Haloperidol regulates the phosphorylation level of the MEK-ERK-p90RSK signal pathway via protein phosphatase 2A in the rat frontal cortex

International Journal of Neuropsychopharmacology

Volumn 11, Issue 4, 2008, Pages 509-517

  Kim, Se Hyun ^a   Seo, Myoung Suk ^b   Jeon, Won Je ^b   Yu, Hyun Sook ^b   Park, Hong Geun ^b   Jung, Gyung Ah ^b   Lee, Hee Young ^b   Kang, Ung Gu ^a   Kim, Yong Sik ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Antipsychotics; Mitogen activated protein kinase; Protein serine threonine phosphatase 2A

Indexed keywords

HALOPERIDOL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; P90 RIBOSOMAL S6 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; RAF PROTEIN; S6 KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; FRONTAL CORTEX; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIPSYCHOTIC AGENTS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HALOPERIDOL; IMMUNOPRECIPITATION; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PREFRONTAL CORTEX; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-RAF; RAF KINASES; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION;

EID: 44349083035     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145707008292     Document Type: Article

References (50)

1. Adams DG, Coffee Jr. RL, Zhang H, Pelech S, Strack S, Wadzinski BE (2005). Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. Journal of Biological Chemistry 280, 42644-42654.
2. Ahn S, Shenoy SK, Wei H, Lefkowitz RJ (2004). Differential kinetic and spatial patterns of β-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. Journal of Biological Chemistry 279, 35518-35525.
3. Ahn YM, Seo MS, Kim SH, Kim Y, Juhnn YS, Kim YS (2006). The effects of MK-801 on the phosphorylation of Ser338-Raf-1-MEK-ERK pathway in the rat frontal cortex. International Journal of Neuropsychopharmacology 9, 451-456.
4. Alessi DR, Gomez N, Moorhead G, Lewis T, Keyse SM, Cohen P (1995). Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Current Biology 5, 283-295.
5. Baccarini M (2005). Second nature: biological functions of the Raf-1 'kinase'. FEBS Letters 579, 3271-3277.
6. Banihashemi B, Albert PR (2002). Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Gα and Gβγ requirements. Molecular Endocrinology 16, 2393-2404.
7. Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG (2006). Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. Journal of Biological Chemistry 281, 32072-32080.
8. Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG (2005). An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122, 261-273.
9. Bibb JA (2005). Decoding dopamine signaling. Cell 122, 153-155.
10. Borda T, Genaro AM, Cremaschi G (1999). Haloperidol effect on intracellular signals system coupled to alpha1-adrenergic receptor in rat cerebral frontal cortex. Cellular Signalling 11, 293-300.
11. Cai G, Gurdal H, Smith C, Wang HY, Friedman E (1999). Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Molecular Pharmacology 56, 989-996.
12. Cai G, Zhen X, Uryu K, Friedman E (2000). Activation of extracellular signal-regulated protein kinases is associated with a sensitized locomotor response to D(2) dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. Journal of Neuroscience 20, 1849-1857.
13. Creese I, Burt DR, Snyder SH (1976). Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192, 481-483.
14. Cussac D, Pasteau V, Millan MJ (2004). Characterisation of Gs activation by dopamine D1 receptors using an antibody capture assay: antagonist properties of clozapine. European Journal of Pharmacology 485, 111-117.
15. Fumagalli F, Frasca A, Sparta M, Drago F, Racagni G, Riva MA (2006). Long-term exposure to the atypical antipsychotic olanzapine differently up-regulates extracellular signal-regulated kinases 1 and 2 phosphorylation in subcellular compartments of rat prefrontal cortex. Molecular Pharmacology 69, 1366-1372.
16. Garris PA, Budygin EA, Phillips PE, Venton BJ, Robinson DL, Bergstrom BP, Rebec GV, Wightman RM (2003). A role for presynaptic mechanisms in the actions of nomifensine and haloperidol. Neuroscience 118, 819-829.
17. Horacek J, Bubenikova-Valesova V, Kopecek M, Palenicek T, Dockery C, Mohr P, Höschl C (2006). Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs 20, 389-409.
18. Imperato A, Di Chiara G (1985). Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis. Journal of Neuroscience 5, 297-306.
19. Johnson-Farley NN, Kertesy SB, Dubyak GR, Cowen DS (2005). Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells. Journal of Neurochemistry 92, 72-82.
20. Kang UG, Jeon WJ, Kim Y, Chung CK, Park JB, Juhnn YS, Kim YS (2005). Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex. Neuroscience Letters 390, 171-175.
21. Kim HS, Song M, Yumkham S, Choi JH, Lee T, Kwon J, Lee SJ, Kim JI, Lee KW, Han PL, et al. (2006). Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid. Journal of Neurochemistry 99, 458-469.
22. Li X, Rosborough KM, Friedman AB, Zhu W, Roth KA (2007). Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics. International Journal of Neuropsychopharmacology 10, 7-19.
23. Lidsky TI, Banerjee SP (1993). Acute administration of haloperidol enhances dopaminergic transmission. Journal of Pharmacology and Experimental Therapeutics 265, 1193-1198.
24. Liu JC, Baker RE, Sun C, Sundmark VC, Elsholtz HP (2002). Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene. Journal of Biological Chemistry 277, 35819-35825.
25. MacDonald ML, Eaton ME, Dudman JT, Konradi C (2005). Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biological Psychiatry 57, 1041-1051.
26. Mao L, Yang L, Arora A, Choe ES, Zhang G, Liu Z, Fibuch EE, Wang JQ (2005). Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. Journal of Biological Chemistry 280, 12602-12610.
27. Meltzer HY (1991). The mechanism of action of novel antipsychotic drugs. Schizophrenia Bulletin 17, 263-287.
28. Murphy LO, Blenis J (2006). MAPK signal specificity: the right place at the right time. Trends in Biochemical Sciences 31, 268-275.
29. Nalepa I (1993). The effects of chlorpromazine and haloperidol on second messenger systems related to adrenergic receptors. Polish Journal of Pharmacology 45, 399-412.
30. Ohta M (1976). Haloperidol bocks an alpha adrenergic receptor in the reticulo-cortical inhibitory input. Physiology and Behavior 16, 505-507.
31. Pascoli V, Valjent E, Corbille AG, Corvol JC, Tassin JP, Girault JA, Herve D (2005). cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors. Molecular Pharmacology 68, 421-429.
32. Pei JJ, Gong CX, An WL, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K (2003). Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. American Journal of Pathology 163, 845-858.
33. Pozzi L, Hakansson K, Usiello A, Borgkvist A, Lindskog M, Greengard P, Fisone G (2003). Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum. Journal of Neurochemistry 86, 451-459.
34. Quinn JC, Johnson-Farley NN, Yoon J, Cowen DS (2002). Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases. Journal of Pharmacology and Experimental Therapeutics 303, 746-752.
35. Reimold M, Solbach C, Noda S, Schaefer JE, Bartels M, Beneke M, Machulla HJ, Bares R, Glaser T, Wormstall H (2007). Occupancy of dopamine D1, D2 and serotonin 2A receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol. Psychopharmacology 190, 241-249.
36. Rushlow WJ, Seah YH, Belliveau DJ, Rajakumar N (2005). Changes in calcineurin expression induced in the rat brain by the administration of antipsychotics. Journal of Neurochemistry 94, 587-596.
37. Schotte A, Janssen PF, Megens AA, Leysen JE (1993). Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain Research 631, 191-202.
38. Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ (2006). β-arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor. Journal of Biological Chemistry 281, 1261-1273.
39. Sontag E (2001). Protein phosphatase 2A: the Trojan horse of cellular signaling. Cellular Signalling 13, 7-16.
40. Suganuma M, Fujiki H, Okabe S, Nishiwaki S, Brautigan D, Ingebritsen TS, Rosner MR (1992). Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. Toxicon 30, 873-878.
41. Sweatt JD (2004). Mitogen-activated protein kinases in synaptic plasticity and memory. Current Opinion in Neurobiology 14, 311-317.
42. Valjent E, Corvol JC, Pages C, Besson MJ, Maldonado R, Caboche J (2000). Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. Journal of Neuroscience 20, 8701-8709.
43. Valjent E, Pages C, Herve D, Girault JA, Caboche J (2004). Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain. European Journal of Neuroscience 19, 1826-1836.
44. Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, Corvol JC, Stipanovich A, Caboche J, Lombroso PJ, Nairn AC, et al. (2005). Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proceedings of the National Academy of Sciences USA 102, 491-496.
45. Van-Ham II, Banihashemi B, Wilson AM, Jacobsen KX, Czesak M, Albert PR (2007). Differential signaling of dopamine-D2S and -D2L receptors to inhibit ERK1/2 phosphorylation. Journal of Neurochemistry 102, 1796-1804.
46. Vaughan RA (2004). Phosphorylation and regulation of psychostimulant-sensitive neurotransmitter transporters. Journal of Pharmacology and Experimental Therapeutics 310, 1-7.
47. Wang C, Buck DC, Yang R, Macey TA, Neve KA (2005). Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. Journal of Neurochemistry 93, 899-909.
48. Yang BH, Son H, Kim SH, Nam JH, Choi JH, Lee JS (2004). Phosphorylation of ERK and CREB in cultured hippocampal neurons after haloperidol and risperidone administration. Psychiatry and Clinical Neurosciences 58, 262-267.
49. Zhang L, Lou D, Jiao H, Zhang D, Wang X, Xia Y, Zhang J, Xu M (2004). Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. Journal of Neuroscience 24, 3344-3354.
50. Zhong H, Minneman KP (1999). Differential activation of mitogen-activated protein kinase pathways in PC12 cells by closely related alpha1-adrenergic receptor subtypes. Journal of Neurochemistry 72, 2388-2396.