Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: Case-control study of over 3000 individuals from the UK

British Journal of Psychiatry

Volumn 188, Issue JAN., 2006, Pages 21-25

  Green, Elaine K ^a   Raybould, Rachel ^a   Macgregor, Stuart ^b   Hyde, Sally ^c   Young, Allan H ^d   O'Donovan, Michael C ^b   Owen, Michael J ^b   Kirov, George ^b   Jones, Lisa ^c   Jones, Ian ^b   Craddock, Nick ^b  

^a Department of Psychological Medicine ^*  (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; BIPOLAR DISORDER; CAUCASIAN; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FAMILY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONE TAILED TEST; RAPID CYCLING BIPOLAR DISORDER; SAMPLE; UNITED KINGDOM;

BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; ENGLAND; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; VALINE; WALES;

EID: 29644432625     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.bp.105.009969     Document Type: Article

References (32)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.
2. Chen, X., Levine, L. & Kwok, P.-Y. (1999) Fluorescence polarization in homogenous nucleic acid analysis. Genome Research, 9, 492-498.
3. Craddock, N. & Jones, I. (1999) Genetics of bipolar disorder. Journal of Medical Genetics, 36, 585-594.
4. Craddock, N., Jones, I., Kirov, G., et al (2004) The Bipolar Affective Disorder Dimension Scale (BADDS) - a dimensional scale for rating lifetime psychopathology in bipolar spectrum disorders. BMC Psychiatry, 4, 19.
5. Craddock, N., O'Donovan, M. C. & Owen, M. J. (2005) Genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of Medical Genetics, 42, 288-299.
6. Duman, R. S. (1999) The neurochemistry of mood disorders: preclinical studies. In The Neurobiology of Mental Illness (eds D. S. Charney, E. J. Nestler & B. S. Bunney), pp. 333-347. New York: Oxford University Press.
7. Dunner, D. L. & Fieve, R. R. (1974) Clinical factors in lithium carbonate prophylaxis failure. Archives of General Psychiatry, 30, 229-233.
8. Egan, M. F., Kojima, M., Callicott, J. H., et al (2003) The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-269.
9. Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837-844.
10. Geller, B., Badner, J. A., Tillman, R., et al (2004) Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. American Journal of Psychiatry, 161, 1698-1700.
11. Green, E. & Craddock, N. (2004) Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications. Current Psychiatry Reports, 5, 469-476.
12. Hong, C. J., Huo, S. J., Yen, F. C., et al (2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology, 48, 186-189.
13. Kunugi, H., Iijima, Y., Tatsumi, M., et al (2004) No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biological Psychiatry, 56, 376-378.
14. Leckman, J. F., Sholomskas, D., Thompson, W. D., et al (1982) Best estimate of lifetime psychiatric diagnosis: a methodological study. Archives of General Psychiatry, 39, 879-883.
15. Mackin, P. & Young, A. H. (2004) Rapid cycling bipolar disorder: historical overview and focus on emerging treatments. Bipolar Disorders, 6, 523-529.
16. MacKinnon, D. F., Zandi, P. P., Gershon, E., et al (2003) Rapid switching of mood in families with multiple cases of bipolar disorder. Archives of General Psychiatry, 60, 921-928.
17. Maj, M., Pirozzi, R., Formicola, A. M., et al (1999) Reliability and validity of four alternative definitions of rapid-cycling bipolar disorder. American Journal of Psychiatry, 156, 1421-1424.
18. McGuffin, P., Farmer, A. & Harvey, I. (1991) A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Archives of General Psychiatry, 48, 764-770.
19. Moskvina, V., Holmans, N., Schmidt, K. M., et al (2005) Design of case-control studies with unscreened controls. Annals of Human Genetics, 69, 566-576.
20. Müller, D. J., De Luca, V., Sicard, T., et al (2004) 'Rapid cycling' mainly determines significant findings between the BDNF gene and bipolar disorder. American Journal of Medical Genetics Part B. Neurospychiatric Genetics, 130B, 45.
21. Müller, D. J., De Luca, V., Sicard, T., et al (2006) The brain derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder. British Journal of Psychiatry, in press.
22. Nakata, K., Ujike, H., Sakai, A., et al (2003) Association study of brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neuroscience Letters, 337, 17-20.
23. Neves-Pereira, M., Mundo, E., Muglia, P., et al (2002) The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. American Journal of Human Genetics, 71, 651-655.
24. Neves-Pereira, M., Cheung, J. K., Pasdar, A., et al (2005) BDNF gene is a risk factor for schizophrenia in a Scottish population. Molecular Psychiatry, 10, 208-212.
25. Nurnberger, J. I. Jr, Blehar, M. C., Kaufmann, C. A., et al (1994) Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry, 51, 849-859.
26. Oswald, P., Del-Favero, J., Massat, I., et al (2004) Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study. American Journal of Medical Genetics, 129B, 34-35.
27. Purcell, S., Cherny, S. S. & Sham, P. C. (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics, 19, 149-150.
28. Skibinska, M., Hauser, J., Czerski, P. M., et al (2004) Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. World Journal of Biological Psychiatry, 5, 215-220.
29. Sklar, P., Gabriel, S. B., McInnis, M. G., et al (2002) Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neurotrophic factor. Molecular Psychiatry, 7, 579-593.
30. Spielman, R. S., McGinnis, R. E. & Ewens, W. J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics, 52, 506-516.
31. Tsai, S. J. (2004) Is mania caused by overactivity of central brain-derived neurotrophic factor? Medical Hypotheses, 62, 19-22.
32. Wing, J. K., Babor, T., Brugha, T., et al (1990) SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Archives of General Psychiatry, 47, 589-593.