메뉴 건너뛰기




Volumn 51, Issue 9, 2010, Pages 2642-2654

Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice

Author keywords

Diabetes; Elovl5; Fatty liver; FoxO1; Gluconeogenesis; PGC1

Indexed keywords

FATTY ACID; FATTY ACID ELONGASE 5; GLUCOSE; GLUCOSE 6 PHOSPHATE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

EID: 77956838705     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M006080     Document Type: Article
Times cited : (57)

References (54)
  • 1
    • 0026544667 scopus 로고
    • The fatty acid chain elongation system of mammalian endoplasmic reticulum
    • Cinti, D. L., L. Cook, M. N. Nagi, and S. K. Suneja. 1992. The fatty acid chain elongation system of mammalian endoplasmic reticulum. Prog. Lipid Res. 31: 1-51.
    • (1992) Prog. Lipid Res. , vol.31 , pp. 1-51
    • Cinti, D.L.1    Cook, L.2    Nagi, M.N.3    Suneja, S.K.4
  • 2
    • 33646018341 scopus 로고    scopus 로고
    • Fatty acid elongases in mammals: Their regulation and role in metabolism
    • Jakobsson, A., R. Westerberg, and A. Jacobsson. 2006. Fatty acid elongases in mammals: their regulation and role in metabolism. Prog. Lipid Res. 45: 237-249.
    • (2006) Prog. Lipid Res. , vol.45 , pp. 237-249
    • Jakobsson, A.1    Westerberg, R.2    Jacobsson, A.3
  • 4
    • 34547947625 scopus 로고    scopus 로고
    • A molecular caliper mechanism for determining very long-chain fatty acid length
    • Denic, V., and J. S. Weissman. 2007. A molecular caliper mechanism for determining very long-chain fatty acid length. Cell. 130: 663-677.
    • (2007) Cell , vol.130 , pp. 663-677
    • Denic, V.1    Weissman, J.S.2
  • 5
    • 0037470063 scopus 로고    scopus 로고
    • Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
    • Moon, Y. A., and J. D. Horton. 2003. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. J. Biol. Chem. 278: 7335-7343.
    • (2003) J. Biol. Chem. , vol.278 , pp. 7335-7343
    • Moon, Y.A.1    Horton, J.D.2
  • 6
    • 0001819717 scopus 로고
    • Fatty acid desaturation and chain elongation in eucaryotes
    • D. E. Vance and J. E. Vance, eds. Benjamin Cummings Publishing Co., Don Mill, ON
    • Cook, H. W. 1985. Fatty acid desaturation and chain elongation in eucaryotes. In Biochemistry of Lipids and Membranes. D. E. Vance and J. E. Vance, eds. Benjamin Cummings Publishing Co., Don Mill, ON. 181-212.
    • (1985) Biochemistry of Lipids and Membranes , pp. 181-212
    • Cook, H.W.1
  • 8
    • 21744446895 scopus 로고    scopus 로고
    • Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases
    • Wang, Y., D. Botolin, B. Christian, J. Busik, J. Xu, and D. B. Jump. 2005. Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. J. Lipid Res. 46: 706-715.
    • (2005) J. Lipid Res. , vol.46 , pp. 706-715
    • Wang, Y.1    Botolin, D.2    Christian, B.3    Busik, J.4    Xu, J.5    Jump, D.B.6
  • 9
    • 0035977004 scopus 로고    scopus 로고
    • Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
    • Moon, Y. A., N. A. Shah, S. Mohapatra, J. A. Warrington, and J. D. Horton. 2001. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J. Biol. Chem. 276: 45358-45366.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45358-45366
    • Moon, Y.A.1    Shah, N.A.2    Mohapatra, S.3    Warrington, J.A.4    Horton, J.D.5
  • 10
    • 50949112066 scopus 로고    scopus 로고
    • Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition
    • Wang, Y., M. Torres-Gonzalez, S. Tripathy, D. Botolin, B. Christian, and D. B. Jump. 2008. Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition. J. Lipid Res. 49: 1538-1552.
    • (2008) J. Lipid Res. , vol.49 , pp. 1538-1552
    • Wang, Y.1    Torres-Gonzalez, M.2    Tripathy, S.3    Botolin, D.4    Christian, B.5    Jump, D.B.6
  • 11
    • 0034686664 scopus 로고    scopus 로고
    • Metabolism of highly unsaturated n-3 and n-6 fatty acids
    • Sprecher, H. 2000. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim. Biophys. Acta. 1486: 219-231.
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 219-231
    • Sprecher, H.1
  • 14
    • 43249114663 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    • Jump, D. B. 2008. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr. Opin. Lipidol. 19: 242-247.
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 242-247
    • Jump, D.B.1
  • 15
    • 1542344471 scopus 로고    scopus 로고
    • Fatty acid regulation of gene transcription
    • Jump, D. B. 2004. Fatty acid regulation of gene transcription. Crit. Rev. Clin. Lab. Sci. 41: 41-78.
    • (2004) Crit. Rev. Clin. Lab. Sci. , vol.41 , pp. 41-78
    • Jump, D.B.1
  • 17
    • 64149083800 scopus 로고    scopus 로고
    • Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
    • Moon, Y. A., R. E. Hammer, and J. D. Horton. 2008. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J. Lipid Res. 50: 412-423.
    • (2008) J. Lipid Res. , vol.50 , pp. 412-423
    • Moon, Y.A.1    Hammer, R.E.2    Horton, J.D.3
  • 18
    • 70350464163 scopus 로고    scopus 로고
    • Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha
    • Yang, J., X. Kong, M. E. Martins-Santos, G. Aleman, E. Chaco, G. E. Liu, S. Y. Wu, D. Samols, P. Hakimi, C. M. Chiang, et al. 2009. Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. J. Biol. Chem. 284: 27042-27053.
    • (2009) J. Biol. Chem. , vol.284 , pp. 27042-27053
    • Yang, J.1    Kong, X.2    Martins-Santos, M.E.3    Aleman, G.4    Chaco, E.5    Liu, G.E.6    Wu, S.Y.7    Samols, D.8    Hakimi, P.9    Chiang, C.M.10
  • 19
    • 0242349197 scopus 로고    scopus 로고
    • Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): Requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    • Rhee, J., Y. Inoue, J. C. Yoon, P. Puigserver, M. Fan, F. J. Gonzalez, and B. M. Spiegelman. 2003. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc. Natl. Acad. Sci. USA. 100: 4012-4017.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4012-4017
    • Rhee, J.1    Inoue, Y.2    Yoon, J.C.3    Puigserver, P.4    Fan, M.5    Gonzalez, F.J.6    Spiegelman, B.M.7
  • 20
    • 33744515637 scopus 로고    scopus 로고
    • FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
    • Zhang, W., S. Patil, B. Chauhan, S. Guo, D. R. Powell, J. Le, A. Klotsas, R. Matika, X. Xiao, R. Franks, et al. 2006. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281: 10105-10117.
    • (2006) J. Biol. Chem. , vol.281 , pp. 10105-10117
    • Zhang, W.1    Patil, S.2    Chauhan, B.3    Guo, S.4    Powell, D.R.5    Le, J.6    Klotsas, A.7    Matika, R.8    Xiao, X.9    Franks, R.10
  • 21
    • 26644472453 scopus 로고    scopus 로고
    • Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit
    • Cassuto, H., K. Kochan, K. Chakravarty, H. Cohen, B. Blum, Y. Olswang, P. Hakimi, C. Xu, D. Massillon, R. W. Hanson, et al. 2005. Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. J. Biol. Chem. 280: 33873-33884.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33873-33884
    • Cassuto, H.1    Kochan, K.2    Chakravarty, K.3    Cohen, H.4    Blum, B.5    Olswang, Y.6    Hakimi, P.7    Xu, C.8    Massillon, D.9    Hanson, R.W.10
  • 25
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    • Matsumoto, M., A. Pocai, L. Rossetti, R. A. Depinho, and D. Accili. 2007. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 6: 208-216.
    • (2007) Cell Metab , vol.6 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 26
    • 4544312844 scopus 로고    scopus 로고
    • Proteasomal degradation of FoxO1 transcriptional regulator in cells transformed by P3K and Akt oncoproteins
    • Aoki, M., H. Jiang, and P. K. Vogt. 2004. Proteasomal degradation of FoxO1 transcriptional regulator in cells transformed by P3K and Akt oncoproteins. Proc. Natl. Acad. Sci. USA. 101: 13613-13617.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13613-13617
    • Aoki, M.1    Jiang, H.2    Vogt, P.K.3
  • 27
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • Guo, S., G. Rena, S. Cichy, X. He, P. Cohen, and T. Unterman. 1999. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J. Biol. Chem. 274: 17184-17192.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17184-17192
    • Guo, S.1    Rena, G.2    Cichy, S.3    He, X.4    Cohen, P.5    Unterman, T.6
  • 31
    • 65349111390 scopus 로고    scopus 로고
    • Synthesis and characterization of a BODIPY-labeled derivative of Soraphen a that binds to acetyl-CoA carboxylase
    • Raymer, B., M. Kavana, A. Price, B. Wang, L. Corcoran, R. Kulathila, J. Groarke, and T. Mann. 2009. Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase. Bioorg. Med. Chem. Lett. 19: 2804-2807.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2804-2807
    • Raymer, B.1    Kavana, M.2    Price, A.3    Wang, B.4    Corcoran, L.5    Kulathila, R.6    Groarke, J.7    Mann, T.8
  • 32
    • 0037342151 scopus 로고    scopus 로고
    • Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
    • Daitoku, H., K. Yamagata, H. Matsuzaki, M. Hatta, and A. Fukamizu. 2003. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes. 52: 642-649.
    • (2003) Diabetes , vol.52 , pp. 642-649
    • Daitoku, H.1    Yamagata, K.2    Matsuzaki, H.3    Hatta, M.4    Fukamizu, A.5
  • 33
  • 34
    • 0038242819 scopus 로고    scopus 로고
    • TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
    • Du, K., S. Herzig, R. N. Kulkarni, and M. Montminy. 2003. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 300: 1574-1577.
    • (2003) Science , vol.300 , pp. 1574-1577
    • Du, K.1    Herzig, S.2    Kulkarni, R.N.3    Montminy, M.4
  • 35
    • 0035850916 scopus 로고    scopus 로고
    • Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
    • Maira, S. M., I. Galetic, D. P. Brazil, S. Kaech, E. Ingley, M. Thelen, and B. A. Hemmings. 2001. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science. 294: 374-380.
    • (2001) Science , vol.294 , pp. 374-380
    • Maira, S.M.1    Galetic, I.2    Brazil, D.P.3    Kaech, S.4    Ingley, E.5    Thelen, M.6    Hemmings, B.A.7
  • 36
    • 4544314719 scopus 로고    scopus 로고
    • Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3L1 adipocytes
    • Ugi, S., T. Imamura, H. Maegawa, K. Egawa, T. Yoshizaki, K. Shi, T. Obata, Y. Ebina, A. Kashiwagi, and J. M. Olefsky. 2004. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3L1 adipocytes. Mol. Cell. Biol. 24: 8778-8789.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8778-8789
    • Ugi, S.1    Imamura, T.2    Maegawa, H.3    Egawa, K.4    Yoshizaki, T.5    Shi, K.6    Obata, T.7    Ebina, Y.8    Kashiwagi, A.9    Olefsky, J.M.10
  • 38
    • 0026786471 scopus 로고
    • Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
    • Chen, J., B. L. Martin, and D. L. Brautigan. 1992. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science. 257: 1261-1264.
    • (1992) Science , vol.257 , pp. 1261-1264
    • Chen, J.1    Martin, B.L.2    Brautigan, D.L.3
  • 40
    • 0141592581 scopus 로고    scopus 로고
    • Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes
    • Pawar, A., and D. B. Jump. 2003. Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes. J. Biol. Chem. 278: 35931-35939.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35931-35939
    • Pawar, A.1    Jump, D.B.2
  • 41
    • 0037088677 scopus 로고    scopus 로고
    • The biochemistry of n-3 polyunsaturated fatty acids
    • Jump, D. B. 2002. The biochemistry of n-3 polyunsaturated fatty acids. J. Biol. Chem. 277: 8755-8758.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8755-8758
    • Jump, D.B.1
  • 42
    • 0035813215 scopus 로고    scopus 로고
    • Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition
    • Stulnig, T. M., J. Huber, N. Leitinger, E. M. Imre, P. Angelisova, P. Nowotny, and W. Waldhausl. 2001. Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition. J. Biol. Chem. 276: 37335-37340.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37335-37340
    • Stulnig, T.M.1    Huber, J.2    Leitinger, N.3    Imre, E.M.4    Angelisova, P.5    Nowotny, P.6    Waldhausl, W.7
  • 43
    • 33846898577 scopus 로고    scopus 로고
    • Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid
    • Chen, W., D. B. Jump, W. J. Esselman, and J. V. Busik. 2007. Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid. Invest. Ophthalmol. Vis. Sci. 48: 18-26.
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 18-26
    • Chen, W.1    Jump, D.B.2    Esselman, W.J.3    Busik, J.V.4
  • 44
    • 33644691914 scopus 로고    scopus 로고
    • Antiinfl ammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells
    • Chen, W., W. J. Esselman, D. B. Jump, and J. V. Busik. 2005. Antiinfl ammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. Invest. Ophthalmol. Vis. Sci. 46: 4342-4347.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 4342-4347
    • Chen, W.1    Esselman, W.J.2    Jump, D.B.3    Busik, J.V.4
  • 45
    • 0142200820 scopus 로고    scopus 로고
    • Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells
    • Chen, W., D. B. Jump, M. B. Grant, W. J. Esselman, and J. V. Busik. 2003. Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells. Invest. Ophthalmol. Vis. Sci. 44: 5016-5022.
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 5016-5022
    • Chen, W.1    Jump, D.B.2    Grant, M.B.3    Esselman, W.J.4    Busik, J.V.5
  • 46
    • 77449154762 scopus 로고    scopus 로고
    • Remodeling of retinal fatty acids in an animal model of diabetes. A decrease in long chain PUFA is associated with a decrease in fatty acid elongases Elovl2 and Elovl4
    • Tikhonenko, M., T. Lydic, Y. Wang, W. Chen, M. Opreanu, A. Sochacki, K. M. McSorley, R. L. Renis, T. Kern, D. B. Jump, et al. 2010. Remodeling of retinal fatty acids in an animal model of diabetes. A decrease in long chain PUFA is associated with a decrease in fatty acid elongases Elovl2 and Elovl4. Diabetes. 59: 219-227.
    • (2010) Diabetes , vol.59 , pp. 219-227
    • Tikhonenko, M.1    Lydic, T.2    Wang, Y.3    Chen, W.4    Opreanu, M.5    Sochacki, A.6    McSorley, K.M.7    Renis, R.L.8    Kern, T.9    Jump, D.B.10
  • 48
    • 20044370885 scopus 로고    scopus 로고
    • Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
    • Sakamoto, K., A. McCarthy, D. Smith, K. A. Green, D. Grahame Hardie, A. Ashworth, and D. R. Alessi. 2005. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 24: 1810-1820.
    • (2005) EMBO J , vol.24 , pp. 1810-1820
    • Sakamoto, K.1    McCarthy, A.2    Smith, D.3    Green, K.A.4    Grahame Hardie, D.5    Ashworth, A.6    Alessi, D.R.7
  • 50
    • 33947580628 scopus 로고    scopus 로고
    • Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver
    • Burgess, S. C., T. He, Z. Yan, J. Lindner, A. D. Sherry, C. R. Malloy, J. D. Browning, and M. A. Magnuson. 2007. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 5: 313-320.
    • (2007) Cell Metab , vol.5 , pp. 313-320
    • Burgess, S.C.1    He, T.2    Yan, Z.3    Lindner, J.4    Sherry, A.D.5    Malloy, C.R.6    Browning, J.D.7    Magnuson, M.A.8
  • 51
    • 33644769373 scopus 로고    scopus 로고
    • The greater contribution of gluconeogenesis to glucose production in obesity is related to increased wholebody protein catabolism
    • Chevalier, S., S. C. Burgess, C. R. Malloy, R. Gougeon, E. B. Marliss, and J. A. Morais. 2006. The greater contribution of gluconeogenesis to glucose production in obesity is related to increased wholebody protein catabolism. Diabetes. 55: 675-681.
    • (2006) Diabetes , vol.55 , pp. 675-681
    • Chevalier, S.1    Burgess, S.C.2    Malloy, C.R.3    Gougeon, R.4    Marliss, E.B.5    Morais, J.A.6
  • 54
    • 74949099984 scopus 로고    scopus 로고
    • Mammalian fatty acid elongases
    • Jump, D. B. 2009. Mammalian fatty acid elongases. Methods Mol. Biol. 579: 375-389.
    • (2009) Methods Mol. Biol. , vol.579 , pp. 375-389
    • Jump, D.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.