TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

Journal of Cell Science

Volumn 123, Issue 23, 2010, Pages 4145-4155

  Amasheh, Maren ^a   Fromm, Anja ^a   Krug, Susanne M ^a   Amasheh, Salah ^a   Andres, Susanne ^a   Zeitz, Martin ^a   Fromm, Michael ^a   Schulzke, Jörg Dieter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Barrier function; Claudins; Occludin; Plant alkaloid; Tight junction; TNF ; Two path impedance spectroscopy

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BERBERINE; CLAUDIN 1; CLAUDIN 2; CLAUDIN 3; CLAUDIN 4; CLAUDIN 5; CLAUDIN 7; FLUORESCEIN; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA; NF KAPPA B KINASE; NF-KAPPA B KINASE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IMMUNOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPECTROSCOPY; TIGHT JUNCTION; UPREGULATION; ANIMAL; COLON; ENZYMOLOGY; GENETICS; IN VITRO STUDY; METABOLISM; TUMOR CELL LINE; WISTAR RAT;

RATTUS;

ANIMALS; BERBERINE; CELL LINE, TUMOR; COLON; HUMANS; MALE; ONCOGENE PROTEIN V-AKT; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78649730159     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.070896     Document Type: Article

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