Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects

Archives of General Psychiatry

Volumn 60, Issue 3, 2003, Pages 273-282

  Dwivedi, Yogesh ^a   Rao, Jagadeesh Sridhara ^a   Rizavi, Hooriyah S ^a   Kotowski, Jacek ^a   Conley, Robert R ^b   Roberts, Rosalinda C ^b   Tamminga, Carol A ^b   Pandey, Ghanshyam N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NEURON SPECIFIC ENOLASE; PROTEIN KINASE; TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; BINDING AFFINITY; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DNA BINDING; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUICIDAL BEHAVIOR; SUICIDE; WESTERN BLOTTING;

ADULT; AGED; AUTORADIOGRAPHY; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSIVE DISORDER; DISEASE SUSCEPTIBILITY; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUICIDE;

EID: 0037338519     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.60.3.273     Document Type: Article

References (55)

1. Gross-Iseroff R, Biegon A, Voet H, Weizman A. The suicide brain: a review of postmortem receptor/transporter binding studies. Neurosci Biobehav Rev. 1998; 22:653-661.
2. Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol. 1993;13:4852-4859.
3. 3H]cyclic AMP binding sites and PKA activity in the prefrontal cortex of suicide subjects. Am J Psychiatry. 2002;159:66-73.
4. 3H]cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder. J Neurochem. 1997;68:297-304.
5. Shelton RC, Mainer DH, Sulser F. cAMP-dependent protein kinase activity in major depression. Am J Psychiatry. 1996;153:1037-1042.
6. Manier DH, Eiring A, Shelton RC, Sulser F. β-Adrenoceptor-linked protein kinase A (PKA) activity in human fibroblasts from normal subjects and from patients with major depression. Neuropsychopharmacology. 1996;15:555-561.
7. Perez J, Tardito D, Racagni G, Smeraldi E, Zanardi R. Protein kinase A and Rap1 levels in platelets of untreated patients with major depression. Mol Psychiatry. 2001;6:44-49.
8. Nestler EJ, Terwilliger RZ, Duman RS. Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem. 1989;53:1644-1647.
9. Perez J, Tinelli D, Bianchi E, Brunello N, Racagni G. cAMP-binding proteins in the rat cerebral cortex after administration of selective 5-HT and NE reuptake blockers with antidepressant activity. Neuropsychopharmacology. 1991;4:57-64.
10. Mori S, Zanardi R, Popoli M, Garbini S, Brunello N, Smeraldi E, Racagni G, Perez J. cAMP-dependent phosphorylation system after short- and long-term administration of moclobemide. J Psychiatr Res. 1998;32:111-115.
11. Popoli M, Brunello N, Perez J, Racagni G. Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs. J Neurochem. 2000;74:21-33.
12. Borrelli E, Montmayeur JP, Foulkes NS, Sassone-Corsi P. Signal transduction and gene control: the cAMP pathway. Crit Rev Oncog. 1992;3:321-338.
13. Montminy MR, Gonzalez GA, Yamamoto K. Regulation of cAMP-inducible genes by CREB. Trend Neurosci. 1990;13:184-188.
14. Moore AN, Waxham MN, Dash PK. Neuronal activity increases the phosphorylation of the transcription factor cyclic AMP response element binding protein (CREB) in rat hippocampus and cortex. J Biol Chem. 1996;271:14214-14220.
15. Imaki J, Yoshida K, Yamashita K. A developmental study of cyclic AMP response element binding protein (CREB) by in situ hybridization histochemistry and immunocytochemistry in the rat neocortex. Brain Res. 1994;651:269-274.
16. Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and memory. Annu Rev Neurosci. 1998;21:127-148.
17. Marshall R, Dragunow M. Is CREB a key to neuronal survival? Trends Neurosci. 2000;23:48-53.
18. Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci. 1996;16:2365-2372.
19. Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased temporal cortex CREB concentrations and antidepressant treatment in major depression [letter]. Lancet. 1998;352:1754-1755.
20. Conti AC, Cryan JF, Dalvi A, Lucki I, Blendy JA. CAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs. J Neurosci. 2002;22:3262-3268.
21. Pandey GN, Dwivedi Y, Pandey SC, Conley R, Roberts R, Tamminga C. Protein kinase C in the postmortem brain of teenage suicide victims. Neurosci Lett. 1997; 228:111-114.
22. Dwivedi Y, Conley R, Roberts R, Tamminga C, Pandey GN. Reduced activation and expression of ERK1/2 MAP kinase in the postmortem brain of depressed suicide subjects. J Neurochem. 2001;77:916-928.
23. Xie H, Rothstein TL. Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig. J Immunol 1995;154:1717-1723.
24. Impey S, Obrietan K, Storm DR. Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity. Neuron. 1999;23:11-14.
25. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994;14:6107-6116.
26. Salzman S, Endicott J, Clayton P, Winokur G. Diagnostic Evaluation After Death (DEAD). Rockville, Md: National Institute of Mental Health, Neuroscience Research Branch; 1983.
27. Spitzer RL, Williams JB, Gibbon M, First MB. The structured clinical interview for DSM-III-R (SCID), I: history, rationale, and description. Arch Gen Psychiatry. 1992;49:624-629.
28. 3H] cyclic AMP binding to protein kinase A (PKA), cyclic AMP-dependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brain. J Pharmacol Exp Ther. 2000;294:103-116.
29. Yoshimura T, Fujisawa J, Yoshida M. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J. 1990;9:2537-2542.
30. McAleese SM, Dunbar B, Fothergill JE, Hinks LJ, Day IN. Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE). Eur J Biochem. 1988;178:413-417.
31. Waeber G, Habener JF, Nuclear translocation and DNA recognition signals colocalized within the bZIP domain of cyclic adenosine 3′5′-monophosphate response element binding protein CREB. Mol Endocrinol. 1991;5:1431-1438.
32. Herdegen T, Blume A, Buschmann T, Georgakopoulos E, Winter C, Schmid W, Hsieh TF, Zimmermann M, Gass P. Expression of activating transcription factor-2, serum response factor and cAMP/Ca response element binding protein in the adult rat brain following generalized seizures, nerve fibre lesion and ultraviolet irradiation. Neuroscience. 1997;81:199-212.
33. Ferrer I, Blanco R, Rivera R, Carmona M, Ballabriga J, Olive M, Planas AM. CREB-1 and CREB-2 immunoreactivity in the rat brain. Brain Res. 1996;712:159-164.
34. Cadd G, McKnight GS. Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain. Neuron. 1989;3:71-79.
35. Stein JC, Farooq M, Norton WT, Rubin CS. Differential expression of isoforms of the regulatory subunit of type II cAMP-dependent protein kinase in rat neurons, astrocytes and oligodendrocytes. J Biot Chem. 1987;262:3002-3006.
36. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34:13-25.
37. Chen AC-H, Shirayama Y, Shin K-H, Neve RL, Duman RS. Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect. Biol Psychiatry. 2001;49:753-762.
38. Clayton PJ. Suicide. Psychiatr Clin North Am. 1985;8:203-214.
39. Monk M. Epidemilogy of suicide. Epidemiol Rev. 1987;9:51-69.
40. Arato M, Banki CM, Bissette G, Nemeroff CB. Elevated CSF CRF in suicide victims. Biol Psychiatry. 1989;25:355-359.
41. Hiroi N, Wong ML, Licinio J, Park C, Young M, Gold PW, Chrousos GP, Bornstein SR. Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Mol Psychiatry. 2001;6:540-546.
42. Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry. 1988;45:577-579.
43. Lopez JF, Palkovits M, Arato M, Mansour A, Akil H, Watson SJ. Localization and quantification of pro-opiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victims. Neuroendocrinology. 1992;56:491-501.
44. Legradi G, Holzer D, Kapcala LP, Lechan RM. The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology. 1998;139: 3262-3270.
45. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MP, Goodman RH. Phosphorylation CREB binds specifically to the nuclear protein CBP. Nature. 1993; 365:855-859.
46. Usukura J, Nishizawa Y, Shimomura A, Kobayashi K, Nagatsu T, Hagiwara M. Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy. Genes Cells. 2000;5:515-522.
47. George MS, Ketter TA, Post RM. Prefrontal cortex dysfunction in clinical depression. Depression. 1994;2:59-72.
48. Walton MR, Dragunow M. Is CREB a key to neuronal survival? Trends Neurosci. 2000;23:48-53.
49. Bonni A, Ginty DD, Dudek M, Greenberg ME. Serine-113 phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin responses. Neuron. 1995;6:168-183.
50. Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME. CREB: a major mediator of neuronal neurotrophin responses. Neuron. 1997;19: 1031-1047.
51. Smith MA, Makino S, Kvetnansky R, Post RM. Effects of stress on neurotrophic factor expression in the rat brain. Ann N Y Acad Sci. 1995;771:234-239.
52. Sheline YL, Wang P, Gado MH, Csernansky JG, Vannier MW, Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci U S A. 1996;93:3908-3913.
53. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997; 386:824-827.
54. Ongur D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A. 1998;95:13290-13295.
55. Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY, Overholser JC, Roth BL, Stockmeier CA. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry. 1999;45: 1085-1098.