A cryptic polyreactive antibody recognizes distinct clades of HIV-1 glycoprotein 120 by an identical binding mechanism

Journal of Biological Chemistry

Volumn 289, Issue 25, 2014, Pages 17767-17779

  Dimitrov, Jordan D ^a,b   Planchais, Cyril ^a,b   Scheel, Tobias ^c   Ohayon, Delphine ^a,b   Mesnage, Stephane ^d   Berek, Claudia ^c   Kaveri, Srinivas V ^a,b   Lacroix Desmazes, Seb́astien ^a,b  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BINDING ENERGY; DISEASES; GLYCOPROTEINS; METAL IONS; PORPHYRINS; THERMOANALYSIS; VIRUSES;

HEALTHY INDIVIDUALS; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR HETEROGENEITY; PHYSIOLOGICAL ROLES; REACTIVE OXYGEN SPECIES; REDOX-ACTIVE SUBSTANCES; THERMO DYNAMIC ANALYSIS; THERMODYNAMIC PARAMETER;

ANTIBODIES;

ANTIBODY; F425 B12 ANTIBODY; F425 B4A1 ANTIBODY; GLYCOPROTEIN GP 120; HEME; NEUTRALIZING ANTIBODY; POLYREACTIVE ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE SPECTROSCOPY; GENETIC HETEROGENEITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; THERMODYNAMICS; VIRUS NEUTRALIZATION;

ANTIBODY; ANTIBODY POLYREACTIVITY; GP120; HEME; HIV-1 PROTEASE; PROTEIN-PROTEIN INTERACTION; THERMODYNAMICS;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BINDING SITES, ANTIBODY; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; KINETICS; THERMODYNAMICS;

EID: 84903485204     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.556266     Document Type: Article

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