-
1
-
-
33745188660
-
Screening in a spirit haunted world
-
Shoichet, B. K. Screening in a spirit haunted world Drug Discovery Today 2006, 11, 607-615
-
(2006)
Drug Discovery Today
, vol.11
, pp. 607-615
-
-
Shoichet, B.K.1
-
2
-
-
77952545106
-
Apparent activity in high-throughput screening: Origins of compound-dependent assay interference
-
Thorne, N.; Auld, D. S.; Inglese, J. Apparent activity in high-throughput screening: origins of compound-dependent assay interference Curr. Opin. Chem. Biol. 2010, 14, 315-324
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, pp. 315-324
-
-
Thorne, N.1
Auld, D.S.2
Inglese, J.3
-
3
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern, S. L.; Caselli, E.; Grigorieff, N.; Shoichet, B. K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening J. Med. Chem. 2002, 45, 1712-1722
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
4
-
-
33745381593
-
An empirical process for the design of high-throughput screening deck filters
-
Pearce, B. C.; Sofia, M. J.; Good, A. C.; Drexler, D. M.; Stock, D. A. An empirical process for the design of high-throughput screening deck filters J. Chem. Inf. Model. 2006, 46, 1060-1068
-
(2006)
J. Chem. Inf. Model.
, vol.46
, pp. 1060-1068
-
-
Pearce, B.C.1
Sofia, M.J.2
Good, A.C.3
Drexler, D.M.4
Stock, D.A.5
-
5
-
-
77950571108
-
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
-
Baell, J. B.; Holloway, G. A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays J. Med. Chem. 2010, 53, 2719-2740
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2719-2740
-
-
Baell, J.B.1
Holloway, G.A.2
-
6
-
-
0030756360
-
Reactive compounds and in vitro false positives in HTS
-
Rishton, G. M. Reactive compounds and in vitro false positives in HTS Drug Discovery Today 1997, 2, 382-384
-
(1997)
Drug Discovery Today
, vol.2
, pp. 382-384
-
-
Rishton, G.M.1
-
7
-
-
0033194752
-
Strategic pooling of compounds for high-throughput screening
-
Hann, M.; Hudson, B.; Lewell, X.; Lifely, R.; Miller, L.; Ramsden, N. Strategic pooling of compounds for high-throughput screening J. Chem. Inf. Comput. Sci. 1999, 39, 897-902
-
(1999)
J. Chem. Inf. Comput. Sci.
, vol.39
, pp. 897-902
-
-
Hann, M.1
Hudson, B.2
Lewell, X.3
Lifely, R.4
Miller, L.5
Ramsden, N.6
-
8
-
-
0037394124
-
Designing screens: How to make your hits a hit
-
Walters, W. P.; Namchuk, M. Designing screens: how to make your hits a hit Nat. Rev. Drug Discovery 2003, 2, 259-266
-
(2003)
Nat. Rev. Drug Discovery
, vol.2
, pp. 259-266
-
-
Walters, W.P.1
Namchuk, M.2
-
9
-
-
0037439447
-
Nonleadlikeness and leadlikeness in biochemical screening
-
Rishton, G. M. Nonleadlikeness and leadlikeness in biochemical screening Drug Discovery Today 2003, 8, 86-96
-
(2003)
Drug Discovery Today
, vol.8
, pp. 86-96
-
-
Rishton, G.M.1
-
11
-
-
84871078958
-
-
MSI Cerius2. http://www.chem.cmu.edu/courses/09-560/docs/msi/modenv/D- Files.html#948951
-
MSI Cerius2
-
-
-
12
-
-
18644364289
-
A series of C-terminal amino alcohol dipeptide A[beta] inhibitors
-
Garofalo, A. W.; Wone, D. W. G.; Phuc, A.; Audia, J. E.; Bales, C. A.; Dovey, H. F.; Dressen, D. B.; Folmer, B.; Goldbach, E. G.; Guinn, A. C.; Latimer, L. H.; Mabry, T. E.; Nissen, J. S.; Pleiss, M. A.; Sohn, S.; Thorsett, E. D.; Tung, J. S.; Wu, J. A series of C-terminal amino alcohol dipeptide A[beta] inhibitors Bioorg. Med. Chem. Lett. 2002, 12, 3051-3053
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 3051-3053
-
-
Garofalo, A.W.1
Wone, D.W.G.2
Phuc, A.3
Audia, J.E.4
Bales, C.A.5
Dovey, H.F.6
Dressen, D.B.7
Folmer, B.8
Goldbach, E.G.9
Guinn, A.C.10
Latimer, L.H.11
Mabry, T.E.12
Nissen, J.S.13
Pleiss, M.A.14
Sohn, S.15
Thorsett, E.D.16
Tung, J.S.17
Wu, J.18
-
13
-
-
4544338170
-
Assessment of the consistency of medicinal chemists in reviewing sets of compounds
-
Lajiness, M. S.; Maggiora, G. M.; Shanmugasundaram, V. Assessment of the consistency of medicinal chemists in reviewing sets of compounds J. Med. Chem. 2004, 47, 4891-4896
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4891-4896
-
-
Lajiness, M.S.1
Maggiora, G.M.2
Shanmugasundaram, V.3
-
15
-
-
0036882396
-
Irreversible inhibitors of serine, cysteine, and threonine proteases
-
Powers, J. C.; Asgian, J. L.; Ekici, Ö. D.; James, K. E. Irreversible inhibitors of serine, cysteine, and threonine proteases Chem. Rev. 2002, 102, 4639-4750
-
(2002)
Chem. Rev.
, vol.102
, pp. 4639-4750
-
-
Powers, J.C.1
Asgian, J.L.2
Ekici, Ö.D.3
James, K.E.4
-
16
-
-
0343433408
-
Cysteine proteases and their inhibitors
-
Otto, H.-H.; Schirmeister, T. Cysteine proteases and their inhibitors Chem. Rev. 1997, 97, 133-172
-
(1997)
Chem. Rev.
, vol.97
, pp. 133-172
-
-
Otto, H.-H.1
Schirmeister, T.2
-
17
-
-
2542425429
-
Structure-activity relationships of pyrithiones: IPC-81 toxicity tests with the antifouling biocide zinc pyrithione and structural analogs
-
Doose, C. A.; Ranke, J.; Stock, F.; Bottin-Weber, U.; Jastorff, B. Structure-activity relationships of pyrithiones: IPC-81 toxicity tests with the antifouling biocide zinc pyrithione and structural analogs Green Chem. 2004, 6, 259-266
-
(2004)
Green Chem.
, vol.6
, pp. 259-266
-
-
Doose, C.A.1
Ranke, J.2
Stock, F.3
Bottin-Weber, U.4
Jastorff, B.5
-
19
-
-
0013793175
-
Complex formation between ethidium bromide and nucleic acids
-
Waring, M. J. Complex formation between ethidium bromide and nucleic acids J. Mol. Biol. 1965, 13, 269-282
-
(1965)
J. Mol. Biol.
, vol.13
, pp. 269-282
-
-
Waring, M.J.1
-
20
-
-
3543031079
-
The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase α is mediated by hydrogen peroxide
-
Bova, M. P.; Mattson, M. N.; Vasile, S.; Tam, D.; Holsinger, L.; Bremer, M.; Hui, T.; McMahon, G.; Rice, A.; Fukuto, J. M. The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase α is mediated by hydrogen peroxide Arch. Biochem. Biophys. 2004, 429, 30-41
-
(2004)
Arch. Biochem. Biophys.
, vol.429
, pp. 30-41
-
-
Bova, M.P.1
Mattson, M.N.2
Vasile, S.3
Tam, D.4
Holsinger, L.5
Bremer, M.6
Hui, T.7
McMahon, G.8
Rice, A.9
Fukuto, J.M.10
-
21
-
-
71049126548
-
Escape from Flatland: Increasing saturation as an approach to improving clinical success
-
Lovering, F.; Bikker, J.; Humblet, C. Escape from Flatland: increasing saturation as an approach to improving clinical success J. Med. Chem. 2009, 52, 6752-6756
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6752-6756
-
-
Lovering, F.1
Bikker, J.2
Humblet, C.3
-
22
-
-
0000781607
-
Absorption of drugs from the stomach. II. The human
-
Hogben, C. A. M.; Schanker, L. S.; Tocco, D. J.; Brodie, B. B. Absorption of drugs from the stomach. II. The human J. Pharmacol. Exp. Ther. 1957, 120, 540-545
-
(1957)
J. Pharmacol. Exp. Ther.
, vol.120
, pp. 540-545
-
-
Hogben, C.A.M.1
Schanker, L.S.2
Tocco, D.J.3
Brodie, B.B.4
-
23
-
-
0018612308
-
Antimalaria studies on qinghaosu
-
Qinghaosu Antimalarial Coordinating Research Group.
-
Qinghaosu Antimalarial Coordinating Research Group. Antimalaria studies on qinghaosu Chin. Med. J. 1979, 92, 811-816
-
(1979)
Chin. Med. J.
, vol.92
, pp. 811-816
-
-
-
24
-
-
49949151887
-
Molecular diversity in the context of leadlikeness: Compound properties that enable effective biochemical screening
-
Rishton, G. M. Molecular diversity in the context of leadlikeness: compound properties that enable effective biochemical screening Curr. Opin. Chem. Biol. 2008, 12, 340-351
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 340-351
-
-
Rishton, G.M.1
-
25
-
-
33749623901
-
Leadlikeness and structural diversity of synthetic screening libraries
-
Verheij, H. Leadlikeness and structural diversity of synthetic screening libraries Mol. Diversity 2006, 10, 377-388
-
(2006)
Mol. Diversity
, vol.10
, pp. 377-388
-
-
Verheij, H.1
-
26
-
-
43049129991
-
2-lactamase
-
2-lactamase J. Med. Chem. 2008, 51, 2502-2511
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2502-2511
-
-
Babaoglu, K.1
Simeonov, A.2
Irwin, J.J.3
Nelson, M.E.4
Feng, B.5
Thomas, C.J.6
Cancian, L.7
Costi, M.P.8
Maltby, D.A.9
Jadhav, A.10
Inglese, J.11
Austin, C.P.12
Shoichet, B.K.13
-
27
-
-
84871061583
-
-
The Research Group of Jon Tryggvi Njardarson at the University of Arizona
-
The Research Group of Jon Tryggvi Njardarson at the University of Arizona. http://cbc.arizona.edu/njardarson/group/.
-
-
-
-
28
-
-
0035438391
-
Is there a difference between leads and drugs? A historical perspective
-
Oprea, T. I.; Davis, A. M.; Teague, S. J.; Leeson, P. D. Is there a difference between leads and drugs? A historical perspective J. Chem. Inf. Comput. Sci. 2001, 41, 1308-1315
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 1308-1315
-
-
Oprea, T.I.1
Davis, A.M.2
Teague, S.J.3
Leeson, P.D.4
-
29
-
-
84986251317
-
-
US 2007/0015756 A1.
-
Boloor, A. C., M.; Davis, R.; Harris, P. A.; Hinkle, K.; Mook, R. A., Jr.; Stafford, J. A.; Veal, J. M. Chemical Compounds. US 2007/0015756 A1, 2007.
-
(2007)
Chemical Compounds
-
-
Boloor, A.C.M.1
Davis, R.2
Harris, P.A.3
Hinkle, K.4
Mook Jr., R.A.5
Stafford, J.A.6
Veal, J.M.7
-
30
-
-
0026198534
-
Automation of the resazurin reduction test using fluorometry of microtitration trays
-
Ali-Vehmas, T.; Louhi, M.; Sandholm, M. Automation of the resazurin reduction test using fluorometry of microtitration trays J. Vet. Med., Ser. B 1991, 38, 358-372
-
(1991)
J. Vet. Med., Ser. B
, vol.38
, pp. 358-372
-
-
Ali-Vehmas, T.1
Louhi, M.2
Sandholm, M.3
-
31
-
-
34548351239
-
A simple assay for detection of small-molecule redox activity
-
Lor, L. A.; Schneck, J.; McNulty, D. E.; Diaz, E.; Brandt, M.; Thrall, S. H.; Schwartz, B. A simple assay for detection of small-molecule redox activity J. Biomol. Screening 2007, 12, 881-890
-
(2007)
J. Biomol. Screening
, vol.12
, pp. 881-890
-
-
Lor, L.A.1
Schneck, J.2
McNulty, D.E.3
Diaz, E.4
Brandt, M.5
Thrall, S.H.6
Schwartz, B.7
-
32
-
-
77958044565
-
Observations on screening-based research and some concerning trends in the literature
-
Baell, J. B. Observations on screening-based research and some concerning trends in the literature Future Med. Chem. 2010, 2, 1529-1546
-
(2010)
Future Med. Chem.
, vol.2
, pp. 1529-1546
-
-
Baell, J.B.1
-
33
-
-
84859269944
-
Can we discover pharmacological promiscuity early in the drug discovery process?
-
Peters, J.-U.; Hert, J.; Bissantz, C.; Hillebrecht, A.; Gerebtzoff, G.; Bendels, S.; Tillier, F.; Migeon, J.; Fischer, H.; Guba, W.; Kansy, M. Can we discover pharmacological promiscuity early in the drug discovery process? Drug Discovery Today 2012, 17, 325-335
-
(2012)
Drug Discovery Today
, vol.17
, pp. 325-335
-
-
Peters, J.-U.1
Hert, J.2
Bissantz, C.3
Hillebrecht, A.4
Gerebtzoff, G.5
Bendels, S.6
Tillier, F.7
Migeon, J.8
Fischer, H.9
Guba, W.10
Kansy, M.11
-
34
-
-
0017395981
-
A new alkaloid AM-2282 of Streptomyces origin: Taxonomy, fermentation, isolation and preliminary characterization
-
Omura, S. I., Y.; Hirano, A.; Nakagawa, A.; Awaya, J.; Tsuchiya, H.; Takahashi, Y.; Masuma, R. A new alkaloid AM-2282 of Streptomyces origin: taxonomy, fermentation, isolation and preliminary characterization J. Antibiot. 1977, 30, 275-282
-
(1977)
J. Antibiot.
, vol.30
, pp. 275-282
-
-
Omura, S.I..Y.1
Hirano, A.2
Nakagawa, A.3
Awaya, J.4
Tsuchiya, H.5
Takahashi, Y.6
Masuma, R.7
-
35
-
-
0037431421
-
Kinase inhibitors: Not just for kinases anymore
-
McGovern, S. L.; Shoichet, B. K. Kinase inhibitors: not just for kinases anymore J. Med. Chem. 2003, 46, 1478-1483
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1478-1483
-
-
McGovern, S.L.1
Shoichet, B.K.2
-
36
-
-
23844500772
-
High-throughput assays for promiscuous inhibitors
-
Feng, B. Y.; Shelat, A.; Doman, T. N.; Guy, R. K.; Shoichet, B. K. High-throughput assays for promiscuous inhibitors Nat. Chem. Biol. 2005, 1, 146-148
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 146-148
-
-
Feng, B.Y.1
Shelat, A.2
Doman, T.N.3
Guy, R.K.4
Shoichet, B.K.5
-
37
-
-
0141792701
-
A specific mechanism of nonspecific inhibition
-
McGovern, S. L.; Helfand, B. T.; Feng, B.; Shoichet, B. K. A specific mechanism of nonspecific inhibition J. Med. Chem. 2003, 46, 4265-4272
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4265-4272
-
-
McGovern, S.L.1
Helfand, B.T.2
Feng, B.3
Shoichet, B.K.4
-
38
-
-
39149130730
-
Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors
-
Giannetti, A. M.; Koch, B. D.; Browner, M. F. Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors J. Med. Chem. 2008, 51, 574-580
-
(2008)
J. Med. Chem.
, vol.51
, pp. 574-580
-
-
Giannetti, A.M.1
Koch, B.D.2
Browner, M.F.3
-
39
-
-
0041842684
-
Effect of detergent on "promiscuous" inhibitors
-
Ryan, A. J.; Gray, N. M.; Lowe, P. N.; Chung, C.-w. Effect of detergent on "promiscuous" inhibitors J. Med. Chem. 2003, 46, 3448-3451
-
(2003)
J. Med. Chem.
, vol.46
, pp. 3448-3451
-
-
Ryan, A.J.1
Gray, N.M.2
Lowe, P.N.3
Chung, C.-W.4
|