메뉴 건너뛰기




Volumn 6, Issue 2, 2016, Pages

Understanding the physiology of the ageing individual: Computational modelling of changes in metabolism and endurance

Author keywords

Computational modelling; Endurance; Heart rate variability; Homeodynamics; Metabolism; Oxygen transport

Indexed keywords


EID: 84958817356     PISSN: 20428898     EISSN: 20428901     Source Type: Journal    
DOI: 10.1098/rsfs.2015.0079     Document Type: Review
Times cited : (53)

References (100)
  • 1
    • 84923790921 scopus 로고    scopus 로고
    • Tipping the metabolic scales towards increased longevity in mammals
    • Riera CE, Dillin A. 2015 Tipping the metabolic scales towards increased longevity in mammals. Nat. Cell Biol. 17, 196–203. (doi:10.1038/ncb3107)
    • (2015) Nat. Cell Biol , vol.17 , pp. 196-203
    • Riera, C.E.1    Dillin, A.2
  • 2
    • 84925852614 scopus 로고    scopus 로고
    • Promoting health and longevity through diet: From model organisms to humans
    • Fontana L, Partridge L. 2015 Promoting health and longevity through diet: from model organisms to humans. Cell 161, 106–118. (doi:10.1016/j.cell.2015.02.020)
    • (2015) Cell , vol.161 , pp. 106-118
    • Fontana, L.1    Partridge, L.2
  • 3
    • 0032791445 scopus 로고    scopus 로고
    • Further evidence for age-related deficits in human postural function
    • Matheson A. 1999 Further evidence for age-related deficits in human postural function. J. Vestib. Res. 9, 261–264.
    • (1999) J. Vestib. Res , vol.9 , pp. 261-264
    • Matheson, A.1
  • 5
    • 80052337295 scopus 로고    scopus 로고
    • Analyzing the functional properties of the creatine kinase system with multiscale ’sloppy’ modeling
    • Hettling H, van Beek JH. 2011 Analyzing the functional properties of the creatine kinase system with multiscale ’sloppy’ modeling. PLoS Comput. Biol. 7, e1002130. (doi:10.1371/journal.pcbi.1002130)
    • (2011) Plos Comput. Biol , vol.7
    • Hettling, H.1    Van Beek, J.H.2
  • 6
    • 0004224763 scopus 로고
    • London, UK: Paul, Trechn, Trubner
    • Cannon WB. 1947 (first edition 1932) The wisdom of the body. London, UK: Paul, Trechn, Trubner.
    • (1947) The Wisdom of the Body
    • Cannon, W.B.1
  • 7
    • 79251471783 scopus 로고    scopus 로고
    • Systems biology of ageing and longevity
    • Kirkwood TBL. 2011 Systems biology of ageing and longevity. Phil. Trans. R. Soc. B 366, 64–70. (doi:10.1098/rstb.2010.0275)
    • (2011) Phil. Trans. R. Soc. B , vol.366 , pp. 64-70
    • Kirkwood, T.B.L.1
  • 8
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. 2005 Understanding the odd science of aging. Cell 120, 437–447. (doi:10.1016/j.cell.2005.01.027)
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 9
    • 84863863145 scopus 로고    scopus 로고
    • The free-radical theory of ageing—older, wiser and still alive: Modelling positional effects of the primary targets of ROS reveals new support
    • Kirkwood TB, Kowald A. 2012 The free-radical theory of ageing—older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support. Bioessays 34, 692–700. (doi:10.1002/bies.201200014)
    • (2012) Bioessays , vol.34 , pp. 692-700
    • Kirkwood, T.B.1    Kowald, A.2
  • 10
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span—from yeast to humans
    • Fontana L, Partridge L, Longo VD. 2010 Extending healthy life span—from yeast to humans. Science 328, 321–326. (doi:10.1126/science.1172539)
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 12
    • 0036245337 scopus 로고    scopus 로고
    • Mechanisms of ageing: Public or private?
    • Partridge L, Gems D. 2002 Mechanisms of ageing: public or private? Nat. Rev. Genet. 3, 165–175. (doi:10.1038/nrg753)
    • (2002) Nat. Rev. Genet , vol.3 , pp. 165-175
    • Partridge, L.1    Gems, D.2
  • 13
    • 80052338389 scopus 로고    scopus 로고
    • Macromolecular deterioration as the ultimate constraint on human lifespan
    • Truscott RJ. 2011 Macromolecular deterioration as the ultimate constraint on human lifespan. Ageing Res. Rev. 10, 397–403. (doi:10.1016/j.arr.2010.12.001)
    • (2011) Ageing Res. Rev , vol.10 , pp. 397-403
    • Truscott, R.J.1
  • 14
    • 0026328187 scopus 로고
    • Rudolf Schoenheimer and the concept of the dynamic state of body constituents
    • Guggenheim KY. 1991 Rudolf Schoenheimer and the concept of the dynamic state of body constituents. J. Nutr. 121, 1701–1704.
    • (1991) J. Nutr , vol.121 , pp. 1701-1704
    • Guggenheim, K.Y.1
  • 15
    • 84908233371 scopus 로고    scopus 로고
    • Rethinking cardiac metabolism: Metabolic cycles to refuel and rebuild the failing heart
    • Taegtmeyer H, Lubrano G. 2014 Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart. F1000Prime Rep. 6, 90. (doi:10.12703/P6-90)
    • (2014) F1000prime Rep , vol.6
    • Taegtmeyer, H.1    Lubrano, G.2
  • 16
    • 43449094351 scopus 로고    scopus 로고
    • Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems—role in ageing and disease
    • Thornalley PJ. 2008 Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems—role in ageing and disease. Drug Metabol. Drug Interact. 23, 125–150. (doi:10.1515/DMDI.2008.23.1-2.125)
    • (2008) Drug Metabol. Drug Interact , vol.23 , pp. 125-150
    • Thornalley, P.J.1
  • 17
    • 84903543600 scopus 로고    scopus 로고
    • Defining the toxicology of aging. Trends Mol
    • Sorrentino JA, Sanoff HK, Sharpless NE. 2014 Defining the toxicology of aging. Trends Mol. Med. 20, 375–384. (doi:10.1016/j.molmed.2014.04.004)
    • (2014) Med , vol.20 , pp. 375-384
    • Sorrentino, J.A.1    Sanoff, H.K.2    Sharpless, N.E.3
  • 18
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman K, Ames B. 1998 The free radical theory of aging matures. Physiol. Rev. 78, 548–581.
    • (1998) Physiol. Rev , vol.78 , pp. 548-581
    • Beckman, K.1    Ames, B.2
  • 19
    • 84859568041 scopus 로고    scopus 로고
    • The metabolic footprint of aging in mice
    • Houtkooper RH et al. 2011 The metabolic footprint of aging in mice. Sci. Rep. 1, 134. (doi:10.1038/srep00134)
    • (2011) Sci. Rep , vol.1
    • Houtkooper, R.H.1
  • 20
    • 0345596416 scopus 로고    scopus 로고
    • Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging
    • Tian L, Cai Q, Wei H. 1998 Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic. Biol. Med. 24, 1477–1484. (doi:10.1016/S0891-5849(98)00025-2)
    • (1998) Free Radic. Biol. Med , vol.24 , pp. 1477-1484
    • Tian, L.1    Cai, Q.2    Wei, H.3
  • 21
    • 84920507351 scopus 로고    scopus 로고
    • A midlife crisis for the mitochondrial free radical theory of aging
    • Stuart J, Maddalena L, Merilovich M, Robb E. 2014 A midlife crisis for the mitochondrial free radical theory of aging. Longevity Healthspan 3, 1–15. (doi:10.1186/2046-2395-3-4)
    • (2014) Longevity Healthspan , vol.3 , pp. 1-15
    • Stuart, J.1    Maddalena, L.2    Merilovich, M.3    Robb, E.4
  • 22
    • 79959350253 scopus 로고    scopus 로고
    • Extending life span by increasing oxidative stress
    • Ristow M, Schmeisser S. 2011 Extending life span by increasing oxidative stress. Free Radic. Biol. Med. 51, 327–336. (doi:10.1016/j.freeradbiomed.2011.05.010)
    • (2011) Free Radic. Biol. Med , vol.51 , pp. 327-336
    • Ristow, M.1    Schmeisser, S.2
  • 23
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn EH. 2000 Telomere states and cell fates. Nature 408, 53–56. (doi:10.1038/35040500)
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 24
    • 84906254220 scopus 로고    scopus 로고
    • Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
    • Flach J et al. 2014 Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature 512, 198–202. (doi:10.1038/nature13619)
    • (2014) Nature , vol.512 , pp. 198-202
    • Flach, J.1
  • 25
    • 84920053873 scopus 로고    scopus 로고
    • Age-related clonal hematopoiesis associated with adverse outcomes
    • Jaiswal S et al. 2014 Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498. (doi:10.1056/NEJMoa1408617)
    • (2014) N. Engl. J. Med , vol.371 , pp. 2488-2498
    • Jaiswal, S.1
  • 26
    • 84920024296 scopus 로고    scopus 로고
    • Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
    • Genovese G et al. 2014 Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371, 2477–2487. (doi:10.1056/NEJMoa1409405)
    • (2014) N. Engl. J. Med , vol.371 , pp. 2477-2487
    • Genovese, G.1
  • 27
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E, Depinho RA. 2010 Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 464, 520–528. (doi:10.1038/nature08982)
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 28
    • 79951812916 scopus 로고    scopus 로고
    • Telomere dysfunction induces metabolic and mitochondrial compromise
    • Sahin E et al. 2011 Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470, 359–365. (doi:10.1038/nature09787)
    • (2011) Nature , vol.470 , pp. 359-365
    • Sahin, E.1
  • 30
    • 84952639987 scopus 로고    scopus 로고
    • Aginginduced stem cell mutations as drivers for disease and cancer
    • Adams PD, Jasper H, Rudolph KL. 2015 Aginginduced stem cell mutations as drivers for disease and cancer. Cell Stem Cell 16, 601–612. (doi:10.1016/j.stem.2015.05.002)
    • (2015) Cell Stem Cell , vol.16 , pp. 601-612
    • Adams, P.D.1    Jasper, H.2    Rudolph, K.L.3
  • 31
    • 84900323323 scopus 로고    scopus 로고
    • Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
    • Sinha M, Jang YC, Oh J, Khong D, Wu EY, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. 2014 Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science 344, 649–652. (doi:10.1126/science.1251152)
    • (2014) Science , vol.344 , pp. 649-652
    • Sinha, M.1    Jang, Y.C.2    Oh, J.3    Khong, D.4    Wu, E.Y.5    Goodyear, L.J.6    Rosner, B.7    Lee, R.T.8    Wagers, A.J.9
  • 32
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut microbiome and the immune system
    • Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. 2011 Human nutrition, the gut microbiome and the immune system. Nature 474, 327–336. (doi:10.1038/nature10213)
    • (2011) Nature , vol.474 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3    Goodman, A.L.4    Gordon, J.I.5
  • 33
    • 84949237262 scopus 로고    scopus 로고
    • Metabolism: Inflammation keeps old mice healthy
    • Maillard I, Saltiel AR. 2015 Metabolism: inflammation keeps old mice healthy. Nature 528, 44–46. (doi:10.1038/nature15648)
    • (2015) Nature , vol.528 , pp. 44-46
    • Maillard, I.1    Saltiel, A.R.2
  • 34
    • 0000130814 scopus 로고
    • Experimental studies of physical fitness in relation to age
    • Robinson SM. 1938 Experimental studies of physical fitness in relation to age. Arbeitsphysiologie 10, 251–323. (doi:10.1007/bf02011412)
    • (1938) Arbeitsphysiologie , vol.10 , pp. 251-323
    • Robinson, S.M.1
  • 35
  • 36
    • 85020709464 scopus 로고    scopus 로고
    • Male and female age division VO2max–comparison with age division marathon and ironman triathlon performance
    • Malkinson TJ. 2014 Male and female age division VO2max–comparison with age division marathon and ironman triathlon performance. Med. Sci. Sports Med. 46, 892–893.
    • (2014) Med. Sci. Sports Med , vol.46 , pp. 892-893
    • Malkinson, T.J.1
  • 37
    • 0142180210 scopus 로고    scopus 로고
    • Invited review: Dynamic exercise performance in masters athletes: Insight into the effects of primary human aging on physiological functional capacity
    • Tanaka H, Seals DR. 2003 Invited review: dynamic exercise performance in masters athletes: insight into the effects of primary human aging on physiological functional capacity. J. Appl. Physiol. 95, 2152–2162. (doi:10.1152/japplphysiol.00320.2003)
    • (2003) J. Appl. Physiol , vol.95 , pp. 2152-2162
    • Tanaka, H.1    Seals, D.R.2
  • 38
    • 70349493058 scopus 로고    scopus 로고
    • Frailty syndrome: A transitional state in a dynamic process
    • Lang PO, Michel JP, Zekry D. 2009 Frailty syndrome: a transitional state in a dynamic process. Gerontology 55, 539–549. (doi:10.1159/000211949)
    • (2009) Gerontology , vol.55 , pp. 539-549
    • Lang, P.O.1    Michel, J.P.2    Zekry, D.3
  • 39
    • 67650033386 scopus 로고    scopus 로고
    • Sitting time and mortality from all causes, cardiovascular disease, and cancer
    • Katzmarzyk PT, Church TS, Craig CL, Bouchard C. 2009 Sitting time and mortality from all causes, cardiovascular disease, and cancer. Med. Sci. Sports Exerc. 41, 998–1005. (doi:10.1249/MSS.0b013e3181930355)
    • (2009) Med. Sci. Sports Exerc , vol.41 , pp. 998-1005
    • Katzmarzyk, P.T.1    Church, T.S.2    Craig, C.L.3    Bouchard, C.4
  • 40
    • 76649095246 scopus 로고    scopus 로고
    • Television viewing time and mortality: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    • Dunstan DW et al. 2010 Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Circulation 121, 384-391. (doi:10.1161/circulationaha.109.894824)
    • (2010) Circulation , vol.121 , pp. 384-391
    • Dunstan, D.W.1
  • 41
    • 78651268593 scopus 로고    scopus 로고
    • Screenbased entertainment time, all-cause mortality, and cardiovascular events: Population-based study with ongoing mortality and hospital events follow-up
    • Stamatakis E, Hamer M, Dunstan DW. 2011 Screenbased entertainment time, all-cause mortality, and cardiovascular events: population-based study with ongoing mortality and hospital events follow-up. J. Amer. College Cardiol. 57, 292–299. (doi:10.1016/j.jacc.2010.05.065)
    • (2011) J. Amer. College Cardiol , vol.57 , pp. 292-299
    • Stamatakis, E.1    Hamer, M.2    Dunstan, D.W.3
  • 42
    • 0021464649 scopus 로고
    • Changes in actin synthesis and alpha-actin-mRNA content in rat muscle during immobilization
    • Watson PA, Stein JP, Booth FW. 1984 Changes in actin synthesis and alpha-actin-mRNA content in rat muscle during immobilization. Amer. J. Physiol. 247, C39–C44.
    • (1984) Amer. J. Physiol , vol.247
    • Watson, P.A.1    Stein, J.P.2    Booth, F.W.3
  • 43
    • 84892548042 scopus 로고    scopus 로고
    • Increased expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading: Identification by oligonucleotide microarray
    • Reijnders CMA, van Essen HW, van Rens BTTM, van Beek JHGM, Ylstra B, Blankenstein MA, Lips P, Bravenboer N. 2013 Increased expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading: identification by oligonucleotide microarray. PLoS ONE 8, e79672. (doi:10.1371/journal.pone.0079672)
    • (2013) Plos ONE , vol.8
    • Reijnders, C.1    Van Essen, H.W.2    Van Rens, B.3    Van Beek, J.4    Ylstra, B.5    Blankenstein, M.A.6    Lips, P.7    Bravenboer, N.8
  • 45
    • 80955164777 scopus 로고    scopus 로고
    • Simulating the physiology of athletes during endurance sports events: Modelling human energy conversion and metabolism
    • van Beek JH, Supandi F, Gavai AK, de Graaf AA, Binsl TW, Hettling H. 2011 Simulating the physiology of athletes during endurance sports events: modelling human energy conversion and metabolism. Phil. Trans. R. Soc. A 369, 4295–4315. (doi:10.1098/rsta.2011.0166)
    • (2011) Phil. Trans. R. Soc. A , vol.369 , pp. 4295-4315
    • Van Beek, J.H.1    Supandi, F.2    Gavai, A.K.3    De Graaf, A.A.4    Binsl, T.W.5    Hettling, H.6
  • 46
    • 0001458227 scopus 로고
    • The energetic paradox of human running and hominid evolution
    • Carrier D. 1984 The energetic paradox of human running and hominid evolution. Curr. Anthropol. 25, 483–495. (doi:10.1086/203165)
    • (1984) Curr. Anthropol , vol.25 , pp. 483-495
    • Carrier, D.1
  • 49
    • 79960105112 scopus 로고    scopus 로고
    • Glycolytic oscillations and limits on robust efficiency
    • Chandra FA, Buzi G, Doyle JC. 2011 Glycolytic oscillations and limits on robust efficiency. Science 333, 187–192. (doi:10.1126/science.1200705)
    • (2011) Science , vol.333 , pp. 187-192
    • Chandra, F.A.1    Buzi, G.2    Doyle, J.C.3
  • 51
    • 0023100673 scopus 로고
    • Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
    • Kleiger RE, Miller JP, Bigger Jr JT, Moss AJ. 1987 Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Amer. J. Cardiol. 59, 256–262. (doi:10.1016/0002-9149(87)90795-8)
    • (1987) Amer. J. Cardiol , vol.59 , pp. 256-262
    • Kleiger, R.E.1    Miller, J.P.2    Bigger, J.T.3    Moss, A.J.4
  • 52
    • 0019365101 scopus 로고
    • The lungs as receptor sites for cardiovascular regulation
    • Shepherd JT. 1981 The lungs as receptor sites for cardiovascular regulation. Circulation 63, 1–10. (doi:10.1161/01.CIR.63.1.1)
    • (1981) Circulation , vol.63 , pp. 1-10
    • Shepherd, J.T.1
  • 53
    • 0024207280 scopus 로고
    • Nonlinear dynamics in sudden cardiac death syndrome: Heartrate oscillations and bifurcations
    • Goldberger AL, Rigney DR, Mietus J, Antman EM, Greenwald S. 1988 Nonlinear dynamics in sudden cardiac death syndrome: heartrate oscillations and bifurcations. Experientia 44, 983–987. (doi:10.1007/BF01939894)
    • (1988) Experientia , vol.44 , pp. 983-987
    • Goldberger, A.L.1    Rigney, D.R.2    Mietus, J.3    Antman, E.M.4    Greenwald, S.5
  • 54
    • 84895465792 scopus 로고    scopus 로고
    • Monitoring training status with HR measures: Do all roads lead to Rome? Front
    • Buchheit M. 2014 Monitoring training status with HR measures: do all roads lead to Rome? Front. Physiol. 5, 73. (doi:10.3389/fphys.2014.00073)
    • (2014) Physiol , vol.5
    • Buchheit, M.1
  • 55
    • 77954415435 scopus 로고    scopus 로고
    • Metabolic networks of longevity
    • Houtkooper RH, Williams RW, Auwerx J. 2010 Metabolic networks of longevity. Cell 142, 9–14. (doi:10.1016/j.cell.2010.06.029)
    • (2010) Cell , vol.142 , pp. 9-14
    • Houtkooper, R.H.1    Williams, R.W.2    Auwerx, J.3
  • 56
    • 84866163081 scopus 로고    scopus 로고
    • Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    • Mattison JA et al. 2012 Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489, 318–321. (doi:10.1038/nature11432)
    • (2012) Nature , vol.489 , pp. 318-321
    • Mattison, J.A.1
  • 58
    • 84943239001 scopus 로고    scopus 로고
    • A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity
    • Ravussin E et al. 2015 A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. J. Gerontol. A Biol. Sci. Med. Sci. 70, 1097–1104. (doi:10.1093/gerona/glv057)
    • (2015) J. Gerontol. A Biol. Sci. Med. Sci , vol.70 , pp. 1097-1104
    • Ravussin, E.1
  • 59
    • 84928963751 scopus 로고    scopus 로고
    • Widespread proteome remodeling and aggregation in aging C. Elegans
    • Walther DM et al. 2015 Widespread proteome remodeling and aggregation in aging C. elegans. Cell 161, 919–932. (doi:10.1016/j.cell.2015.03.032)
    • (2015) Cell , vol.161 , pp. 919-932
    • Walther, D.M.1
  • 60
    • 79953231670 scopus 로고    scopus 로고
    • Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging
    • Walther DM, Mann M. 2011 Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging. Mol. Cell Proteomics 10, M110004523. (doi:10.1074/mcp.M110.004523)
    • (2011) Mol. Cell Proteomics , vol.10
    • Walther, D.M.1    Mann, M.2
  • 62
    • 0026231542 scopus 로고
    • Exercise-related changes in protein turnover in mammalian striated muscle
    • Goldspink DF. 1991 Exercise-related changes in protein turnover in mammalian striated muscle. J. Exp. Biol. 160, 127–148.
    • (1991) J. Exp. Biol , vol.160 , pp. 127-148
    • Goldspink, D.F.1
  • 63
    • 77955380974 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
    • Hiona A et al. 2010 Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS ONE 5, e11468. (doi:10.1371/journal.pone.0011468)
    • (2010) Plos ONE , vol.5
    • Hiona, A.1
  • 64
    • 84941730889 scopus 로고    scopus 로고
    • Mitochondria: Are they causal players in cellular senescence?
    • Correia-Melo C, Passos JF. 2015 Mitochondria: are they causal players in cellular senescence? Biochim Biophys Acta 1847, 1373–1379. (doi:10.1016/j.bbabio.2015.05.017)
    • (2015) Biochim Biophys Acta , vol.1847 , pp. 1373-1379
    • Correia-Melo, C.1    Passos, J.F.2
  • 65
    • 84863442278 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and cell senescence—skin deep into mammalian aging
    • Passos JF, Von Zglinicki T. 2012 Mitochondrial dysfunction and cell senescence—skin deep into mammalian aging. Aging 4, 74–75.
    • (2012) Aging , vol.4 , pp. 74-75
    • Passos, J.F.1    Von Zglinicki, T.2
  • 66
    • 84877315835 scopus 로고    scopus 로고
    • A community-driven global reconstruction of human metabolism
    • Thiele I et al. 2013 A community-driven global reconstruction of human metabolism. Nat. Biotechnol. 31, 419–425. (doi:10.1038/nbt.2488)
    • (2013) Nat. Biotechnol , vol.31 , pp. 419-425
    • Thiele, I.1
  • 67
    • 84926292452 scopus 로고    scopus 로고
    • Using bioconductor package BiGGR for metabolic flux estimation based on gene expression changes in brain
    • Gavai AK, Supandi F, Hettling H, Murrell P, Leunissen JA, van Beek JH. 2015 Using bioconductor package BiGGR for metabolic flux estimation based on gene expression changes in brain. PLoS ONE 10, e0119016. (doi:10.1371/journal.pone.0119016)
    • (2015) Plos ONE , vol.10
    • Gavai, A.K.1    Supandi, F.2    Hettling, H.3    Murrell, P.4    Leunissen, J.A.5    Van Beek, J.H.6
  • 69
    • 0019521834 scopus 로고
    • Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids
    • Lying-Tunell U, Lindblad BS, Malmlund HO, Persson B. 1981 Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids. Acta Neurol. Scand. 63, 337–350. (doi:10.1111/j.1600-0404.1981.tb00788.x)
    • (1981) Acta Neurol. Scand , vol.63 , pp. 337-350
    • Lying-Tunell, U.1    Lindblad, B.S.2    Malmlund, H.O.3    Persson, B.4
  • 70
    • 78650002545 scopus 로고    scopus 로고
    • Large-scale in silico modeling of metabolic interactions between cell types in the human brain
    • Lewis NE et al. 2010 Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nat. Biotechnol. 28, 1279–1285. (doi:10.1038/nbt.1711)
    • (2010) Nat. Biotechnol , vol.28 , pp. 1279-1285
    • Lewis, N.E.1
  • 71
    • 84914127469 scopus 로고    scopus 로고
    • New and notable: Uncertainty quantification
    • Bassingthwaighte JB. 2014 New and notable: uncertainty quantification. Biophys. J. 107, 2481-2483. (doi:10.1016/j.bpj.2014.10.040)
    • (2014) Biophys. J , vol.107 , pp. 2481-2483
    • Bassingthwaighte, J.B.1
  • 72
    • 39549114844 scopus 로고    scopus 로고
    • Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: Application to cerebral hypoxia
    • Cakir T, Alsan S, Saybasili H, Akin A, Ulgen KO. 2007 Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia. Theor. Biol. Med. Model 4, 48. (doi:10.1186/1742-4682-4-48)
    • (2007) Theor. Biol. Med. Model , vol.4
    • Cakir, T.1    Alsan, S.2    Saybasili, H.3    Akin, A.4    Ulgen, K.O.5
  • 73
    • 84884565153 scopus 로고    scopus 로고
    • The evolution of genome-scale models of cancer metabolism
    • Lewis NE, Abdel-Haleem AM. 2013 The evolution of genome-scale models of cancer metabolism. Front. Physiol. 4, 237. (doi:10.3389/fphys.2013.00237)
    • (2013) Front. Physiol , vol.4
    • Lewis, N.E.1    Abdel-Haleem, A.M.2
  • 74
    • 84878949529 scopus 로고    scopus 로고
    • Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells
    • Sahoo S, Thiele I. 2013 Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells. Hum. Mol. Genet. 22, 2705–2722. (doi:10.1093/hmg/ddt119)
    • (2013) Hum. Mol. Genet , vol.22 , pp. 2705-2722
    • Sahoo, S.1    Thiele, I.2
  • 75
    • 77955476576 scopus 로고    scopus 로고
    • Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses
    • Kriete A, Bosl WJ, Booker G. 2010 Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. PLoS Comput. Biol. 6, e1000820. (doi:10.1371/journal.pcbi.1000820)
    • (2010) Plos Comput. Biol , vol.6
    • Kriete, A.1    Bosl, W.J.2    Booker, G.3
  • 76
    • 84874105434 scopus 로고    scopus 로고
    • Exercise efficiency is reduced by mitochondrial uncoupling in the elderly
    • Conley KE, Jubrias SA, Cress ME, Esselman P. 2013 Exercise efficiency is reduced by mitochondrial uncoupling in the elderly. Exp. Physiol. 98, 768-777. (doi:10.1113/expphysiol.2012.067314)
    • (2013) Exp. Physiol , vol.98 , pp. 768-777
    • Conley, K.E.1    Jubrias, S.A.2    Cress, M.E.3    Esselman, P.4
  • 78
    • 84875493199 scopus 로고    scopus 로고
    • Elevated energy coupling and aerobic capacity improves exercise performance in endurance-trained elderly subjects
    • Conley KE, Jubrias SA, Cress ME, Esselman PC. 2013 Elevated energy coupling and aerobic capacity improves exercise performance in endurance-trained elderly subjects. Exp. Physiol. 98, 899–907. (doi:10.1113/expphysiol.2012.069633)
    • (2013) Exp. Physiol , vol.98 , pp. 899-907
    • Conley, K.E.1    Jubrias, S.A.2    Cress, M.E.3    Esselman, P.C.4
  • 79
    • 0034234773 scopus 로고    scopus 로고
    • Oxidative capacity and ageing in human muscle
    • Conley KE, Jubrias SA, Esselman PC. 2000 Oxidative capacity and ageing in human muscle. J. Physiol. 526, 203–210. (doi:10.1111/j.1469-7793.2000.t01-1-00203.x)
    • (2000) J. Physiol , vol.526 , pp. 203-210
    • Conley, K.E.1    Jubrias, S.A.2    Esselman, P.C.3
  • 80
    • 84872225149 scopus 로고    scopus 로고
    • PGC1a and mitochondrial metabolism–emerging concepts and relevance in ageing and neurodegenerative disorders
    • Austin S, St-Pierre J. 2012 PGC1a and mitochondrial metabolism–emerging concepts and relevance in ageing and neurodegenerative disorders. J. Cell Sci. 125, 4963–4971. (doi:10.1242/jcs.113662)
    • (2012) J. Cell Sci , vol.125 , pp. 4963-4971
    • Austin, S.1    St-Pierre, J.2
  • 81
    • 0034695436 scopus 로고    scopus 로고
    • Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells
    • Kowald A, Kirkwood TB. 2000 Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. J. Theor. Biol. 202, 145–160. (doi:10.1006/jtbi.1999.1046)
    • (2000) J. Theor. Biol , vol.202 , pp. 145-160
    • Kowald, A.1    Kirkwood, T.B.2
  • 82
    • 84896810730 scopus 로고    scopus 로고
    • Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging
    • Kowald A, Kirkwood TBL. 2014 Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging. Proc. Natl Acad. Sci. USA 111, 2972–2977. (doi:10.1073/pnas.1314970111)
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 2972-2977
    • Kowald, A.1    Kirkwood, T.B.L.2
  • 84
    • 84891388331 scopus 로고    scopus 로고
    • Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart
    • Sen S et al. 2013 Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J. Am. Heart Assoc. 2, e004796. (doi:10.1161/JAHA.113.004796)
    • (2013) J. Am. Heart Assoc , vol.2
    • Sen, S.1
  • 85
    • 12844278044 scopus 로고    scopus 로고
    • The oxidative environment and protein damage
    • Davies MJ. 2005 The oxidative environment and protein damage. Biochim. Biophys. Acta 1703, 93-109. (doi:10.1016/j.bbapap.2004.08.007)
    • (2005) Biochim. Biophys. Acta , vol.1703 , pp. 93-109
    • Davies, M.J.1
  • 86
    • 84883582239 scopus 로고    scopus 로고
    • A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans
    • Benson AP, Grassi B, Rossiter HB. 2013 A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. J. Appl. Physiol. (1985) 115, 743–755. (doi:10.1152/japplphysiol.00184.2013)
    • (2013) J. Appl. Physiol. (1985) , vol.115 , pp. 743-755
    • Benson, A.P.1    Grassi, B.2    Rossiter, H.B.3
  • 87
    • 85020704403 scopus 로고    scopus 로고
    • Computer modelling of energy turnover and body temperature in elite cyclists during climbing. Cold, colder
    • van Beek JH. 2015 Computer modelling of energy turnover and body temperature in elite cyclists during climbing. Cold, colder, Gavia. Steep, steeper, Angliru. J. Sci. Cycling. 4, 35.
    • (2015) Gavia. Steep, Steeper, Angliru. J. Sci. Cycling , vol.4
    • Van Beek, J.H.1
  • 89
    • 84938586730 scopus 로고    scopus 로고
    • Quantifying diet-induced metabolic changes of the human gut microbiome
    • Shoaie S et al. 2015 Quantifying diet-induced metabolic changes of the human gut microbiome. Cell Metab. 22, 320–331. (doi:10.1016/j.cmet.2015.07.001)
    • (2015) Cell Metab , vol.22 , pp. 320-331
    • Shoaie, S.1
  • 90
    • 54249093810 scopus 로고    scopus 로고
    • Hyperpolarized 13C lactate, pyruvate, and alanine: Noninvasive biomarkers for prostate cancer detection and grading
    • Albers MJ et al. 2008 Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 68, 8607–8615. (doi:10.1158/0008-5472.CAN-08-0749)
    • (2008) Cancer Res , vol.68 , pp. 8607-8615
    • Albers, M.J.1
  • 91
    • 84929273341 scopus 로고    scopus 로고
    • On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and creatine kinase reaction kinetics using in vivo (3)(1)P MRS
    • Weiss K, Bottomley PA, Weiss RG. 2015 On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and creatine kinase reaction kinetics using in vivo (3)(1)P MRS. NMR Biomed. 28, 694–705. (doi:10.1002/nbm.3302)
    • (2015) NMR Biomed , vol.28 , pp. 694-705
    • Weiss, K.1    Bottomley, P.A.2    Weiss, R.G.3
  • 92
    • 77949639865 scopus 로고    scopus 로고
    • Computational quantification of metabolic fluxes from a single isotope snapshot: Application to an animal biopsy
    • Binsl TW, Alders DJ, Heringa J, Groeneveld AB, van Beek JH. 2010 Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy. Bioinformatics 26, 653–660. (doi:10.1093/bioinformatics/btq018)
    • (2010) Bioinformatics , vol.26 , pp. 653-660
    • Binsl, T.W.1    Alders, D.J.2    Heringa, J.3    Groeneveld, A.B.4    Van Beek, J.H.5
  • 94
    • 84947253155 scopus 로고    scopus 로고
    • Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle
    • Alders DJ, Groeneveld AB, Binsl TW, van Beek JH. 2015 Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle. Am. J. Physiol. Heart Circ. Physiol. 309, H1708-H1719. (doi:10.1152/ajpheart.00657.2014)
    • (2015) Am. J. Physiol. Heart Circ. Physiol , vol.309 , pp. H1708-H1719
    • Alders, D.J.1    Groeneveld, A.B.2    Binsl, T.W.3    Van Beek, J.H.4
  • 95
    • 84882312544 scopus 로고    scopus 로고
    • Computational estimation of tricarboxylic acid cycle fluxes using noisy NMR data from cardiac biopsies
    • Hettling H, Alders DJ, Heringa J, Binsl TW, Groeneveld AB, Van Beek JH. 2013 Computational estimation of tricarboxylic acid cycle fluxes using noisy NMR data from cardiac biopsies. BMC Syst. Biol. 7, 1–12. (doi:10.1186/1752-0509-7-82)
    • (2013) BMC Syst. Biol , vol.7 , pp. 1-12
    • Hettling, H.1    Alders, D.J.2    Heringa, J.3    Binsl, T.W.4    Groeneveld, A.B.5    Van Beek, J.H.6
  • 96
    • 84874659340 scopus 로고    scopus 로고
    • Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy
    • Hyder F, Fulbright RK, Shulman RG, Rothman DL. 2013 Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy. J. Cereb. Blood Flow Metab. 33, 339–347. (doi:10.1038/jcbfm.2012.207)
    • (2013) J. Cereb. Blood Flow Metab , vol.33 , pp. 339-347
    • Hyder, F.1    Fulbright, R.K.2    Shulman, R.G.3    Rothman, D.L.4
  • 97
    • 84860909299 scopus 로고    scopus 로고
    • A theory of biological relativity: No privileged level of causation
    • Noble D. 2012 A theory of biological relativity: no privileged level of causation. Interface Focus 2, 55–64. (doi:10.1098/rsfs.2011.0067)
    • (2012) Interface Focus , vol.2 , pp. 55-64
    • Noble, D.1
  • 98
    • 64749110869 scopus 로고    scopus 로고
    • The Cardiac Physiome: Perspectives for the future
    • Bassingthwaighte J, Hunter P, Noble D. 2009 The Cardiac Physiome: perspectives for the future. Exp. Physiol. 94, 597–605. (doi:10.1113/expphysiol.2008.044099)
    • (2009) Exp. Physiol , vol.94 , pp. 597-605
    • Bassingthwaighte, J.1    Hunter, P.2    Noble, D.3
  • 99
    • 0035032929 scopus 로고    scopus 로고
    • Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging
    • Spindler SR. 2001 Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Ann. NY Acad. Sci. 928, 296–304. (doi:10.1111/j.1749-6632.2001.tb05659.x)
    • (2001) Ann. NY Acad. Sci , vol.928 , pp. 296-304
    • Spindler, S.R.1
  • 100
    • 84912115519 scopus 로고    scopus 로고
    • MTOR and the health benefits of exercise. Semin
    • Watson K, Baar K. 2014 mTOR and the health benefits of exercise. Semin. Cell Dev. Biol. 36, 130–139. (doi:10.1016/j.semcdb.2014.08.013)
    • (2014) Cell Dev. Biol , vol.36 , pp. 130-139
    • Watson, K.1    Baar, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.