Identification of small-molecule frequent hitters from alphascreen high-throughput screens

Journal of Biomolecular Screening

Volumn 19, Issue 5, 2014, Pages 715-726

  Schorpp, Kenji ^a   Rothenaigner, Ina ^a   Salmina, Elena ^b   Reinshagen, Jeanette ^c   Low, Terence ^c   Brenke, Jara K ^a   Gopalakrishnan, Jay ^d   Tetko, Igor V ^b,e,f   Gul, Sheraz ^c   Hadian, Kamyar ^a  

^a Institute of Toxicology   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c European Screeningport GmbH   (Germany)

^d Department of Animal Physiology   (Germany)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^f EADMET GmbH   (Germany)

Author keywords

Alphascreen; Assay development; Drug discovery; Frequent hitter; High throughput screening; Protein protein interaction

Indexed keywords

BIOTIN; FREQUENT HITTER; NICKEL COMPLEX; POLYHISTIDINE TAG; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; MOLECULAR LIBRARY; NITRILOTRIACETATE NICKEL; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUND; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARTICLE; BINDING ASSAY; CHEMICAL ANALYSIS; CHEMOINFORMATICS ANALYSIS; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TIME RESOLVED FLUORESCENCE RESONANCE ENERGY TRANSFER; ANALOGS AND DERIVATIVES; AUTOMATION; BIOASSAY; CHEMISTRY; DRUG DEVELOPMENT; ESCHERICHIA COLI; KINETICS; METABOLISM; PROCEDURES; PROTEIN ANALYSIS;

AUTOMATION; BIOLOGICAL ASSAY; DRUG DISCOVERY; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-THROUGHPUT SCREENING ASSAYS; KINETICS; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUNDS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84900455031     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113516861     Document Type: Article

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