Clinical and genetic factors associated with suicide in mood disorder patients

European Archives of Psychiatry and Clinical Neuroscience

Volumn 266, Issue 2, 2016, Pages 181-193

  Antypa, Niki ^b   Souery, Daniel ^c   Tomasini, Mario ^a   Albani, Diego ^d   Fusco, Federica ^d   Mendlewicz, Julien ^c   Serretti, Alessandro ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Bipolar; Depression; Genetic association study; Mood disorder; Single nucleotide polymorphism; Suicide

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; CREBBP PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; MAPK1 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ADULT; AGE; ALLELE; ARTICLE; BIPOLAR DISORDER; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; DISABILITY; EDUCATIONAL STATUS; EXON; FEMALE; FUNCTIONAL DISABILITY; GENDER; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAMILTON DEPRESSION RATING SCALE; HEREDITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MARRIAGE; MENTAL PATIENT; MONTGOMERY ASBERG DEPRESSION RATING SCALE; MOOD DISORDER; OBSESSIVE COMPULSIVE DISORDER; PANIC; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROMOTER REGION; SECOND DEGREE RELATIVE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING HABIT; SUICIDE; SUICIDE ATTEMPT; CHI SQUARE DISTRIBUTION; FAMILY HEALTH; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; MIDDLE AGED; PSYCHOLOGY; RETROSPECTIVE STUDY; SEX DIFFERENCE; STATISTICAL MODEL;

ADULT; AGE FACTORS; CHI-SQUARE DISTRIBUTION; CREB-BINDING PROTEIN; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MOOD DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; SEX FACTORS; SUICIDE;

EID: 84958661433     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-015-0658-1     Document Type: Article

References (118)

1. Lester D, Abdel-Khalek AM (1999) Manic-depression, suicidality, and obsessive-compulsive tendencies. Psychol Rep 85:1100
2. Moffitt TE, Caspi A, Taylor A, Kokaua J, Milne BJ, Polanczyk G, Poulton R (2010) How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychol Med 40:899–909
3. Tsuang MT, Taylor L, Faraone SV (2004) An overview of the genetics of psychotic mood disorders. J Psychiatr Res 38:3–15
4. Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170:205–228
5. Conwell Y, Duberstein PR, Cox C, Herrmann JH, Forbes NT, Caine ED (1996) Relationships of age and Axis I diagnoses in victims of completed suicide: a psychological autopsy study. Am J Psychiatry 153:1001–1008
6. Chen YW, Dilsaver SC (1996) Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders. Biol Psychiatry 39:896–899
7. Angst J, Hengartner MP, Gamma A, von Zerssen D, Angst F (2013) Mortality of 403 patients with mood disorders 48 to 52 years after their psychiatric hospitalisation. Eur Arch Psychiatry Clin Neurosci 263:425–434
8. Oquendo MA, Galfalvy H, Russo S, Ellis SP, Grunebaum MF, Burke A, Mann JJ (2004) Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder. Am J Psychiatry 161:1433–1441
9. Nivoli AM, Pacchiarotti I, Rosa AR, Popovic D, Murru A, Valenti M, Bonnin CM, Grande I, Sanchez-Moreno J, Vieta E, Colom F (2011) Gender differences in a cohort study of 604 bipolar patients: the role of predominant polarity. J Affect Disord 133:443–449
10. Victor SE, Klonsky ED (2014) Correlates of suicide attempts among self-injurers: a meta-analysis. Clin Psychol Rev 34:282–297
11. Angst J, Hengartner MP, Rogers J, Schnyder U, Steinhausen HC, Ajdacic-Gross V, Rossler W (2014) Suicidality in the prospective Zurich study: prevalence, risk factors and gender. Eur Arch Psychiatry Clin Neurosci 264:557–565
12. Coryell W, Fiedorowicz J, Leon AC, Endicott J, Keller MB (2013) Age of onset and the prospectively observed course of illness in bipolar disorder. J Affect Disord 146:34–38
13. Goldstein TR, Ha W, Axelson DA, Goldstein BI, Liao F, Gill MK, Ryan ND, Yen S, Hunt J, Hower H, Keller M, Strober M, Birmaher B (2012) Predictors of prospectively examined suicide attempts among youth with bipolar disorder. Arch Gen Psychiatry 69:1113–1122
14. Altamura AC, Dell’Osso B, Berlin HA, Buoli M, Bassetti R, Mundo E (2010) Duration of untreated illness and suicide in bipolar disorder: a naturalistic study. Eur Arch Psychiatry Clin Neurosci 260:385–391
15. Seemuller F, Meier S, Obermeier M, Musil R, Bauer M, Adli M, Kronmuller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Riedel M, Falkai P, Moller HJ (2014) Three-year long-term outcome of 458 naturalistically treated inpatients with major depressive episode: severe relapse rates and risk factors. Eur Arch Psychiatry Clin Neurosci 264:567–575
16. Hawton K, Sutton L, Haw C, Sinclair J, Harriss L (2005) Suicide and attempted suicide in bipolar disorder: a systematic review of risk factors. J Clin Psychiatry 66:693–704
17. Acosta FJ, Vega D, Torralba L, Navarro S, Ramallo-Farina Y, Fiuza D, Hernandez JL, Siris SG (2012) Hopelessness and suicidal risk in bipolar disorder. A study in clinically nonsyndromal patients. Compr Psychiatry 53:1103–1109
18. Coryell W, Young EA (2005) Clinical predictors of suicide in primary major depressive disorder. J Clin Psychiatry 66:412–417
19. Mann JJ, Waternaux C, Haas GL, Malone KM (1999) Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156:181–189
20. Hawton K, Casanas ICC, Haw C, Saunders K (2013) Risk factors for suicide in individuals with depression: a systematic review. J Affect Disord 147:17–28
21. Valtonen HM, Suominen K, Mantere O, Leppamaki S, Arvilommi P, Isometsa E (2007) Suicidal behaviour during different phases of bipolar disorder. J Affect Disord 97:101–107
22. Statham DJ, Heath AC, Madden PA, Bucholz KK, Bierut L, Dinwiddie SH, Slutske WS, Dunne MP, Martin NG (1998) Suicidal behaviour: an epidemiological and genetic study. Psychol Med 28:839–855
23. Baldassano CF (2006) Illness course, comorbidity, gender, and suicidality in patients with bipolar disorder. J Clin Psychiatry 67(Suppl 11):8–11
24. Neves FS, Malloy-Diniz LF, Barbosa IG, Brasil PM, Correa H (2009) Bipolar disorder first episode and suicidal behavior: are there differences according to type of suicide attempt? Rev Bras Psiquiatr 31:114–118
25. Finseth PI, Morken G, Andreassen OA, Malt UF, Vaaler AE (2012) Risk factors related to lifetime suicide attempts in acutely admitted bipolar disorder inpatients. Bipolar Disord 14:727–734
26. Beghi M, Rosenbaum JF, Cerri C, Cornaggia CM (2013) Risk factors for fatal and nonfatal repetition of suicide attempts: a literature review. Neuropsychiatr Dis Treat 9:1725–1736
27. Nordstrom P, Asberg M, Aberg-Wistedt A, Nordin C (1995) Attempted suicide predicts suicide risk in mood disorders. Acta Psychiatr Scand 92:345–350
28. Antypa N, Antonioli M, Serretti A (2013) Clinical, psychological and environmental predictors of prospective suicide events in patients with bipolar disorder. J Psychiatr Res 47:1800–1808
29. McElroy SL, Frye MA, Hellemann G, Altshuler L, Leverich GS, Suppes T, Keck PE, Nolen WA, Kupka R, Post RM (2011) Prevalence and correlates of eating disorders in 875 patients with bipolar disorder. J Affect Disord 128:191–198
30. Simpson SG, Jamison KR (1999) The risk of suicide in patients with bipolar disorders. J Clin Psychiatry 60(Suppl 2):53–56 (discussion 75–56, 113–116)
31. Pompili M, Serafini G, Innamorati M, Biondi M, Siracusano A, Di Giannantonio M, Giupponi G, Amore M, Lester D, Girardi P, Moller-Leimkuhler AM (2012) Substance abuse and suicide risk among adolescents. Eur Arch Psychiatry Clin Neurosci 262(6):469–485
32. Dumais A, Lesage AD, Alda M, Rouleau G, Dumont M, Chawky N, Roy M, Mann JJ, Benkelfat C, Turecki G (2005) Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry 162:2116–2124
33. Maser JD, Akiskal HS, Schettler P, Scheftner W, Mueller T, Endicott J, Solomon D, Clayton P (2002) Can temperament identify affectively ill patients who engage in lethal or near-lethal suicidal behavior? A 14-year prospective study. Suicide Life Threat Behav 32:10–32
34. McGuffin P, Marusic A, Farmer A (2001) What can psychiatric genetics offer suicidology? Crisis 22:61–65
35. Bortolato M, Pivac N, Muck Seler D, Nikolac Perkovic M, Pessia M, Di Giovanni G (2013) The role of the serotonergic system at the interface of aggression and suicide. Neuroscience 236:160–185
36. Joiner TE Jr, Brown JS, Wingate LR (2005) The psychology and neurobiology of suicidal behavior. Annu Rev Psychol 56:287–314
37. Antypa N, Serretti A, Rujescu D (2013) Serotonergic genes and suicide: a systematic review. Eur Neuropsychopharmacol 23:1125–1142
38. Stanley B, Molcho A, Stanley M, Winchel R, Gameroff MJ, Parsons B, Mann JJ (2000) Association of aggressive behavior with altered serotonergic function in patients who are not suicidal. Am J Psychiatry 157:609–614
39. Mann JJ, Arango VA, Avenevoli S, Brent DA, Champagne FA, Clayton P, Currier D, Dougherty DM, Haghighi F, Hodge SE, Kleinman J, Lehner T, McMahon F, Moscicki EK, Oquendo MA, Pandey GN, Pearson J, Stanley B, Terwilliger J, Wenzel A (2009) Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry 65:556–563
40. Rujescu D, Giegling I (2010) The genetics of neurosystems in mental ill-health and suicidality: beyond serotonin. Eur Psychiatry 25:272–274
41. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243–250
42. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR (2004) Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mrna, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75:807–821
43. Antypa N, Drago A, Serretti A (2013) The role of COMT gene variants in depression: bridging neuropsychological, behavioral and clinical phenotypes. Neurosci Biobehav Rev 37:1597–1610
44. Kia-Keating BM, Glatt SJ, Tsuang MT (2007) Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 144B:1048–1053
45. Calati R, Porcelli S, Giegling I, Hartmann AM, Moller HJ, De Ronchi D, Serretti A, Rujescu D (2011) Catechol-O-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study. J Psychiatr Res 45:309–321
46. De Luca V, Strauss J, Kennedy JL (2008) Power based association analysis (PBAT) of serotonergic and noradrenergic polymorphisms in bipolar patients with suicidal behaviour. Prog Neuropsychopharmacol Biol Psychiatry 32:197–203
47. Zalsman G, Huang YY, Oquendo MA, Brent DA, Giner L, Haghighi F, Burke AK, Ellis SP, Currier D, Mann JJ (2008) No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders. Arch Suicide Res 12:327–335
48. Schosser A, Calati R, Serretti A, Massat I, Kocabas NA, Papageorgiou K, Linotte S, Mendlewicz J, Souery D, Zohar J, Juven-Wetzler A, Montgomery S, Kasper S (2012) The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder—a European multicenter study. Eur Neuropsychopharmacol 22:259–266
49. Golimbet VE, Alfimova MV, Gritsenko IK, Ebstein RP (2007) Relationship between dopamine system genes and extraversion and novelty seeking. Neurosci Behav Physiol 37:601–606
50. Hoth KF, Paul RH, Williams LM, Dobson-Stone C, Todd E, Schofield PR, Gunstad J, Cohen RA, Gordon E (2006) Associations between the COMT Val/Met polymorphism, early life stress, and personality among healthy adults. Neuropsychiatr Dis Treat 2:219–225
51. Kulikova MA, Maluchenko NV, Timofeeva MA, Shlepzova VA, Schegolkova JV, Sysoeva OV, Ivanitsky AM, Tonevitsky AG (2008) Effect of functional catechol-O-methyltransferase Val158Met polymorphism on physical aggression. Bull Exp Biol Med 145:62–64
52. Rujescu D, Giegling I, Gietl A, Hartmann AM, Moller HJ (2003) A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 54:34–39
53. Hong JP, Lee JS, Chung S, Jung J, Yoo HK, Chang SM, Kim CY (2008) New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia. Am J Med Genet B Neuropsychiatr Genet 147B:658–660
54. Soyka M (2011) Neurobiology of aggression and violence in schizophrenia. Schizophr Bull 37:913–920
55. Dwivedi Y (2010) Brain-derived neurotrophic factor and suicide pathogenesis. Ann Med 42:87–96
56. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:804–815
57. Sen S, Duman R, Sanacora G (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 64:527–532
58. Piccinni A, Marazziti D, Catena M, Domenici L, Del Debbio A, Bianchi C, Mannari C, Martini C, Da Pozzo E, Schiavi E, Mariotti A, Roncaglia I, Palla A, Consoli G, Giovannini L, Massimetti G, Dell’Osso L (2008) Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments. J Affect Disord 105:279–283
59. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24:4401–4411
60. Liu L, Foroud T, Xuei X, Berrettini W, Byerley W, Coryell W, El-Mallakh R, Gershon ES, Kelsoe JR, Lawson WB, MacKinnon DF, McInnis M, McMahon FJ, Murphy DL, Rice J, Scheftner W, Zandi PP, Lohoff FW, Niculescu AB, Meyer ET, Edenberg HJ, Nurnberger JI Jr (2008) Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Psychiatr Genet 18:267–274
61. Lohoff FW, Sander T, Ferraro TN, Dahl JP, Gallinat J, Berrettini WH (2005) Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet 139B:51–53
62. Green EK, Raybould R, Macgregor S, Hyde S, Young AH, O’Donovan MC, Owen MJ, Kirov G, Jones L, Jones I, Craddock N (2006) Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. Br J Psychiatry 188:21–25
63. Muller DJ, de Luca V, Sicard T, King N, Strauss J, Kennedy JL (2006) Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: family-based association study. Br J Psychiatry 189:317–323
64. Kim B, Kim CY, Hong JP, Kim SY, Lee C, Joo YH (2008) Brain-derived neurotrophic factor Val/Met polymorphism and bipolar disorder. Association of the met allele with suicidal behavior of bipolar patients. Neuropsychobiology 58:97–103
65. Zai CC, Manchia M, De Luca V, Tiwari AK, Chowdhury NI, Zai GC, Tong RP, Yilmaz Z, Shaikh SA, Strauss J, Kennedy JL (2012) The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis. Int J Neuropsychopharmacol 15:1037–1042
66. Sarchiapone M, Carli V, Roy A, Iacoviello L, Cuomo C, Latella MC, di Giannantonio M, Janiri L, de Gaetano M, Janal MN (2008) Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Neuropsychobiology 57:139–145
67. Schenkel LC, Segal J, Becker JA, Manfro GG, Bianchin MM, Leistner-Segal S (2010) The BDNF Val66Met polymorphism is an independent risk factor for high lethality in suicide attempts of depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 34:940–944
68. Niitsu T, Fabbri C, Bentini F, Serretti A (2013) Pharmacogenetics in major depression: a comprehensive meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 45:183–194
69. Pae CU, Chiesa A, Porcelli S, Han C, Patkar AA, Lee SJ, Park MH, Serretti A, De Ronchi D (2012) Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia. Neuropsychobiology 65:1–11
70. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH (2001) Map kinases. Chem Rev 101:2449–2476
71. Sweatt JD (2001) The neuronal map kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76:1–10
72. Bogoyevitch MA, Court NW (2004) Counting on mitogen-activated protein kinases—ERKs 3, 4, 5, 6, 7 and 8. Cell Signal 16:1345–1354
73. Dwivedi Y, Rizavi HS, Zhang H, Roberts RC, Conley RR, Pandey GN (2009) Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: role of ERK kinase 1 (MEK1). Int J Neuropsychopharmacol 12:1337–1354
74. Yuan P, Zhou R, Wang Y, Li X, Li J, Chen G, Guitart X, Manji HK (2010) Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia. J Affect Disord 124:164–169
75. Qi X, Lin W, Li J, Pan Y, Wang W (2006) The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress. Behav Brain Res 175:233–240
76. Qi X, Lin W, Li J, Li H, Wang W, Wang D, Sun M (2008) Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. Neurobiol Dis 31:278–285
77. Qi H, Mailliet F, Spedding M, Rocher C, Zhang X, Delagrange P, McEwen B, Jay TM, Svenningsson P (2009) Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation. Neuropharmacology 56:37–46
78. Wang Z, Wang J, Li J, Wang X, Yao Y, Zhang X, Li C, Cheng Y, Ding G, Liu L, Ding Z (2011) MEK/ERKs signaling is essential for lithium-induced neurite outgrowth in N2a cells. Int J Dev Neurosci 29:415–422
79. Kim SH, Seo MS, Jeon WJ, Yu HS, Park HG, Jung GA, Lee HY, Kang UG, Kim YS (2008) Haloperidol regulates the phosphorylation level of the MEK-ERK-p90RSK signal pathway via protein phosphatase 2A in the rat frontal cortex. Int J Neuropsychopharmacol 11:509–517
80. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251–3261
81. Xing J, Ginty DD, Greenberg ME (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273:959–963
82. Drago A, Crisafulli C, Sidoti A, Serretti A (2011) The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes. Prog Neurobiol 94:418–460
83. Serretti A, Chiesa A, Calati R, Massat I, Linotte S, Kasper S, Lecrubier Y, Antonijevic I, Forray C, Snyder L, Bollen J, Zohar J, De Ronchi D, Souery D, Mendlewicz J (2011) A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression. J Affect Disord 128:56–63
84. Boer U, Cierny I, Krause D, Heinrich A, Lin H, Mayr G, Hiemke C, Knepel W (2008) Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice. Neuropsychopharmacology 33:2407–2415
85. Dwivedi Y, Rao JS, Rizavi HS, Kotowski J, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2003) Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:273–282
86. Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Roberts RC, Conley RR (2007) Cyclic amp response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus. Int J Neuropsychopharmacol 10:621–629
87. Souery D, Zaninotto L, Calati R, Linotte S, Mendlewicz J, Sentissi O, Serretti A (2012) Depression across mood disorders: review and analysis in a clinical sample. Compr Psychiatry 53:24–38
88. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33 (quiz 34–57)
89. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
90. Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389
91. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429–435
92. Park S, Choi JW, Kyoung Yi K, Hong JP (2013) Suicide mortality and risk factors in the 12 months after discharge from psychiatric inpatient care in Korea: 1989–2006. Psychiatry Res 208:145–150
93. Wilkowska-Chmielewska J, Szelenberger W, Wojnar M (2013) Age-dependent symptomatology of depression in hospitalized patients and its implications for DSM-5. J Affect Disord 150:142–145
94. Oostervink F, Boomsma MM, Nolen WA, Board EA (2009) Bipolar disorder in the elderly; different effects of age and of age of onset. J Affect Disord 116:176–183
95. Angold A, Costello EJ, Erkanli A, Worthman CM (1999) Pubertal changes in hormone levels and depression in girls. Psychol Med 29:1043–1053
96. Angold A, Costello EJ (2006) Puberty and depression. Child Adolesc Psychiatr Clin N Am 15:919–937 (ix)
97. Clarke MC, Coughlan H, Harley M, Connor D, Power E, Lynch F, Fitzpatrick C, Cannon M (2014) The impact of adolescent cannabis use, mood disorder and lack of education on attempted suicide in young adulthood. World Psychiatry 13:322–323
98. Ostacher MJ, Lebeau RT, Perlis RH, Nierenberg AA, Lund HG, Moshier SJ, Sachs GS, Simon NM (2009) Cigarette smoking is associated with suicidality in bipolar disorder. Bipolar Disord 11:766–771
99. Seo HJ, Jung YE, Jeong S, Kim JB, Lee MS, Kim JM, Yim HW, Jun TY (2014) Personality traits associated with suicidal behaviors in patients with depression: the CRESCEND study. Compr Psychiatry 55(5):1085–1092
100. Sareen J, Cox BJ, Afifi TO, de Graaf R, Asmundson GJ, ten Have M, Stein MB (2005) Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Arch Gen Psychiatry 62:1249–1257
101. McElroy SL, Altshuler LL, Suppes T, Keck PE Jr, Frye MA, Denicoff KD, Nolen WA, Kupka RW, Leverich GS, Rochussen JR, Rush AJ, Post RM (2001) Axis i psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry 158:420–426
102. Bauer MS, Altshuler L, Evans DR, Beresford T, Williford WO, Hauger R, Team VACS (2005) Prevalence and distinct correlates of anxiety, substance, and combined comorbidity in a multi-site public sector sample with bipolar disorder. J Affect Disord 85:301–315
103. Cassano GB, Pini S, Saettoni M, Dell’Osso L (1999) Multiple anxiety disorder comorbidity in patients with mood spectrum disorders with psychotic features. Am J Psychiatry 156:474–476
104. Chen YW, Dilsaver SC (1995) Comorbidity of panic disorder in bipolar illness: evidence from the epidemiologic catchment area survey. Am J Psychiatry 152:280–282
105. Chen YW, Dilsaver SC (1995) Comorbidity for obsessive-compulsive disorder in bipolar and unipolar disorders. Psychiatry Res 59:57–64
106. Rao KN, Kulkarni RR, Begum S (2013) Comorbidity of psychiatric and personality disorders in first suicide attempters. Indian J Psychol Med 35:75–79
107. Brent DA, Perper JA, Moritz G, Liotus L, Schweers J, Balach L, Roth C (1994) Familial risk factors for adolescent suicide: a case-control study. Acta Psychiatr Scand 89:52–58
108. Gould MS, Fisher P, Parides M, Flory M, Shaffer D (1996) Psychosocial risk factors of child and adolescent completed suicide. Arch Gen Psychiatry 53:1155–1162
109. Pawlak J, Dmitrzak-Weglarz M, Skibinska M, Szczepankiewicz A, Leszczynska-Rodziewicz A, Rajewska-Rager A, Zaremba D, Czerski P, Hauser J (2013) Suicide attempts and clinical risk factors in patients with bipolar and unipolar affective disorders. Gen Hosp Psychiatry 35:427–432
110. Tondo L, Lepri B, Baldessarini RJ (2007) Suicidal risks among 2826 sardinian major affective disorder patients. Acta Psychiatr Scand 116:419–428
111. Pompili M, Innamorati M, Raja M, Falcone I, Ducci G, Angeletti G, Lester D, Girardi P, Tatarelli R, De Pisa E (2008) Suicide risk in depression and bipolar disorder: do impulsiveness-aggressiveness and pharmacotherapy predict suicidal intent? Neuropsychiatr Dis Treat 4:247–255
112. Kim YK, Lee HP, Won SD, Park EY, Lee HY, Lee BH, Lee SW, Yoon D, Han C, Kim DJ, Choi SH (2007) Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 31:78–85
113. Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V, Sacchetti S, Lembo F, Angiolillo A, Jovanovic N, Pisanti F, Tomaiuolo R, Monticelli A, Balazic J, Roy A, Marusic A, Cocozza S, Fusco A, Bruni CB, Castaldo G, Chiariotti L (2010) Increased BDNF promoter methylation in the wernicke area of suicide subjects. Arch Gen Psychiatry 67:258–267
114. Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ (2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48:186–189
115. Pregelj P, Nedic G, Paska AV, Zupanc T, Nikolac M, Balazic J, Tomori M, Komel R, Seler DM, Pivac N (2011) The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord 128:287–290
116. Dwivedi Y, Rizavi HS, Roberts RC, Conley RC, Tamminga CA, Pandey GN (2001) Reduced activation and expression of ERK1/2 map kinase in the post-mortem brain of depressed suicide subjects. J Neurochem 77:916–928
117. Einat H, Manji HK, Gould TD, Du J, Chen G (2003) Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice. Drug News Perspect 16:453–463
118. Schild AH, Pietschnig J, Tran US, Voracek M (2013) Genetic association studies between SNPs and suicidal behavior: a meta-analytical field synopsis. Prog Neuropsychopharmacol Biol Psychiatry 46:36–42