메뉴 건너뛰기




Volumn 75, Issue 1, 2016, Pages 1-9

Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr-/- mice

Author keywords

Fibrosis; Inflammation; N 3 PUFA; Non alcoholic steatohepatitis; Oxidative stress

Indexed keywords

ACYL COENZYME A DESATURASE; ALANINE AMINOTRANSFERASE; CD14 ANTIGEN; CHOLESTEROL; COLLAGEN TYPE 1; CRYOPYRIN; DOCOSAPENTAENOIC ACID; FIBRIC ACID DERIVATIVE; GLITAZONE DERIVATIVE; GLUCOSE; GLUCOSE TRANSPORTER 5; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; MAX PROTEIN; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN P50; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SUCROSE; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 84959183349     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S002966511500244X     Document Type: Conference Paper
Times cited : (34)

References (109)
  • 1
    • 84928952647 scopus 로고    scopus 로고
    • Centers for Disease Control (accessed April 2015)
    • Centers for Disease Control (2015) Adult obesity facts. http://www.cdc. gov/obesity/data/adult. html (accessed April 2015).
    • (2015) Adult Obesity Facts
  • 2
    • 84946736977 scopus 로고    scopus 로고
    • Centers for Disease Control (accessed April 2015)
    • Centers for Disease Control (2015) Childhood obesity facts. http://www.cdc. gov/obesity/data/childhood. html (accessed April 2015).
    • (2015) Childhood Obesity Facts
  • 3
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC & Larter CZ (2006) Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43, S99-S112.
    • (2006) Hepatology , vol.43 , pp. S99-S112
    • Farrell, G.C.1    Larter, C.Z.2
  • 4
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • Cohen JC, Horton JD & Hobbs HH (2011) Human fatty liver disease: old questions and new insights. Science 332, 1519-1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 5
    • 77952576769 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease
    • Bellentani S, Scaglioni F, Marino M et al. (2010) Epidemiology of non-alcoholic fatty liver disease. Dig Dis 28, 155-161.
    • (2010) Dig Dis , vol.28 , pp. 155-161
    • Bellentani, S.1    Scaglioni, F.2    Marino, M.3
  • 6
    • 0036103602 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • Angulo P & Lindor KD (2002) Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 17, Suppl. , S186-S190.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. S186-S190
    • Angulo, P.1    Lindor, K.D.2
  • 7
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD single topic conference
    • Neuschwander-Tetri BA & Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology 37, 1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 8
    • 54849436663 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome
    • Kim CH & Younossi ZM (2008) Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. Cleve Clin J Med 75, 721-728.
    • (2008) Cleve Clin J Med , vol.75 , pp. 721-728
    • Kim, C.H.1    Younossi, Z.M.2
  • 9
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome-A new worldwide definition
    • Alberti KG, Zimmet P & Shaw J (2005) The metabolic syndrome-a new worldwide definition. Lancet 366, 1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 10
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of nonalcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G, Baranova A & Younossi ZM (2011) Systematic review: the epidemiology and natural history of nonalcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34, 274-285.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 11
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346, 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 12
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani N, Younossi Z, Lavine JE et al. (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142, 1592-1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 13
    • 33748150370 scopus 로고    scopus 로고
    • Pathophysiology of nonalcoholic steatohepatitis
    • McCullough AJ (2006) Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 40, Suppl. 1, S17-S29.
    • (2006) J Clin Gastroenterol , vol.40 , pp. S17-S29
    • McCullough, A.J.1
  • 14
    • 68949129467 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
    • PrashanthM, GaneshHK, VimaMVet al. (2009) Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. J Assoc Physicians India 57, 205-210.
    • (2009) J Assoc Physicians India , vol.57 , pp. 205-210
    • Prashanth, M.1    Ganesh, H.K.2    Vima, M.V.3
  • 15
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Soderberg C, Stal P, Askling J et al. (2010) Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 51, 595-602.
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Soderberg, C.1    Stal, P.2    Askling, J.3
  • 16
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL et al. (2006) Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 44, 865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 17
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A populationbased cohort study
    • Adams LA, Lymp JF, St Sauver J et al. (2005) The natural history of nonalcoholic fatty liver disease: a populationbased cohort study. Gastroenterology 129, 113-121.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 18
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • McCullough AJ (2004) The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 8, 521-533.
    • (2004) Clin Liver Dis , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 19
    • 80053397336 scopus 로고    scopus 로고
    • Epidemiology of the metabolic syndrome in the USA
    • McCollough AJ (2011) Epidemiology of the metabolic syndrome in the USA. J Dig Dis 12, 333-340.
    • (2011) J Dig Dis , vol.12 , pp. 333-340
    • McCollough, A.J.1
  • 20
    • 84936791821 scopus 로고    scopus 로고
    • The liver's weight problem
    • Leslie M (2015) The liver's weight problem. Science 18-20.
    • (2015) Science , pp. 18-20
    • Leslie, M.1
  • 21
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two hits?
    • Day CP & James OF (1998) Steatohepatitis: a tale of two hits? Gastroenterology 114, 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 23
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • Tilg H & Moschen AR (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52, 1836-1846.
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 24
    • 84155184594 scopus 로고    scopus 로고
    • Histological features of non-alcoholic fatty liver disease: What is important?
    • Hashimoto E, Tokushige K & Farrell GC (2011) Histological features of non-alcoholic fatty liver disease: what is important? J Gastroenterol Hepatol 27, 5-7.
    • (2011) J Gastroenterol Hepatol , vol.27 , pp. 5-7
    • Hashimoto, E.1    Tokushige, K.2    Farrell, G.C.3
  • 25
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 26
    • 77952692915 scopus 로고    scopus 로고
    • Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek MF, Suzuki A, Guy C et al. (2010) Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51, 1961-1971.
    • (2010) Hepatology , vol.51 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3
  • 27
    • 84869148767 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis: Role of obesity, insulin resistance and mechanisms of hepatotoxicity
    • Guturu P & Duchini A (2012) Etiopathogenesis of nonalcoholic steatohepatitis: role of obesity, insulin resistance and mechanisms of hepatotoxicity. Int J Hepatol 2012, 212865.
    • (2012) Int J Hepatol , vol.2012 , pp. 212865
    • Guturu, P.1    Duchini, A.2
  • 28
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters K, van Gorp PJ, Bieghs V et al. (2008) Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48, 474-486.
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1    Van Gorp, P.J.2    Bieghs, V.3
  • 30
    • 77950419928 scopus 로고    scopus 로고
    • Elevated endotoxin levels in non-alcoholic fatty liver disease
    • PubMed
    • Harte AL, da Silva NF, Creely SJ et al. (2010) Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflammation 7, 15. PubMed.
    • (2010) J Inflammation , vol.7 , pp. 15
    • Harte, A.L.1    Da Silva, N.F.2    Creely, S.J.3
  • 31
    • 79953321200 scopus 로고    scopus 로고
    • Genetic determinants of hepatic steatosis in man
    • Hooper AJ, Adams LA & Burnett JR (2011) Genetic determinants of hepatic steatosis in man. J Lipid Res 52, 593-617.
    • (2011) J Lipid Res , vol.52 , pp. 593-617
    • Hooper, A.J.1    Adams, L.A.2    Burnett, J.R.3
  • 32
    • 84856297712 scopus 로고    scopus 로고
    • LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease
    • Bieghs V, Van Gorp PJ, Wouters K et al. (2012) LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS ONE 7, e30668.
    • (2012) PLoS ONE , vol.7 , pp. e30668
    • Bieghs, V.1    Van Gorp, P.J.2    Wouters, K.3
  • 33
    • 84901020405 scopus 로고    scopus 로고
    • Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
    • Joyce SA, MacSharry J, Casey PG et al. (2014) Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci USA 111, 7421-7426.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 7421-7426
    • Joyce, S.A.1    MacSharry, J.2    Casey, P.G.3
  • 34
    • 58949090376 scopus 로고    scopus 로고
    • Competitive in hibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function
    • Elinav E, Ali M, Bruck R et al. (2009) Competitive in hibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function. Hepatology 49, 278-286.
    • (2009) Hepatology , vol.49 , pp. 278-286
    • Elinav, E.1    Ali, M.2    Bruck, R.3
  • 35
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115, 1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 36
    • 84864090834 scopus 로고    scopus 로고
    • Mechanisms of simple hepatic steatosis: Not so simple after all
    • Matherly SC & Puri P (2012) Mechanisms of simple hepatic steatosis: not so simple after all. Clin Liver Dis 16, 505-524.
    • (2012) Clin Liver Dis , vol.16 , pp. 505-524
    • Matherly, S.C.1    Puri, P.2
  • 37
    • 33845632821 scopus 로고    scopus 로고
    • Dietary habits and nutrient intake in non-alcoholic steatohepatitis
    • Toshimitsu K, Matsuura B, Ohkubo I et al. (2007) Dietary habits and nutrient intake in non-alcoholic steatohepatitis. Nutrition 23, 46-52.
    • (2007) Nutrition , vol.23 , pp. 46-52
    • Toshimitsu, K.1    Matsuura, B.2    Ohkubo, I.3
  • 38
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • Musso G, Gambino R, De Michieli F et al. (2003) Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 37, 909-916.
    • (2003) Hepatology , vol.37 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De Michieli, F.3
  • 39
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • Capanni M, Calella F, Biagini MR et al. (2006) Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther 23, 1143-1151.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1143-1151
    • Capanni, M.1    Calella, F.2    Biagini, M.R.3
  • 40
    • 33747469042 scopus 로고    scopus 로고
    • How different is the dietary pattern in non-alcoholic steatohepatitis patients?
    • Cortez-Pinto H, Jesus L, Barros H et al. (2006) How different is the dietary pattern in non-alcoholic steatohepatitis patients? Clin Nutr 25, 816-823.
    • (2006) Clin Nutr , vol.25 , pp. 816-823
    • Cortez-Pinto, H.1    Jesus, L.2    Barros, H.3
  • 41
    • 1542410333 scopus 로고    scopus 로고
    • Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats
    • Levy JR, Clore JN & StevensW (2004) Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. Hepatology 39, 608-616.
    • (2004) Hepatology , vol.39 , pp. 608-616
    • Levy, J.R.1    Clore, J.N.2    Stevens, W.3
  • 42
    • 80051501874 scopus 로고    scopus 로고
    • Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: Genomic analysis of cellular targets
    • Pachikian BD, Essaghir A, Demoulin JB et al. . Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. PLoS ONE 6, e23365.
    • PLoS ONE , vol.6 , pp. e23365
    • Pachikian, B.D.1    Essaghir, A.2    Demoulin, J.B.3
  • 43
    • 84880692101 scopus 로고    scopus 로고
    • Fatty acidregulated transcription factors in the liver
    • Jump DB, Tripathy S & Depner CM (2013) Fatty acidregulated transcription factors in the liver. Annu Rev Nutr 33, 249-269.
    • (2013) Annu Rev Nutr , vol.33 , pp. 249-269
    • Jump, D.B.1    Tripathy, S.2    Depner, C.M.3
  • 44
    • 80051979813 scopus 로고    scopus 로고
    • Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence
    • Zelber-Sagi S, Ratziu V & Oren R (2011) Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence. World J Gastroenterol 17, 3377-3389.
    • (2011) World J Gastroenterol , vol.17 , pp. 3377-3389
    • Zelber-Sagi, S.1    Ratziu, V.2    Oren, R.3
  • 45
    • 57349137214 scopus 로고    scopus 로고
    • Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    • Tetri LH, Basaranoglu M, Brunt EM et al. (2008) Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 295, G987-G995.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , pp. G987-G995
    • Tetri, L.H.1    Basaranoglu, M.2    Brunt, E.M.3
  • 46
    • 84865079644 scopus 로고    scopus 로고
    • The role of dietary fatty acids in the pathology of metabolic syndrome
    • Lottenberg AM, Afonso Mda S, Lavrador MS et al. (2012) The role of dietary fatty acids in the pathology of metabolic syndrome. J Nutr Biochem 23, 1027-1040.
    • (2012) J Nutr Biochem , vol.23 , pp. 1027-1040
    • Lottenberg, A.M.1    Afonso Mda, S.2    Lavrador, M.S.3
  • 47
    • 77049094855 scopus 로고    scopus 로고
    • Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
    • Wouters K, van Bilsen M, van Gorp PJ et al. (2010) Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice. FEBS Lett 584, 1001-1005.
    • (2010) FEBS Lett , vol.584 , pp. 1001-1005
    • Wouters, K.1    Van Bilsen, M.2    Van Gorp, P.J.3
  • 48
    • 83755163159 scopus 로고    scopus 로고
    • A highcholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
    • e10
    • Teratani T, Tomita K, Suzuki T et al. (2012) A highcholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. Gastroenterology 142, 152-164 e10.
    • (2012) Gastroenterology , vol.142 , pp. 152-164
    • Teratani, T.1    Tomita, K.2    Suzuki, T.3
  • 49
    • 84866296564 scopus 로고    scopus 로고
    • Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/-mice
    • Depner CM, Torres-Gonzalez M, Tripathy S et al. (2012) Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/-mice. J Nutr 142, 1495-1503.
    • (2012) J Nutr , vol.142 , pp. 1495-1503
    • Depner, C.M.1    Torres-Gonzalez, M.2    Tripathy, S.3
  • 50
    • 67049114700 scopus 로고    scopus 로고
    • Nutritional investigation of non-obese patients with nonalcoholic fatty liver disease: The significance of dietary cholesterol
    • Yasutake K, Nakamuta M, Shima Y et al. (2009) Nutritional investigation of non-obese patients with nonalcoholic fatty liver disease: the significance of dietary cholesterol. Scand J Gastroenterol 44, 471-477.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 471-477
    • Yasutake, K.1    Nakamuta, M.2    Shima, Y.3
  • 51
    • 84880953279 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: The role of oxidized lowdensity lipoproteins
    • Walenbergh SMA, Koek GH, Bieghs V et al. (2013) Non-alcoholic steatohepatitis: the role of oxidized lowdensity lipoproteins. J Hepatol 58, 801-820.
    • (2013) J Hepatol , vol.58 , pp. 801-820
    • Walenbergh, S.M.A.1    Koek, G.H.2    Bieghs, V.3
  • 52
    • 82355188291 scopus 로고    scopus 로고
    • Intake of added sugars in the United States: What is the measure?
    • Marriott BP, Olsho L, Hadden L et al. (2010) Intake of added sugars in the United States: what is the measure? Am J Clin Nutr 94, 1652-1653.
    • (2010) Am J Clin Nutr , vol.94 , pp. 1652-1653
    • Marriott, B.P.1    Olsho, L.2    Hadden, L.3
  • 53
    • 79952063514 scopus 로고    scopus 로고
    • Changes in intakes of total and added sugar and their contribution to energy intake in the U.S.
    • Chun OK, Chung CE, Wang Y et al. (2010) Changes in intakes of total and added sugar and their contribution to energy intake in the U. S. Nutrients 2, 834-854.
    • (2010) Nutrients , vol.2 , pp. 834-854
    • Chun, O.K.1    Chung, C.E.2    Wang, Y.3
  • 54
    • 0042207392 scopus 로고    scopus 로고
    • Did fat intake in the United States really decline between 1989-1991 and 1994-1996?
    • Chanmugam P, Guthrie JF, Cecilio S et al. (2003) Did fat intake in the United States really decline between 1989-1991 and 1994-1996? J Am Diet Assoc 103, 867-872.
    • (2003) J Am Diet Assoc , vol.103 , pp. 867-872
    • Chanmugam, P.1    Guthrie, J.F.2    Cecilio, S.3
  • 55
    • 33846348619 scopus 로고    scopus 로고
    • Trends in diet quality for coronary heart disease prevention between 1980-1982 and 2000-2002: The Minnesota Heart Survey
    • Lee S, Harnack L, Jacobs DR Jr et al. (2007) Trends in diet quality for coronary heart disease prevention between 1980-1982 and 2000-2002: the Minnesota Heart Survey. J Am Diet Assoc 107, 213-222.
    • (2007) J Am Diet Assoc , vol.107 , pp. 213-222
    • Lee, S.1    Harnack, L.2    Jacobs, D.R.3
  • 56
    • 77949557516 scopus 로고    scopus 로고
    • Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003-2006
    • Marriott BP, Olsho L, Hadden L et al. (2010) Intake of added sugars and selected nutrients in the United States, National Health and Nutrition Examination Survey (NHANES) 2003-2006. Crit Rev Food Sci Nutr 50, 228-258.
    • (2010) Crit Rev Food Sci Nutr , vol.50 , pp. 228-258
    • Marriott, B.P.1    Olsho, L.2    Hadden, L.3
  • 57
    • 49449098216 scopus 로고    scopus 로고
    • Dietary fructose consumption among US children and adults: The Third National Health and Nutrition Examination Survey
    • Vos MB, Kimmons JE, Gillespie C et al. (2008) Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med 10, 160.
    • (2008) Medscape J Med , vol.10 , pp. 160
    • Vos, M.B.1    Kimmons, J.E.2    Gillespie, C.3
  • 58
    • 77952096918 scopus 로고    scopus 로고
    • The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
    • Lim JS, Mietus-Snyder M, Valente A et al. (2010) The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol 7, 251-264.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 251-264
    • Lim, J.S.1    Mietus-Snyder, M.2    Valente, A.3
  • 59
    • 23944443756 scopus 로고    scopus 로고
    • Hepatic adaptations to sucrose and fructose
    • Bizeau ME & Pagliassotti MJ (2005) Hepatic adaptations to sucrose and fructose. Metabolism 54, 1189-1201.
    • (2005) Metabolism , vol.54 , pp. 1189-1201
    • Bizeau, M.E.1    Pagliassotti, M.J.2
  • 60
    • 0034673344 scopus 로고    scopus 로고
    • Constitutive and inducible expression of hepatic CYP2E1 in leptindeficient ob/ob mice
    • Leclercq IA, Field J, Enriquez A et al. (2000) Constitutive and inducible expression of hepatic CYP2E1 in leptindeficient ob/ob mice. Biochem Biophys Res Commun 268, 337-344.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 337-344
    • Leclercq, I.A.1    Field, J.2    Enriquez, A.3
  • 61
  • 62
    • 0019796775 scopus 로고
    • Reaction of monosaccharides with proteins: Possible evolutionary significance
    • Bunn HF & Higgins PJ (1981) Reaction of monosaccharides with proteins: possible evolutionary significance. Science 213, 222-224.
    • (1981) Science , vol.213 , pp. 222-224
    • Bunn, H.F.1    Higgins, P.J.2
  • 63
    • 45049086294 scopus 로고    scopus 로고
    • Fructose-induced structural and functional modifications of hemoglobin: Implication for oxidative stress in diabetes mellitus
    • Bose T & Chakraborti AS (2008) Fructose-induced structural and functional modifications of hemoglobin: implication for oxidative stress in diabetes mellitus. Biochim Biophys Acta 1780, 800-808.
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 800-808
    • Bose, T.1    Chakraborti, A.S.2
  • 64
    • 84875853704 scopus 로고    scopus 로고
    • Fructose-induced stress signaling in the liver involves methylglyoxal
    • Wei Y, Wang D, Moran G et al. (2013) Fructose-induced stress signaling in the liver involves methylglyoxal. Nutr Meta (Lond) 10, 32-38.
    • (2013) Nutr Meta (Lond) , vol.10 , pp. 32-38
    • Wei, Y.1    Wang, D.2    Moran, G.3
  • 65
    • 33947284587 scopus 로고    scopus 로고
    • How should we manage patients with non-alcoholic fatty liver disease in 2007?
    • Chan HL, de Silva HJ, Leung NW et al. (2007) How should we manage patients with non-alcoholic fatty liver disease in 2007? J Gastroenterol Hepatol 22, 801-808.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 801-808
    • Chan, H.L.1    De Silva, H.J.2    Leung, N.W.3
  • 66
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD) : A systematic review and meta-analysis of randomised trials
    • Musso G, Cassader M, Rosina F et al. (2012) Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD) : a systematic review and meta-analysis of randomised trials. Diabetologia 55, 885-904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3
  • 67
    • 84863087186 scopus 로고    scopus 로고
    • Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes
    • Petit JM, Guiu B, Duvillard L et al. (2012) Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes. Clin Nutr 31, 520-525.
    • (2012) Clin Nutr , vol.31 , pp. 520-525
    • Petit, J.M.1    Guiu, B.2    Duvillard, L.3
  • 68
    • 84863430608 scopus 로고    scopus 로고
    • Low docosahexaenoic acid content in plasma phospholipids is associated with increased non-alcoholic fatty liver disease in China
    • Zheng JS, Xu A, Huang T et al. (2012) Low docosahexaenoic acid content in plasma phospholipids is associated with increased non-alcoholic fatty liver disease in China. Lipids 47, 549-556.
    • (2012) Lipids , vol.47 , pp. 549-556
    • Zheng, J.S.1    Xu, A.2    Huang, T.3
  • 69
    • 84858703583 scopus 로고    scopus 로고
    • Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Parker HM, Johnson NA, Burdon CA et al. (2012) Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 56, 944-951.
    • (2012) J Hepatol , vol.56 , pp. 944-951
    • Parker, H.M.1    Johnson, N.A.2    Burdon, C.A.3
  • 70
    • 84873914743 scopus 로고    scopus 로고
    • Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease
    • Di Minno MN, Russolillo A, Lupoli R et al. (2012) Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease. World J Gastroenterol 18, 5839-5847.
    • (2012) World J Gastroenterol , vol.18 , pp. 5839-5847
    • Di Minno, M.N.1    Russolillo, A.2    Lupoli, R.3
  • 71
    • 79953177813 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: Double-blind randomised controlled clinical trial
    • Nobili V, Bedogni G, Alisi A et al. (2011) Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch Dis Child 96, 350-353.
    • (2011) Arch Dis Child , vol.96 , pp. 350-353
    • Nobili, V.1    Bedogni, G.2    Alisi, A.3
  • 72
    • 79451476075 scopus 로고    scopus 로고
    • The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease
    • Shapiro H, Tehilla M, Attal-Singer J et al. (2011) The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease. Clin Nutr 30, 6-19.
    • (2011) Clin Nutr , vol.30 , pp. 6-19
    • Shapiro, H.1    Tehilla, M.2    Attal-Singer, J.3
  • 73
    • 80054758173 scopus 로고    scopus 로고
    • Current status of novel antifibrotic thearpies in patients with chronic liver disease
    • Cohen-Naftaly M & Friedman SL (2011) Current status of novel antifibrotic thearpies in patients with chronic liver disease. Ther Adv Gastroenterol 4, 391-417.
    • (2011) Ther Adv Gastroenterol , vol.4 , pp. 391-417
    • Cohen-Naftaly, M.1    Friedman, S.L.2
  • 74
    • 84877141184 scopus 로고    scopus 로고
    • Evolving therapies for liver fibrosis
    • Schuppan D & Kim YO (2013) Evolving therapies for liver fibrosis. J Clin Invest 123, 1887-1901.
    • (2013) J Clin Invest , vol.123 , pp. 1887-1901
    • Schuppan, D.1    Kim, Y.O.2
  • 75
    • 21744446895 scopus 로고    scopus 로고
    • Tissuespecific, nutritional, and developmental regulation of rat fatty acid elongases
    • Wang Y, Botolin D, Christian B et al. (2005) Tissuespecific, nutritional, and developmental regulation of rat fatty acid elongases. J Lipid Res 46, 706-715.
    • (2005) J Lipid Res , vol.46 , pp. 706-715
    • Wang, Y.1    Botolin, D.2    Christian, B.3
  • 76
    • 77956838705 scopus 로고    scopus 로고
    • Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice
    • Tripathy S, Torres-Gonzalez M & Jump DB (2010) Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice. J Lipid Res 51, 2642-2654.
    • (2010) J Lipid Res , vol.51 , pp. 2642-2654
    • Tripathy, S.1    Torres-Gonzalez, M.2    Jump, D.B.3
  • 77
    • 84874682905 scopus 로고    scopus 로고
    • Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr (-/-) mouse model of western diet-induced nonalcoholic steatohepatitis
    • Depner CM, Philbrick KA & Jump DB (2013) Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr (-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. J Nutr 143, 315-323.
    • (2013) J Nutr , vol.143 , pp. 315-323
    • Depner, C.M.1    Philbrick, K.A.2    Jump, D.B.3
  • 78
    • 84892930540 scopus 로고    scopus 로고
    • A metabolomic analysis of omega-3 fatty acid mediated attenuation of western diet-induced non-alcoholic steatohepatitis in LDLR-/-mice
    • Depner CM, Traber MG, Bobe G et al. (2013) A metabolomic analysis of omega-3 fatty acid mediated attenuation of western diet-induced non-alcoholic steatohepatitis in LDLR-/-mice. Plos ONE 8, e83756.
    • (2013) Plos ONE , vol.8 , pp. e83756
    • Depner, C.M.1    Traber, M.G.2    Bobe, G.3
  • 79
    • 84871180269 scopus 로고    scopus 로고
    • Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-Vaccenic acid synthesis in diet-induced obese mice
    • Tripathy S & Jump DB (2013) Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-Vaccenic acid synthesis in diet-induced obese mice. J Lipid Res 54, 71-84.
    • (2013) J Lipid Res , vol.54 , pp. 71-84
    • Tripathy, S.1    Jump, D.B.2
  • 80
    • 84904008964 scopus 로고    scopus 로고
    • Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice
    • Tripathy S, Lytle KA, Stevens RD et al. (2014) Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. J Lipid Res 55, 1448-1464.
    • (2014) J Lipid Res , vol.55 , pp. 1448-1464
    • Tripathy, S.1    Lytle, K.A.2    Stevens, R.D.3
  • 81
    • 34447126323 scopus 로고    scopus 로고
    • Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice
    • Saraswathi V, Gao L, Morrow JD et al. (2007) Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr 137, 1776-1782.
    • (2007) J Nutr , vol.137 , pp. 1776-1782
    • Saraswathi, V.1    Gao, L.2    Morrow, J.D.3
  • 82
    • 84931272963 scopus 로고    scopus 로고
    • Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterolsugar diet model in mice
    • Ganz M, Bukong TN, Csak T et al. (2015) Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterolsugar diet model in mice. J Transl Med 13, 193-207.
    • (2015) J Transl Med , vol.13 , pp. 193-207
    • Ganz, M.1    Bukong, T.N.2    Csak, T.3
  • 83
    • 80055026523 scopus 로고    scopus 로고
    • Fast food diet mouse: Novel small animal model of NASH with balloning, progressive fibrosis and high physiological facelity to the human condition
    • Charlton M, Krishnan A, Viker K et al. (2011) Fast food diet mouse: novel small animal model of NASH with balloning, progressive fibrosis and high physiological facelity to the human condition. Am J Physiol Gastrointest Liver Physiol 301, G825-GG34.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G825-G834
    • Charlton, M.1    Krishnan, A.2    Viker, K.3
  • 84
    • 14544275997 scopus 로고    scopus 로고
    • Orgins and evolution of the western diet: Health implications for the 21st century
    • Cordain L, Eaton SB, Sebastian A et al. (2005) Orgins and evolution of the western diet: health implications for the 21st century. Am J Clin Nutr 81, 341-354.
    • (2005) Am J Clin Nutr , vol.81 , pp. 341-354
    • Cordain, L.1    Eaton, S.B.2    Sebastian, A.3
  • 85
    • 84887023370 scopus 로고    scopus 로고
    • High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    • Ishimoto T, Lanaspa MA, Rivard CJ et al. (2013) High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology 58, 1632-1643.
    • (2013) Hepatology , vol.58 , pp. 1632-1643
    • Ishimoto, T.1    Lanaspa, M.A.2    Rivard, C.J.3
  • 86
    • 84924772254 scopus 로고    scopus 로고
    • Altered hepatic gene expression in non-alcoholic fatty liver disease is associated with lower n-3 and n-6 polyunsaturated fatty acids
    • Arendt BM, Comelli EM, Ma DW et al. (2015) Altered hepatic gene expression in non-alcoholic fatty liver disease is associated with lower n-3 and n-6 polyunsaturated fatty acids. Hepatology 61, 1565-1578.
    • (2015) Hepatology , vol.61 , pp. 1565-1578
    • Arendt, B.M.1    Comelli, E.M.2    Ma, D.W.3
  • 87
    • 84919626918 scopus 로고    scopus 로고
    • Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
    • Lee JJ, Lambert JE, Hovhannisyan Y et al. (2015) Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis. Am J Clin Nutr 101, 34-43.
    • (2015) Am J Clin Nutr , vol.101 , pp. 34-43
    • Lee, J.J.1    Lambert, J.E.2    Hovhannisyan, Y.3
  • 88
    • 78649823911 scopus 로고    scopus 로고
    • Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: A preliminary study
    • Sofi F, GiangranDi I, Cesari F et al. (2011) Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study. Int J Food Sci Nutr 61, 792-802.
    • (2011) Int J Food Sci Nutr , vol.61 , pp. 792-802
    • Sofi, F.1    GiangranDi, I.2    Cesari, F.3
  • 89
    • 77957560313 scopus 로고    scopus 로고
    • Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis
    • Bulchandani DG, Nachnani JS, Nookala A et al. (2011) Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis. Eur J Gastroenterol Hepatol 22, 1245-1252.
    • (2011) Eur J Gastroenterol Hepatol , vol.22 , pp. 1245-1252
    • Bulchandani, D.G.1    Nachnani, J.S.2    Nookala, A.3
  • 90
    • 77954493183 scopus 로고    scopus 로고
    • Preventive effects of eicosapentaenoic acid on coronary artery disease in patients with peripheral artery disease
    • Ishikawa Y, Yokoyama M, Saito Y et al. (2011) Preventive effects of eicosapentaenoic acid on coronary artery disease in patients with peripheral artery disease. Circ J 74, 1451-1457.
    • (2011) Circ J , vol.74 , pp. 1451-1457
    • Ishikawa, Y.1    Yokoyama, M.2    Saito, Y.3
  • 91
    • 79953126783 scopus 로고    scopus 로고
    • Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury
    • Kishino T, Ohnishi H, Ohtsuka K et al. (2011) Low concentrations of serum n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease patients with liver injury. Clin Chem Lab Med 49, 159-162.
    • (2011) Clin Chem Lab Med , vol.49 , pp. 159-162
    • Kishino, T.1    Ohnishi, H.2    Ohtsuka, K.3
  • 92
    • 84927776586 scopus 로고    scopus 로고
    • Effects of purified eicosapentaenoic and docosahexaenoic acids in non-alcoholic fatty liver disease: Results from the WELCOME study
    • Scorletti E, Bhatia L, McCormick KG et al. (2014) Effects of purified eicosapentaenoic and docosahexaenoic acids in non-alcoholic fatty liver disease: results from the WELCOME study. Hepatology 60, 1211-1221.
    • (2014) Hepatology , vol.60 , pp. 1211-1221
    • Scorletti, E.1    Bhatia, L.2    McCormick, K.G.3
  • 93
    • 13844297589 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress study II: Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
    • Kadiiska MB, Gladen BC, Baird DD et al. (2005) Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med 38, 698-710.
    • (2005) Free Radic Biol Med , vol.38 , pp. 698-710
    • Kadiiska, M.B.1    Gladen, B.C.2    Baird, D.D.3
  • 94
    • 84959454032 scopus 로고    scopus 로고
    • US National Institute of health. (accessed April 2015)
    • US National Institute of health (2015) NAFLD, NASH and omega-3 fatty acids. http://www.clinicaltrials. gov. (accessed April 2015).
    • (2015) NAFLD, NASH and omega-3 Fatty Acids
  • 95
    • 54549097065 scopus 로고    scopus 로고
    • Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia
    • Barter P & Ginsberg HN (2008) Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia. Am J Cardiol 102, 1040-1045.
    • (2008) Am J Cardiol , vol.102 , pp. 1040-1045
    • Barter, P.1    Ginsberg, H.N.2
  • 97
    • 84870009669 scopus 로고    scopus 로고
    • STAT gene dietary model to implement diets of differing fat composition in prospectively genotyped groups (apoE) using commercially available foods
    • Lockyer S, Tzanetou M, Carvalho-Wells AL et al. (2012) STAT gene dietary model to implement diets of differing fat composition in prospectively genotyped groups (apoE) using commercially available foods. Br J Nutr 108, 1705-1713.
    • (2012) Br J Nutr , vol.108 , pp. 1705-1713
    • Lockyer, S.1    Tzanetou, M.2    Carvalho-Wells, A.L.3
  • 98
    • 2942532780 scopus 로고    scopus 로고
    • Early modification of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 PUFA
    • Di Stasi D, Bernasconi R, Marchioli R et al. (2004) Early modification of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 PUFA. Eur J Clin Pharmacol 60, 183-190.
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 183-190
    • Di Stasi, D.1    Bernasconi, R.2    Marchioli, R.3
  • 99
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 100
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq IA, Farrell GC, Schriemer R et al. (2002) Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 37, 206-213.
    • (2002) J Hepatol , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3
  • 101
    • 39149104311 scopus 로고    scopus 로고
    • Molecular basis and mechanisms of progression of nonalcoholic steatohepatitis
    • Marra F, Gastaldelli A, Baroni GS et al. (2008) Molecular basis and mechanisms of progression of nonalcoholic steatohepatitis. Trends Mol Med 14, 72-81.
    • (2008) Trends Mol Med , vol.14 , pp. 72-81
    • Marra, F.1    Gastaldelli, A.2    Baroni, G.S.3
  • 102
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S & Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4, 499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 103
    • 36249005027 scopus 로고    scopus 로고
    • A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation
    • Erridge C, Attina T, Spickett CM et al. (2007) A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 86, 1286-1292.
    • (2007) Am J Clin Nutr , vol.86 , pp. 1286-1292
    • Erridge, C.1    Attina, T.2    Spickett, C.M.3
  • 104
    • 78649978620 scopus 로고    scopus 로고
    • Emulsified lipids increase endotoxemia: Possible role in early postprandial low-grade inflammation
    • Laugerette F, Vors C, Geloen A et al. (2011) Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutritional Biochem 22, 53-59.
    • (2011) J Nutritional Biochem , vol.22 , pp. 53-59
    • Laugerette, F.1    Vors, C.2    Geloen, A.3
  • 106
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 108
    • 79959793959 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase
    • Brenner DA, Seki E, Taura K et al. (2011) Non-alcoholic steatohepatitis-induced fibrosis: toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res 41, 683-686.
    • (2011) Hepatol Res , vol.41 , pp. 683-686
    • Brenner, D.A.1    Seki, E.2    Taura, K.3
  • 109
    • 84928704699 scopus 로고    scopus 로고
    • Notch signaling as a novel regulator of metabolism
    • Bi P & Kuang S (2015) Notch signaling as a novel regulator of metabolism. Trends EndocrinolMetabol 26, 248-255.
    • (2015) Trends EndocrinolMetabol , vol.26 , pp. 248-255
    • Bi, P.1    Kuang, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.