Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 931-943

  Deuel, Jeremy W ^a   Vallelian, Florence ^a   Schaer, Christian A ^a   Puglia, Michele ^a,b   Buehler, Paul W ^c   Schaer, Dominik J ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Endothelial cell; Haptoglobin; Hemoglobin; Hemolysis; Hemopexin; Lipid oxidation; Lipoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATE; HAPTOGLOBIN; HEME; HEMOGLOBIN; HEMOPEXIN; LIPOPROTEIN; OXYHEMOGLOBIN; SCAVENGER; LIPID; MESSENGER RNA;

AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENDOTHELIUM LESION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; LIPOPHILICITY; OXIDATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; IMPEDANCE; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

BLOTTING, WESTERN; CELLS, CULTURED; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; HAPTOGLOBINS; HEMOGLOBINS; HEMOPEXIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPID PEROXIDATION; LIPIDS; OXIDATION-REDUCTION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84946195292     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.09.016     Document Type: Article

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