-
1
-
-
0028821439
-
Heme binds to a short sequence that serves a regulatory function in diverse proteins
-
Zhang L., Guarente L. Heme binds to a short sequence that serves a regulatory function in diverse proteins. EMBO J. 1995, 14:313-320.
-
(1995)
EMBO J.
, vol.14
, pp. 313-320
-
-
Zhang, L.1
Guarente, L.2
-
2
-
-
0141963861
-
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels
-
Tang X.D., et al. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature 2003, 425:531-535.
-
(2003)
Nature
, vol.425
, pp. 531-535
-
-
Tang, X.D.1
-
3
-
-
3343024625
-
Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
-
Kaasik K., Lee C.C. Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. Nature 2004, 430:467-471.
-
(2004)
Nature
, vol.430
, pp. 467-471
-
-
Kaasik, K.1
Lee, C.C.2
-
4
-
-
36849084107
-
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
-
Raghuram S., et al. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat. Struct. Mol. Biol. 2007, 14:1207-1213.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 1207-1213
-
-
Raghuram, S.1
-
5
-
-
84908157635
-
Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography
-
Kuhl T., Imhof D. Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography. Chembiochem 2014, 15:2024-2035.
-
(2014)
Chembiochem
, vol.15
, pp. 2024-2035
-
-
Kuhl, T.1
Imhof, D.2
-
6
-
-
19444386445
-
Free heme toxicity and its detoxification systems in human
-
Kumar S., Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol. Lett. 2005, 157:175-188.
-
(2005)
Toxicol. Lett.
, vol.157
, pp. 175-188
-
-
Kumar, S.1
Bandyopadhyay, U.2
-
7
-
-
84874439878
-
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
-
Schaer D.J., et al. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 2013, 121:1276-1284.
-
(2013)
Blood
, vol.121
, pp. 1276-1284
-
-
Schaer, D.J.1
-
8
-
-
0008239743
-
Accelerated autoxidation and heme loss due to instability of sickle hemoglobin
-
Hebbel R.P., et al. Accelerated autoxidation and heme loss due to instability of sickle hemoglobin. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:237-241.
-
(1988)
Proc. Natl. Acad. Sci. U.S.A.
, vol.85
, pp. 237-241
-
-
Hebbel, R.P.1
-
9
-
-
33846476692
-
Methemoglobin - it's not just blue: a concise review
-
Umbreit J. Methemoglobin - it's not just blue: a concise review. Am. J. Hematol. 2007, 82:134-144.
-
(2007)
Am. J. Hematol.
, vol.82
, pp. 134-144
-
-
Umbreit, J.1
-
10
-
-
0027358877
-
Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage
-
Balla J., et al. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:9285-9289.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 9285-9289
-
-
Balla, J.1
-
11
-
-
0035885926
-
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase
-
Wagener F.A., et al. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood 2001, 98:1802-1811.
-
(2001)
Blood
, vol.98
, pp. 1802-1811
-
-
Wagener, F.A.1
-
12
-
-
0041967387
-
Different faces of the heme-heme oxygenase system in inflammation
-
Wagener F.A., et al. Different faces of the heme-heme oxygenase system in inflammation. Pharmacol. Rev. 2003, 55:551-571.
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 551-571
-
-
Wagener, F.A.1
-
13
-
-
28944447412
-
Hemoglobin and heme scavenging
-
Ascenzi P., et al. Hemoglobin and heme scavenging. IUBMB Life 2005, 57:749-759.
-
(2005)
IUBMB Life
, vol.57
, pp. 749-759
-
-
Ascenzi, P.1
-
14
-
-
84980319854
-
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
-
Chiabrando D., et al. Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes. Front. Pharmacol. 2014, 5:61.
-
(2014)
Front. Pharmacol.
, vol.5
, pp. 61
-
-
Chiabrando, D.1
-
15
-
-
77449098529
-
Serum heme-albumin: an allosteric protein
-
Ascenzi P., Fasano M. Serum heme-albumin: an allosteric protein. IUBMB Life 2009, 61:1118-1122.
-
(2009)
IUBMB Life
, vol.61
, pp. 1118-1122
-
-
Ascenzi, P.1
Fasano, M.2
-
16
-
-
84859712543
-
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
-
Baek J.H., et al. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J. Clin. Invest. 2012, 122:1444-1458.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1444-1458
-
-
Baek, J.H.1
-
17
-
-
84940029623
-
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders
-
Smith A., McCulloh R.J. Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders. Front. Physiol. 2015, 6:187.
-
(2015)
Front. Physiol.
, vol.6
, pp. 187
-
-
Smith, A.1
McCulloh, R.J.2
-
18
-
-
84875475916
-
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases
-
Vinchi F., et al. Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases. Circulation 2013, 127:1317-1329.
-
(2013)
Circulation
, vol.127
, pp. 1317-1329
-
-
Vinchi, F.1
-
19
-
-
84946195292
-
Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity
-
Deuel J.W., et al. Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity. Free Rad. Biol. Med. 2015, 89:931-943.
-
(2015)
Free Rad. Biol. Med.
, vol.89
, pp. 931-943
-
-
Deuel, J.W.1
-
20
-
-
0014360531
-
Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases
-
Muller-Eberhard U., et al. Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood 1968, 32:811-815.
-
(1968)
Blood
, vol.32
, pp. 811-815
-
-
Muller-Eberhard, U.1
-
21
-
-
0014713324
-
Disposal of plasma heme in normal man and patients with intravascular hemolysis
-
Sears D.A. Disposal of plasma heme in normal man and patients with intravascular hemolysis. J. Clin. Invest. 1970, 49:5-14.
-
(1970)
J. Clin. Invest.
, vol.49
, pp. 5-14
-
-
Sears, D.A.1
-
22
-
-
0019073710
-
Kinetics and mechanism of the interaction between human serum albumin and monomeric haemin
-
Adams P.A., Berman M.C. Kinetics and mechanism of the interaction between human serum albumin and monomeric haemin. Biochem. J. 1980, 191:95-102.
-
(1980)
Biochem. J.
, vol.191
, pp. 95-102
-
-
Adams, P.A.1
Berman, M.C.2
-
23
-
-
7944227387
-
The lipocalin alpha1-microglobulin binds heme in different species
-
Larsson J., et al. The lipocalin alpha1-microglobulin binds heme in different species. Arch. Biochem. Biophys. 2004, 432:196-204.
-
(2004)
Arch. Biochem. Biophys.
, vol.432
, pp. 196-204
-
-
Larsson, J.1
-
24
-
-
84931271446
-
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vaso-occlusions in sickle cell disease
-
Camus S.M., et al. Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vaso-occlusions in sickle cell disease. Blood 2015, 125:3805-3814.
-
(2015)
Blood
, vol.125
, pp. 3805-3814
-
-
Camus, S.M.1
-
25
-
-
77949525185
-
Mechanisms of cell protection by heme oxygenase-1
-
Gozzelino R., et al. Mechanisms of cell protection by heme oxygenase-1. Annu. Rev. Pharmacol. Toxicol. 2010, 50:323-354.
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 323-354
-
-
Gozzelino, R.1
-
26
-
-
34547120742
-
Characterization of heme as activator of Toll-like receptor 4
-
Figueiredo R.T., et al. Characterization of heme as activator of Toll-like receptor 4. J. Biol. Chem. 2007, 282:20221-20229.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20221-20229
-
-
Figueiredo, R.T.1
-
27
-
-
84894567032
-
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
-
Belcher J.D., et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 2014, 123:377-390.
-
(2014)
Blood
, vol.123
, pp. 377-390
-
-
Belcher, J.D.1
-
28
-
-
84907546730
-
Hemolysis-induced lethality involves inflammasome activation by heme
-
Dutra F.F., et al. Hemolysis-induced lethality involves inflammasome activation by heme. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:E4110-E4118.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. E4110-E4118
-
-
Dutra, F.F.1
-
29
-
-
41149102924
-
Coagulation in the pathophysiology of hemolytic anemias
-
Cappellini M.D. Coagulation in the pathophysiology of hemolytic anemias. Hematology 2007, 74-78.
-
(2007)
Hematology
, pp. 74-78
-
-
Cappellini, M.D.1
-
30
-
-
84883275259
-
Hemostatic abnormalities in sickle cell disease
-
Lim M.Y., et al. Hemostatic abnormalities in sickle cell disease. Curr. Opin. Hematol. 2013, 20:472-477.
-
(2013)
Curr. Opin. Hematol.
, vol.20
, pp. 472-477
-
-
Lim, M.Y.1
-
31
-
-
84890549289
-
Coagulopathy in malaria
-
Angchaisuksiri P. Coagulopathy in malaria. Thromb. Res. 2014, 133:5-9.
-
(2014)
Thromb. Res.
, vol.133
, pp. 5-9
-
-
Angchaisuksiri, P.1
-
32
-
-
84887457415
-
Extracellular hemin crisis triggers acute chest syndrome in sickle mice
-
Ghosh S., et al. Extracellular hemin crisis triggers acute chest syndrome in sickle mice. J. Clin. Invest. 2013, 123:4809-4820.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 4809-4820
-
-
Ghosh, S.1
-
33
-
-
84880923632
-
Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome
-
Frimat M., et al. Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome. Blood 2013, 122:282-292.
-
(2013)
Blood
, vol.122
, pp. 282-292
-
-
Frimat, M.1
-
34
-
-
84894451322
-
The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status
-
Rayes J., et al. The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status. Blood 2014, 123:121-125.
-
(2014)
Blood
, vol.123
, pp. 121-125
-
-
Rayes, J.1
-
35
-
-
0021254826
-
Effect of hematin on endothelial cells and endothelial cell-platelet interactions
-
Neely S.M., et al. Effect of hematin on endothelial cells and endothelial cell-platelet interactions. Am. J. Pathol. 1984, 115:390-396.
-
(1984)
Am. J. Pathol.
, vol.115
, pp. 390-396
-
-
Neely, S.M.1
-
36
-
-
84930181394
-
Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease
-
Lu R.N., et al. Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease. J. Thromb. Haemost. 2015, 13:1064-1072.
-
(2015)
J. Thromb. Haemost.
, vol.13
, pp. 1064-1072
-
-
Lu, R.N.1
-
37
-
-
0023021344
-
The interaction of the factor VIII/von Willebrand factor complex with hematin
-
Green D., et al. The interaction of the factor VIII/von Willebrand factor complex with hematin. Thromb. Haemost. 1986, 56:277-282.
-
(1986)
Thromb. Haemost.
, vol.56
, pp. 277-282
-
-
Green, D.1
-
38
-
-
0020696961
-
Hematin: unique effects of hemostasis
-
Glueck R., et al. Hematin: unique effects of hemostasis. Blood 1983, 61:243-249.
-
(1983)
Blood
, vol.61
, pp. 243-249
-
-
Glueck, R.1
-
39
-
-
0021149876
-
Mechanism and characteristics of platelet activation by haematin
-
Neely S.M., et al. Mechanism and characteristics of platelet activation by haematin. Br. J. Haematol. 1984, 58:305-316.
-
(1984)
Br. J. Haematol.
, vol.58
, pp. 305-316
-
-
Neely, S.M.1
-
40
-
-
0019510007
-
Treatment with haematin in acute hepatic porphyria
-
McColl K.E., et al. Treatment with haematin in acute hepatic porphyria. Quart. J. Med. 1981, 50:161-174.
-
(1981)
Quart. J. Med.
, vol.50
, pp. 161-174
-
-
McColl, K.E.1
-
41
-
-
0019771271
-
Coagulopathy associated with hematin treatment for acute intermittent porphyria
-
Morris D.L., et al. Coagulopathy associated with hematin treatment for acute intermittent porphyria. Ann. Intern. Med. 1981, 95:700-701.
-
(1981)
Ann. Intern. Med.
, vol.95
, pp. 700-701
-
-
Morris, D.L.1
-
42
-
-
84861715437
-
Heme binds to factor VIII and inhibits its interaction with activated factor IX
-
Repesse Y., et al. Heme binds to factor VIII and inhibits its interaction with activated factor IX. J. Thromb. Haemost. 2012, 10:1062-1071.
-
(2012)
J. Thromb. Haemost.
, vol.10
, pp. 1062-1071
-
-
Repesse, Y.1
-
43
-
-
0032402122
-
The life cycle of coagulation factor VIII in view of its structure and function
-
Lenting P.J., et al. The life cycle of coagulation factor VIII in view of its structure and function. Blood 1998, 92:3983-3996.
-
(1998)
Blood
, vol.92
, pp. 3983-3996
-
-
Lenting, P.J.1
-
44
-
-
79960697365
-
Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report
-
Nielsen V.G., et al. Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report. Blood Coagul. Fibrinolysis 2011, 22:443-447.
-
(2011)
Blood Coagul. Fibrinolysis
, vol.22
, pp. 443-447
-
-
Nielsen, V.G.1
-
45
-
-
0020513314
-
The inactivation of hemostatic factors by hematin
-
Green D., et al. The inactivation of hemostatic factors by hematin. J. Lab. Clin. Med. 1983, 102:361-369.
-
(1983)
J. Lab. Clin. Med.
, vol.102
, pp. 361-369
-
-
Green, D.1
-
46
-
-
0023755912
-
Thrombophlebitis and disturbed hemostasis following administration of intravenous hematin in normal volunteers
-
Simionatto C.S., et al. Thrombophlebitis and disturbed hemostasis following administration of intravenous hematin in normal volunteers. Am. J. Med. 1988, 85:538-540.
-
(1988)
Am. J. Med.
, vol.85
, pp. 538-540
-
-
Simionatto, C.S.1
-
47
-
-
0022572359
-
Hematin-derived anticoagulant. Generation in vitro and in vivo
-
Jones R.L. Hematin-derived anticoagulant. Generation in vitro and in vivo. J. Exp. Med. 1986, 163:724-739.
-
(1986)
J. Exp. Med.
, vol.163
, pp. 724-739
-
-
Jones, R.L.1
-
48
-
-
0023899466
-
Heme arginate: effects on hemostasis
-
Volin L., et al. Heme arginate: effects on hemostasis. Blood 1988, 71:625-628.
-
(1988)
Blood
, vol.71
, pp. 625-628
-
-
Volin, L.1
-
49
-
-
0025263817
-
Hematin: effects on hemostasis
-
Green D., Ts'ao C.H. Hematin: effects on hemostasis. J. Lab. Clin. Med. 1990, 115:144-147.
-
(1990)
J. Lab. Clin. Med.
, vol.115
, pp. 144-147
-
-
Green, D.1
Ts'ao, C.H.2
-
50
-
-
56749170891
-
Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia
-
Setty B.N., et al. Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia. J. Thromb. Haemost. 2008, 6:2202-2209.
-
(2008)
J. Thromb. Haemost.
, vol.6
, pp. 2202-2209
-
-
Setty, B.N.1
-
51
-
-
84924703145
-
Excess of heme induces tissue factor-dependent activation of coagulation in mice
-
Sparkenbaugh E.M., et al. Excess of heme induces tissue factor-dependent activation of coagulation in mice. Haematologica 2015, 100:308-314.
-
(2015)
Haematologica
, vol.100
, pp. 308-314
-
-
Sparkenbaugh, E.M.1
-
52
-
-
7044245628
-
The appearance and disappearance of antiphospholipid autoantibodies subsequent to oxidation-reduction reactions
-
McIntyre J.A. The appearance and disappearance of antiphospholipid autoantibodies subsequent to oxidation-reduction reactions. Thromb. Res. 2004, 114:579-587.
-
(2004)
Thromb. Res.
, vol.114
, pp. 579-587
-
-
McIntyre, J.A.1
-
53
-
-
20144365035
-
Autoantibodies unmasked by redox reactions
-
McIntyre J.A., et al. Autoantibodies unmasked by redox reactions. J. Autoimmun. 2005, 24:311-317.
-
(2005)
J. Autoimmun.
, vol.24
, pp. 311-317
-
-
McIntyre, J.A.1
-
54
-
-
83455228517
-
Autoimmune reactivity of IgM acquired after oxidation
-
Omersel J., et al. Autoimmune reactivity of IgM acquired after oxidation. Redox. Rep. 2011, 16:248-256.
-
(2011)
Redox. Rep.
, vol.16
, pp. 248-256
-
-
Omersel, J.1
-
55
-
-
28744455410
-
Redox-reactive autoantibodies: detection and physiological relevance
-
McIntyre J.A., et al. Redox-reactive autoantibodies: detection and physiological relevance. Autoimmun. Rev. 2006, 5:76-83.
-
(2006)
Autoimmun. Rev.
, vol.5
, pp. 76-83
-
-
McIntyre, J.A.1
-
56
-
-
34848859317
-
Antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions
-
Dimitrov J.D., et al. Antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions. J. Biol. Chem. 2007, 282:26696-26706.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26696-26706
-
-
Dimitrov, J.D.1
-
57
-
-
77953694372
-
Autoantibody potential of cancer therapeutic monoclonal antibodies
-
McIntyre J.A., Faulk A.W. Autoantibody potential of cancer therapeutic monoclonal antibodies. Int. J. Cancer 2010, 127:491-496.
-
(2010)
Int. J. Cancer
, vol.127
, pp. 491-496
-
-
McIntyre, J.A.1
Faulk, A.W.2
-
58
-
-
84903485204
-
A cryptic polyreactive antibody recognizes distinct clades of HIV-1 glycoprotein 120 by an identical binding mechanism
-
Dimitrov J.D., et al. A cryptic polyreactive antibody recognizes distinct clades of HIV-1 glycoprotein 120 by an identical binding mechanism. J. Biol. Chem. 2014, 289:17767-17779.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 17767-17779
-
-
Dimitrov, J.D.1
-
59
-
-
70350436670
-
Redox-reactive autoantibodies: biochemistry, characterization, and specificities
-
McIntyre J.A., Faulk W.P. Redox-reactive autoantibodies: biochemistry, characterization, and specificities. Clin. Rev. Allergy Immunol. 2009, 37:49-54.
-
(2009)
Clin. Rev. Allergy Immunol.
, vol.37
, pp. 49-54
-
-
McIntyre, J.A.1
Faulk, W.P.2
-
60
-
-
84925426576
-
Mechanism and functional implications of the heme-induced binding promiscuity of IgE
-
Hadzhieva M., et al. Mechanism and functional implications of the heme-induced binding promiscuity of IgE. Biochemistry 2015, 54:2061-2072.
-
(2015)
Biochemistry
, vol.54
, pp. 2061-2072
-
-
Hadzhieva, M.1
-
61
-
-
84925415904
-
Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity
-
Lecerf M., et al. Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity. J. Biol. Chem. 2015, 290:5203-5213.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 5203-5213
-
-
Lecerf, M.1
-
62
-
-
84946781326
-
Neutralization of Japanese encephalitis virus by heme-induced broadly reactive human monoclonal antibody
-
Gupta N., et al. Neutralization of Japanese encephalitis virus by heme-induced broadly reactive human monoclonal antibody. Sci. Rep. 2015, 5:16248.
-
(2015)
Sci. Rep.
, vol.5
, pp. 16248
-
-
Gupta, N.1
-
63
-
-
84899150270
-
Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma
-
Mahendra A., et al. Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma. Mol. Immunol. 2014, 60:54-61.
-
(2014)
Mol. Immunol.
, vol.60
, pp. 54-61
-
-
Mahendra, A.1
-
64
-
-
33644871684
-
Ferrous ions and reactive oxygen species increase antigen-binding and anti-inflammatory activities of immunoglobulin G
-
Dimitrov J.D., et al. Ferrous ions and reactive oxygen species increase antigen-binding and anti-inflammatory activities of immunoglobulin G. J. Biol. Chem. 2006, 281:439-446.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 439-446
-
-
Dimitrov, J.D.1
-
65
-
-
77955055848
-
Heterogeneous antigen recognition behavior of induced polyspecific antibodies
-
Dimitrov J.D., et al. Heterogeneous antigen recognition behavior of induced polyspecific antibodies. Biochem. Biophys. Res. Commun. 2010, 398:266-271.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.398
, pp. 266-271
-
-
Dimitrov, J.D.1
-
66
-
-
0030821164
-
Structural insights into the evolution of an antibody combining site
-
Wedemayer G.J., et al. Structural insights into the evolution of an antibody combining site. Science 1997, 276:1665-1669.
-
(1997)
Science
, vol.276
, pp. 1665-1669
-
-
Wedemayer, G.J.1
-
68
-
-
34848918252
-
Redox-reactive autoantibodies in cerebrospinal fluids
-
McIntyre J.A., et al. Redox-reactive autoantibodies in cerebrospinal fluids. Ann. N.Y. Acad. Sci. 2007, 1109:296-302.
-
(2007)
Ann. N.Y. Acad. Sci.
, vol.1109
, pp. 296-302
-
-
McIntyre, J.A.1
-
69
-
-
70449433880
-
Redox-reactive antiphospholipid antibody differences between serum from Alzheimer's patients and age-matched controls
-
McIntyre J.A., et al. Redox-reactive antiphospholipid antibody differences between serum from Alzheimer's patients and age-matched controls. Autoimmunity 2009, 42:646-652.
-
(2009)
Autoimmunity
, vol.42
, pp. 646-652
-
-
McIntyre, J.A.1
-
70
-
-
84942509989
-
Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease
-
McIntyre J.A., et al. Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease. Autoimmunity 2015, 48:344-351.
-
(2015)
Autoimmunity
, vol.48
, pp. 344-351
-
-
McIntyre, J.A.1
-
71
-
-
79251598193
-
Intravenous immunoglobulins exposed to heme (heme IVIG) are more efficient than IVIG in attenuating autoimmune diabetes
-
Pavlovic S., et al. Intravenous immunoglobulins exposed to heme (heme IVIG) are more efficient than IVIG in attenuating autoimmune diabetes. Clin. Immunol. 2011, 138:162-171.
-
(2011)
Clin. Immunol.
, vol.138
, pp. 162-171
-
-
Pavlovic, S.1
-
72
-
-
0018129333
-
Immunologic defect of the alternate pathway-of-complement activation postsplenectomy: a possible relation between splenectomy and infection
-
de Ciutiis A., et al. Immunologic defect of the alternate pathway-of-complement activation postsplenectomy: a possible relation between splenectomy and infection. J. Natl. Med. Assoc. 1978, 70:667-670.
-
(1978)
J. Natl. Med. Assoc.
, vol.70
, pp. 667-670
-
-
de Ciutiis, A.1
-
73
-
-
0029098827
-
Complement activation during painful crisis in sickle cell anemia
-
Mold C., et al. Complement activation during painful crisis in sickle cell anemia. Clin. Immunol. Immunopathol. 1995, 76:314-320.
-
(1995)
Clin. Immunol. Immunopathol.
, vol.76
, pp. 314-320
-
-
Mold, C.1
-
74
-
-
84899623435
-
Complement activation in malaria: friend or foe?
-
Biryukov S., Stoute J.A. Complement activation in malaria: friend or foe?. Trends Mol. Med. 2014, 20:293-301.
-
(2014)
Trends Mol. Med.
, vol.20
, pp. 293-301
-
-
Biryukov, S.1
Stoute, J.A.2
-
75
-
-
0021995681
-
Activation of factor XII-dependent pathways in human plasma by hematin and protoporphyrin
-
Becker C.G., et al. Activation of factor XII-dependent pathways in human plasma by hematin and protoporphyrin. J. Clin. Invest. 1985, 76:413-419.
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 413-419
-
-
Becker, C.G.1
-
76
-
-
0026581210
-
Effects of extraerythrocytic hemoglobin and its components on mononuclear cell procoagulant activity
-
Smith D.J., Winslow R.M. Effects of extraerythrocytic hemoglobin and its components on mononuclear cell procoagulant activity. J. Lab. Clin. Med. 1992, 119:176-182.
-
(1992)
J. Lab. Clin. Med.
, vol.119
, pp. 176-182
-
-
Smith, D.J.1
Winslow, R.M.2
-
77
-
-
38449088657
-
Hematin promotes complement alternative pathway-mediated deposition of C3 activation fragments on human erythrocytes: potential implications for the pathogenesis of anemia in malaria
-
Pawluczkowycz A.W., et al. Hematin promotes complement alternative pathway-mediated deposition of C3 activation fragments on human erythrocytes: potential implications for the pathogenesis of anemia in malaria. J. Immunol. 2007, 179:5543-5552.
-
(2007)
J. Immunol.
, vol.179
, pp. 5543-5552
-
-
Pawluczkowycz, A.W.1
-
78
-
-
0032773099
-
Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytes
-
Jakeman G.N., et al. Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytes. Parasitology 1999, 119:127-133.
-
(1999)
Parasitology
, vol.119
, pp. 127-133
-
-
Jakeman, G.N.1
-
79
-
-
84877829193
-
Plasmodium coatneyi in rhesus macaques replicates the multisystemic dysfunction of severe malaria in humans
-
Moreno A., et al. Plasmodium coatneyi in rhesus macaques replicates the multisystemic dysfunction of severe malaria in humans. Infect. Immun. 2013, 81:1889-1904.
-
(2013)
Infect. Immun.
, vol.81
, pp. 1889-1904
-
-
Moreno, A.1
-
80
-
-
33748904355
-
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
-
Hillmen P., et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. New Engl. J. Med. 2006, 355:1233-1243.
-
(2006)
New Engl. J. Med.
, vol.355
, pp. 1233-1243
-
-
Hillmen, P.1
-
81
-
-
65449188713
-
Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab
-
Risitano A.M., et al. Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab. Blood 2009, 113:4094-4100.
-
(2009)
Blood
, vol.113
, pp. 4094-4100
-
-
Risitano, A.M.1
-
82
-
-
84940023131
-
Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria
-
Lin Z., et al. Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria. Blood 2015, 126:891-894.
-
(2015)
Blood
, vol.126
, pp. 891-894
-
-
Lin, Z.1
-
83
-
-
0001644020
-
The human plasma proteome: history, character, and diagnostic prospects
-
Anderson N.L., Anderson N.G. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell. Proteomics 2002, 1:845-867.
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 845-867
-
-
Anderson, N.L.1
Anderson, N.G.2
-
84
-
-
17144418992
-
Platelet activation leads to activation and propagation of the complement system
-
Del Conde I., et al. Platelet activation leads to activation and propagation of the complement system. J. Exp. Med. 2005, 201:871-879.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 871-879
-
-
Del Conde, I.1
-
85
-
-
79960435714
-
Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis
-
Morigi M., et al. Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis. J. Immunol. 2011, 187:172-180.
-
(2011)
J. Immunol.
, vol.187
, pp. 172-180
-
-
Morigi, M.1
-
86
-
-
84935041763
-
Complement system part II. Role in immunity
-
Merle N.S., et al. Complement system part II. Role in immunity. Front. Immunol. 2015, 6:257.
-
(2015)
Front. Immunol.
, vol.6
, pp. 257
-
-
Merle, N.S.1
-
87
-
-
0022382427
-
Increased activation of the alternative complement pathway in sickle cell disease
-
Chudwin D.S., et al. Increased activation of the alternative complement pathway in sickle cell disease. Clin. Immunol. Immunopathol. 1985, 37:93-97.
-
(1985)
Clin. Immunol. Immunopathol.
, vol.37
, pp. 93-97
-
-
Chudwin, D.S.1
-
88
-
-
77957147176
-
Complement driven innate immune response to malaria: fuelling severe malarial diseases
-
Silver K.L., et al. Complement driven innate immune response to malaria: fuelling severe malarial diseases. Cell. Microbiol. 2010, 12:1036-1045.
-
(2010)
Cell. Microbiol.
, vol.12
, pp. 1036-1045
-
-
Silver, K.L.1
-
89
-
-
33847058366
-
Iron ions and haeme modulate the binding properties of complement subcomponent C1q and of immunoglobulins
-
Dimitrov J.D., et al. Iron ions and haeme modulate the binding properties of complement subcomponent C1q and of immunoglobulins. Scand. J. Immunol. 2007, 65:230-239.
-
(2007)
Scand. J. Immunol.
, vol.65
, pp. 230-239
-
-
Dimitrov, J.D.1
-
90
-
-
79955537165
-
Heme interacts with c1q and inhibits the classical complement pathway
-
Roumenina L.T., et al. Heme interacts with c1q and inhibits the classical complement pathway. J. Biol. Chem. 2011, 286:16459-16469.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16459-16469
-
-
Roumenina, L.T.1
-
91
-
-
84935118905
-
Complement system part I. Molecular mechanisms of activation and regulation
-
Merle N.S., et al. Complement system part I. Molecular mechanisms of activation and regulation. Front. Immunol. 2015, 6:262.
-
(2015)
Front. Immunol.
, vol.6
, pp. 262
-
-
Merle, N.S.1
-
92
-
-
84908376176
-
Red blood cell, hemoglobin and heme in the progression of atherosclerosis
-
Jeney V., et al. Red blood cell, hemoglobin and heme in the progression of atherosclerosis. Front. Physiol. 2014, 5:379.
-
(2014)
Front. Physiol.
, vol.5
, pp. 379
-
-
Jeney, V.1
-
93
-
-
0031697123
-
Expression of heme oxygenase-1 can determine cardiac xenograft survival
-
Soares M.P., et al. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat. Med. 1998, 4:1073-1077.
-
(1998)
Nat. Med.
, vol.4
, pp. 1073-1077
-
-
Soares, M.P.1
-
94
-
-
33646356719
-
Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway
-
Kim J.H., et al. Heme oxygenase-1 protects rat kidney from ureteral obstruction via an antiapoptotic pathway. J. Am. Soc. Nephrol. 2006, 17:1373-1381.
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1373-1381
-
-
Kim, J.H.1
-
95
-
-
84869118509
-
Transcriptome analysis of renal ischemia/reperfusion injury and its modulation by ischemic pre-conditioning or hemin treatment
-
Correa-Costa M., et al. Transcriptome analysis of renal ischemia/reperfusion injury and its modulation by ischemic pre-conditioning or hemin treatment. PLoS ONE 2012, 7:e49569.
-
(2012)
PLoS ONE
, vol.7
, pp. e49569
-
-
Correa-Costa, M.1
-
96
-
-
84864428068
-
Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects
-
Andreas M., et al. Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects. J. Cardiovas. Magn. Res. 2012, 14:55.
-
(2012)
J. Cardiovas. Magn. Res.
, vol.14
, pp. 55
-
-
Andreas, M.1
-
97
-
-
84952334326
-
Hemin preconditioning upregulates heme oxygenase-1 in deceased donor renal transplant recipients: a randomized, controlled, phase IIB trial
-
Thomas R.A., et al. Hemin preconditioning upregulates heme oxygenase-1 in deceased donor renal transplant recipients: a randomized, controlled, phase IIB trial. Transplantation 2016, 100:176-183.
-
(2016)
Transplantation
, vol.100
, pp. 176-183
-
-
Thomas, R.A.1
-
98
-
-
84950326846
-
Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: a translational cross-over study
-
Dekker D., et al. Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: a translational cross-over study. Diabetes Vasc. Dis. Res. 2016, 13:41-48.
-
(2016)
Diabetes Vasc. Dis. Res.
, vol.13
, pp. 41-48
-
-
Dekker, D.1
-
99
-
-
78650420124
-
Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice
-
Burgess A., et al. Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice. Hypertension 2010, 56:1124-1130.
-
(2010)
Hypertension
, vol.56
, pp. 1124-1130
-
-
Burgess, A.1
-
100
-
-
84885324545
-
Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes
-
Ndisang J.F., Jadhav A. Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. Diabetes Obes. Metabol. 2013, 15:1029-1039.
-
(2013)
Diabetes Obes. Metabol.
, vol.15
, pp. 1029-1039
-
-
Ndisang, J.F.1
Jadhav, A.2
-
101
-
-
84896950203
-
Plasma signature of neurological disease in the monogenetic disorder Niemann-Pick type C
-
Alam M.S., et al. Plasma signature of neurological disease in the monogenetic disorder Niemann-Pick type C. J. Biol. Chem. 2014, 289:8051-8066.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 8051-8066
-
-
Alam, M.S.1
-
102
-
-
84899942981
-
Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation
-
Hada H., et al. Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation. Biochim. Biophys. Acta 2014, 1840:2351-2360.
-
(2014)
Biochim. Biophys. Acta
, vol.1840
, pp. 2351-2360
-
-
Hada, H.1
-
103
-
-
84866046917
-
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases
-
Larsen R., et al. Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front. Pharmacol. 2012, 3:77.
-
(2012)
Front. Pharmacol.
, vol.3
, pp. 77
-
-
Larsen, R.1
-
104
-
-
84878718784
-
Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia
-
Dong B., et al. Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia. BMC Neurosci. 2013, 14:58.
-
(2013)
BMC Neurosci.
, vol.14
, pp. 58
-
-
Dong, B.1
-
105
-
-
77955823775
-
Heme proteins - diversity in structural characteristics, function, and folding
-
Smith L.J., et al. Heme proteins - diversity in structural characteristics, function, and folding. Proteins 2010, 78:2349-2368.
-
(2010)
Proteins
, vol.78
, pp. 2349-2368
-
-
Smith, L.J.1
-
106
-
-
84926453297
-
A1 M/alpha1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation
-
Cederlund M., et al. A1 M/alpha1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation. Front. Physiol. 2015, 6:11.
-
(2015)
Front. Physiol.
, vol.6
, pp. 11
-
-
Cederlund, M.1
-
107
-
-
0032997659
-
Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation
-
Miller Y.I., Shaklai N. Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation. Biochim. Biophys. Acta 1999, 1454:153-164.
-
(1999)
Biochim. Biophys. Acta
, vol.1454
, pp. 153-164
-
-
Miller, Y.I.1
Shaklai, N.2
-
108
-
-
84939460546
-
Impact of heme and heme degradation products on vascular diameter in mouse visual cortex
-
Joerk A., et al. Impact of heme and heme degradation products on vascular diameter in mouse visual cortex. J. Am. Heart Assoc. 2014, 3:e001220.
-
(2014)
J. Am. Heart Assoc.
, vol.3
, pp. e001220
-
-
Joerk, A.1
-
109
-
-
0037085766
-
Processing of the lipocalin alpha1-microglobulin by hemoglobin induces heme-binding and heme-degradation properties
-
Allhorn M., et al. Processing of the lipocalin alpha1-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. Blood 2002, 99:1894-1901.
-
(2002)
Blood
, vol.99
, pp. 1894-1901
-
-
Allhorn, M.1
-
110
-
-
0033485566
-
Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice
-
Tolosano E., et al. Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Blood 1999, 94:3906-3914.
-
(1999)
Blood
, vol.94
, pp. 3906-3914
-
-
Tolosano, E.1
-
111
-
-
77958023093
-
A central role for free heme in the pathogenesis of severe sepsis
-
Larsen R., et al. A central role for free heme in the pathogenesis of severe sepsis. Sci. Transl. Med. 2010, 2:51ra71.
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 51ra71
-
-
Larsen, R.1
-
112
-
-
0024850694
-
Immune stimulatory properties of metalloporphyrins
-
Novogrodsky A., et al. Immune stimulatory properties of metalloporphyrins. J. Immunol. 1989, 143:3981-3987.
-
(1989)
J. Immunol.
, vol.143
, pp. 3981-3987
-
-
Novogrodsky, A.1
-
113
-
-
79956292375
-
Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2
-
Watanabe-Matsui M., et al. Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2. Blood 2011, 117:5438-5448.
-
(2011)
Blood
, vol.117
, pp. 5438-5448
-
-
Watanabe-Matsui, M.1
-
114
-
-
84858017083
-
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
-
Fortes G.B., et al. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood 2012, 119:2368-2375.
-
(2012)
Blood
, vol.119
, pp. 2368-2375
-
-
Fortes, G.B.1
-
115
-
-
84903637752
-
Hemin controls T cell polarization in sickle cell alloimmunization
-
Zhong H., et al. Hemin controls T cell polarization in sickle cell alloimmunization. J. Immunol. 2014, 193:102-110.
-
(2014)
J. Immunol.
, vol.193
, pp. 102-110
-
-
Zhong, H.1
-
116
-
-
0036624989
-
Neutrophil activation by heme: implications for inflammatory processes
-
Graca-Souza A.V., et al. Neutrophil activation by heme: implications for inflammatory processes. Blood 2002, 99:4160-4165.
-
(2002)
Blood
, vol.99
, pp. 4160-4165
-
-
Graca-Souza, A.V.1
-
117
-
-
34548226931
-
Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors
-
Porto B.N., et al. Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors. J. Biol. Chem. 2007, 282:24430-24436.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24430-24436
-
-
Porto, B.N.1
-
118
-
-
84902585238
-
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
-
Chen G., et al. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood 2014, 123:3818-3827.
-
(2014)
Blood
, vol.123
, pp. 3818-3827
-
-
Chen, G.1
-
119
-
-
84925868213
-
Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage
-
Kwon M.S., et al. Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage. Intl. J. Mol. Sci. 2015, 16:5028-5046.
-
(2015)
Intl. J. Mol. Sci.
, vol.16
, pp. 5028-5046
-
-
Kwon, M.S.1
-
120
-
-
84936817005
-
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1
-
Schallner N., et al. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J. Clin. Invest. 2015, 125:2609-2625.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 2609-2625
-
-
Schallner, N.1
-
121
-
-
34250008488
-
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
-
Pamplona A., et al. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat. Med. 2007, 13:703-710.
-
(2007)
Nat. Med.
, vol.13
, pp. 703-710
-
-
Pamplona, A.1
-
122
-
-
52549119182
-
A central role for free heme in the pathogenesis of severe malaria: the missing link?
-
Ferreira A., et al. A central role for free heme in the pathogenesis of severe malaria: the missing link?. J. Mol. Med. 2008, 86:1097-1111.
-
(2008)
J. Mol. Med.
, vol.86
, pp. 1097-1111
-
-
Ferreira, A.1
-
123
-
-
77955883153
-
Complement: a key system for immune surveillance and homeostasis
-
Ricklin D., et al. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 2010, 11:785-797.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 785-797
-
-
Ricklin, D.1
|