Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

Journal of Clinical Investigation

Volumn 122, Issue 4, 2012, Pages 1444-1458

  Baek, Jin Hyen ^a   D'Agnillo, Felice ^a   Vallelian, Florence ^b   Pereira, Claudia P ^a   Williams, Matthew C ^a   Jia, Yiping ^a   Schaer, Dominik J ^b,c   Buehler, Paul W ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BANK; BLOOD STORAGE; BLOOD TRANSFUSION; BLOOD VESSEL INJURY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; ERYTHROCYTE PRESERVATION; HYPERTENSION; IN VIVO STUDY; INTRAVASCULAR HEMOLYSIS; KIDNEY DYSFUNCTION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ACUTE KIDNEY INJURY; ANIMALS; AORTA; BLOOD PRESERVATION; BLOOD TRANSFUSION; CARDIO-RENAL SYNDROME; ERYTHROCYTE DEFORMABILITY; GUINEA PIGS; HAPTOGLOBINS; HEME OXYGENASE-1; HEMOGLOBINS; HEMOLYSIS; HUMANS; KIDNEY; LIVER; MALE; NITRIC OXIDE; OSMOTIC FRAGILITY; PROTEOMICS; SPLEEN; TIME FACTORS;

EID: 84859712543     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59770     Document Type: Article

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