Suicidal risks among 2826 Sardinian major affective disorder patients

Acta Psychiatrica Scandinavica

Volumn 116, Issue 6, 2007, Pages 419-428

  Tondo, L ^b,c   Lepri, B ^c   Baldessarini, R J ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Attempts; Bipolar disorders; Ideation; Major depression; Risk factors; Sex; Suicide; Temperament

Indexed keywords

ADULT; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HOSPITALIZATION; HUMAN; MAJOR AFFECTIVE DISORDER; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; RISK; SUICIDAL BEHAVIOR; SUICIDAL IDEATION; SUICIDE ATTEMPT;

ADULT; BIPOLAR DISORDER; DEMOGRAPHY; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; ITALY; MALE; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SUICIDE, ATTEMPTED;

EID: 36048989384     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.2007.01066.x     Document Type: Article

References (55)

1. Goldsmith SK, Pellman TC, Kleinman AM, Bunney WE Jr., editors. Reducing suicide: a national imperative. Institute of Medicine of the US National Academy of Sciences. Washington, DC : National Academies Press, 2002.
2. American Psychiatric Association (APA) Task Force, Jacobs D (chairman). APA practice guideline for the assessment and treatment of patients with suicidal behaviors (Part B). Am J Psychiatry 2003 160 (Suppl. 11 1 44.
3. Simon RI, Hales RE, editors. Textbook of suicide assessment and management. Washington, DC : American Psychiatric Publishing, Inc., 2006 : 1 32.
4. Meltzer HY, Alphs L, Green AI et al. Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry 2003 60 : 82 91.
5. Hennen J, Baldessarini RJ. Reduced suicidal risk during treatment with clozapine: a meta-analysis. Schizophr Res 2005 73 : 139 145.
6. Hammad TA, Laughren T, Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry 2006 63 : 332 339.
7. Laughren TP. Overview for a meeting of the Psychopharmacology Drug Advisory Committee (PDAC) concerning suicidal risk in trials of antidepressant drugs in juvenile and adult patients. Available at: < http://www.fda.gov/ ohrms/dockets/ac/06/briefing/2006-4272b1-index.htm > (accessed on 26 December, 2006).
8. Baldessarini RJ, Tondo L. Psychopharmacology for suicide prevention. In : Tatarelli R, Pompili M, Girardi P, eds. Suicide in psychiatric disorders. New York : Nova Publishers, Inc., 2007 (in press).
9. Gibbons RD, Hur K, Bhaumik DK, Mann JJ. The relationship between antidepressant prescription rates and rate of early adolescent suicide. Am J Psychiatry 2006 163 : 1898 1904.
10. Tondo L, Albert M, Baldessarini RJ. Suicide rates in relation to health-care access in the United States. J Clin Psychiatry 2006 67 : 517 523.
11. World Health Organization (WHO). International suicide rates. Available at: < http://www.who.int/mental_health/Topic_Suicide/suicide_rates.html > (accessed on 7 January, 2007).
12. Kessler RC, Berglund P, Borges G, Nock M, Wang PS. Trends in suicide ideation, plans, gestures, and attempts in the United States, 1990-1992 to 2001-2003. JAMA 2005 293 : 2487 2495.
13. Acharya N, Rosen AS, Polzer JP et al. Duloxetine: meta-analyses of suicidal behaviors and ideation in clinical trials for major depressive disorder. J Clin Psychopharmacol 2006 26 : 587 594.
14. Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J. Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord 2006 8 : 625 639.
15. Tondo L, Baldessarini RH, Floris G. Long-term effectiveness of lithium maintenance treatment in types I and II bipolar disorders. Br J Psychiatry 2001 178 (Suppl. 40 184 190.
16. Kukopulos A, Caliari B, Tundo A et al. Rapid cyclers, temperament, and antidepressants. Compr Psychiatry 1983 24 : 249 258.
17. Akiskal HS, Mendlowicz MV, Jean-Louis G et al. TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament. J Affect Disord 2005 85 : 45 52.
18. Serretti A, Mandelli L, Lorenzi C et al. Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology 2006 53 : 9 16.
19. Istituto Italiano di Statistica (ISTAT). Annual Report of Statistical Data, table 2.04: Mortality due to AIDS, drugs, suicides, and traffic accidents, by sex, social status, and geographical region, 2004. Available at: < http://www.istat.it/dati/catalogo/rapporto2004/dati.html > (accessed on 9 December 2006).
20. Tondo L, Isacsson G, Baldessarini RJ. Suicide in bipolar disorder: risk and prevention. CNS Drugs 2003 17 : 491 511.
21. Baldessarini RJ, Pompili M, Tondo L. Suicidal risk in antidepressant trials. Arch Gen Psychiatry 2006 63 : 246 248.
22. Rihmer Z, Pestality P. Bipolar II disorder and suicidal behavior. Psychiatr Clin North Am 1999 22 : 667 673.
23. Rihmer Z, Kiss K. Bipolar disorders and suicidal behavior. Bipolar Disord 2002 4 (Suppl. 1 21 25.
24. Baldessarini RJ, Pompili M, Tondo L et al. Antidepressants and suicidal behavior: are we hurting or helping? Clin Neuropsychiatry 2005 2 : 73 75.
25. Akiskal HS, Benazzi F, Perugi G, Rihmer Z. Agitated "unipolar" depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy. J Affect Disord 2005 85 : 245 258.
26. McElroy SL, Kotwal R, Kaneria R, Keck PE Jr. Antidepressants and suicidal behavior in bipolar disorder. Bipolar Disord 2006 8 (5 Pt 2 596 617.
27. Goldring N, Fieve RR. Attempted suicide in manic-depressive disorder. Am J Psychother 1984 38 : 373 383.
28. Buchholtz-Hansen PE, Wang AG, Kragh-Sorensen P, Danish University Antidepressant Group. Mortality in major affective disorder: relationship to subtype of depression. Acta Psychiatr Scand 1993 87 : 329 335.
29. Nordstrom P, Samuelsson M, Asberg M. Survival analysis of suicide risk after attempted suicide. Acta Psychiatr Scand 1995 91 : 336 340.
30. Harris EC, Barraclough B. Excess mortality of mental disorder. Br J Psychiatry 1998 173 : 11 53.
31. Bostwick JM, Pankratz VS. Affective disorders and suicide risk: a reexamination. Am J Psychiatry 2000 157 : 1925 1932.
32. Raja M, Azzoni A. Suicide attempts: differences between unipolar and bipolar patients and among groups with different lethality risk. J Affect Disord 2004 82 : 437 442.
33. Akiskal HS, Benazzi F. Psychopathologic correlates of suicidal ideation in major depressive outpatients: is it all due to unrecognized (bipolar) depressive mixed states?. Psychopathology 2005 38 : 273 280.
34. Valtonen H, Suominen K, Mantere O, Leppamaki S, Arvilommi P, Isometsa ET. Suicidal ideation and attempts in bipolar I and II disorders. J Clin Psychiatry 2005 66 : 1456 1462.
35. Valtonen HM, Suominen K, Mantere O, Leppamaki S, Arvilommi P, Isometsa E. Suicidal behaviour during different phases of bipolar disorder. J Affect Disord 2007 97 : 101 107.
36. Angst J, Angst F, Gerber-Werder R, Gamma A. Suicide in 406 mood-disorder patients with and without long-term medication: a 40-44 years' follow-up. Arch Suicide Res 2005 9 : 279 300.
37. Judd LL, Akiskal HS, Schettler PJ et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 2002 59 : 530 537.
38. Post RM, Denicoff KD, Leverich GS et al. Morbidity in 258 bipolar outpatients followed for one year with daily prospective ratings on the NIMH life chart method. J Clin Psychiatry 2003 64 : 680 690.
39. Baldessarini RJ, Salvatore P, Tohen M et al. Morbidity from onset in first-episode bipolar I disorder patients: the International-300 study. Neuropsychopharmacology 2004 29 (Suppl. 1 88.
40. Joffe RT, MacQueen GM, Marriott M, Trevor Young L. A prospective, longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders. Bipolar Disord 2004 6 : 62 66.
41. Ghaemi SN, Hsu DJ, Soldani F, Goodwin FK. Antidepressants in bipolar disorder: the case for caution. Bipolar Disord 2003 5 : 421 433.
42. Ghaemi SN, Rosenquist KJ, Ko JY, Baldassano CF, Kontos NJ, Baldessarini RJ. Antidepressant treatment in bipolar versus unipolar depression. Am J Psychiatry 2004 161 : 163 165.
43. Tsai SY, Kuo CJ, Chen CC, Lee HC. Risk factors for completed suicide in bipolar disorder. J Clin Psychiatry 2002 63 : 469 476.
44. Schneider B, Philipp M, Muller MJ. Psychopathological predictors of suicide in patients with major depression during a 5-year follow-up. Eur Psychiatry 2001 16 : 283 288.
45. Tondo L, Hennen J, Baldessarini RJ. Reduced suicide risk with long-term lithium treatment in major affective illness: meta-analysis. Acta Psychiatr Scand 2001 104 : 163 172.
46. Beasley CM Jr., Dornseif BE, Bosomworth JC et al. Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression. BMJ 1991 303 : 685 692.
47. Khan A, Warner HA, Brown WA. Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: analysis of the FDA database. Arch Gen Psychiatry 2000 57 : 311 317.
48. Storosum JG, Van Zwieten BJ, Van den Brink W, Gersons BP, Broekmans AW. Suicide risk in placebo-controlled studies of major depression. Am J Psychiatry 2001 158 : 1271 1275.
49. Khan A, Khan S, Kolts R, Brown WA. Suicide rates in clinical trials with SRIs, other antidepressants, and placebo: analysis of FDA reports. Am J Psychiatry 2003 160 : 790 792.
50. Fergusson D, Doucette S, Glass KC et al. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomized controlled trials. BMJ 2005 330 : 396 398.
51. Gunnell D, Saperia J, Ashby D. Selective serotonin reuptake inhibitors (SRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomized controlled trials submitted to the MHRA's safety review. BMJ 2005 330 : 385 388.
52. Hammad TA, Laughren TP, Racoosin JA. Suicide rates in short-term randomized controlled trials of newer antidepressants. J Clin Psychopharmacol 2006 26 : 203 207.
53. Filteau M-J, Lapierre YD, Bakish D, Blanchard A. Reduction in suicidal ideation with SSRIs: review of 459 depressed patients. J Psychiatry Neurosci 1993 18 : 114 118.
54. Tollefson GD, Rampey AH Jr., Beasley CM Jr. et al. Absence of a relationship between adverse events and suicidality during pharmacotherapy for depression. J Clin Psychopharmacol 1994 14 : 163 169.
55. Pedersen AG. Escitalopram and suicidality in adult depression and anxiety. Int Clin Psychopharmacol 2005 20 : 139 143.