2:223-238.
7. Chesebro B., Nishio J., Perryman S., Cann A., O'Brien W., Chen I.S., Wehrly K. Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages. J. Virol. 1991, 65:5782-5789.
8. Chesebro B., Wehrly K., Nishio J., Perryman S. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism. J. Virol. 1992, 66:6547-6554.
9. Denton P.W., Estes J.D., Sun Z., Othieno F.A., Wei B.L., Wege A.K., Powell D.A., Payne D., Haase A.T., Garcia J.V. Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med. 2008, 5:e16.
10. Denton P.W., Krisko J.F., Powell D.A., Mathias M., Kwak Y.T., Martinez-Torres F., Zou W., Payne D.A., Estes J.D., Garcia J.V. Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One 2010, 5:e8829.
11. Denton P.W., Othieno F., Martinez-Torres F., Zou W., Krisko J.F., Fleming E., Zein S., Powell D.A., Wahl A., Kwak Y.T., Welch B.D., Kay M.S., Payne D.A., Gallay P., Appella E., Estes J.D., Lu M., Garcia J.V. Topically applied 1% tenofovir in humanized BLT mice using the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection validating the BLT model for the evaluation of new microbicide candidates. J. Virol. 2011, (Electronic publication ahead of print May 18).
12. Dick J.E., Bhatia M., Gan O., Kapp U., Wang J.C. Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells 1997, 15(Suppl. 1):199-203. discussion 204-197.
13. DiSanto J.P., Muller W., Guy-Grand D., Fischer A., Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl Acad. Sci. U. S. A. 1995, 92:377-381.
14. Greenberg M.L., Cammack N. Resistance to enfuvirtide, the first HIV fusion inhibitor. J. Antimicrob. Chemother. 2004, 54:333-340.
15. Haltiner M., Kempe T., Tjian R. A novel strategy for constructing clustered point mutations. Nucleic Acids Res. 1985, 13:1015-1025.
16. Hofer U., Baenziger S., Heikenwalder M., Schlaepfer E., Gehre N., Regenass S., Brunner T., Speck R.F. RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. J. Virol. 2008, 82:12145-12153.
17. Ito M., Hiramatsu H., Kobayashi K., Suzue K., Kawahata M., Hioki K., Ueyama Y., Koyanagi Y., Sugamura K., Tsuji K., Heike T., Nakahata T. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 2002, 100:3175-3182.
18. Koyanagi Y., Miles S., Mitsuyasu R.T., Merrill J.E., Vinters H.V., Chen I.S. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 1987, 236:819-822.
19. Lan P., Tonomura N., Shimizu A., Wang S., Yang Y.G. Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood 2006, 108:487-492.
20. McDermott S.P., Eppert K., Lechman E.R., Doedens M., Dick J.E. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 2010, 116:193-200.
21. Melkus M.W., Estes J.D., Padgett-Thomas A., Gatlin J., Denton P.W., Othieno F.A., Wege A.K., Haase A.T., Garcia J.V. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat. Med. 2006, 12:1316-1322.
22. Neff C.P., Ndolo T., Tandon A., Habu Y., Akkina R. Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model. PLoS One 2010, 5:e15257.
23. Ohbo K., Suda T., Hashiyama M., Mantani A., Ikebe M., Miyakawa K., Moriyama M., Nakamura M., Katsuki M., Takahashi K., Yamamura K., Sugamura K. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood 1996, 87:956-967.
24. Shultz L.D., Lyons B.L., Burzenski L.M., Gott B., Chen X., Chaleff S., Kotb M., Gillies S.D., King M., Mangada J., Greiner D.L., Handgretinger R. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 2005, 174:6477-6489.
25. Shultz L.D., Ishikawa F., Greiner D.L. Humanized mice in translational biomedical research. Nat. Rev. Immunol. 2007, 7:118-130.
26. Stoddart C.A., Nault G., Galkina S.A., Thibaudeau K., Bakis P., Bousquet-Gagnon N., Robitaille M., Bellomo M., Paradis V., Liscourt P., Lobach A., Rivard M.E., Ptak R.G., Mankowski M.K., Bridon D., Quraishi O. Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice. J. Biol. Chem. 2008, 283:34045-34052.
27. Stoddart C.A., Keir M.E., McCune J.M. IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathog 2010, 6:e1000766.
28. Sugamura K., Asao H., Kondo M., Tanaka N., Ishii N., Ohbo K., Nakamura M., Takeshita T. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu. Rev. Immunol. 1996, 14:179-205.
29. Sun Z., Denton P.W., Estes J.D., Othieno F.A., Wei B.L., Wege A.K., Melkus M.W., Padgett-Thomas A., Zupancic M., Haase A.T., Garcia J.V. Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J. Exp. Med. 2007, 204:705-714.
30. Toohey K., Wehrly K., Nishio J., Perryman S., Chesebro B. Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread. Virology 1995, 213:70-79.
31. Walter B.L., Wehrly K., Swanstrom R., Platt E., Kabat D., Chesebro B. Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages. J. Virol. 2005, 79:4828-4837.