Seminal plasma reduces the effectiveness of topical polyanionic microbicides

Journal of Infectious Diseases

Volumn 196, Issue 9, 2007, Pages 1394-1402

  Patel, Sarju ^a   Hazrati, Ehsan ^a   Cheshenko, Natalia ^a   Galen, Benjamin ^a   Yang, Heyi ^a   Guzman, Esmeralda ^a   Wang, Rong ^a   Herold, Betsy C ^a   Keller, Marla J ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CELLULOSE SULFATE; PENICILLIN G; PRO 2000; STREPTOMYCIN; NAPHTHALENESULFONIC ACID DERIVATIVE; POLYMER; TOPICAL ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SEMEN ANALYSIS; TANDEM MASS SPECTROMETRY; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECT; SPERM; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CELL LINE; FEMALE; HERPESVIRUS 2, HUMAN; HUMANS; MALE; MICE; MICE, INBRED BALB C; NAPHTHALENESULFONATES; POLYMERS; SEMEN;

EID: 38049074585     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/522606     Document Type: Article

References (19)

1. Celum C, Levine R, Weaver M, Wald A. Genital herpes and human immunodeficiency virus: double trouble. Bull World Health Organ 2004; 82:447-53.
2. Cohen MS. Sexually transmitted diseases enhance HIV transmission: no longer a hypothesis. Lancet 1998; 351:5-7.
3. Stanberry LR, Spruance SL, Cunningham AL, et al. Glycoprotein-Dadjuvant vaccine to prevent genital herpes. N Engl J Med 2002; 347:1652-61.
4. Spearman P. Current progress in the development of HIV vaccines. Curr Pharm Des 2006; 12:1147-67.
5. Cheshenko N, Keller MJ, MasCasullo V, et al. Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. Antimicrob Agents Chemother 2004; 48:2025-36.
6. Scordi-Bello IA, Mosoian A, He C, et al. Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. Antimicrob Agents Chemother 2005; 49:3607-15.
7. John M, Keller MJ, Fam EH, et al. Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. J Infect Dis 2005; 192:1731-40.
8. Keller MJ, Zerhouni-Layachi B, Cheshenko N, et al. PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial. J Infect Dis 2006; 193:27-35.
9. Herold BC, Siston A, Bremer J, et al. Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens. Antimicrob Agents Chemother 1997; 41:2776-80.
10. Tuyama AC, Cheshenko N, Carlucci MJ, et al. ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. J Infect Dis 2006; 194:795-803.
11. Hendrickson BA, Guo J, Brown I, et al. Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. Virology 2000; 271:155-62.
12. Ylatupa S, Mertaniemi P, Haglund C, Partanen P. An improved method for quantification of extra domain A-containing cellular fibronectin (EDAcFN) in different body fluids. Clin Chim Acta 1995; 234:79-90.
13. Gressner AM, Wallraff P. The use of laser nephelometry for the determination and computer-assisted calculation of the fibronectin concentration in various body fluids [in German]. J Clin Chem Clin Biochem 1980; 18:797-805.
14. Mestecky J, Lamm ME, Strober W, Bienenstock J, Mayer L. Mucosal immunology. 3rd ed. Vol. 1. Amsterdam: Elsevier Academic Press, 2005
15. Marchetti M, Trybala E, Superti F, Johansson M, Bergstrom T. Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans. Virology 2004; 318:405-13.
16. Nozaki A, Ikeda M, Naganuma A, et al. Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein. J Biol Chem 2003; 278:10162-73.
17. Swart PJ, Kuipers ME, Smit C, et al. Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro. AIDS Res Hum Retroviruses 1996; 12:769-75.
18. Bozzini S, Falcone V, Conaldi PG, et al. Heparin-binding domain of human fibronectin binds HIV-1 gp120/160 and reduces virus infectivity. J Med Virol 1998; 54:44-53.
19. Neurath AR, Strick N, Li YY. Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides. BMC Infect Dis 2006; 6:150.