A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation

American Journal of Clinical Nutrition

Volumn 86, Issue 5, 2007, Pages 1286-1292

  Erridge, Clett ^a   Attina, Teresa ^b   Spickett, Corinne M ^a   Webb, David J ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Atherosclerosis; Diet; Endotoxin; Inflammation; Postprandial lipemia; Smoking

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ATHEROSCLEROSIS; BLOOD ANALYSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENDOTOXEMIA; HUMAN; HYPERLIPIDEMIA; INFLAMMATION; LIPID DIET; MALE; MONOCYTE; POSTPRANDIAL STATE; PROTEIN EXPRESSION; SMOKING;

BACTERIA (MICROORGANISMS); LIMULUS;

EID: 36249005027     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/86.5.1286     Document Type: Article

References (37)

1. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J 1999;138(suppl):S419-20.
2. Aljada A, Mohanty P, Ghanim H, et al. Increase in intranuclear nuclear factor κB and decrease in inhibitor κB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am J Clin Nutr 2004;79:682-90.
3. Blanco-Colio LM, Valderrama M, Alvarez-Sala LA, et al. Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation 2000;102:1020-6.
4. van Oostrom AJ, Rabelink TJ, Verseyden C, et al. Activation of leukocytes by postprandial lipemia in healthy volunteers. Atherosclerosis 2004;177:175-82.
5. van Oostrom AJ, Sijmonsma TP, Verseyden C, et al. Postprandial recruitment of neutrophils may contribute to endothelial dysfunction. J Lipid Res 2003;44:576-83.
6. van Wijk JP, Cabezas MC, Coll B, Joven J, Rabelink TJ, de Koning EJ. Effects of rosiglitazone on postprandial leukocytes and cytokines in type 2 diabetes. Atherosclerosis 2006;186:152-9.
7. Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 2002;39:1145-50.
8. Berg RD. The indigenous gastrointestinal microflora. Trends Microbiol 1996;4:430-5.
9. Wiedermann CI, Kiechl S, Dunzendorfer S, et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J Am Coll Cardiol 1999;34:1975-81.
10. Goto T, Eden S, Nordenstam G, Sundh V, Svanborg-Edin C, Matfsby-Baltzer I. Endotoxin levels in sera of elderly individuals. Clin Diagnost Lab Immunol 1994;1:684-8.
11. Hasday JD, Bascom R, Costa JJ, Fitzgerald T, Dubin W. Bacterial endotoxin is an active component of cigarette smoke. Chest 1999;115:829-35.
12. Bolke E, Jehle PM, Storck M, Nothnagel B, Stanescu A, Orth K. Endotoxin release and endotoxin neutralizing capacity during colonoscopy. Clin Chim Acta 2001;303:49-53.
13. Niebauer J, Volk HD, Kemp M, et al. Endotoxin and immune activation in chronic heart failure: a prospective cohort study. Lancet 1999;353:1838-42.
14. Stoll LL, Denning GM, Weintraub NL. Potential role of endotoxin as a proinflammatory mediator of atherosclerosis. Arterioscler Thromb Vasc Biol 2004;24:2227-36.
15. Greaves DR, Channon KM. Inflammation and immune responses in atherosclerosis. Trends Immunol 2002;23:535-41.
16. Funk JL, Feingold KR, Moser AH, Grunfeld C. Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation. Atherosclerosis 1993;98:67-82.
17. Ostos MA, Recalde D, Zakin MM, Scott-Algara D. Implication of natural killer T cells in atherosclerosis development during a LPS-induced chronic inflammation. FEBS Lett 2002;519:23-9.
18. Lehr HA, Sagban TA, Ihling C, et al. Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet. Circulation 2001;104:914-20.
19. Michelson KS, Wong MH, Shah PK, et al. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 2004;101:10679-84.
20. Rao RK, Seth A, Sheth P. Recent advances in alcoholic liver disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2004;286:881-4.
21. Hiki N, Berger D, Dentener MA, et al. Changes in endotoxin-binding proteins during major elective surgery: important role for soluble CD14 in regulation of biological activity of systemic endotoxin. Clin Diagnost Lab Immunol 1999;6:844-50.
22. Erridge C, Stewart J, Poxton IR. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in LPS signalling. J Exp Med 2003;197:1787-91.
23. Leitinger N, Tyner TR, Oslund L, et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci U S A 1999;96:12010-5.
24. Windsor JA, Fearon KCH, Ross JA, et al. Role of serum endotoxin and antiendotoxin core antibody levels in predicting the development of multiple organ failure in acute pancreatitis. Br J Surg 1993;80:1042-6.
25. van Deventer SJ, Buller HR, ten Cate JW, Aarden LA, Hack CE, Sturk A. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways. Blood 1990;76:2520-6.
26. Goto H, Rylander R. Kinetics of inhaled lipopolysaccharide in the guinea pig. J Lab Clin Med 1987;110:287-91.
27. Jeukendrup AE, Vet-Joop K, Sturk A, et al. Relationship between gastrointestinal complaints and endotoxemia, cytokine release and the acutephase reaction during and after a long-distance triathlon in highly trained men. Clin Sci 2000;98:47-55.
28. Urbaschek R, McCuskey RS, Rudi V, et al. Endotoxin, endotoxinneutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease. Alcohol Clin Exp Res 2001;25:261-8.
29. Brun P, Castagliuolo I, Di Leo V, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G518-25.
30. Yoshimatsu M, Terasaki Y, Sakashita N, et al. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. J Exp Pathol 2004;85:335-43.
31. Rice JB, Stoll LL, Li WG, et al. Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. Arterioscler Thromb Vasc Biol 2003;23:1576-82.
32. Skoog T, Dichtl W, Boquist S, et al. Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men. Eur Heart J 2002;23:376-83.
33. Bellido C, Lopez-Miranda J, Blanco-Colio LM, et al. Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor κB in peripheral blood mononuclear cells from healthy men. Am J Clin Nutr 2004;80:1487-91.
34. Leite MS, Pacheco P, Gomes RN, et al. Mechanisms of increased survival after lipopolysaccharide-induced endotoxic shock in mice consuming olive oil-enriched diet. Shock 2005;23:173-8.
35. Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol 2005;175:3339-46.
36. Kim F, Pham M, Luttrell I, et al. Toll like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 2007;100:1589-96.
37. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007;56:1761-72.