The effect of initial purity on the stability of solutions in storage

Journal of Biomolecular Screening

Volumn 19, Issue 2, 2014, Pages 308-316

  Popa Burke, Ioana ^a   Novick, Steven ^a   Lane, Charles A ^b   Hogan, Robin ^a   Torres Saavedra, Pedro ^b   Hardy, Brian ^a   Ray, Brenda ^a   Lindsay, Melissa ^c   Paulus, Iris ^a   Miller, Luke ^a  

^a GLAXOSMITHKLINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c NONE

Author keywords

purity; stability; storage

Indexed keywords

DIMETHYL SULFOXIDE;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL PARAMETERS; FREEZE THAWING; LABORATORY; MATERIALS HANDLING; MOLECULAR STABILITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PURITY; QUALITY CONTROL; SCREENING; STORAGE; WATER CONTENT;

PURITY; STABILITY; STORAGE;

DIMETHYL SULFOXIDE; DRUG STABILITY; DRUG STORAGE; HUMANS; SOLUTIONS;

EID: 84892755338     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113492201     Document Type: Article

References (17)

1. Bertelli F. Management of Chemical and Biological Samples for Screening Applications. Wiley-VCH: Germany ; 2012: 275-304.
2. Bowes S., Sun D., Kaffashan A., et al. Quality Assessment and Analysis of Biogen Idec Compound Library. J. Biomol. Screen. 2006 ; 11: 828-835 (Pubitemid 44562324)
3. Blaxill Z., Holland-Crimmin S., Lifely R. Stability through the Ages: The GSK Experience. J. Biomol. Screen. 2009 ; 14: 547-556
4. Cheng X., Hochlowski J., Tang H., et al. Studies on Repository Compound Stability in DMSO under Various Conditions. J. Biomol. Screen. 2003 ; 8: 292-304
5. Kozikowski B., Burt T., Tirey D., et al. The Effect of Room-Temperature Storage on the Stability of Compounds in DMSO. J. Biomol. Screen. 2003 ; 8: 205-209
6. Kozikowski B., Burt T., Tirey D., et al. The Effect of Freeze/Thaw Cycles on the Stability of Compounds in DMSO. J. Biomol. Screen. 2003 ; 8: 210-215
7. Matson S. L., Chatterjee M., Stock D. A., et al. Best Practices in Compound Management for Preserving Compound Integrity and Accurately Providing Samples for Assays. J. Biomol. Screen. 2009 ; 14: 476-484
8. Waybright T. J., Britt J. R., McCloud T. G. Overcoming Problems of Compound Storage in DMSO: Solvent and Process Alternatives. J. Biomol. Screen. 2009 ; 14: 708-715
9. MacArthur R., Leister W., Veith H., et al. Monitoring Compound Integrity with Cytochrome P450 Assays and qHTS. J. Biomol. Screen. 2009 ; 14: 538-546
10. Ilouga P. E., Winkler D., Kirchhoff C., et al. Investigation of 3 Industry-Wide Applied Storage Conditions for Compound Libraries. J. Biomol. Screen. 2007 ; 12: 21-32 (Pubitemid 46224916)
11. Zitha-Bovens E., Maas P., Wife D., et al. COMDECOM: Predicting the Lifetime of Screening Compounds in DMSO Solution. J. Biomol. Screen. 2009 ; 14: 557-565
12. Smith G. K., Leesnitzer M. A., Wright L. L., et al. UV-Vis Scan-Based Quality Control of Assay-Ready Plates for Improved Data Integrity. Eur. Pharma. Rev. 2011 ; 16: 48-53
13. Hann M. M., Leach A. R., Harper G. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery. J. Chem. Inf. Comput. Sci. 2001 ; 41: 856-864
14. Breiman L. Random Forests. Machine Learning. 2001 ; 45: 5-32 (Pubitemid 32933532)
15. Young R. L., Green D. V. S., Luscombe C. N., et al. Getting Physical in Drug Discovery II: The Impact of Chromatographic Hydrophobicity Measurements and Aromaticity. Drug Disc. Today. 2011 ; 16: 822-830
16. Fillers W. S. Compound Libraries: Cost of Ownership. Drug Disc. World. 2004 ; 5 (2). 86-90
17. Engeloch C., Schopfer U., Muckenschnabel I., et al. Stability of Screening Compounds in Wet DMSO. J. Biomol. Screen. 2008 ; 13: 999-1006