Fibrinogen is a heme-associated, carbon monoxide sensing molecule: A preliminary report

Blood Coagulation and Fibrinolysis

Volumn 22, Issue 5, 2011, Pages 443-447

  Nielsen, Vance G ^a   Cohen, Jack B ^a   Malayaman, S Nini ^a   Nowak, Mathew ^a   Vosseller, Keith ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

carbon monoxide releasing molecule; fibrinogen; heme; mass spectroscopy; thrombelastography

Indexed keywords

AMINO ACID; CARBON MONOXIDE; FIBRINOGEN; HEME; HYDROQUINONE; NITROPRUSSIDE SODIUM; THROMBOPLASTIN; TRICARBONYLDICHLORORUTHENIUM (II) DIMER; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CARBON MONOXIDE BLOOD LEVEL; CONTROLLED STUDY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; THROMBOELASTOGRAPHY; THROMBOGENESIS;

BLOOD COAGULATION; CARBON MONOXIDE; FIBRINOGEN; HEME; HUMANS; KINETICS; ORGANOMETALLIC COMPOUNDS; PLASMA; TANDEM MASS SPECTROMETRY; THROMBELASTOGRAPHY; THROMBOSIS;

EID: 79960697365     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e328345c069     Document Type: Article

References (13)

1. Nielsen VG, Kirklin JK, George JF. Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in human plasma. Blood Coagul Fibrinolysis 2009; 20:377-380
2. Nielsen VG, Kirklin JK, George JF. Carbon monoxide releasing molecule-2(CORM-2) decreases fibrinolysis in human plasma. Blood Coagul Fibrinolysis 2009; 20:448-455
3. Nielsen VG, Malayaman SN, Khan ES, Kirklin JK, George JF. Carbon monoxide releasing molecule-2 increases fibrinogen-dependent coagulation kinetics but does not enhance prothrombin activity. Blood Coagul Fibrinolysis 2010; 21:349-353
4. Nielsen VG, Kirklin JK, George JF, Messinger JD. Carbon monoxide releasing molecule-2 decreases thick diameter fibrin fibre formation in normal and factor XIII deficient plasma. Blood Coagul Fibrinolysis 2010; 21:101-105
5. Nielsen VG. The antifibrinolytic effects of carbon monoxide releasing molecule-2 are fibrin and (2-antiplasmin dependent. Blood Coagul Fibrinolysis 2010; 21:584-587
6. Spiro TG, Jarzecki AA. Heme-based sensors: theoretical modeling of heme-ligand-protein inter actions. Current Opin Chem Biol 2001; 5:715-723 (Pubitemid 33153169)
7. Gilles-Gonzalez MA, Gonzalez G. Heme-based sensors: defining characteristics, recent developments, and regulatory hypotheses. J Inorganic Biochem 2005; 99:1-22 (Pubitemid 39642968)
8. Jaggar JH, Li A, Parfenova H, Liu J, Umstot ES, Dopico AM, Leffer CW. Heme is a carbon monoxide receptor for large-conductance Ca2'activated K' channels. Circ Res 2005; 97:805-812 (Pubitemid 41447131)
9. Yi L, Morgan JT, Ragsdale SW. Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO. J Biol Chem 2010; 285:20117-20127
10. Kajimura M, Fukuda R, Bateman RM, Yamamoto T, Suematsu M. Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO and H2S gas biology. Antioxid Redox Signal 2010; 13:157-192
11. Castro CE, Wade RS, Belser NO. Conversion of oxyhemoglobin to methemoglobin by organic and inorganic reductants. Biochemistry 1978; 17:225-231 (Pubitemid 8270205)
12. Blombaeck B, Hessel B, Hogg D. Disulfide bridges in NH2-terminal part of human fibrinogen. Throm Res 1976; 8:639-658
13. Hoeprich PD, Doolittle RF. Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation. Biochemistry 1983; 22:2049-2055