Redox-reactive autoantibodies: Biochemistry, characterization, and specificities

Clinical Reviews in Allergy and Immunology

Volumn 37, Issue 1, 2009, Pages 49-54

  McIntyre, John A ^a,b   Faulk, W Page ^a,c  

^a St Francis Hospital   (United States)

^b INDIANA UNIVERSITY   (United States)

^c Faulk Pharmaceuticals Inc   (United States)

Author keywords

Biochemistry; Characterization; Oxidation reduction reaction; Redox reactive autoantibodies; Specificities; Unmasked autoantibody activity

Indexed keywords

AUTOANTIBODY; HEMIN; IMMUNOGLOBULIN G;

ANIMAL; ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASE; BLOOD; CHEMISTRY; DOG; HUMAN; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; REVIEW;

ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DOGS; HEMIN; HUMANS; IMMUNOGLOBULIN G; MICE; OXIDATION-REDUCTION;

EID: 70350436670     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-008-8093-y     Document Type: Article

References (20)

1. Shoenfeld Y, Gershwin ME, Meroni PL (eds) (2008) Autoantibodies, 2nd edn. Elsevier, Philadelphia
2. Silverstein AM (2001) Autoimmunity versus horror autotoxicus: the struggle for recognition. Nat Immunol 2:279-281
3. National Institutes of Health, The Autoimmune Diseases Coordinating Committee (2005) Progress in autoimmune diseases research. Report to Congress. U.S. Department of Health and Human Services, March
4. Gershwin LJ (2007) Veterinary autoimmunity: autoimmune diseases in domestic animals. Ann N Y Acad Sci 1109:109-116
5. McIntyre JA (2004) The appearance and disappearance of antiphospholipid antibodies subsequent to oxidation-reduction reactions. Thromb Res 114:579-587
6. McIntyre JA, Wagenknecht DR, Faulk WP (2005) Autoantibodies unmasked by redox reactions. J Autoimmun 24:311-317 (Pubitemid 40775855)
7. McIntyre JA, Wagenknecht DR, Faulk WP (2003) Antiphospholipid antibodies: discovery, definition, detection and disease. Prog Lipid Res 42:176-237 (Pubitemid 36411692)
8. McIntyre JA, Wagenknecht DR, Faulk WP (2006) Redox-reactive autoantibodies: detection and physiological relevance. Autoimmun Rev 5:76-83 (Pubitemid 41759446)
9. Fellouse FA, Barthelemy PA, Kelley RF, Sidhu SS (2006) Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code. J Mol Biol 357:100-114 (Pubitemid 43339317)
10. Cabiedes J, Cabral AR, Alarcón-Segovia (1998) Hidden antiphospholipid antibodies in normal human sera circulate as immune complexes whose antigen can be removed by heat, acid, hypermolar buffers or phospholipase treatments. Eur J Immunol 7:2108-2114 (Pubitemid 28321294)
11. Lorber M, Shoenfeld Y (2000) Hidden autoantibodies. Clin Rev Allergy Immunol 1:51-58 (Pubitemid 30415585)
12. Tomer Y, Shoenfeld Y (1988) The significance of natural autoantibodies. Immunol Invest 5:389-424
13. Matsuura E, Hughes GRV, Khamashta MA (2008) Oxidation of LDL and its clinical implication. Autoimmun Rev 7:558-566
14. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320:915-924 (Pubitemid 19101597)
15. Tabuchi M, Inoue K, Usui-Kataoka H, Kobayashi K, Teramoto M, Takasugi K et al (2007) The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis. J Lipid Res 48:768-781 (Pubitemid 46557882)
16. Shoenfeld Y, Wu R, Dearing LD, Matsuura E (2004) Are antioxidized low-density lipoprotein antibodies pathogenic or protective? Circulation 110:2552-2558 (Pubitemid 39453000)
17. Matsuura E, Kobayashi K, Tabuchi M, Lopez LR (2006) Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis. Prog Lipid Res 45:466-486 (Pubitemid 44331411)
18. Camejo G, Halberg C, Monschik-Lundin A et al (1998) Hemin binding and oxidation of lipoproteins in serum: mechanisms and effect on the interaction of LDL with human macrophages. J Lipid Res 39:755-766 (Pubitemid 28163278)
19. Miller YI, Shaklai N (1999) Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation. Biochim Biophys Acta 1454:153-164 (Pubitemid 29322022)
20. McIntyre JA, Faulk WP (eds) (2008) Special issue: redox and autoimmunity. Autoimmun Rev 7:515-584