MEK/ERKs signaling is essential for lithium-induced neurite outgrowth in N2a cells

International Journal of Developmental Neuroscience

Volumn 29, Issue 4, 2011, Pages 415-422

  Wang, Zhuyao ^a,b   Wang, Juan ^c   Li, Jingjin ^c   Wang, Xiaohui ^a   Yao, Yuzhen ^a   Zhang, Xiaojin ^a   Li, Chuanfu ^d   Cheng, Yunlin ^a   Ding, Guoxian ^a   Liu, Li ^a   Ding, Zhengnian ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d East Tennessee State University   (United States)

Author keywords

Cross talk; Lithium; MEK ERKs pathway; Neurite outgrowth; PI3K Akt pathway

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; MOUSE; N2A CELL; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIMANIC AGENTS; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LITHIUM CHLORIDE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEURITES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 79955785660     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2011.03.001     Document Type: Article

References (34)

1. Chang Y.M., Kuo W.H., Lai T.Y., Shih Y.T., Tsai F.J., Tsai C.H., Shu W.T., Chen Y.Y., Chen Y.S., Kuo W.W., Huang C.Y. RSC96 Schwann cell proliferation and survival induced by Dilong through PI3K/Akt signaling mediated by IGF-I. Evid. Based Complement Altern. Med. 2009, (December). [Epub ahead of print] [PMID: 20040524].
2. Chen D.F., Jhaveri S., Schneider G.E. Intrinsic changes in developing retinal neurons result in regenerative failure of their axons. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:7287-7291. [Pubmed: 6171034].
3. Chen G., Bower K.A., Ma C., Fang S., Thiele C.J., Luo J. Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death. FASEB J. 2004, 18:1162-1164. [PMID: 15132987].
4. Chen J., Zacharek A., Cui X., Shehadah A., Jiang H., Roberts C., Lu M., Chopp M. Treatment of stroke with a synthetic liver X receptor agonist TO901317, promotes synaptic plasticity and axonal regeneration in mice. J. Cereb. Blood Flow Metab. 2010, 30:102-109. [Pubmed: 19724285].
5. Chen X., Fu W., Tung C.E., Ward N.L. Angiopoietin-1 induces neurite outgrowth of PC12 cells in a Tie2-independent, beta1-integrin-dependent manner. Neurosci. Res. 2009, 64:348-354. [Pubmed: 19379779].
6. Condello S., Caccamo D., Currò M., Ferlazzo N., Parisi G., Ientile R. Transglutaminase 2 and NF-kappaB interplay during NGF-induced differentiation of neuroblastoma cells. Brain Res. 2008, 1207:1-8.
7. Dai R., Chen R., Li H. Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells. Int. J. Oncol. 2009, 34:1749-1757.
8. David S., Aguayo A.J. Axonal elongation into peripheral nervous system " bridges" after central nervous system injury in adult rats. Science 1981, 214:931-933. [Pubmed: 6171034].
9. Di Daniel E., Mudge A.W., Maycox P.R. Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons. Bipolar Disord. 2005, 7:33-41. [Pubmed: 15654930].
10. Dill J., Wang H., Zhou F., Li S. Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. J. Neurosci. 2008, 28:8914-8928. [Pubmed: 18768685].
11. Goldberg J.L., Klassen M.P., Hua Y., Barres B.A. Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 2002, 296:1860-1864. [Pubmed: 12052959].
12. Harada H., Sugiyama T., Suketa Y. Characterization of inhibition by chronic treatment with lithium ion on nerve growth factor-induced neuronal differentiation of rat PC12 pheochromocytoma cells. J. Toxicol. Environ. Health 1996, 49:197-206.
13. Kim S.Y., Shin D.H., Kim S.J., Koo B.S., Bae C.D., Park J., Jeon S. Chloride channel conductance is required for NGF-induced neurite outgrowth in PC12 cells. Neurochem. Int. 2010, 56:663-669. [PMID: 20144672].
14. Kouroupi G., Lavdas A.A., Gaitanou M., Thomaidou D., Stylianopoulou F., Matsas R. Lentivirus-mediated expression of insulin-like growth factor-I promotes neural stem/precursor cell proliferation and enhances their potential to generate neurons. J. Neurochem. 2010, 115:460-474. [PMID: 20681949].
15. Ma R., Wang X., Lu C., Li C., Cheng Y., Ding G., Liu L., Ding Z. Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine-serine protein kinase B-dependent mechanism. Neuroscience 2010, 167:329-342. [PMID: 20038443].
16. Mairet-Coello G., Tury A., DiCicco-Bloom E. Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex. J. Neurosci. 2009, 29:775-788. [PMID: 19158303].
17. Manji H.K., Moore G.J., Chen G. Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?. Biol. Psychiatry 1999, 46:929-940. [Pubmed: 10509176].
18. Meng X.L., Rennert O.M., Chan W.Y. Human chorionic gonadotropin induces neuronal differentiation of PC12 cells through activation of stably expressed lutropin/choriogonadotropin receptor. Endocrinology 2007, 148:5865-5873. [Pubmed: 17761763].
19. Min J.Y., Park M.H., Park M.K., Park K.W., Lee N.W., Kim T., Kim H.J., Lee D.H. Staurosporin induces neurite outgrowth through ROS generation in HN33 hippocampal cell lines. J. Neural Transm. 2006, 113:1821-1826. [PubMed: 16715208].
20. Mizutani R., Yamauchi J., Kusakawa S., Nakamura K., Sanbe A., Torii T., Miyamoto Y., Tanoue A. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Cell. Signal. 2009, 21:1586-1594. [Pubmed: 19576982].
21. Mueller B.K., Mack H., Teusch N. Rho kinase, a promising drug target for neurological disorders. Nat. Rev. Drug Discov. 2005, 4:387-398. [Pubmed: 15864268].
22. Obara Y., Yamauchi A., Takehara S., Nemoto W., Takahashi M., Stork P.J., Nakahata N. ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. J. Biol. Chem. 2009, 284:23564-23573. [Pubmed: 19581298].
23. Papadopoulos C.M., Tsai S.Y., Guillen V., Ortega J., Kartje G.L., Wolf W.A. Motor recovery and axonal plasticity with short-term amphetamine after stroke. Stroke 2009, 40:294-302. [Pubmed: 19038917].
24. Riese U., Ziegler E., Hamburger M. Militarinone A induces differentiation in PC12 cells via MAP and Akt kinase signal transduction pathways. FEBS Lett. 2004, 577:455-459. [Pubmed: 15556627].
25. Schiwy N., Brazda N., Müller H.W. Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment. Eur. J. Neurosci. 2009, 30:1544-1553. [Pubmed: 19817844].
26. Suzukawa K., Miura K., Mitsushita J., Resau J., Hirose K., Crystal R., Kamata T. Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J. Biol. Chem. 2000, 275:13175-13178. [Pubmed: 10788420].
27. Wang X., Zhang X., Cheng Y., Li C., Zhang W., Liu L., Ding Z. Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism. Neurotoxicology 2010, 31:101-112. [Pubmed: 19879292].
28. Washio A., Kitamura C., Jimi E., Terashita M., Nishihara T. Mechanisms involved in suppression of NGF-induced neuronal differentiation of PC12 cells by hyaluronic acid. Exp. Cell Res. 2009, 315:3036-3043. [Pubmed: 19615362].
29. Wu H., Ichikawa S., Tani C., Zhu B., Tada M., Shimoishi Y., Murata Y., Nakamura Y. Docosahexaenoic acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells. Biochim. Biophys. Acta 2009, 1791:8-16. [Pubmed: 18996496].
30. Young W. Review of lithium effects on brain and blood. Cell Transplant 2009, 18:951-975. [Pubmed: 19523343].
31. Zheng B., Ohkawa S., Li H., Roberts-Wilson T.K., Price S.R. FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy. FASEB J. 2010, 24:2660-2669.
32. Zhuang J., Li F., Liu X., Liu Z., Lin J., Ge Y., Kaminski J.M., Summers J.B., Wang Z., Ge J., Yu K. Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining. Biochem. Biophys. Res. Commun. 2009, 380:650-654. [Pubmed: 19285016].
33. Zhou F.Q., Snider W.D. Intracellular control of developmental and regenerative axon growth. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361:1575-1592. [Pubmed: 16939976].
34. Zhou H., Qian J., Li C., Li J., Zhang X., Ding Z., Gao X., Han Z., Cheng Y., Liu L. Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism. Cardiovasc. Res. 2011, 89:109-118. [PMID: 20733008].