Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

Journal of Medicinal Chemistry

Volumn 59, Issue 5, 2016, Pages 1671-1690

  Bisson, Jonathan ^a   McAlpine, James B ^a   Friesen, J Brent ^a,b   Chen, Shao Nong ^a   Graham, James ^a   Pauli, Guido F ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b DOMINICAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; METAL; NATURAL PRODUCT; SURFACTANT; BIOLOGICAL PRODUCT;

BIOASSAY; BIOLOGICAL ACTIVITY; CHELATION; DATA ANALYSIS; DRUG PURITY; FLUORESCENCE; HUMAN; META ANALYSIS (TOPIC); PHYTOCHEMISTRY; REVIEW; CHEMISTRY; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; METABOLISM; REPRODUCIBILITY;

BIOLOGICAL PRODUCTS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; REPRODUCIBILITY OF RESULTS;

EID: 84958997845     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01009     Document Type: Review

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