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Volumn 3, Issue 1, 2015, Pages

Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation

Author keywords

Celiac disease; Claudin 2; Crohn s disease; HIV; IFN ; Inflammatory bowel disease; Tight junction; TNF ; Ulcerative colitis

Indexed keywords

ADALIMUMAB; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CLAUDIN 15; CLAUDIN 2; GAMMA INTERFERON; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MANNITOL; MITOGEN ACTIVATED PROTEIN KINASE; OCCLUDIN; OCCLUDIN 1; OCCLUDIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; RHO KINASE; STAT6 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR GATA 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84958555991     PISSN: 21688362     EISSN: 21688370     Source Type: Journal    
DOI: 10.4161/21688370.2014.977176     Document Type: Review
Times cited : (215)

References (116)
  • 1
    • 0035354574 scopus 로고    scopus 로고
    • Molecular structure of tight junctions and their role in epithelial transport
    • PMID:11443232
    • Anderson JM. Molecular structure of tight junctions and their role in epithelial transport. News Physiol Sci 2001; 16:126-30; PMID:11443232
    • (2001) News Physiol Sci , vol.16 , pp. 126-130
    • Anderson, J.M.1
  • 3
    • 0037115724 scopus 로고    scopus 로고
    • Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
    • PMID:12432083
    • Amasheh S, Meiri N, Gitter AH, Schoneberg T, Mankertz J, Schulzke JD, Fromm M. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 2002; 115:4969-76; PMID:12432083; http://dx.doi.org/10.1242/jcs.00165
    • (2002) J Cell Sci , vol.115 , pp. 4969-4976
    • Amasheh, S.1    Meiri, N.2    Gitter, A.H.3    Schoneberg, T.4    Mankertz, J.5    Schulzke, J.D.6    Fromm, M.7
  • 4
    • 77953162593 scopus 로고    scopus 로고
    • Claudin-2, a component of the tight junction, forms a paracellular water channel
    • PMID:20460438
    • Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Gunzel D, Fromm M. Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci 2010; 123:1913-21; PMID:20460438; http://dx.doi.org/10.1242/jcs.060665
    • (2010) J Cell Sci , vol.123 , pp. 1913-1921
    • Rosenthal, R.1    Milatz, S.2    Krug, S.M.3    Oelrich, B.4    Schulzke, J.D.5    Amasheh, S.6    Gunzel, D.7    Fromm, M.8
  • 5
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • PMID:9647647
    • Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998; 141:1539-50; PMID:9647647; http://dx.doi.org/10.1083/jcb.141.7.1539
    • (1998) J Cell Biol , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 6
    • 0033552629 scopus 로고    scopus 로고
    • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    • PMID:10601346
    • Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 1999; 147:1351-63; PMID:10601346; http://dx.doi.org/10.1083/jcb.147.6.1351
    • (1999) J Cell Biol , vol.147 , pp. 1351-1363
    • Itoh, M.1    Furuse, M.2    Morita, K.3    Kubota, K.4    Saitou, M.5    Tsukita, S.6
  • 8
    • 0033571047 scopus 로고    scopus 로고
    • Manner of interaction of heterogeneous claudin species within and between tight junction strands
    • PMID:10562289
    • Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999; 147:891-903; PMID:10562289; http://dx.doi.org/10.1083/jcb.147.4.891
    • (1999) J Cell Biol , vol.147 , pp. 891-903
    • Furuse, M.1    Sasaki, H.2    Tsukita, S.3
  • 9
    • 48049122836 scopus 로고    scopus 로고
    • Kinetics of adhesion mediated by extracellular loops of claudin-2 as revealed by single-molecule force spectroscopy
    • PMID:18635194
    • Lim TS, Vedula SR, Hunziker W, Lim CT. Kinetics of adhesion mediated by extracellular loops of claudin-2 as revealed by single-molecule force spectroscopy. J Mol Biol 2008; 381:681-91; PMID:18635194; http://dx.doi.org/10.1016/j. jmb.2008.06.009
    • (2008) J Mol Biol , vol.381 , pp. 681-691
    • Lim, T.S.1    Vedula, S.R.2    Hunziker, W.3    Lim, C.T.4
  • 10
    • 2942659788 scopus 로고    scopus 로고
    • The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability
    • PMID:15366421
    • Van Itallie CM, Colegio OR, Anderson JM. The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability. J Membr Biol 2004; 199:29-38; PMID:15366421; http://dx.doi.org/10.1007/s00232-004-0673-z
    • (2004) J Membr Biol , vol.199 , pp. 29-38
    • Van Itallie, C.M.1    Colegio, O.R.2    Erson, J.M.3
  • 11
    • 67249098565 scopus 로고    scopus 로고
    • Cysteine mutagenesis to study the structure of claudin-2 paracellular pores
    • PMID:19538299
    • Angelow S, Yu AS. Cysteine mutagenesis to study the structure of claudin-2 paracellular pores. Ann N Y Acad Sci 2009; 1165:143-7; PMID:19538299; http://dx.doi.org/10.1111/j.1749-6632.2009.04038.x
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 143-147
    • Angelow, S.1    Yu, A.S.2
  • 12
    • 60549090106 scopus 로고    scopus 로고
    • Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site
    • PMID:19114638
    • Yu AS, Cheng MH, Angelow S, Gunzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD. Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol 2009; 133:111-27; PMID:19114638; http://dx.doi.org/10.1085/jgp.200810154
    • (2009) J Gen Physiol , vol.133 , pp. 111-127
    • Yu, A.S.1    Cheng, M.H.2    Angelow, S.3    Gunzel, D.4    Kanzawa, S.A.5    Schneeberger, E.E.6    Fromm, M.7    Coalson, R.D.8
  • 13
    • 56749141792 scopus 로고    scopus 로고
    • Biology of claudins
    • PMID:18480174
    • Angelow S, Ahlstrom R, Yu AS. Biology of claudins. Am J Physiol Renal Physiol 2008; 295:F867-76; PMID:18480174; http://dx.doi.org/10.1152/ajprenal.90264.2008
    • (2008) Am J Physiol Renal Physiol , vol.295 , pp. F867-F876
    • Angelow, S.1    Ahlstrom, R.2    Yu, A.S.3
  • 14
    • 84880163557 scopus 로고    scopus 로고
    • Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines
    • PMID:23677799
    • Li J, Angelow S, Linge A, Zhuo M, Yu AS. Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines. Am J Physiol Cell Physiol 2013; 305:C190-6; PMID:23677799; http://dx.doi.org/10.1152/ajpcell.00074.2013
    • (2013) Am J Physiol Cell Physiol , vol.305 , pp. C190-C196
    • Li, J.1    Angelow, S.2    Linge, A.3    Zhuo, M.4    Yu, A.S.5
  • 15
    • 84896797690 scopus 로고    scopus 로고
    • Comprehensive cysteine-scanning mutagenesis reveals claudin-2 pore-lining residues with different intrapore locations
    • PMID:24436330
    • Li J, Zhuo M, Pei L, Rajagopal M, Yu AS. Comprehensive cysteine-scanning mutagenesis reveals claudin-2 pore-lining residues with different intrapore locations. J Biol Chem 2014; 289:6475-84P; PMID:24436330
    • (2014) J Biol Chem , vol.289 , pp. 6475-6484
    • Li, J.1    Zhuo, M.2    Pei, L.3    Rajagopal, M.4    Yu, A.S.5
  • 16
    • 84881256884 scopus 로고    scopus 로고
    • Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b
    • PMID:23760508
    • Li J, Zhuo M, Pei L, Yu AS. Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b. J Biol Chem 2013; 288:22790-7; PMID:23760508; http://dx.doi.org/10.1074/jbc.M113.484238
    • (2013) J Biol Chem , vol.288 , pp. 22790-22797
    • Li, J.1    Zhuo, M.2    Pei, L.3    Yu, A.S.4
  • 17
    • 39149138174 scopus 로고    scopus 로고
    • Comparative characterization of mouse rectum CMT93-I and -II cells by expression of claudin isoforms and tight junction morphology and function
    • PMID:18034259
    • Inai T, Sengoku A, Hirose E, Iida H, Shibata Y. Comparative characterization of mouse rectum CMT93-I and -II cells by expression of claudin isoforms and tight junction morphology and function. Histochem Cell Biol 2008; 129:223-32; PMID:18034259; http://dx.doi.org/10.1007/s00418-007-0360-0
    • (2008) Histochem Cell Biol , vol.129 , pp. 223-232
    • Inai, T.1    Sengoku, A.2    Hirose, E.3    Iida, H.4    Shibata, Y.5
  • 18
    • 2942615071 scopus 로고    scopus 로고
    • Setting up a selective barrier at the apical junction complex
    • PMID:15196556
    • Anderson JM, Van Itallie CM, Fanning AS. Setting up a selective barrier at the apical junction complex. Curr Opin Cell Biol 2004; 16:140-5; PMID:15196556; http://dx.doi.org/10.1016/j.ceb.2004.01.005
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 140-145
    • Anderson, J.M.1    Van Itallie, C.M.2    Fanning, A.S.3
  • 19
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
    • PMID:11309408
    • Furuse M, Furuse K, Sasaki H, Tsukita S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 2001; 153:263-72; PMID:11309408; http://dx.doi.org/10.1083/jcb.153.2.263
    • (2001) J Cell Biol , vol.153 , pp. 263-272
    • Furuse, M.1    Furuse, K.2    Sasaki, H.3    Tsukita, S.4
  • 20
    • 36049034205 scopus 로고    scopus 로고
    • Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance
    • PMID:17855771
    • Singh AB, Sugimoto K, Dhawan P, Harris RC. Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Am J Physiol Cell Physiol 2007; 293:C1660-8; PMID:17855771; http://dx.doi.org/10.1152/ajpcell.00274.2007
    • (2007) Am J Physiol Cell Physiol , vol.293 , pp. C1660-C16C8
    • Singh, A.B.1    Sugimoto, K.2    Dhawan, P.3    Harris, R.C.4
  • 21
    • 0035195390 scopus 로고    scopus 로고
    • Claudin-2 is selectively expressed in proximal nephron in mouse kidney
    • PMID:11592954
    • Enck AH, Berger UV, Yu AS. Claudin-2 is selectively expressed in proximal nephron in mouse kidney. Am J Physiol Renal Physiol 2001; 281:F966-74; PMID:11592954
    • (2001) Am J Physiol Renal Physiol , vol.281 , pp. F966-F974
    • Enck, A.H.1    Berger, U.V.2    Yu, A.S.3
  • 22
    • 0036208599 scopus 로고    scopus 로고
    • Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
    • PMID:11912246
    • Kiuchi-Saishin Y, Gotoh S, Furuse M, Takasuga A, Tano Y, Tsukita S. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J Am Soc Nephrol 2002; 13:875-86; PMID:11912246
    • (2002) J am Soc Nephrol , vol.13 , pp. 875-886
    • Kiuchi-Saishin, Y.1    Gotoh, S.2    Furuse, M.3    Takasuga, A.4    Tano, Y.5    Tsukita, S.6
  • 23
    • 84871360027 scopus 로고    scopus 로고
    • Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease
    • PMID:23205909
    • Lameris AL, Huybers S, Kaukinen K, Makela TH, Bindels RJ, Hoenderop JG, Nevalainen PI. Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease. Scand J Gastroenterol 2013; 48:58-69; PMID:23205909; http://dx.doi.org/10.3109/00365521.2012.741616
    • (2013) Scand J Gastroenterol , vol.48 , pp. 58-69
    • Lameris, A.L.1    Huybers, S.2    Kaukinen, K.3    Makela, T.H.4    Bindels, R.J.5    Hoenderop, J.G.6    Nevalainen, P.I.7
  • 24
    • 14744270867 scopus 로고    scopus 로고
    • Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells
    • PMID:15389642
    • Escaffit F, Boudreau F, Beaulieu JF. Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 2005; 203:15-26; PMID:15389642; http://dx.doi.org/10.1002/jcp.20189
    • (2005) J Cell Physiol , vol.203 , pp. 15-26
    • Escaffit, F.1    Boudreau, F.2    Beaulieu, J.F.3
  • 25
    • 79952286129 scopus 로고    scopus 로고
    • Loss of claudin-15, but not claudin-2, causes NaC deficiency and glucose malabsorption in mouse small intestine
    • PMID:20727355
    • Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y, Tsukita S. Loss of claudin-15, but not claudin-2, causes NaC deficiency and glucose malabsorption in mouse small intestine. Gastroenterology 2011; 140:913-23; PMID:20727355; http://dx.doi.org/10.1053/j.gastro.2010.08.006
    • (2011) Gastroenterology , vol.140 , pp. 913-923
    • Tamura, A.1    Hayashi, H.2    Imasato, M.3    Yamazaki, Y.4    Hagiwara, A.5    Wada, M.6    Noda, T.7    Watanabe, M.8    Suzuki, Y.9    Tsukita, S.10
  • 27
    • 84861966218 scopus 로고    scopus 로고
    • Claudins and other tight junction proteins
    • PMID:23723025
    • Gunzel D, Fromm M. Claudins and other tight junction proteins. Compr Physiol 2012; 2:1819-52; PMID:23723025
    • (2012) Compr Physiol , vol.2 , pp. 1819-1852
    • Gunzel, D.1    Fromm, M.2
  • 28
    • 69849111327 scopus 로고    scopus 로고
    • Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease
    • PMID:19488769
    • Amasheh S, Dullat S, Fromm M, Schulzke JD, Buhr HJ, Kroesen AJ. Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease. Int J Colorectal Dis 2009; 24:1149-56; PMID:19488769; http://dx.doi.org/10.1007/s00384-009-0737-8
    • (2009) Int J Colorectal Dis , vol.24 , pp. 1149-1156
    • Amasheh, S.1    Dullat, S.2    Fromm, M.3    Schulzke, J.D.4    Buhr, H.J.5    Kroesen, A.J.6
  • 29
    • 27744551342 scopus 로고    scopus 로고
    • Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    • PMID:16007110
    • Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest 2005; 85:1139-62; PMID:16007110; http://dx.doi.org/10.1038/labinvest.3700316
    • (2005) Lab Invest , vol.85 , pp. 1139-1162
    • Prasad, S.1    Mingrino, R.2    Kaukinen, K.3    Hayes, K.L.4    Powell, R.M.5    Macdonald, T.T.6    Collins, J.E.7
  • 30
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
    • PMID:16822808
    • Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease. Gut 2007; 56:61-72; PMID:16822808; http://dx.doi.org/10.1136/gut.2006.094375
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.D.10
  • 31
    • 54349114505 scopus 로고    scopus 로고
    • Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: Effect of pro-inflammatory interleukin-13 on epithelial cell function
    • PMID:19079233
    • Heller F, Fromm A, Gitter AH, Mankertz J, Schulzke JD. Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function. Mucosal Immunol 2008; 1 Suppl 1:S58-61; PMID:19079233; http://dx.doi.org/10.1038/mi.2008.46
    • (2008) Mucosal Immunol , vol.1 , pp. S58-S61
    • Heller, F.1    Fromm, A.2    Gitter, A.H.3    Mankertz, J.4    Schulzke, J.D.5
  • 32
    • 77954655235 scopus 로고    scopus 로고
    • TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling
    • PMID:19214581
    • Mankertz J, Amasheh M, Krug SM, Fromm A, Amasheh S, Hillenbrand B, Tavalali S, Fromm M, Schulzke JD. TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tissue Res 2009; 336:67-77; PMID:19214581; http://dx.doi.org/10.1007/s00441-009-0751-8
    • (2009) Cell Tissue Res , vol.336 , pp. 67-77
    • Mankertz, J.1    Amasheh, M.2    Krug, S.M.3    Fromm, A.4    Amasheh, S.5    Hillenbrand, B.6    Tavalali, S.7    Fromm, M.8    Schulzke, J.D.9
  • 33
    • 80052400212 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • PMID:21771795
    • Suzuki T, Yoshinaga N, Tanabe S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 2011; 286:31263-71; PMID:21771795; http://dx.doi.org/10.1074/jbc.M111.238147
    • (2011) J Biol Chem , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 34
    • 78649730159 scopus 로고    scopus 로고
    • TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling
    • PMID:21062898
    • Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD. TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling. J Cell Sci 2010; 123:4145-55; PMID:21062898; http://dx.doi.org/10.1242/jcs.070896
    • (2010) J Cell Sci , vol.123 , pp. 4145-4155
    • Amasheh, M.1    Fromm, A.2    Krug, S.M.3    Amasheh, S.4    Res, S.5    Zeitz, M.6    Fromm, M.7    Schulzke, J.D.8
  • 35
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • PMID:10833473
    • Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000; 118:1001-11; PMID:10833473; http://dx.doi.org/10.1016/S0016-5085(00)70351-9
    • (2000) Gastroenterology , vol.118 , pp. 1001-1011
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.C.4
  • 36
    • 0037077248 scopus 로고    scopus 로고
    • Cloning of the human claudin-2 5’-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha
    • PMID:11934881
    • Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, Reinecker HC. Cloning of the human claudin-2 5’-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem 2002; 277:21361-70; PMID:11934881; http://dx.doi.org/10.1074/jbc.M110261200
    • (2002) J Biol Chem , vol.277 , pp. 21361-21370
    • Sakaguchi, T.1    Gu, X.2    Golden, H.M.3    Suh, E.4    Rhoads, D.B.5    Reinecker, H.C.6
  • 37
    • 0942268163 scopus 로고    scopus 로고
    • Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity
    • PMID:14751232
    • Mankertz J, Hillenbrand B, Tavalali S, Huber O, Fromm M, Schulzke JD. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun 2004; 314:1001-7; PMID:14751232; http://dx.doi.org/10.1016/j.bbrc.2003.12.185
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 1001-1007
    • Mankertz, J.1    Hillenbrand, B.2    Tavalali, S.3    Huber, O.4    Fromm, M.5    Schulzke, J.D.6
  • 38
    • 0037200071 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene
    • PMID:12060663
    • Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 2002; 277:31909-17; PMID:12060663; http://dx.doi.org/10.1074/jbc.M204622200
    • (2002) J Biol Chem , vol.277 , pp. 31909-31917
    • Boudreau, F.1    Rings, E.H.2    Van Wering, H.M.3    Kim, R.K.4    Swain, G.P.5    Krasinski, S.D.6    Moffett, J.7    Grand, R.J.8    Suh, E.R.9    Traber, P.G.10
  • 39
    • 84899722895 scopus 로고    scopus 로고
    • Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene
    • PMID:24662742
    • Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L, Ma TY. Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS One 2014; 9:e85345; PMID:24662742; http://dx.doi.org/10.1371/journal.pone.0085345
    • (2014) Plos One , vol.9
    • Al-Sadi, R.1    Ye, D.2    Boivin, M.3    Guo, S.4    Hashimi, M.5    Ereifej, L.6    Ma, T.Y.7
  • 42
    • 77950588683 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    • PMID:20177070
    • Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem 2010; 285:12037-46; PMID:20177070; http://dx.doi.org/10.1074/jbc.M109.064808
    • (2010) J Biol Chem , vol.285 , pp. 12037-12046
    • Weber, C.R.1    Raleigh, D.R.2    Su, L.3    Shen, L.4    Sullivan, E.A.5    Wang, Y.6    Turner, J.R.7
  • 43
    • 34547698923 scopus 로고    scopus 로고
    • Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis
    • PMID:17515853
    • Mazzon E, Cuzzocrea S. Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis. Shock 2007; 28:192-201; PMID:17515853; http://dx.doi.org/10.1097/SHK.0b013e318033eb29
    • (2007) Shock , vol.28 , pp. 192-201
    • Mazzon, E.1    Cuzzocrea, S.2
  • 44
    • 77954644289 scopus 로고    scopus 로고
    • Regulation of claudins by posttranslational modifications and cell-signaling cascades
    • Gonzalez-Mariscal L, Garay E, Quiros M. Regulation of claudins by posttranslational modifications and cell-signaling cascades. Curr Top Membr 65: 113-150, 2010.
    • (2010) Curr Top Membr , vol.65 , pp. 113-150
    • Gonzalez-Mariscal, L.1    Garay, E.2    Quiros, M.3
  • 45
    • 84872188573 scopus 로고    scopus 로고
    • Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes
    • PMID:22825868
    • Van Itallie CM, Tietgens AJ, LoGrande K, Aponte A, Gucek M, Anderson JM. Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes. J Cell Sci 2012; 125:4902-12; PMID:22825868; http://dx.doi.org/10.1242/jcs.111237
    • (2012) J Cell Sci , vol.125 , pp. 4902-4912
    • Van Itallie, C.M.1    Tietgens, A.J.2    Logrande, K.3    Aponte, A.4    Gucek, M.5    Erson, J.M.6
  • 46
    • 84862878910 scopus 로고    scopus 로고
    • SUMOylation of claudin-2
    • PMID:22731716
    • Van Itallie CM, Mitic LL, Anderson JM. SUMOylation of claudin-2. Ann N Y Acad Sci 2012; 1258:60-4; PMID:22731716; http://dx.doi.org/10.1111/j.1749-6632.2012.06541.x
    • (2012) Ann N Y Acad Sci , vol.1258 , pp. 60-64
    • Van Itallie, C.M.1    Mitic, L.L.2    Erson, J.M.3
  • 47
    • 34547921509 scopus 로고    scopus 로고
    • Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2
    • PMID:17516019
    • Angelow S, Schneeberger EE, Yu AS. Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2. J Membr Biol 2007; 215:147-59; PMID:17516019; http://dx.doi.org/10.1007/s00232-007-9014-3
    • (2007) J Membr Biol , vol.215 , pp. 147-159
    • Angelow, S.1    Schneeberger, E.E.2    Yu, A.S.3
  • 48
    • 0037930880 scopus 로고    scopus 로고
    • Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation
    • PMID:12615928
    • Yu AS, Enck AH, Lencer WI, Schneeberger EE. Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem 2003; 278:17350-9; PMID:12615928; http://dx.doi.org/10.1074/jbc.M213286200
    • (2003) J Biol Chem , vol.278 , pp. 17350-17359
    • Yu, A.S.1    Enck, A.H.2    Lencer, W.I.3    Schneeberger, E.E.4
  • 49
    • 84862894334 scopus 로고    scopus 로고
    • Zeitz M. Intestinal mucosal barrier function in HIV infection
    • Epple HJ, Zeitz M. Intestinal mucosal barrier function in HIV infection. Ann. N.Y. Acad. Sci. 2012; 1258:19-24.
    • (2012) Ann. N.Y. Acad. Sci , vol.1258 , pp. 19-24
    • Epple, H.J.1
  • 50
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • PMID:16083712
    • Heller F, Florian P, Bojarski C, Richter J, Christ M, Hillenbrand B, Mankertz J, Gitter AH, Burgel N, Fromm M, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005; 129:550-64; PMID:16083712; http://dx.doi.org/10.1016/j.gastro.2005.05.002
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3    Richter, J.4    Christ, M.5    Hillenbrand, B.6    Mankertz, J.7    Gitter, A.H.8    Burgel, N.9    Fromm, M.10
  • 51
    • 57449095650 scopus 로고    scopus 로고
    • Changes in the expression of claudins in active ulcerative colitis
    • PMID:19120888
    • Oshima T, Miwa H, Joh T. Changes in the expression of claudins in active ulcerative colitis. J Gastroenterol Hepatol 2008; 23 Suppl 2:S146-50; PMID:19120888; http://dx.doi.org/10.1111/j.1440-1746.2008.05405.x
    • J Gastroenterol Hepatol 2008; 23 Suppl , vol.2 , pp. S146-S150
    • Oshima, T.1    Miwa, H.2    Joh, T.3
  • 52
    • 85028094075 scopus 로고    scopus 로고
    • Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease
    • PMID:21865402
    • Schumann M, Gunzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, et al. Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut 2011; 61:220-8; PMID:21865402; http://dx.doi.org/10.1136/gutjnl-2011-300123
    • (2011) Gut , vol.61 , pp. 220-228
    • Schumann, M.1    Gunzel, D.2    Buergel, N.3    Richter, J.F.4    Troeger, H.5    May, C.6    Fromm, A.7    Sorgenfrei, D.8    Daum, S.9    Bojarski, C.10
  • 53
    • 84860340266 scopus 로고    scopus 로고
    • Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: A new perspective
    • PMID:22297703
    • Das P, Goswami P, Das TK, Nag T, Sreenivas V, Ahuja V, Panda SK, Gupta SD, Makharia GK. Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: a new perspective. Virchows Arch 2012; 460:261-70; PMID:22297703; http://dx.doi.org/10.1007/s00428-012-1195-1
    • (2012) Virchows Arch , vol.460 , pp. 261-270
    • Das, P.1    Goswami, P.2    Das, T.K.3    Nag, T.4    Sreenivas, V.5    Ahuja, V.6    Panda, S.K.7    Gupta, S.D.8    Makharia, G.K.9
  • 56
    • 0025216985 scopus 로고
    • The jejunal secretion of histamine is increased in active Crohn’s disease
    • PMID:1690156
    • Knutson L, Ahrenstedt O, Odlind B, Hallgren R. The jejunal secretion of histamine is increased in active Crohn’s disease. Gastroenterology 1990; 98:849-54; PMID:1690156; http://dx.doi.org/10.1016/0016-5085(90)90006-M
    • (1990) Gastroenterology , vol.98 , pp. 849-854
    • Knutson, L.1    Ahrenstedt, O.2    Odlind, B.3    Hallgren, R.4
  • 58
    • 24144477540 scopus 로고    scopus 로고
    • Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    • PMID:16143135
    • Andoh A, Zhang Z, Inatomi O, Fujino S, Deguchi Y, Araki Y, Tsujikawa T, Kitoh K, Kim-Mitsuyama S, Takayanagi A, et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 2005; 129:969-84; PMID:16143135; http://dx.doi.org/10.1053/j.gastro.2005.06.071
    • (2005) Gastroenterology , vol.129 , pp. 969-984
    • Andoh, A.1    Zhang, Z.2    Inatomi, O.3    Fujino, S.4    Deguchi, Y.5    Araki, Y.6    Tsujikawa, T.7    Kitoh, K.8    Kim-Mitsuyama, S.9    Takayanagi, A.10
  • 60
    • 79960772834 scopus 로고    scopus 로고
    • Epithelial barriers in intestinal inflammation
    • PMID:21294654
    • John LJ, Fromm M, Schulzke JD. Epithelial barriers in intestinal inflammation. Antioxid Redox Signal 2011; 15:1255-70; PMID:21294654; http://dx.doi.org/10.1089/ars.2011.3892
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1255-1270
    • John, L.J.1    Fromm, M.2    Schulzke, J.D.3
  • 61
    • 70350648021 scopus 로고    scopus 로고
    • Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines
    • PMID:19658020
    • Amasheh M, Grotjohann I, Amasheh S, Fromm A, Soderholm JD, Zeitz M, Fromm M, Schulzke JD. Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: a novel model for studying the pathomechanisms of inflammatory bowel disease cytokines. Scand J Gastroenterol 2009; 44:1226-35; PMID:19658020; http://dx.doi.org/10.1080/00365520903131973
    • (2009) Scand J Gastroenterol , vol.44 , pp. 1226-1235
    • Amasheh, M.1    Grotjohann, I.2    Amasheh, S.3    Fromm, A.4    Soderholm, J.D.5    Zeitz, M.6    Fromm, M.7    Schulzke, J.D.8
  • 62
    • 30944443377 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    • PMID:16402035
    • Blair SA, Kane SV, Clayburgh DR, Turner JR. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest 2006; 86:191-201; PMID:16402035; http://dx.doi.org/10.1038/labinvest.3700373
    • (2006) Lab Invest , vol.86 , pp. 191-201
    • Blair, S.A.1    Kane, S.V.2    Clayburgh, D.R.3    Turner, J.R.4
  • 63
    • 79955671365 scopus 로고    scopus 로고
    • Cellular and molecular mechanism of interleukin-1beta modulation of Caco-2 intestinal epithelial tight junction barrier
    • PMID:20406328
    • Al-Sadi R, Ye D, Said HM, Ma TY. Cellular and molecular mechanism of interleukin-1beta modulation of Caco-2 intestinal epithelial tight junction barrier. J Cell Mol Med 2011; 15:970-82; PMID:20406328; http://dx.doi.org/10.1111/j.1582-4934.2010.01065.x
    • (2011) J Cell Mol Med , vol.15 , pp. 970-982
    • Al-Sadi, R.1    Ye, D.2    Said, H.M.3    Ma, T.Y.4
  • 64
    • 49549104243 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alphainduced regulation of myosin light chain kinase gene activity
    • PMID:18363837
    • Ye D, Ma TY. Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alphainduced regulation of myosin light chain kinase gene activity. J Cell Mol Med 2008; 12:1331-46; PMID:18363837; http://dx.doi.org/10.1111/j.1582-4934.2008.00302.x
    • (2008) J Cell Mol Med , vol.12 , pp. 1331-1346
    • Ye, D.1    Ma, T.Y.2
  • 65
    • 33745193296 scopus 로고    scopus 로고
    • Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
    • PMID:16638813
    • Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci 2006; 119:2095-106; PMID:16638813; http://dx.doi.org/10.1242/jcs.02915
    • (2006) J Cell Sci , vol.119 , pp. 2095-2106
    • Shen, L.1    Black, E.D.2    Witkowski, E.D.3    Lencer, W.I.4    Guerriero, V.5    Schneeberger, E.E.6    Turner, J.R.7
  • 66
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • PMID:15923402
    • Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. Faseb J 2005; 19:923-33; PMID:15923402; http://dx.doi.org/10.1096/fj.04-3260com
    • (2005) Faseb J , vol.19 , pp. 923-933
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 67
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohn’s disease in a subject with familial risk
    • PMID:11113095
    • Irvine EJ, Marshall JK. Increased intestinal permeability precedes the onset of Crohn’s disease in a subject with familial risk. Gastroenterology 2000; 119:1740-4; PMID:11113095; http://dx.doi.org/10.1053/gast.2000.20231
    • (2000) Gastroenterology , vol.119 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2
  • 68
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohn’s disease
    • PMID:8099141
    • Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H. Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet 1993; 341:1437-9; PMID:8099141; http://dx.doi.org/10.1016/0140-6736(93)90882-H
    • (1993) Lancet , vol.341 , pp. 1437-1439
    • Wyatt, J.1    Vogelsang, H.2    Hubl, W.3    Waldhoer, T.4    Lochs, H.5
  • 70
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohn’s disease: Role of CARD15 3020insC mutation?
    • PMID:16000642
    • Buhner S, Buning C, Genschel J, Kling K, Herrmann D, Dignass A, Kuechler I, Krueger S, Schmidt HH, Lochs H. Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? Gut 2006; 55:342-7; PMID:16000642; http://dx.doi.org/10.1136/gut.2005.065557
    • (2006) Gut , vol.55 , pp. 342-347
    • Buhner, S.1    Buning, C.2    Genschel, J.3    Kling, K.4    Herrmann, D.5    Dignass, A.6    Kuechler, I.7    Krueger, S.8    Schmidt, H.H.9    Lochs, H.10
  • 72
    • 33644849605 scopus 로고    scopus 로고
    • NOD2/CARD15 mediates induction of the antimicrobial peptide human betadefensin-2
    • PMID:16319062
    • Voss E, Wehkamp J, Wehkamp K, Stange EF, Schroder JM, Harder J. NOD2/CARD15 mediates induction of the antimicrobial peptide human betadefensin-2. J Biol Chem 2006; 281:2005-11; PMID:16319062; http://dx.doi.org/10.1074/jbc.M511044200
    • (2006) J Biol Chem , vol.281 , pp. 2005-2011
    • Voss, E.1    Wehkamp, J.2    Wehkamp, K.3    Stange, E.F.4    Schroder, J.M.5    Harder, J.6
  • 73
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal alpha-defensin expression
    • PMID:15479689
    • Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, et al. NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal alpha-defensin expression. Gut 2004; 53:1658-64; PMID:15479689; http://dx.doi.org/10.1136/gut.2003.032805
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3    Schwab, M.4    Schaffeler, E.5    Schlee, M.6    Herrlinger, K.R.7    Stallmach, A.8    Noack, F.9    Fritz, P.10
  • 74
    • 0037379915 scopus 로고    scopus 로고
    • TNFalpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
    • PMID:12671897
    • Rosenstiel P, Fantini M, Brautigam K, Kuhbacher T, Waetzig GH, Seegert D, Schreiber S. TNFalpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 2003; 124:1001-9; PMID:12671897; http://dx.doi.org/10.1053/gast.2003.50157
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Brautigam, K.3    Kuhbacher, T.4    Waetzig, G.H.5    Seegert, D.6    Schreiber, S.7
  • 75
    • 70349320390 scopus 로고    scopus 로고
    • Arcobacter butzleri induces barrier dysfunction in intestinal HT-29/B6 cells
    • PMID:19604116
    • Bucker R, Troeger H, Kleer J, Fromm M, Schulzke JD. Arcobacter butzleri induces barrier dysfunction in intestinal HT-29/B6 cells. J Infect Dis 2009; 200:756-64; PMID:19604116; http://dx.doi.org/10.1086/600868
    • (2009) J Infect Dis , vol.200 , pp. 756-764
    • Bucker, R.1    Troeger, H.2    Kleer, J.3    Fromm, M.4    Schulzke, J.D.5
  • 76
    • 79551611956 scopus 로고    scopus 로고
    • Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers
    • PMID:20956974
    • Hering NA, Richter JF, Krug SM, Gunzel D, Fromm A, Bohn E, Rosenthal R, Bucker R, Fromm M, Troeger H, et al. Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab Invest 2011; 91:310-24; PMID:20956974; http://dx.doi.org/10.1038/labinvest.2010.180
    • (2011) Lab Invest , vol.91 , pp. 310-324
    • Hering, N.A.1    Richter, J.F.2    Krug, S.M.3    Gunzel, D.4    Fromm, A.5    Bohn, E.6    Rosenthal, R.7    Bucker, R.8    Fromm, M.9    Troeger, H.10
  • 78
    • 36849042673 scopus 로고    scopus 로고
    • Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4
    • PMID:17640674
    • Wisner DM, Harris LR 3rd, Green CL, Poritz LS. Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4. J Surg Res 2008; 144:1-7; PMID:17640674; http://dx.doi.org/10.1016/j.jss.2007.03.059
    • (2008) J Surg Res , vol.144 , pp. 1-7
    • Wisner, D.M.1    Harris, L.R.2    Green, C.L.3    Poritz, L.S.4
  • 80
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging
    • PMID:11729111
    • Gitter AH, Wullstein F, Fromm M, Schulzke JD. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 2001; 121:1320-8; PMID:11729111; http://dx.doi.org/10.1053/gast.2001.29694
    • (2001) Gastroenterology , vol.121 , pp. 1320-1328
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 81
    • 0032958705 scopus 로고    scopus 로고
    • Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
    • PMID:9922310
    • Schmitz H, Barmeyer C, Fromm M, Runkel N, Foss HD, Bentzel CJ, Riecken EO, Schulzke JD. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 1999; 116:301-9; PMID:9922310; http://dx.doi.org/10.1016/S0016-5085(99)70126-5
    • (1999) Gastroenterology , vol.116 , pp. 301-309
    • Schmitz, H.1    Barmeyer, C.2    Fromm, M.3    Runkel, N.4    Foss, H.D.5    Bentzel, C.J.6    Riecken, E.O.7    Schulzke, J.D.8
  • 82
  • 83
    • 0033818743 scopus 로고    scopus 로고
    • Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis
    • PMID:10973924
    • Gitter AH, Bendfeldt K, Schulzke JD, Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. Faseb J 2000; 14:1749-53; PMID:10973924; http://dx.doi.org/10.1096/fj.99-0898com
    • (2000) Faseb J , vol.14 , pp. 1749-1753
    • Gitter, A.H.1    Bendfeldt, K.2    Schulzke, J.D.3    Fromm, M.4
  • 84
    • 47949083278 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease
    • PMID:18338782
    • Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, et al. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis 2008; 14:908-20; PMID:18338782; http://dx.doi.org/10.1002/ibd.20413
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 908-920
    • Ahn, S.H.1    Shah, Y.M.2    Inoue, J.3    Morimura, K.4    Kim, I.5    Yim, S.6    Lambert, G.7    Kurotani, R.8    Nagashima, K.9    Gonzalez, F.J.10
  • 85
    • 71949092030 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium
    • PMID:19805521
    • Cattin AL, Le Beyec J, Barreau F, Saint-Just S, Houllier A, Gonzalez FJ, Robine S, Pincon-Raymond M, Cardot P, Lacasa M, et al. Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium. Mol Cell Biol 2009; 29:6294-308; PMID:19805521; http://dx.doi.org/10.1128/MCB.00939-09
    • (2009) Mol Cell Biol , vol.29 , pp. 6294-6308
    • Cattin, A.L.1    Le Beyec, J.2    Barreau, F.3    Saint-Just, S.4    Houllier, A.5    Gonzalez, F.J.6    Robine, S.7    Pincon-Raymond, M.8    Cardot, P.9    Lacasa, M.10
  • 86
    • 67249096227 scopus 로고    scopus 로고
    • Tight junctions, intestinal permeability, and autoimmunity: Celiac disease and type 1 diabetes paradigms
    • PMID:19538307
    • Visser J, Rozing J, Sapone A, Lammers K, Fasano A. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci 2009; 1165:195-205; PMID:19538307; http://dx.doi.org/10.1111/j.1749-6632.2009.04037.x
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 195-205
    • Visser, J.1    Rozing, J.2    Sapone, A.3    Lammers, K.4    Fasano, A.5
  • 87
    • 0042324662 scopus 로고    scopus 로고
    • Alterations of the intestinal transport and processing of gliadin peptides in celiac disease
    • PMID:12949716
    • Matysiak-Budnik T, Candalh C, Dugave C, Namane A, Cellier C, Cerf-Bensussan N, Heyman M. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 2003; 125:696-707; PMID:12949716; http://dx.doi.org/10.1016/S0016-5085(03)01049-7
    • (2003) Gastroenterology , vol.125 , pp. 696-707
    • Matysiak-Budnik, T.1    Candalh, C.2    Dugave, C.3    Namane, A.4    Cellier, C.5    Cerf-Bensussan, N.6    Heyman, M.7
  • 89
    • 33645537265 scopus 로고    scopus 로고
    • Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease
    • PMID:16627260
    • Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR. Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease. Am J Clin Pathol 2006; 125:502-11; PMID:16627260; http://dx.doi.org/10.1309/DTYRA91G8R0KTM8M
    • (2006) Am J Clin Pathol , vol.125 , pp. 502-511
    • Ciccocioppo, R.1    Finamore, A.2    Ara, C.3    Di Sabatino, A.4    Mengheri, E.5    Corazza, G.R.6
  • 91
    • 77949720519 scopus 로고    scopus 로고
    • Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease
    • PMID:20143085
    • Szakal DN, Gyorffy H, Arato A, Cseh A, Molnar K, Papp M, Dezsofi A, Veres G. Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch 2010; 456:245-50; PMID:20143085; http://dx.doi.org/10.1007/s00428-009-0879-7
    • (2010) Virchows Arch , vol.456 , pp. 245-250
    • Szakal, D.N.1    Gyorffy, H.2    Arato, A.3    Cseh, A.4    Molnar, K.5    Papp, M.6    Dezsofi, A.7    Veres, G.8
  • 92
    • 0027409890 scopus 로고
    • Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease
    • PMID:8472983
    • van Elburg RM, Uil JJ, Mulder CJ, Heymans HS. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 1993; 34:354-7; PMID:8472983; http://dx.doi.org/10.1136/gut.34.3.354
    • (1993) Gut , vol.34 , pp. 354-357
    • Van Elburg, R.M.1    Uil, J.J.2    Mulder, C.J.3    Heymans, H.S.4
  • 94
    • 0023135087 scopus 로고
    • Tight junctions of jejunal surface and crypt cells in celiac disease: A freeze-fracture study
    • PMID:3794934
    • Kohl D, Ashkenazi A, Ben-Shaul Y, Bacher A. Tight junctions of jejunal surface and crypt cells in celiac disease: a freeze-fracture study. J Pediatr Gastroenterol Nutr 1987; 6:57-65; PMID:3794934
    • (1987) J Pediatr Gastroenterol Nutr , vol.6 , pp. 57-65
    • Kohl, D.1    Ashkenazi, A.2    Ben-Shaul, Y.3    Bacher, A.4
  • 95
    • 0031944553 scopus 로고    scopus 로고
    • Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue
    • PMID:9544995
    • Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998; 43:435-41; PMID:9544995; http://dx.doi.org/10.1203/00006450-199804000-00001
    • (1998) Pediatr Res , vol.43 , pp. 435-441
    • Schulzke, J.D.1    Bentzel, C.J.2    Schulzke, I.3    Riecken, E.O.4    Fromm, M.5
  • 96
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • PMID:16055505
    • Utech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, Parkos CA, Nusrat A. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 2005; 16:5040-52; PMID:16055505; http://dx.doi.org/10.1091/mbc.E05-03-0193
    • (2005) Mol Biol Cell , vol.16 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6    Parkos, C.A.7    Nusrat, A.8
  • 100
    • 58949102533 scopus 로고    scopus 로고
    • Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients
    • PMID:18936106
    • Epple HJ, Schneider T, Troeger H, Kunkel D, Allers K, Moos V, Amasheh M, Loddenkemper C, Fromm M, Zeitz M, et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 2009; 58:220-7; PMID:18936106; http://dx.doi.org/10.1136/gut.2008.150425
    • (2009) Gut , vol.58 , pp. 220-227
    • Epple, H.J.1    Schneider, T.2    Troeger, H.3    Kunkel, D.4    Allers, K.5    Moos, V.6    Amasheh, M.7    Loddenkemper, C.8    Fromm, M.9    Zeitz, M.10
  • 101
  • 102
    • 37349078686 scopus 로고    scopus 로고
    • Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration
    • PMID:17959677
    • Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, Dandekar S. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J Virol 2008; 82:538-45; PMID:17959677; http://dx.doi.org/10.1128/JVI.01449-07
    • (2008) J Virol , vol.82 , pp. 538-545
    • Sankaran, S.1    George, M.D.2    Reay, E.3    Guadalupe, M.4    Flamm, J.5    Prindiville, T.6    Dandekar, S.7
  • 103
    • 6844258844 scopus 로고    scopus 로고
    • HIV-1 p24 but not proviral load is increased in the intestinal mucosa compared with the peripheral blood in HIV-infected patients
    • PMID:9468362
    • Fackler OT, Schafer M, Schmidt W, Zippel T, Heise W, Schneider T, Zeitz M, Riecken EO, Mueller-Lantzsch N, Ullrich R. HIV-1 p24 but not proviral load is increased in the intestinal mucosa compared with the peripheral blood in HIV-infected patients. Aids 1998; 12:139-46; PMID:9468362; http://dx.doi.org/10.1097/00002030-199802000-00003
    • (1998) Aids , vol.12 , pp. 139-146
    • Fackler, O.T.1    Schafer, M.2    Schmidt, W.3    Zippel, T.4    Heise, W.5    Schneider, T.6    Zeitz, M.7    Riecken, E.O.8    Mueller-Lantzsch, N.9    Ullrich, R.10
  • 104
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4C T cells in multiple tissues during acute SIV infection
    • PMID:15793563
    • Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4C T cells in multiple tissues during acute SIV infection. Nature 2005; 434:1093-7; PMID:15793563; http://dx.doi.org/10.1038/nature03501
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 105
    • 84455192447 scopus 로고    scopus 로고
    • The HIV-1 transactivator factor (Tat) induces enterocyte apoptosis through a redoxmediated mechanism
    • PMID:22216281
    • Buccigrossi V, Laudiero G, Nicastro E, Miele E, Esposito F, Guarino A. The HIV-1 transactivator factor (Tat) induces enterocyte apoptosis through a redoxmediated mechanism. PLoS One 2011; 6:e29436; PMID:22216281; http://dx.doi.org/10.1371/journal. pone.0029436
    • (2011) Plos One , vol.6
    • Buccigrossi, V.1    Laudiero, G.2    Nicastro, E.3    Miele, E.4    Esposito, F.5    Guarino, A.6
  • 106
    • 0035156681 scopus 로고    scopus 로고
    • Gp120-induced Bob/GPR15 activation: A possible cause of human immunodeficiency virus enteropathy
    • PMID:11696454
    • Clayton F, Kotler DP, Kuwada SK, Morgan T, Stepan C, Kuang J, Le J, Fantini J. Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy. Am J Pathol 2001; 159:1933-9; PMID:11696454; http://dx.doi.org/10.1016/S0002-9440(10)63040-4
    • (2001) Am J Pathol , vol.159 , pp. 1933-1939
    • Clayton, F.1    Kotler, D.P.2    Kuwada, S.K.3    Morgan, T.4    Stepan, C.5    Kuang, J.6    Le, J.7    Fantini, J.8
  • 108
    • 2942737129 scopus 로고    scopus 로고
    • Abundant expression of granzyme A, but not perforin, in granules of CD8C T cells in GALT: Implications for immune control of HIV-1 infection
    • PMID:15210827
    • Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF. Abundant expression of granzyme A, but not perforin, in granules of CD8C T cells in GALT: implications for immune control of HIV-1 infection. J Immunol 2004; 173:641-8; PMID:15210827; http://dx.doi.org/10.4049/jimmunol.173.1.641
    • (2004) J Immunol , vol.173 , pp. 641-648
    • Shacklett, B.L.1    Cox, C.A.2    Quigley, M.F.3    Kreis, C.4    Stollman, N.H.5    Jacobson, M.A.6    Ersson, J.7    Sandberg, J.K.8    Nixon, D.F.9
  • 110
    • 84878667737 scopus 로고    scopus 로고
    • Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNFalpha on tight junction proteins and signaling pathways in intestinal epithelial cells
    • PMID:23538493
    • Fischer A, Gluth M, Pape UF, Wiedenmann B, Theuring F, Baumgart DC. Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNFalpha on tight junction proteins and signaling pathways in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2013; 304:G970-9; PMID:23538493; http://dx.doi.org/10.1152/ajpgi.00183.2012
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304 , pp. G970-G979
    • Fischer, A.1    Gluth, M.2    Pape, U.F.3    Wiedenmann, B.4    Theuring, F.5    Baumgart, D.C.6
  • 112
    • 30644463203 scopus 로고    scopus 로고
    • Microarray analysis of butyrate regulated genes in colonic epithelial cells
    • PMID:16405400
    • Daly K, Shirazi-Beechey SP. Microarray analysis of butyrate regulated genes in colonic epithelial cells. DNA Cell Biol 2006; 25:49-62; PMID:16405400; http://dx.doi.org/10.1089/dna.2006.25.49
    • (2006) DNA Cell Biol , vol.25 , pp. 49-62
    • Daly, K.1    Shirazi-Beechey, S.P.2
  • 114
    • 78650261067 scopus 로고    scopus 로고
    • Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides
    • PMID:20932871
    • Zhang Q, Piao XL, Piao XS, Lu T, Wang D, Kim SW. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. Food Chem Toxicol 2011; 49:61-9; PMID:20932871; http://dx.doi.org/10.1016/j.fct.2010.09.032
    • (2011) Food Chem Toxicol , vol.49 , pp. 61-69
    • Zhang, Q.1    Piao, X.L.2    Piao, X.S.3    Lu, T.4    Wang, D.5    Kim, S.W.6
  • 115
    • 76749157865 scopus 로고    scopus 로고
    • Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients
    • PMID:20095884
    • Wang N, Yu H, Ma J, Wu W, Zhao D, Shi X, Tian H, Jiang H. Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients. Scand J Gastroenterol 2010; 45:191-9; PMID:20095884; http://dx.doi.org/10.3109/00365520903406701
    • (2010) Scand J Gastroenterol , vol.45 , pp. 191-199
    • Wang, N.1    Yu, H.2    Ma, J.3    Wu, W.4    Zhao, D.5    Shi, X.6    Tian, H.7    Jiang, H.8


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