Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: Role of ERK kinase 1 (MEK1)

International Journal of Neuropsychopharmacology

Volumn 12, Issue 10, 2009, Pages 1337-1354

  Dwivedi, Yogesh ^a   Rizavi, Hooriyah S ^a   Zhang, Hui ^a   Roberts, Rosalinda C ^b   Conley, Robert R ^c   Pandey, Ghanshyam N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Depression; ERK kinase; ERK1 2 signalling; post mortem brain; suicide

Indexed keywords

B RAF KINASE; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; RAF PROTEIN; SERINE; THREONINE; TRANSCRIPTION FACTOR ELK 1; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NERVE CELL PLASTICITY; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SUICIDE; BIOSYNTHESIS; BRAIN; COMPARATIVE STUDY; DOWN REGULATION; ENZYME ACTIVE SITE; ENZYMOLOGY; MAJOR DEPRESSION; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BRAIN; CATALYTIC DOMAIN; DEPRESSIVE DISORDER, MAJOR; DOWN-REGULATION; FEMALE; HUMANS; MALE; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; SUICIDE; UP-REGULATION; YOUNG ADULT;

EID: 77954075814     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145709990575     Document Type: Article

References (47)

1. Alessi DR, Saito Y, Campbell DG, Cohen P, et al. (1994). Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO Journal 13, 1610-1619.
2. Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD (1998). The MAPK cascade is required for mammalian associative learning. Nature Neuroscience 7, 602-609.
3. Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ (1997). Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 90, 859-869. (Pubitemid 27381625)
4. Clayton PJ (1985). Suicide. Psychiatric Clinics of North America 8, 203-214. (Pubitemid 15052884)
5. Dhanasekaran N, Premkumar Reddy E (1998). Signaling by dual specificity kinases. Oncogene 17, 1447-1455. (Pubitemid 28458412)
6. Duman CH, Schlesinger L, Kodama M, Russell DS, Duman RS (2007). A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biological Psychiatry 61, 661-670. (Pubitemid 46328865)
7. Dwivedi Y, Mondal AC, Rizavi HS, Conley RR (2005). Suicide brain is associated with decreased expression of neurotrophins. Biological Psychiatry 58, 315-324. (Pubitemid 41133625)
8. Dwivedi Y, Rizavi H, Conley RR, Roberts RC, et al. (2002). mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims. Neuropsychopharmacology 27, 499-517.
9. Dwivedi Y, Rizavi HS, Conley RR, Pandey GN (2006). ERK MAP kinase signaling in post-mortem brain of suicide subjects : differential regulation of upstream Raf kinases Raf-1 and B-Raf. Molecular Psychiatry 11, 86-98. (Pubitemid 43251091)
10. Dwivedi Y, Rizavi HS, Roberts RC, Conley RC, et al. (2001). Reduced activation and expression of ERK1/2 MAP kinase in the postmortem brain of depressed suicide subjects. Journal of Neurochemistry 77, 916-928. (Pubitemid 32466788)
11. Dwivedi Y, Rizavi HS, Zhang H, Mondal AC, et al. (2009). Neurotrophin receptor activation and expression in human postmortem brain : effect of suicide. Biological Psychiatry 65, 319-328.
12. Einat H, Yuan P, Gould TD, Li J, et al. (2003). The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. Journal of Neuroscience 23, 7311-7316. (Pubitemid 36999520)
13. English J, Pearson G, Wilsbacher J, Swantek J, et al. (1999). New insights into the control of MAP kinase pathways. Experimental Cell Research 253, 255-270.
14. Fukuda M, Gotoh I, Adachi M, Gotoh Y, Nishida E (1997). A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade: role of nuclear export signal of MAP kinase kinase. Journal of Biological Chemistry 272, 32642-32648. (Pubitemid 28011955)
15. George MS, Ketter TA, Post RM (1994). Prefrontal cortex dysfunction in clinical depression. Depression 2, 59-72.
16. Gourley SL, Wu FJ, Kiraly DD, Ploski JE, et al. (2008). Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Biological Psychiatry 63, 353-359.
17. Grewal SS, York RD, Stork PJ (1999). Extracellular-signalregulated kinase signaling in neurons. Current Opinion in Neurobiology 9, 544-553.
18. Harrison PJ, Heath PR, Eastwood SL, Burnet PW, et al. (1995). The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies : selective mRNA vulnerability and comparison with their encoded proteins. Neuroscience Letters 200, 151-154.
19. Haystead TA, Dent P, Wu J, Haystead CM, Sturgill TW (1992). Ordered phosphorylation of p42mapk by MAP kinase kinase. FEBS Letters 306, 17-22.
20. Huang TY, Lin CH (2006). Role of amygdala MAPK activation on immobility behavior of forced swim rats. Behavioral Brain Research 173, 104-111.
21. Jaaro H, Rubinfeld H, Hanoch T, Seger R (1997). Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation. Proceedings of the National Academy of Sciences USA 94, 3742-3747. (Pubitemid 27180443)
22. Jaiswal RK, Moodie SA, Wolfman A, Landreth GE (1994). The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras. Molecular and Cellular Biology 10, 6944-6953.
23. Jelinek T, Catling AD, Reuter CW, Moodie SA, et al. (1994). RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2. Molecular and Cellular Biology 12, 8212-8218. (Pubitemid 24373570)
24. Kelly A, Laroche S, Davis S (2003). Activation of mitogenactivated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory. Journal of Neuroscience 23, 5354-5360. (Pubitemid 36793264)
25. Kolkova K, Novitskaya V, Pedersen N, Berezin V, Bock E (2000). Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-nitogen-activated protein kinase pathway. Journal of Neuroscience 20, 2238-2246. (Pubitemid 30230077)
26. Kornfeld K, Guan KL, Horvitz HR (1995). The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes and Development 9, 756-768.
27. Lin LL, Wartmann M, Lin AY, Knopf JL, et al. (1993). cPLA2 is phosphorylated and activated by MAP kinase. Cell 72, 269-278. (Pubitemid 23044941)
28. Monk M (1987). Epidemiology of suicide. Epidemiology Reviews 9, 51-69.
29. Nimnual AS, Yatsula BA, Bar-Sagi D (1998). Coupling of RAS and RAC guanosine triphosphatases through the RAS exchanger SOS. Science 279, 560-563. (Pubitemid 28067284)
30. Papin C, Brunet EA, Pages BA, Pouyssegur J, et al. (1995). B-Raf protein isoforms interact with and phosphorylate MEK-1 on serine residues 218 and 222. Oncogene 10, 1647-1651.
31. Pouysse´gur J, Volmat V, Lenormand P (2002). Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochemical Pharmacology 64, 755-763. (Pubitemid 35238027)
32. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett J (1991). Phosphorylation of c-jun mediated by MAP kinases. Nature 353, 670-674. (Pubitemid 21912588)
33. Qi X, Lin W, Li J, Li H, et al. (2008). Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. Neurobiology of Disease 31, 278-285.
34. Qi X, Lin W, Li J, Pan Y, WangW(2006). The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress. Behavioral Brain Research 175, 233-240. (Pubitemid 44750226)
35. Reuter CW, Catling AD, Jelinek T, Weber MJ (1995). Biochemical analysis of MEK activation in NIH3T3 fibroblasts : identification of B-Raf and other activators. Journal of Biological Chemistry 270, 7644-7655.
36. Ribeiro MJ, Schofield MG, Kemenes I, O'Shea M, et al. (2005). Activation of MAPK is necessary for long-term memory consolidation following food-reward conditioning. Learning and Memory 5, 538-545. (Pubitemid 41397215)
37. Rubinfeld H, Seger R (2005). The ERK cascade: a prototype of MAPK signaling. Molecular Biotechnology 31, 151-174. (Pubitemid 41306584)
38. Sala M, Perez J, Soloff P, Ucelli di Nemi S, et al. (2004). Stress and hippocampal abnormalities in psychiatric disorders. European Journal of Neuropsychopharmacology 14, 393-405. (Pubitemid 39141682)
39. Salzman S, Clayton P, Winokur G (1983). Diagnostic Evaluation after Death (DEAD). Rockville, MD: National Institute of Mental Health, Neuroscience Research Branch.
40. Seger R, Ahn NG, Posada J, Munar ES, et al. (1992). Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factorstimulated A431 cells. Journal of Biological Chemistry 267, 14373-14381.
41. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neuroscience 22, 3251-3261. (Pubitemid 35379212)
42. Spitzer RL, Williams JBW, Gibbon M, First MB (1995). Structured Clinical Interview for DSM-IV (SCID). New York: New York State Psychiatric Institute, Biometrics Research.
43. Sweatt JD (2004). Hippocampal function in cognition. Psychopharmacology 174, 99-110. (Pubitemid 38925095)
44. Tsuda L, Inoue YH, Yoo MA, Mizuno M, et al. (1993). A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell 72, 407-414. (Pubitemid 23059410)
45. Wolf I, Rubinfeld H, Yoon S, Marmor G, et al. (2001). Involvement of the activation loop of ERK in the detachment from cytosolic anchoring. Journal of Biological Chemistry 276, 24490-24497.
46. Zheng CF, Guan KL (1993). Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. Journal of Biological Chemistry 268, 23933-23939.
47. Zheng CF, Guan KL (1994). Activation of MEK family kinases requires phosphorylation of two conserved Ser/ Thr residues. EMBO Journal 13, 1123-1131.