Relationship between dopamine system genes and extraversion and novelty seeking

Neuroscience and Behavioral Physiology

Volumn 37, Issue 6, 2007, Pages 601-606

  Golimbet, V E ^a   Alfimova, M V ^a   Gritsenko, I K ^b   Ebstein, R P ^b  

^a MENTAL HEALTH RESEARCH CENTER   (Russian Federation)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Catechol O methyltransferase; Dopamine; Dopamine receptor; Extraversion; Gene polymorphism; Novelty seeking; Reinforcement system

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE 4 RECEPTOR; METHIONINE; VALINE;

ADULT; ALLELE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; EXTRAVERSION; FEMALE; GENE IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPOMANIA; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; PERSONALITY; REGULATORY MECHANISM; REINFORCEMENT; RUSSIAN FEDERATION; STIMULATION;

ADULT; CATECHOL O-METHYLTRANSFERASE; EXPLORATORY BEHAVIOR; EXTRAVERSION (PSYCHOLOGY); FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; METHIONINE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4; SEX FACTORS; VALINE;

EID: 34548252922     PISSN: 00970549     EISSN: 1573899X     Source Type: Journal    
DOI: 10.1007/s11055-007-0058-8     Document Type: Article

References (30)

1. V. E. Golimbet, I. K. Gritsenko, M. V. Alfimova, and R. P. Ebstein, "Polymorphic markers of the promoter region of the D4 dopamine receptor gene and temperament in mentally healthy humans from the Russian population," Genetika, 41, No. 7, 966-972 (2005).
2. R. M. Bilder, J. Volavka, H. M. Lachman, and A. A. Grace, "The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes," Neuropsychopharmacology, 29, No. 11, 1943-1961 (2004).
3. E. B. Bookman, R. E. Taylor, L. Adams-Campbell, and R. A. Kittles, "DRD4 promoter SNPs and gender effects on Extraversion in African Americans," Mol. Psychiatry, 7, No. 7, 786-789 (2002).
4. J. Chen, B. K. Lipska, N. Halim, Q. D. Ma, M. Matsumoto, S. Melhem, B. S. Kolachana, T. M. Hyde, M. M. Herman, J. Apud, M. F. Egan, J. E. Kleinman, and D. R. Weinberger, "Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain," Amer. J. Hum. Genet., 75, No. 5, 807-821 (2004).
5. R. P. Ebstein, O. Novick, R. Umansky, B. Priel, Y. Osher, D. Blaine, E. R. Bennett, L. Nemanov, M. Katz, and R. H. Belmaker, "Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking," Nat. Genet., 12, No. 1, 78-80 (1996).
6. J. Ekelund, J. Suhonen, M. R. Jarvelin, L. Peltonen, and D. Lichtermann, "No association of the -521 C/T polymorphism in the promoter of DRD4 with novelty seeking," Mol. Psychiatry, 6, No. 6, 618-719 (2001).
7. J. A. Gogos, M. Morgan, V. Luine, M. Santha, S. Ogawa, D. Pfaff, and M. Karayiorgou, "Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior," Proc. Natl. Acad. Sci. USA, 95, No. 17, 9991-9996 (1998).
8. H. Herken and M. E. Erdal, "Catechol-O-methyltransferase gene polymorphism in schizophrenia: Evidence for association between symptomatology and prognosis," Psychiatr. Genet., 11, No. 2, 105-109 (2001).
9. J. Kauhanen, T. Hallikainen, T. P. Tuomainen, M. Koulu, M. K. Karvonen, and J. T. Aalonen, "Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers," Alcoholism: Clin. Exptl. Res., 24, 135-139 (2000).
10. H. J. Lachman, K. A. Nolan, P. Mohr, T. Saito, and J. Volavka, "Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder," Amer. J. Psychiatry, 155, 835-837 (1998).
11. H. J. Lee, H. S. Lee, Y. K. Kim, S. H. Kim, L. Kim, M. S. Lee, S. H. Joe, I. K. Jung, K. Y. Suh, and S. Kim, "Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population," Amer. J. Med. Genet., 118B, No. 1, 76-80 (2003).
12. A. K. Malhotra, L. J. Kestler, C. Mazzanati, J. A. Bates, T. Goldberg, and D. Goldman, "A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition," Amer. J. Psychiatry, 159, No. 4, 652-654 (2002).
13. M. Matsumoto, K. Hidaka, S. Tada, Y. Tasaki, and T. Yamaguchi, "Low levels of mRNA for dopamine D4 receptor in human cerebral cortex and striatum," J. Neurochem., 66, No. 3, 915-919 (1996).
14. M. Matsumoto, C. S. Weickert, S. Beltaifa, B. Kolachana, J. Chen, T. M. Hyde, M. M. Herman, D. R. Weinberger, and J. E. Kleinman, "Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia," Neuropsychopharmacology, 28, No. 8, 1521-1530 (2003).
15. A. Meyer-Lindenberg, P. D. Kohn, B. Kolachana, S. Kippenham, A. McInerney-Leo, R. Nussbaum, D. R. Weinberger, and K. F. Berman, "Midbrain dopamine and prefrontal function in humans: Interaction and modulation by COMT genotype," Nat. Neurosci., 8, No. 5, 594-596 (2005).
16. K. A. Nolan, J. Volavka, P. Czobor, A. Cseh, H. Lachman, T. Saito, J. Tiihonen, A. Putkonen, T. Hallikainen, I. Kotilainen, P. Rasanen, M. Isohanni, M. R. Jarvelin, and M. K. Karvonen, "Suicidal behavior in patients with schizophrenia is related to COMT polymorphism," Psychiatr. Genet., 10, 117-124 (2000).
17. Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe, and T. Arinami, "Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait," Mol. Psychiatry, 5, 64-69 (2000).
18. M. A. Palmatier, A. M. Kang, and K. K. Kidd, "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles," Biol. Psychiatry, 46, No. 4, 557-567 (1999).
19. M. Reuter and J. Hennig, "Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion," Neuroreport, 16, No. 10, 1135-1138 (2005).
20. Z. Ronai, A. Szekely, Z. Nemoda, K. Lakatos, J. Gervai, M. Staub, and M. Sasvari-Szekely, "Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene," Mol. Psychiatry, 6, No. 1, 35-38 (2001).
21. A. Rotondo, C. Mazzanti, L. Dell-Osso, P. Rucci, P. Sullivan, S. Bouanani, C. Gonnelli, D. Goldman, and G. B. Cassano, "Catechol-O-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder," Amer. J. Psychiatry, 159, 23-29 (2002).
22. M. Rubinstein, T. J. Phillips, J. R. Bunzow, T. L. Falzone, G. Dziewczapolski, G. Zhang, Y. Fang, J. L. Larson, J. A. McDougall, J. A. Chester, C. Saez, T. A. Pugsley, O. Gershanik, M. J. Low, and D. K. Grundy, "Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine," Cell, 90, 991-1001 (1997).
23. D. Rujescu, I. Giegling, A. Gietl, A. M. Hartmann, and H. J. Moller, "A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits," Biol. Psychiatry, 54, 34-39 (2003).
24. I. S. Sanya and H. H. Van Tol, "Review of the role of dopamine D4 receptors in schizophrenia and antipsychotic action," J. Psychiatr. Res., 31, No. 2, 219-232 (1997).
25. J. A. Schinka, E. A. Letsch, and F. C. Crawford, "DRD4 and novelty seeking: Results of meta-analyses," Amer. J. Med. Genet., 114, No. 6, 643-648 (2002).
26. S. Shifman, M. Bronstein, M. Sternfeld, A. Pisante-Shalom, E. Lev-Lehman, A. Weizman, I. Reznik, B. Spivak, N. Grisaru, L. Karp, R. Schiffer, M. Kotler, R. D. Strous, M. Swartz-Vanetik, H.Y. Knobler, E. Shinar, J. S. Beckmann, B. Yakir, N. Risch, N. B. Zak, and A. Darvasi, "A highly significant association between a COMT haplotype and schizophrenia," Amer. J. Hum. Genet., 71, No. 6, 1296-1302 (2002).
27. R. D. Strous, N. Bark, S. S. Parsia, J. Volavka, and H. M. Lachman, "Analysis of a functional catechol-O-methyl-transferase gene polymorphism in schizophrenia: Evidence for association with aggressive and antisocial behavior," Psychiatry Res., 69, 71-77 (1997).
28. S. J. Tsai, C. J. Hong, Y. W. Yu, and T. J. Chen, "Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females," Neuropsychobiology, 50, No. 2, 153-156 (2004).
29. E. M. Tunbridge, D. M. Bannerman, T. Sharp, and P. J. Harrison, "Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex," J. Neurosci., 24, No. 23, 5331-5335 (2004).
30. D. R. Weinberger, M. F. Egan, A. Bertolino, J. H. Callicott, V. S. Mattay, B. K. Lipska, K. F. Berman, and T. E. Goldberg, "Prefrontal neurons and the genetics of schizophrenia," Biol. Psychiatry, 50, No. 11, 825-844 (2001).