Genetic association studies between SNPs and suicidal behavior: A meta-analytical field synopsis

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 46, Issue , 2013, Pages 36-42

  Schild, Anne H E ^a   Pietschnig, Jakob ^a   Tran, Ulrich S ^a   Voracek, Martin ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Association study; Genetics of suicide; Meta analysis; Single nucleotide polymorphism; Suicidal behavior; Systematic review

Indexed keywords

ANGIOTENSIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; NORADRENALIN; RENIN; SEROTONIN;

ARTICLE; EFFECT SIZE; GENETIC ASSOCIATION; HUMAN; MEDICAL RESEARCH; METHODOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; SUICIDAL BEHAVIOR; SYSTEMATIC ERROR; SYSTEMATIC REVIEW; TIME;

5-HIAA; 5-HT; 5-HT(1A) RECEPTOR; 5-HTR1A; 5-HTT; 5-HTTLPR; 5-HYDROXYINDOLEACETIC ACID; 5-HYDROXYTRYPTAMINE (SEROTONIN); ASSOCIATION STUDY; GENETICS OF SUICIDE; GENOME-WIDE ASSOCIATION STUDY; GWAS; META-ANALYSIS; SEROTONIN TRANSPORTER; SEROTONIN-TRANSPORTER-LINKED POLYMORPHIC REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SNP; SUICIDAL BEHAVIOR; SYSTEMATIC REVIEW; TPH; TRYPTOPHAN HYDROXYLASE;

ANIMALS; GENETIC ASSOCIATION STUDIES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RANDOM ALLOCATION; SUICIDAL IDEATION; SUICIDE, ATTEMPTED;

EID: 84880384461     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.06.014     Document Type: Article

References (46)

1. Allen H.L., Estrada K., Lettre G., Berndt S.I., Weedon M.N., Rivadeneira F., et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010, 467:832-838.
2. Angles M.R., Ocana D.B., Medellin B.C., Tovilla-Zarate C. No association between the HTR1A gene and suicidal behavior: a meta-analysis. Rev Bras Psiquiatr 2012, 34:38-42.
3. Anguelova M., Benkelfat C., Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003, 8:646-653.
4. Antypa N., Serretti A., Rujescu D. Serotonergic genes and suicide: a systematic review. Eur Neuropsychopharmacol 2013, (0). [Advance online publication].
5. Bellivier F., Chaste P., Malafosse A. Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2004, 124B:87-91.
6. Bondy B., Buettner A., Zill P. Genetics of suicide. Mol Psychiatry 2006, 11:336-351.
7. Brent D.A., Mann J.J. Family genetic studies, suicide, and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet Semin Med Genet 2005, 133C:13-24.
8. Butler A.W., Breen G., Tozzi F., Craddock N., Gill M., Korszun A., et al. A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12. Am J Med Genet B Neuropsychiatr Genet 2010, 153B:1465-1473.
9. Calati R., Porcelli S., Giegling I., Hartmann A.M., Mller H.J., Ronchi D.D., et al. Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study. J Psychiatr Res 2011, 45:309-321.
10. Cheng R., Juo S.H., Loth J., Nee J., Iossifov I., Blumenthal R., et al. Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry 2006, 11:252-260.
11. Clayden R.C., Zaruk M., Meyre D., Thabane L., Samaan Z. The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis. Transl Psychiatry 2012, 2:e166.
12. Duval S., Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000, 56:455-463.
13. Dwan K., Altman D.G., Arnaiz J.A., Bloom J., Chan A.W., Cronin E., et al. Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One 2008, 3:e3081.
14. The neurobiological basis of suicide. Frontiers in neuroscience 2012, CRC Press. Y. Dwivedi (Ed.).
15. Egeland J.A., Sussex J.N. Suicide and family loading for affective disorders. JAMA 1985, 254(7):915-918.
16. Egger M., Smith G.D., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
17. Ernst C., Mechawar N., Turecki G. Suicide neurobiology. Prog Neurobiol 2009, 89:315-333.
18. Fu Q., Heath A.C., Bucholz K.K., Nelson E.C., Glowinski A.L., Goldberg J., et al. A twin study of genetic and environmental influences on suicidality in men. Psychol Med 2002, 32(1):11-24.
19. Hedges L.V., Tipton E., Johnson M.C. Robust variance estimation in meta-regression with dependent effect size estimates. Res Synth Methods 2010, 1:39-65.
20. 2 index?. Psychol Methods 2006, 11:193-206.
21. JabRef Development Team JabRef URL:. http://jabref.sourceforge.net.
22. Kia-Keating B.M., Glatt S.J., Tsuang M.T. Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2007, 144B:1048-1053.
23. Lalovic A., Turecki G. Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am J Med Genet 2002, 114:533-540.
24. Li D., He L. Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. Hum Genet 2006, 119:233-240.
25. Li D., He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 2007, 12:47-54.
26. Lin P.Y., Tsai G.C. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 2004, 55:1023-1030.
27. Macaskill P., Walter S.D., Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med 2001, 20:641-654.
28. Manolio T.A., Collins F.S., Cox N.J., Goldstein D.B., Hindorff L.A., Hunter D.J., et al. Finding the missing heritability of complex diseases. Nature 2009, 461:747-753.
29. McGauran N., Wieseler B., Kreis J., Schler Y.B., Klsch H., Kaiser T. Reporting bias in medical research - a narrative review. Trials 2010, 11:37.
30. Nielsen D.A., Goldman D., Virkkunen M., Tokola R., Rawling S.R., Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 1994, 51:34-38.
31. Perlis R.H., Huang J., Purcell S., Fava M., Rush A.J., Sullivan P.F., et al. Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry 2010, 167:1499-1507.
32. R Development Core Team R: A language and environment for statistical, computing 2012, [URL: http://www.R-project.org].
33. Ripke S., Wray N.R., Lewis C.M., Hamilton S.P., Weissman M.M., Breen G., et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry 2013, 18:497-511.
34. Rujescu D., Giegling I., Sato T., Hartmann A.M., Möller H.J. Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. Biol Psychiatry 2003, 54:465-473.
35. Saetre P., Lundmark P., Hansen T., Rasmussen H.B., Djurovic S., Melle I., et al. The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2009, 153B:387-396.
36. Schosser A., Butler A.W., Ising M., Perroud N., Uher R., Ng M.Y., et al. Genomewide association scan of suicidal thoughts and behaviour in major depression. PLoS One 2011, 6:e20690.
37. Spencer C.C.A., Su Z., Donnelly P., Marchini J. Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 2009, 5(5):e1000477.
38. Statham D.J., Heath A.C., Madden P.A., Bucholz K.K., Bierut L., Dinwiddie S.H., et al. Suicidal behaviour: an epidemiological and genetic study. Psychol Med 1998, 28(4):839-855.
39. Tovilla-Zarate C., Juarez-Rojop I., Ramon-Frias T., Villar-Soto M., Pool-Garcia S., Medellin B.C., et al. No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data. BMC Psychiatry 2011, 11:151.
40. Viechtbauer W. Hypothesis tests for population heterogeneity in meta-analysis. Br J Math Stat Psychol 2007, 60:29-60.
41. Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw 2010, 36:1-48.
42. Voracek M. Genetic factors in suicide: reassessment of adoption studies and individuals' beliefs about adoption study findings. Psychiatr Danub 2007, 19:139-153.
43. Voracek M., Loibl L.M. Genetics of suicide: a systematic review of twin studies. Wien Klin Wochenschr 2007, 119:463-475.
44. Willour V.L., Seifuddin F., Mahon P.B., Jancic D., Pirooznia M., Steele J., et al. A genome-wide association study of attempted suicide. Mol Psychiatry 2012, 17:433-444.
45. Zai C.C., Manchia M., Luca V.D., Tiwari A.K., Chowdhury N.I., Zai G.C., et al. The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis. Int J Neuropsychopharmacol 2012, 15:1037-1042.
46. Zuk O., Hechter E., Sunyaev S.R., Lander E.S. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci 2012, 109:1193-1198.