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Volumn 61, Issue 5, 2015, Pages 1565-1578

Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; ARACHIDONIC ACID; C PEPTIDE; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; INSULIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; TRIACYLGLYCEROL;

EID: 84924772254     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27695     Document Type: Article
Times cited : (240)

References (43)
  • 1
    • 77950323927 scopus 로고    scopus 로고
    • Pathogenesis of non-alcoholic fatty liver disease
    • Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. Q J Med 2010; 103: 71-83.
    • (2010) Q J Med , vol.103 , pp. 71-83
    • Dowman, J.K.1    Tomlinson, J.W.2    Newsome, P.N.3
  • 2
    • 84880419922 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches
    • Schuppan D, Schattenberg JM. Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches. J Gastroenterol Hepatol 2013; (28 Suppl. 1): 68-76.
    • (2013) J Gastroenterol Hepatol , Issue.28 , pp. 68-76
    • Schuppan, D.1    Schattenberg, J.M.2
  • 4
    • 22844439963 scopus 로고    scopus 로고
    • Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis
    • Younossi ZM, Gorreta F, Ong JP, Schlauch K, Giacco LD, Elariny H, et al. Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis. Liver Int 2005; 25: 760-771.
    • (2005) Liver Int , vol.25 , pp. 760-771
    • Younossi, Z.M.1    Gorreta, F.2    Ong, J.P.3    Schlauch, K.4    Giacco, L.D.5    Elariny, H.6
  • 6
    • 80053162318 scopus 로고    scopus 로고
    • Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease
    • Lake AD, Novak P, Fisher CD, Jackson JP, Hardwick RN, Billheimer DD, et al. Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease. Drug Metab Dispos 2011; 39: 1954-1960.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1954-1960
    • Lake, A.D.1    Novak, P.2    Fisher, C.D.3    Jackson, J.P.4    Hardwick, R.N.5    Billheimer, D.D.6
  • 7
    • 77949677097 scopus 로고    scopus 로고
    • Role of alcohol metabolism in non-alcoholic steatohepatitis
    • Baker SS, Baker RD, Liu W, Nowak NJ, Zhu L. Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS One 2010; 5: e9570.
    • (2010) PLoS One , vol.5
    • Baker, S.S.1    Baker, R.D.2    Liu, W.3    Nowak, N.J.4    Zhu, L.5
  • 8
    • 84871570353 scopus 로고    scopus 로고
    • Systematic analysis of the gene expression in the livers of nonalcoholic steatohepatitis: implications on potential biomarkers and molecular pathological mechanism
    • Zhang Y, Baker SS, Baker RD, Zhu R, Zhu L. Systematic analysis of the gene expression in the livers of nonalcoholic steatohepatitis: implications on potential biomarkers and molecular pathological mechanism. PLoS One 2012; 7: e51131.
    • (2012) PLoS One , vol.7
    • Zhang, Y.1    Baker, S.S.2    Baker, R.D.3    Zhu, R.4    Zhu, L.5
  • 9
    • 84893092076 scopus 로고    scopus 로고
    • Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease
    • Moylan CA, Pang H, Dellinger A, Suzuki A, Garrett ME, Guy CD, et al. Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease. Hepatology 2014; 59: 471-482.
    • (2014) Hepatology , vol.59 , pp. 471-482
    • Moylan, C.A.1    Pang, H.2    Dellinger, A.3    Suzuki, A.4    Garrett, M.E.5    Guy, C.D.6
  • 10
    • 55449094777 scopus 로고    scopus 로고
    • Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis
    • Yoneda M, Endo H, Mawatari H, Nozaki Y, Fujita K, Akiyama T, et al. Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis. Hepatol Res 2008; 38: 1204-1212.
    • (2008) Hepatol Res , vol.38 , pp. 1204-1212
    • Yoneda, M.1    Endo, H.2    Mawatari, H.3    Nozaki, Y.4    Fujita, K.5    Akiyama, T.6
  • 11
    • 84867366175 scopus 로고    scopus 로고
    • Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis
    • Starmann J, Falth M, Spindelbock W, Lanz KL, Lackner C, Zatloukal K, et al. Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis. PLoS One 2012; 7: e46584.
    • (2012) PLoS One , vol.7
    • Starmann, J.1    Falth, M.2    Spindelbock, W.3    Lanz, K.L.4    Lackner, C.5    Zatloukal, K.6
  • 12
    • 84880683621 scopus 로고    scopus 로고
    • Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease
    • Scorletti E, Byrne CD. Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. Annu Rev Nutr 2013; 33: 231-248.
    • (2013) Annu Rev Nutr , vol.33 , pp. 231-248
    • Scorletti, E.1    Byrne, C.D.2
  • 13
    • 84870465239 scopus 로고    scopus 로고
    • Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population
    • Rudkowska I, Paradis AM, Thifault E, Julien P, Tchernof A, Couture P, et al. Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population. J Nutr Biochem 2013; 24: 54-61.
    • (2013) J Nutr Biochem , vol.24 , pp. 54-61
    • Rudkowska, I.1    Paradis, A.M.2    Thifault, E.3    Julien, P.4    Tchernof, A.5    Couture, P.6
  • 14
    • 37849028864 scopus 로고    scopus 로고
    • Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study
    • Allard JP, Aghdassi E, Mohammed S, Raman M, Avand G, Arendt BM, et al. Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study. J Hepatol 2008; 48: 300-307.
    • (2008) J Hepatol , vol.48 , pp. 300-307
    • Allard, J.P.1    Aghdassi, E.2    Mohammed, S.3    Raman, M.4    Avand, G.5    Arendt, B.M.6
  • 15
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2004; 106: 635-643.
    • (2004) Clin Sci (Lond) , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6
  • 17
    • 34848830434 scopus 로고    scopus 로고
    • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study
    • Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Blendis L, Halpern Z, et al. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol 2007; 47: 711-717.
    • (2007) J Hepatol , vol.47 , pp. 711-717
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3    Webb, M.4    Blendis, L.5    Halpern, Z.6
  • 18
    • 84904760759 scopus 로고    scopus 로고
    • A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls
    • Da Silva HE, Arendt BM, Noureldin SA, Therapondos G, Guindi M, Allard JP. A cross-sectional study assessing dietary intake and physical activity in Canadian patients with nonalcoholic fatty liver disease vs healthy controls. J Acad Nutr Diet 2014; 114: 1181-1194.
    • (2014) J Acad Nutr Diet , vol.114 , pp. 1181-1194
    • Da Silva, H.E.1    Arendt, B.M.2    Noureldin, S.A.3    Therapondos, G.4    Guindi, M.5    Allard, J.P.6
  • 19
    • 84858703583 scopus 로고    scopus 로고
    • Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis
    • Parker HM, Johnson NA, Burdon CA, Cohn JS, O'Connor HT, George J. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2012; 56: 944-951.
    • (2012) J Hepatol , vol.56 , pp. 944-951
    • Parker, H.M.1    Johnson, N.A.2    Burdon, C.A.3    Cohn, J.S.4    O'Connor, H.T.5    George, J.6
  • 20
    • 84891737631 scopus 로고    scopus 로고
    • Molecular interplay between delta5/delta6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis
    • Lopez-Vicario C, Gonzalez-Periz A, Rius B, Moran-Salvador E, Garcia-Alonso V, Lozano JJ, et al. Molecular interplay between delta5/delta6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut 2014; 63: 344-355.
    • (2014) Gut , vol.63 , pp. 344-355
    • Lopez-Vicario, C.1    Gonzalez-Periz, A.2    Rius, B.3    Moran-Salvador, E.4    Garcia-Alonso, V.5    Lozano, J.J.6
  • 21
    • 73349125811 scopus 로고    scopus 로고
    • Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
    • Pettinelli P, Del Pozo T, Araya J, Rodrigo R, Araya AV, Smok G, et al. Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion. Biochim Biophys Acta 2009; 1792: 1080-1086.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 1080-1086
    • Pettinelli, P.1    Del Pozo, T.2    Araya, J.3    Rodrigo, R.4    Araya, A.V.5    Smok, G.6
  • 23
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 25
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: a pipeline for processing Illumina microarray
    • Du P, Kibbe WA, Lin SM. Lumi: a pipeline for processing Illumina microarray. Bioinformatics 2008; 24: 1547-1548.
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 26
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources
    • Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nat Protoc 2009; 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 27
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
    • Huang DW, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1-13.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 28
    • 23044515033 scopus 로고    scopus 로고
    • Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis
    • Lau DT, Luxon BA, Xiao SY, Beard MR, Lemon SM. Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis. Hepatology 2005; 42: 273-281.
    • (2005) Hepatology , vol.42 , pp. 273-281
    • Lau, D.T.1    Luxon, B.A.2    Xiao, S.Y.3    Beard, M.R.4    Lemon, S.M.5
  • 30
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 31
    • 33644594766 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland
    • Ma DW, Ngo V, Huot PS, Kang JX. N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland. Lipids 2006; 41: 35-39.
    • (2006) Lipids , vol.41 , pp. 35-39
    • Ma, D.W.1    Ngo, V.2    Huot, P.S.3    Kang, J.X.4
  • 32
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 33
    • 0030935652 scopus 로고    scopus 로고
    • Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study
    • Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997; 20: 537-544.
    • (1997) Diabetes Care , vol.20 , pp. 537-544
    • Pan, X.R.1    Li, G.W.2    Hu, Y.H.3    Wang, J.X.4    Yang, W.Y.5    An, Z.X.6
  • 34
    • 51349089738 scopus 로고    scopus 로고
    • Significant gene expression differences in histologically "normal" liver biopsies: implications for control tissue
    • Asselah T, Bieche I, Laurendeau I, Martinot-Peignoux M, Paradis V, Vidaud D, et al. Significant gene expression differences in histologically "normal" liver biopsies: implications for control tissue. Hepatology 2008; 48: 953-962.
    • (2008) Hepatology , vol.48 , pp. 953-962
    • Asselah, T.1    Bieche, I.2    Laurendeau, I.3    Martinot-Peignoux, M.4    Paradis, V.5    Vidaud, D.6
  • 35
    • 70350778508 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 member B1 inhibitors: old drugs with new perspectives
    • Liu J, Wen G, Cao D. Aldo-keto reductase family 1 member B1 inhibitors: old drugs with new perspectives. Recent Pat Anticancer Drug Discov 2009; 4: 246-253.
    • (2009) Recent Pat Anticancer Drug Discov , vol.4 , pp. 246-253
    • Liu, J.1    Wen, G.2    Cao, D.3
  • 36
    • 0030711745 scopus 로고    scopus 로고
    • Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study
    • Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 1997; 38: 2012-2022.
    • (1997) J Lipid Res , vol.38 , pp. 2012-2022
    • Katan, M.B.1    Deslypere, J.P.2    van Birgelen, A.P.3    Penders, M.4    Zegwaard, M.5
  • 37
    • 73149094933 scopus 로고    scopus 로고
    • A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1
    • Lattka E, Eggers S, Moeller G, Heim K, Weber M, Mehta D, et al. A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. J Lipid Res 2010; 51: 182-191.
    • (2010) J Lipid Res , vol.51 , pp. 182-191
    • Lattka, E.1    Eggers, S.2    Moeller, G.3    Heim, K.4    Weber, M.5    Mehta, D.6
  • 38
    • 79956263594 scopus 로고    scopus 로고
    • Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults
    • Merino DM, Johnston H, Clarke S, Roke K, Nielsen D, Badawi A, et al. Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults. Mol Genet Metab 2011; 103: 171-178.
    • (2011) Mol Genet Metab , vol.103 , pp. 171-178
    • Merino, D.M.1    Johnston, H.2    Clarke, S.3    Roke, K.4    Nielsen, D.5    Badawi, A.6
  • 39
    • 84926660045 scopus 로고    scopus 로고
    • PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
    • Peter A, Kovarova M, Nadalin S, Cermak T, Konigsrainer A, Machicao F, et al. PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans. Diabetologia 2014; 57: 2103-2107.
    • (2014) Diabetologia , vol.57 , pp. 2103-2107
    • Peter, A.1    Kovarova, M.2    Nadalin, S.3    Cermak, T.4    Konigsrainer, A.5    Machicao, F.6
  • 40
    • 84861421970 scopus 로고    scopus 로고
    • Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake
    • Santoro N, Savoye M, Kim G, Marotto K, Shaw MM, Pierpont B, et al. Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake. PLoS One 2012; 7: e37827.
    • (2012) PLoS One , vol.7
    • Santoro, N.1    Savoye, M.2    Kim, G.3    Marotto, K.4    Shaw, M.M.5    Pierpont, B.6
  • 41
  • 42
    • 84904661185 scopus 로고    scopus 로고
    • No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial
    • Sanyal AJ, Abdelmalek MF, Suzuki A, Cummings OW, Chojkier M. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. Gastroenterology 2014; 147: 377-384.
    • (2014) Gastroenterology , vol.147 , pp. 377-384
    • Sanyal, A.J.1    Abdelmalek, M.F.2    Suzuki, A.3    Cummings, O.W.4    Chojkier, M.5
  • 43
    • 84883432733 scopus 로고    scopus 로고
    • A self-directed method for cell-type identification and separation of gene expression microarrays
    • Zuckerman NS, Noam Y, Goldsmith AJ, Lee PP. A self-directed method for cell-type identification and separation of gene expression microarrays. PLoS Comput Biol 2013; 9: e1003189.
    • (2013) PLoS Comput Biol , vol.9
    • Zuckerman, N.S.1    Noam, Y.2    Goldsmith, A.J.3    Lee, P.P.4


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