Quality control in combinatorial chemistry: Determinations of amounts and comparison of the "purity" of LC-MS-purified samples by NMR, LC-UV and CLND

Journal of Combinatorial Chemistry

Volumn 7, Issue 3, 2005, Pages 364-371

  Letot, Elodie ^a   Koch, Guido ^a   Falchetto, Rocco ^a   Bovermann, Günter ^a   Oberer, Lukas ^a   Roth, Hans Jörg ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; NITROGEN;

ANALYTICAL ERROR; ARTICLE; CALIBRATION; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMOLUMINESCENCE; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NITROGEN DETECTOR; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; QUALITY CONTROL; STANDARD; TEMPERATURE;

CHEMILUMINESCENT MEASUREMENTS; CHROMATOGRAPHY; CHROMATOGRAPHY, LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; DIMETHYL SULFOXIDE; MAGNETIC RESONANCE SPECTROSCOPY; NITROGEN; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TIME FACTORS; WEIGHTS AND MEASURES;

EID: 20044379766     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc049850r     Document Type: Article

References (4)

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2. Felder, E. R.; Scarpella, S.; Tatò, M.; CHIMIA 2003, 57, 229.
3. Indeed, the method is so sensitive that differences in the concentration of the satellites from one batch to the other were detected.
4. Taylor, E. W.; Qian, M. G.; Dollinger, G. D. Anal. Chem. 1998, 70, 3339.