Neurobiology of aggression and violence in schizophrenia

Schizophrenia Bulletin

Volumn 37, Issue 5, 2011, Pages 913-920

  Soyka, Michael ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b Privatklinik Meiringen ^*  (Switzerland)

Author keywords

aggression; genetics; neurobiology; neuroimaging; schizophrenia; violence

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CATECHOL METHYLTRANSFERASE; FLUORODEOXYGLUCOSE F 18; METHIONINE; NEU DIFFERENTIATION FACTOR; TRYPTOPHAN HYDROXYLASE; VALINE;

AGGRESSION; ARTICLE; ATTENTION DEFICIT DISORDER; COGNITIVE DEFECT; FRONTAL LOBE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GATED SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; GENETIC ASSOCIATION; GENETIC RISK; HOMICIDE; HUMAN; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPORAL LOBE; VIOLENCE;

AGGRESSION; CATECHOL O-METHYLTRANSFERASE; HUMANS; SCHIZOPHRENIA; VIOLENCE;

EID: 80052187686     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbr103     Document Type: Article

References (54)

1. Fazel S, Gulati G, Linsell L, Geddes JR, Grann M. Schizophrenia and violence: systematic review and meta-analysis. PLoS Med. 2009;6:e1000120.
2. Fazel S, Langstrom N, Hjern A, Grann M, Lichtenstein P. Schizophrenia, substance abuse, and violent crime. JAMA 2009;301:2016-2023.
3. Soyka M, Graz C, Bottlender R, Dirschedl P, Schoech H. Clinical correlates of later violence and criminal offences in schizophrenia. Schizophr Res. 2007;94:89-98. (Pubitemid 47031578)
4. Fazel S, Grann M. The population impact of severe mental illness on violent crime. Am J Psychiatry. 2006;163:1397-1403. (Pubitemid 44464411)
5. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron 2006;52:139-153. (Pubitemid 44466356)
6. Rapoport JL, Addington AM, Frangou S, Psych MR. The neurodevelopmental model of schizophrenia: update 2005. Mol Psychiatry. 2005;10:434-449. (Pubitemid 40646432)
7. Guillin O, Abi-Dargham A, Laruelle M. Neurobiology of dopamine in schizophrenia. Int Rev Neurobiol. 2007;78:1-39.
8. Van Winkel R, Esquivel G, Kenis G, et al. REVIEW: genome-wide findings in schizophrenia and the role of geneenvironment interplay. CNS Neurosci Ther. 2010;16:e185-e192.
9. Williams HJ, Owen MJ, O'Donovan MC. Is COMT a susceptibility gene for schizophrenia? Schizophr Bull. 2007;33:635-641. (Pubitemid 47343721)
10. Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA. Genetic-environmental interaction in the genesis of aggressivity and conduct disorders. Arch Gen Psychiatry 1995;52:916-924.
11. Kotler M, Barak P, Cohen H, et al. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. Am J Med Genet. 1999;88:628-633.
12. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243-250. (Pubitemid 26226317)
13. Lachman HM, Nolan KA, Mohr P, Saito T, Volavka J. Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry. 1998;155:835-837. (Pubitemid 28252668)
14. Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res. 1997;69:71-77. (Pubitemid 27147929)
15. Han DH, Kee BS, Min KJ, et al. Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients. Neuroreport. 2006;17:95-99.
16. Han DH, Park DB, Na C, Kee BS, Lee YS. Association of aggressive behavior in Korean male schizophrenic patients with polymorphisms in the serotonin transporter promoter and catecholamine-O-methyltransferase genes. Psychiatry Res. 2004;129:29-37. (Pubitemid 39574434)
17. Jones G, Zammit S, Norton N, et al. Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. Br J Psychiatry. 2001;179:351-355. (Pubitemid 32996046)
18. Zammit S, Jones G, Jones SJ, et al. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004;128B:19-20. (Pubitemid 38849910)
19. Gu Y, Yun L, Tian Y, Hu Z. Association between COMT gene and Chinese male schizophrenic patients with violent behavior. Med Sci Monit. 2009;15:CR484-CR489.
20. Kim YR, Kim JH, Kim SJ, Lee D, Min SK. Catechol-Omethyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population. Eur Neuropsychopharmacol. 2008;18:820-825.
21. Hong JP, Lee JS, Chung S, et al. New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:658-660. (Pubitemid 351961671)
22. Lious YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC. Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology. 2001;43:11-14.
23. Tosato S, Bonetto C, Forti M, et al. Effect of COMT genotype on aggressive behavior in a community cohort of schizophrenic patients. Neurosci Lett. 2011;495:17-21.
24. Fresan A, Camarena B, Apiquian R, Aguilar A, Urraca N, Nicolini H. Association study of MAO-A and DRD4 genes in schizophrenic patients with aggressive behavior. Neuropsychobiology. 2007;55:171-175. (Pubitemid 47525237)
25. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993;262:578-580. (Pubitemid 23350673)
26. Cases O, Seif I, Grimsby J, et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995;268:1763-1766.
27. Manuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res. 2000;95:9-23. (Pubitemid 30445200)
28. Koen L, Kinnear CJ, Corfield VA, et al. Violence in male patients with schizophrenia: risk markers in a South African population. Aust N Z J Psychiatry. 2004;38:254-259. (Pubitemid 38578582)
29. Strous RD, Nolan KA, Lapidus R, Diaz L, Saito T, Lachman HM. Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:29-34. (Pubitemid 37059375)
30. Kim YR, Lee JY, Min SK. No evidence of an association between A218C polymorphism of the tryptophan hydroxylase 1 gene and aggression in schizophrenia in a Korean population. Yonsei Med J. 2010;51:27-32.
31. Hong CJ, Pan GM, Tsai SJ. Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism. Neuropsychobiology 2004;49:1-4.
32. Chung S, Chung HY, Jung J, Chang JK, Hong JP. Association among aggressiveness, neurocognitive function, and the Val66Met polymorphism of brain-derived neurotrophic factor gene in male schizophrenic patients. Compr Psychiatry 2010;51:367-372.
33. Spalletta G, Morris DW, Angelucci F, et al. BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. Eur Psychiatry 2010;25:311-313.
34. Spalletta G, Romeo E, Bonaviri G, Bernardi G, Caltagirone C, di Michele F. Preliminary evidence for an association between aggressive and hostile behaviour and 3alpha,5alphatetrahydroprogesterone plasma levels in schizophrenia. J Psychiatry Neurosci. 2005;30:49-52. (Pubitemid 40289247)
35. Ritsner M, Modai I, Gibel A, et al. Decreased platelet peripheral-type benzodiazepine receptors in persistently violent schizophrenia patients. J Psychiatr Res. 2003;37: 549-556. (Pubitemid 37238949)
36. Watari M, Hamazaki K, Hirata T, Hamazaki T, Okubo Y. Hostility of drug-free patients with schizophrenia and n-3 polyunsaturated fatty acid levels in red blood cells. Psychiatry Res. 2010;177:22-26.
37. Naudts K, Hodgins S. Schizophrenia and violence: a search for neurobiological correlates. Curr Opin Psychiatry. 2006;19:533-538. (Pubitemid 44166502)
38. Serper M, Beech DR, Harvey PD, Dill C. Neuropsychological and symptom predictors of aggression on the psychiatric inpatient service. J Clin Exp Neuropsychology. 2008;30:700-709. (Pubitemid 351957698)
39. Golimbet V, Gritsenko I, Alfimova M, et al. Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives. World J Biol Psychiatry 2006;7:238-245. (Pubitemid 44650533)
40. Wahlund K, Kristiansson M. Aggression, psychopathy and brain imaging-review and future recommendations. Int J Law Psychiatry 2009;32:266-271.
41. Hoptman MJ, Antonius D. Neuroimaging correlates of aggression in schizophrenia: an update. Curr Opin Psychiatry 2011;24:100-106.
42. Barkataki I, Kumari V, Das M, Taylor P, Sharma T. Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder. Behav Brain Res. 2006;169:239-247.
43. Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO. Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biol Psychiatry. 2002;52:9-14. (Pubitemid 34655551)
44. Wong TH, Lumsden J, Fenton GW, Fenwick PB. Neuroimaging in mentally abnormal offenders. Issues Crim Leg Psychol. 1997;27:49-58.
45. Kumari V, Barkataki I, Goswami S, Flora S, Das M, Taylor P. Dysfunctional, but not functional, impulsivity is associated with a history of seriously violent behaviour and reduced orbitofrontal and hippocampal volumes in schizophrenia. Psychiatry Res. 2009;173:39-44.
46. Hoptman MJ, Volavka J, Weiss EM, et al. Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. Psychiatry Res. 2005;140:133-145. (Pubitemid 41540425)
47. Puri BK, Counsell SJ, Saeed N, Bustos MG, Treasaden IH, Bydder GM. Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brain structure of patients who have seriously and violently offended with that of patients who have not. BMC Psychiatry. 2008;8(suppl 1):S6.
48. Wong MT, Fenwick PB, Lumsden J, et al. Positron emission tomography in male violent offenders with schizophrenia. Psychiatry Res. 1997;68:111-123. (Pubitemid 27191434)
49. Spalletta G, Troisi A, Alimenti S, et al. Reduced prefrontal cognitive activation associated with aggression in schizophrenia. Schizophr Res. 2001;50:134-135. (Pubitemid 32510896)
50. Kumari V, Aasen I, Taylor P, et al. Neural dysfunction and violence in schizophrenia: an fMRI investigation. Schizophr Res. 2006;84:144-164.
51. Brower MC, Price BH. Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review. J Neurol Neurosurg Psychiatry 2001;71:720-726. (Pubitemid 33121911)
52. Joyal CC, Putkonen A,Mancini-Marie A, et al. Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study. Schizophr Res. 2007;91:97-102.
53. Dolan MC, Fullam RS. Psychopathy and functional magnetic resonance imaging blood oxygenation level-dependent responses to emotional faces in violent patients with schizophrenia. Biol Psychiatry 2009;66:570-577.
54. Hoptman MJ, D'Angelo D, Catalano D, et al. Amygdalofrontal functional disconnectivity and aggression in schizophrenia. Schizophr Bull. 2010;36:1020-1028.