A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits

Biological Psychiatry

Volumn 54, Issue 1, 2003, Pages 34-39

  Rujescu, Dan ^a   Giegling, Ina ^a   Gietl, Anton ^a   Hartmann, Annette M ^a   Möller, Hans Jürgen ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Aggression; Anger; COMT gene; Personality traits; Polymorphism; Suicide

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADULT; AGE; AGED; AGGRESSION; ANGER; ARTICLE; BIOLOGICAL TRAIT; CONTROLLED STUDY; EDUCATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PERSONALITY; PHENOTYPE; PRIORITY JOURNAL; QUESTIONNAIRE; RATING SCALE; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDE ATTEMPT; VIOLENCE;

EID: 0038094426     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(02)01831-0     Document Type: Article

References (33)

1. Brent D.A., Bridge J., Johnson B.A., Connolly J. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Arch Gen Psychiatry. 53:1996;1145-1152.
2. Egeland J.A., Sussex J.N. Suicide and family loading for affective disorders. JAMA. 254:1985;915-918.
3. First M.B., Spitzer R.L., Gibbon M. Structured Clinical Interview for DSM-IV Axis I and II Disorders. 1997;American Psychiatric Press, Washington, DC.
4. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A. 95:1998;9991-9996.
5. Haller J., Makara G.B., Kruk M.R. Catecholaminergic involvement in the control of aggression Hormones, the peripheral sympathetic, and central noradrenergic systems . Neurosci Biobehav Rev. 22:1998;85-97.
6. Heila H., Isometsa E.T., Henriksson M.M., Heikkinen M.E., Marttunen M.J., Lonnqvist J.K., et al. Suicide and schizophrenia A nationwide psychological autopsy study on age- and sex-specific clinical characteristics of 92 suicide victims with schizophrenia . Am J Psychiatry. 154:1997;1235-1242.
7. Herpertz S., Sass H., Favazza A. Impulsivity in self-mutilative behavior Psychometric and biological findings . J Psychiatr Res. 31:1997;451-465.
8. Hodapp V., Sicker G., Wick A.D., Winkelstrater R. Anger and risk of suicide. Study of elderly psychiatric patients. Nervenarzt. 68:1997;55-61.
9. Jones G., Zammit S., Norton N., Hamshere M.L., Jones S.J., Milham C., et al. Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. Br J Psychiatry. 179:2001;351-355.
10. Karoum F., Chrapusta S.J., Egan M.F. 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex Reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model . J Neurochem. 63:1994;972-979.
11. Kotler M., Barak P., Cohen H., Averbuch I.E., Grinshpoon A., Gritsenko I., et al. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol-O-methltransferase. Am J Med Genet. 88:1999;628-633.
12. Lachman H.M., Nolan K.A., Mohr P., Saito T., Volavka J. Association between catechol-O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry. 155:1998;835-837.
13. Liou Y.J., Tsai S.J., Hong C.J., Wang Y.C., Lai I.C. Association analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology. 43:2001;11-14.
14. Mann J.J., Brent D.A., Arango V. The neurobiology and genetics of suicide and attempted suicide A focus on the serotonergic system . Neuropsychopharmacology. 24:2001;467-477.
15. Mann J.J., Waternaux C., Haas G.L., Malone K.M. Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry. 156:1999;181-189.
16. Mannisto P.T., Kaakkola S. Catechol-O-methyltransferase (COMT) Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors . Pharmacol Rev. 51:1999;593-628.
17. Müller C., Bongard S., Heiligtag U., Hodapp V. Das State-Trait-Ausdrucksinventar (STAXI) in der klinischen anwendung Reliabilität und fakorielle Valitität [The State-Trait Anger Expression Inventory STAXI) in the clinical application: Reliability and factor validity] . Z Klin Psychol Psychother. 30:2001;172-181.
18. Nolan K.A., Volavka J., Czobor P., Cseh A., Lachman H., Saito T. Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatr Genet. 10:2000;117-124.
19. Pucilowski O., Kostowski W., Bidzinski A., Hauptmann M. Effect of 6-hydroxydopamine-induced lesions of A10 dopaminergic neurons on aggressive behavior in rats. Pharmacol Biochem Behav. 16:1982;547-551.
20. Rice J.P., Reich T., Bucholz K.K., Neuman R.J., Fishman R., Rochberg N. Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res. 19:1995;1018-1023.
21. Roy A. Genetics of suicide. Ann N Y Acad Sci. 487:1986;97-105.
22. Roy A., Segal N.L., Centerwall B.S., Robinette C.D. Suicide in twins. Arch Gen Psychiatry. 48:1991;29-32.
23. Russ M.J., Lachman H.M., Kashdan T., Saito T., Bajmakovic-Kacila S. Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide. Psychiatry Res. 93:2000;73-78.
24. Schulsinger F., Kety S.S., Rosenthal D., Wender P.H. A family study of suicide. Schou M., Stromgren E. Origin, Prevention, and Treatment of Affective Disorders. 1979;277-287 Academic Press, New York.
25. Schwenkmezger P, Hodapp V, Spielberger CD (1992): Das State-Trait-Aergerausdrucks-Inventar (STAXI) [The State-Trait Anger Expression Inventory (STAXI)]. Göttingen: Hogrefe.
26. Siegel A., Roeling T.A., Gregg T.R., Kruk M.R. Neuropharmacology of brain-stimulation-evoked aggression. Neurosci Biobehav Rev. 23:1999;359-389.
27. Spielberger C.D. State-Trait Anger Expression Inventory. 1991;Psychological Assessment Resources, Odessa, FL.
28. Statham D.J., Heath A.C., Madden P.A.F., Bucholz K.K., Biesrut L., Dinwiddie S.H., et al. Suicidal behaviour An epidemiological and genetic study . Psychol Med. 28:1998;839-855.
29. Strous R.D., Bark N., Parsia S.S., Volavka J., Lachman H.M. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia. Psychiatry Res. 69:1997;71-77.
30. Tardiff K. The risk of assaultive behavior in suicidal patients. Acta Psychiatr Scand. 64:1981;295-300.
31. Virkkunen M., de Jong J., Bartko J., Linnoila M. Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry. 46:1989;604-606.
32. Weinshilboum R.M., Raymond F.A. Inherence of low erythrocyte catechol-O-methyltransferase activity in man. Am J Med Genet. 29:1977;125-135.
33. Wittchen HU, Zaudig M, Fydrich T (1997): Strukturiertes Klinisches Interview für DSM-IV, Achse I und II. (Structured Clinical Interview for DSM-IV, Axis I and II.) Göttingen: Hogrefe.