메뉴 건너뛰기




Volumn 17, Issue 9, 2012, Pages 10774-10790

Aggregating behavior of phenolic compounds - A source of false bioassay results?

Author keywords

Aggregation; Bioactivity screening; Dynamic light scattering; Flavonoid; Nonspecific inhibition; Promiscuous binder; Quercetin; Rhamnetin

Indexed keywords

DRUG DERIVATIVE; PHENOL DERIVATIVE; QUERCETIN; RHAMNETIN;

EID: 84866914982     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules170910774     Document Type: Article
Times cited : (92)

References (28)
  • 1
    • 79952066487 scopus 로고    scopus 로고
    • Chemistry and biochemistry of dietary polyphenols
    • Tsao, R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2010, 2, 1231-1246.
    • (2010) Nutrients , vol.2 , pp. 1231-1246
    • Tsao, R.1
  • 5
    • 11344292132 scopus 로고    scopus 로고
    • The role of natural product chemistry in drug discovery
    • Butler, M.S. The role of natural product chemistry in drug discovery. J. Nat. Prod. 2004, 67, 2141-2153.
    • (2004) J. Nat. Prod. , vol.67 , pp. 2141-2153
    • Butler, M.S.1
  • 6
    • 36348987143 scopus 로고    scopus 로고
    • The value of natural products to future pharmaceutical discovery
    • Baker, D.D.; Chu, M.; Oza, U.; Rajgarhia, V. The value of natural products to future pharmaceutical discovery. Nat. Prod. Res. 2007, 24, 1225-1244.
    • (2007) Nat. Prod. Res. , vol.24 , pp. 1225-1244
    • Baker, D.D.1    Chu, M.2    Oza, U.3    Rajgarhia, V.4
  • 7
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: End of an era or an endless frontier?
    • Li, J.W.; Vederas, J.C. Drug discovery and natural products: End of an era or an endless frontier? Science 2009, 325, 161-165.
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.1    Vederas, J.C.2
  • 8
    • 33745188660 scopus 로고    scopus 로고
    • Screening in a spirit haunted world
    • Shoichet, B.K. Screening in a spirit haunted world. Drug Disc. Today 2006, 11, 607-615.
    • (2006) Drug Disc. Today , vol.11 , pp. 607-615
    • Shoichet, B.K.1
  • 9
    • 0037061628 scopus 로고    scopus 로고
    • A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
    • McGovern, S.L.; Caselli, E.; Grigoriedd, N.; Shoichet, B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 2002, 45, 1712-1722.
    • (2002) J. Med. Chem. , vol.45 , pp. 1712-1722
    • McGovern, S.L.1    Caselli, E.2    Grigoriedd, N.3    Shoichet, B.K.4
  • 11
    • 0037431421 scopus 로고    scopus 로고
    • Kinase inhibitors: Not just for kinases anymore
    • McGovern, S.L.; Shoichet, B.K. Kinase inhibitors: Not just for kinases anymore. J. Med. Chem. 2003, 46, 1478-1483.
    • (2003) J. Med. Chem. , vol.46 , pp. 1478-1483
    • McGovern, S.L.1    Shoichet, B.K.2
  • 12
    • 0037439447 scopus 로고    scopus 로고
    • Nonleadlikeness and leadlikeness in biochemical screening
    • Rishton, G.M. Nonleadlikeness and leadlikeness in biochemical screening. Drug Disc. Today 2003, 8, 86-96.
    • (2003) Drug Disc. Today , vol.8 , pp. 86-96
    • Rishton, G.M.1
  • 13
    • 47749106894 scopus 로고    scopus 로고
    • Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors
    • Coan, K.E.; Shoichet, B.K. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors. J. Am. Chem. Soc. 2008, 130, 9606-9612.
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 9606-9612
    • Coan, K.E.1    Shoichet, B.K.2
  • 14
    • 33645665186 scopus 로고    scopus 로고
    • Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures
    • Feng, B.Y.; Shoichet, B.K. Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures. J. Med. Chem. 2006, 49, 2151-2154.
    • (2006) J. Med. Chem. , vol.49 , pp. 2151-2154
    • Feng, B.Y.1    Shoichet, B.K.2
  • 15
    • 15444366107 scopus 로고    scopus 로고
    • Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance for oral bioavailability
    • Frenkel, Y.V.; Clark, A.D.; Das, K.; Wang, Y.H.; Lewi, P.J.; Janssen, P.A.; Arnold, E. Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance for oral bioavailability. J. Med. Chem. 2005, 48, 1974-1983.
    • (2005) J. Med. Chem. , vol.48 , pp. 1974-1983
    • Frenkel, Y.V.1    Clark, A.D.2    Das, K.3    Wang, Y.H.4    Lewi, P.J.5    Janssen, P.A.6    Arnold, E.7
  • 16
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, Metabolic affects and safety
    • Ross, J.A.; Kasum, C.M. Dietary flavonoids: Bioavailability, Metabolic affects and safety. Annu. Rev. Nutr. 2002, 22, 19-34.
    • (2002) Annu. Rev. Nutr. , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 17
    • 34249000046 scopus 로고    scopus 로고
    • A high-throughput screen for aggregation-based inhibition in a large chemical library
    • Feng, B.Y.; Simeonov, A.; Jadhav, A.; Babogiu, K.; Inglese, J.; Shoichet, B.K. A high-throughput screen for aggregation-based inhibition in a large chemical library. J. Med. Chem. 2007, 49, 2385-2390.
    • (2007) J. Med. Chem. , vol.49 , pp. 2385-2390
    • Feng, B.Y.1    Simeonov, A.2    Jadhav, A.3    Babogiu, K.4    Inglese, J.5    Shoichet, B.K.6
  • 18
    • 33751321865 scopus 로고    scopus 로고
    • A detergent-based assay for the detection of promiscuous inhibitors
    • Feng, B.Y.; Shoichet, B.K. A detergent-based assay for the detection of promiscuous inhibitors. Nat. Protoc. 2006, 1, 550-553.
    • (2006) Nat. Protoc. , vol.1 , pp. 550-553
    • Feng, B.Y.1    Shoichet, B.K.2
  • 20
    • 84866888781 scopus 로고    scopus 로고
    • The PubChem Project, accessed on 11 January 2012)
    • The PubChem Project. Available online: http://pubchem.ncbi.nlm.nih.gov (accessed on 11 January 2012).
  • 22
    • 83655212354 scopus 로고    scopus 로고
    • Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays
    • Pohjala, L.; Utt, A.; Varjak, M.; Lulla, A.; Merits, A.; Ahola, T.; Tammela, P. Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS One 2011, 6, e28923.
    • (2011) PLoS One , vol.6
    • Pohjala, L.1    Utt, A.2    Varjak, M.3    Lulla, A.4    Merits, A.5    Ahola, T.6    Tammela, P.7
  • 24
    • 0037523454 scopus 로고    scopus 로고
    • Profiling drug-like properties in discovery process
    • Di, L.; Kerns, E.H. Profiling drug-like properties in discovery process. Curr. Opin. Chem. Biol. 2003, 7, 402-408.
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 402-408
    • Di, L.1    Kerns, E.H.2
  • 25
    • 77950571108 scopus 로고    scopus 로고
    • New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
    • Baell, J.B.; Holloway, G.A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J. Med. Chem. 2010, 53, 2719-2740.
    • (2010) J. Med. Chem. , vol.53 , pp. 2719-2740
    • Baell, J.B.1    Holloway, G.A.2
  • 26
    • 0141923641 scopus 로고    scopus 로고
    • Identification and prediction of promiscuous aggregating inhibitors among known drugs
    • Seidler, J.; McGovern, S.L.; Doman, T.N.; Shoichet, B.K. Identification and prediction of promiscuous aggregating inhibitors among known drugs. J. Med. Chem. 2003, 46, 4477-4486.
    • (2003) J. Med. Chem. , vol.46 , pp. 4477-4486
    • Seidler, J.1    McGovern, S.L.2    Doman, T.N.3    Shoichet, B.K.4
  • 28
    • 33846922033 scopus 로고    scopus 로고
    • Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays
    • Pohjala, L.; Tammela, P.; Samanta S.K.; Yli-Kauhaluoma, J.; Vuorela, P. Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Anal. Biochem. 2007, 362, 221-228.
    • (2007) Anal. Biochem. , vol.362 , pp. 221-228
    • Pohjala, L.1    Tammela, P.2    Samanta, S.K.3    Yli-Kauhaluoma, J.4    Vuorela, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.