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1
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0036773738
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Claudin-based barrier in simple and stratified cellular sheets
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This paper reviews significant developments in TJs over the 12-month period ending August 2002, including the fascinating new insight that stratified epithelia of the skin express the same TJ proteins found in simple epithelia. Prior to this most references denied the existence of TJ-like contacts in stratified epithelia.
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Tsukita S., Furuse M. Claudin-based barrier in simple and stratified cellular sheets. Curr Opin Cell Biol. 14:2002;531-536 This paper reviews significant developments in TJs over the 12-month period ending August 2002, including the fascinating new insight that stratified epithelia of the skin express the same TJ proteins found in simple epithelia. Prior to this most references denied the existence of TJ-like contacts in stratified epithelia.
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Curr Opin Cell Biol
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Tsukita, S.1
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0035991935
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Molecular complexity of vertebrate tight junctions
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D'Atri F., Citi S. Molecular complexity of vertebrate tight junctions. Mol Membr Biol. 19:2002;103-112
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Mol Membr Biol
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D'Atri, F.1
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0041330621
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Claudins and epithelial paracellular transport: The end of the beginning
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Yu A.S. Claudins and epithelial paracellular transport: the end of the beginning. Curr Opin Nephrol Hypertens. 12:2003;503-509
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Curr Opin Nephrol Hypertens
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Yu, A.S.1
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Epithelial cell adhesion and the regulation of gene expression
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Balda M.S., Matter K. Epithelial cell adhesion and the regulation of gene expression. Trends Cell Biol. 13:2003;310-318
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Trends Cell Biol
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Balda, M.S.1
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5
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0037711781
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Claudin complexities at the apical junctional complex
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This is an outstanding and thought-provoking update on the use of claudins to form barriers across animal phyla.
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Tepass U. Claudin complexities at the apical junctional complex. Nat Cell Biol. 5:2003;595-597 This is an outstanding and thought-provoking update on the use of claudins to form barriers across animal phyla.
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Nat Cell Biol
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Tepass, U.1
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6
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0036085515
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Claudins create charge-selective channels in the paracellular pathway between epithelial cells
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This paper provides the first evidence that charged residues on claudins directly influence the paracellular permeability of ions. By mutating negatively charged residues on the extracellular loops of claudin-15 so they become positively charged, they reverse the relative permeability ratio from one favoring cations to anions. This supports a model in which claudins form the charge-selective pores.
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Colegio O.R., Van Itallie C.M., Mccrea H.J., Rahner C., Anderson J.M. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol. 283:2002;C142-C147 This paper provides the first evidence that charged residues on claudins directly influence the paracellular permeability of ions. By mutating negatively charged residues on the extracellular loops of claudin-15 so they become positively charged, they reverse the relative permeability ratio from one favoring cations to anions. This supports a model in which claudins form the charge-selective pores.
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(2002)
Am J Physiol Cell Physiol
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, pp. 142-C147
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Colegio, O.R.1
Van Itallie, C.M.2
McCrea, H.J.3
Rahner, C.4
Anderson, J.M.5
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7
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1542778870
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Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells
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Jeansonne B., Lu Q., Goodenough D.A., Chen Y.H. Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Cell Mol Biol (Noisy-le-grand). 49:2003;13-21
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Cell Mol Biol (Noisy-le-grand)
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Jeansonne, B.1
Lu, Q.2
Goodenough, D.A.3
Chen, Y.H.4
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8
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0037930880
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Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation
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This elegant and detailed study combines cell biology, physiology and ultrastructure to characterize the pore properties of claudin-8 expressed in MDCK cells. It can serve as an excellent primer on how to experimentally define the paracellular pathway in cultured cell models.
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Yu A.S., Enck A.H., Lencer W.I., Schneeberger E.E. Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem. 278:2003;17350-17359 This elegant and detailed study combines cell biology, physiology and ultrastructure to characterize the pore properties of claudin-8 expressed in MDCK cells. It can serve as an excellent primer on how to experimentally define the paracellular pathway in cultured cell models.
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J Biol Chem
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Yu, A.S.1
Enck, A.H.2
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Channels in epithelial cell membranes and junctions
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Diamond J.M. Channels in epithelial cell membranes and junctions. Fed Proc. 37:1978;2639-2644
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Diamond, J.M.1
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10
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0037648580
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Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
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This paper provides the first in vivo evidence that claudins create pores with different dimensions. Incrementally larger molecules are allowed to pass the TJ blood-brain barrier in claudin-5 KO mice than in wild type mice.
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Nitta T., Hata M., Gotoh S., Seo Y., Sasaki H., Hashimoto N., Furuse M., Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 161:2003;653-660 This paper provides the first in vivo evidence that claudins create pores with different dimensions. Incrementally larger molecules are allowed to pass the TJ blood-brain barrier in claudin-5 KO mice than in wild type mice.
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J Cell Biol
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Nitta, T.1
Hata, M.2
Gotoh, S.3
Seo, Y.4
Sasaki, H.5
Hashimoto, N.6
Furuse, M.7
Tsukita, S.8
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11
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0037389578
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Dynamic behavior of paired claudin strands within apposing plasma membranes
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Sasaki H., Matsui C., Furuse K., Mimori-Kiyosue Y., Furuse M., Tsukita S. Dynamic behavior of paired claudin strands within apposing plasma membranes. Proc Natl Acad Sci U S A. 100:2003;3971-3976
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Proc Natl Acad Sci U S a
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Sasaki, H.1
Matsui, C.2
Furuse, K.3
Mimori-Kiyosue, Y.4
Furuse, M.5
Tsukita, S.6
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12
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0035984637
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Adherens junctions: New insight into assembly, modulation and function
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Tepass U. Adherens junctions: new insight into assembly, modulation and function. Bioessays. 24:2002;690-695
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Bioessays
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Tepass, U.1
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13
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0035674837
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Epithelial cell polarity and cell junctions in Drosophila
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Tepass U., Tanentzapf G., Ward R., Fehon R. Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet. 35:2001;747-784
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Annu Rev Genet
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Tepass, U.1
Tanentzapf, G.2
Ward, R.3
Fehon, R.4
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14
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0020168848
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Stages in the assembly of pleated and smooth septate junctions in developing insect embryos
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Lane N.J., Swales L.S. Stages in the assembly of pleated and smooth septate junctions in developing insect embryos. J Cell Sci. 56:1982;245-262
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Lane, N.J.1
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1642458089
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Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control
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in press.
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Wu VM, Schulte J, Hirschi A, Tepass U, Beitel GJ: Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. J Cell Biol 2004, in press.
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J Cell Biol
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Wu, V.M.1
Schulte, J.2
Hirschi, A.3
Tepass, U.4
Beitel, G.J.5
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16
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0141920729
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The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila
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These two elegant studies represent the first demonstrations of the importance of claudin-like proteins to the normal organization and paracellular barrier function of Drosophila septate junctions.
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Behr M., Riedel D., Schuh R. The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Dev Cell. 5:2003;611-620 These two elegant studies represent the first demonstrations of the importance of claudin-like proteins to the normal organization and paracellular barrier function of Drosophila septate junctions.
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Dev Cell
, vol.5
, pp. 611-620
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Behr, M.1
Riedel, D.2
Schuh, R.3
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17
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0037032804
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Composition and formation of intercellular junctions in epithelial cells
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Knust E., Bossinger O. Composition and formation of intercellular junctions in epithelial cells. Science. 298:2002;1955-1959
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Science
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Knust, E.1
Bossinger, O.2
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18
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0038679606
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Claudins in Caenorhabditis elegans: Their distribution and barrier function in the epithelium
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This paper identifies four claudins in C. elegans, and partially characterizes two of them by immunofluorescent analysis and permeability studies.
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Asano A., Asano K., Sasaki H., Furuse M., Tsukita S. Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium. Curr Biol. 13:2003;1042-1046 This paper identifies four claudins in C. elegans, and partially characterizes two of them by immunofluorescent analysis and permeability studies.
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Curr Biol
, vol.13
, pp. 1042-1046
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Asano, A.1
Asano, K.2
Sasaki, H.3
Furuse, M.4
Tsukita, S.5
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19
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0038109935
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The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans
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This careful study documents distribution and function of VAB-9, a claudin-like tetraspan protein. The authors use a variety of techniques to demonstrate that VAB-9 may be important in linkage to the cytoskeleton and in cell adhesion.
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Simske J.S., Koppen M., Sims P., Hodgkin J., Yonkof A., Hardin J. The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Nat Cell Biol. 5:2003;619-625 This careful study documents distribution and function of VAB-9, a claudin-like tetraspan protein. The authors use a variety of techniques to demonstrate that VAB-9 may be important in linkage to the cytoskeleton and in cell adhesion.
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(2003)
Nat Cell Biol
, vol.5
, pp. 619-625
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Simske, J.S.1
Koppen, M.2
Sims, P.3
Hodgkin, J.4
Yonkof, A.5
Hardin, J.6
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20
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0038586530
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NZO-3 expression causes global changes to actin cytoskeleton in Madin-Darby canine kidney cells: Linking a tight junction protein to Rho GTPases
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This paper is one of the first to suggest that TJ proteins might not merely provide a static anchor to the cortical cytoskeleton, but may also direct the assembly and/or reorganization of this structure.
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Wittchen E.S., Haskins J., Stevenson B.R. NZO-3 expression causes global changes to actin cytoskeleton in Madin-Darby canine kidney cells: linking a tight junction protein to Rho GTPases. Mol Biol Cell. 14:2003;1757-1768 This paper is one of the first to suggest that TJ proteins might not merely provide a static anchor to the cortical cytoskeleton, but may also direct the assembly and/or reorganization of this structure.
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(2003)
Mol Biol Cell
, vol.14
, pp. 1757-1768
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Wittchen, E.S.1
Haskins, J.2
Stevenson, B.R.3
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21
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12444336848
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The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: A possible role for JAMs in endothelial cell polarity
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Ebnet K., Aurrand-Lions M., Kuhn A., Kiefer F., Butz S., Zander K., Meyer zu Brickwedde M.K., Suzuki A., Imhof B.A., Vestweber D. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci. 116:2003;3879-3891
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J Cell Sci
, vol.116
, pp. 3879-3891
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Ebnet, K.1
Aurrand-Lions, M.2
Kuhn, A.3
Kiefer, F.4
Butz, S.5
Zander, K.6
Meyer Zu Brickwedde, M.K.7
Suzuki, A.8
Imhof, B.A.9
Vestweber, D.10
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22
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0042466237
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Composition and function of PDZ protein complexes during cell polarization
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Roh M.H., Margolis B. Composition and function of PDZ protein complexes during cell polarization. Am J Physiol Renal Physiol. 285:2003;F377-F387
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Roh, M.H.1
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Adaptation of core mechanisms to generate cell polarity
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Nelson W.J. Adaptation of core mechanisms to generate cell polarity. Nature. 422:2003;766-774
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Nature
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, pp. 766-774
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Nelson, W.J.1
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24
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0041669430
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The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells
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This report established that the Crb-3/Pals1/PAT-J polarity complex, like the PAR proteins, can also regulate the assembly of TJs.
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Roh M.H., Fan S., Liu C.J., Margolis B. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci. 116:2003;2895-2906 This report established that the Crb-3/Pals1/PAT-J polarity complex, like the PAR proteins, can also regulate the assembly of TJs.
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J Cell Sci
, vol.116
, pp. 2895-2906
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Roh, M.H.1
Fan, S.2
Liu, C.J.3
Margolis, B.4
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25
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0037319350
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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
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The authors demonstrate that the Crb-3/Pals1/PAT-J and PAR proteins, which have overlapping functional roles, interact via direct binding between Pals1-PAR6, and that this interaction is required for formation of TJs.
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Hurd T.W., Gao L., Roh M.H., Macara I.G., Margolis B. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol. 5:2003;137-142 The authors demonstrate that the Crb-3/Pals1/PAT-J and PAR proteins, which have overlapping functional roles, interact via direct binding between Pals1-PAR6, and that this interaction is required for formation of TJs.
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Nat Cell Biol
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, pp. 137-142
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Hurd, T.W.1
Gao, L.2
Roh, M.H.3
MacAra, I.G.4
Margolis, B.5
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26
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0037067320
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HINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells
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Lemmers C., Medina E., Delgrossi M.H., Michel D., Arsanto J.P., Le Bivic A. hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J Biol Chem. 277:2002;25408-25415
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Lemmers, C.1
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Delgrossi, M.H.3
Michel, D.4
Arsanto, J.P.5
Le Bivic, A.6
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27
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0037096161
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Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation
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Hirose T., Izumi Y., Nagashima Y., Tamai-Nagai Y., Kurihara H., Sakai T., Suzuki Y., Yamanaka T., Suzuki A., Mizuno K., Ohno S. Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Sci. 115:2002;2485-2495
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Hirose, T.1
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Nagashima, Y.3
Tamai-Nagai, Y.4
Kurihara, H.5
Sakai, T.6
Suzuki, Y.7
Yamanaka, T.8
Suzuki, A.9
Mizuno, K.10
Ohno, S.11
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28
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0037022122
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Assembly of epithelial tight junctions is negatively regulated by Par6
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These investigators found that the PAR3/PAR6/aPKC complex, although required for formation of mature circumferential TJs, does not seem to be required for AJ formation.
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Gao L., Joberty G., Macara I.G. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol. 12:2002;221-225 These investigators found that the PAR3/PAR6/aPKC complex, although required for formation of mature circumferential TJs, does not seem to be required for AJ formation.
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Curr Biol
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, pp. 221-225
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Gao, L.1
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MacAra, I.G.3
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29
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0037178864
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The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions
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Roh M.H., Liu C.J., Laurinec S., Margolis B. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J Biol Chem. 277:2002;27501-27509
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Roh, M.H.1
Liu, C.J.2
Laurinec, S.3
Margolis, B.4
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30
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0035898658
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The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)
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Ebnet K., Suzuki A., Horikoshi Y., Hirose T., Meyer zu Brickwedde M.K., Ohno S., Vestweber D. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J. 20:2001;3738-3748
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, pp. 3738-3748
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Ebnet, K.1
Suzuki, A.2
Horikoshi, Y.3
Hirose, T.4
Meyer Zu Brickwedde, M.K.5
Ohno, S.6
Vestweber, D.7
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31
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0037106581
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APKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization
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Suzuki A., Ishiyama C., Hashiba K., Shimizu M., Ebnet K., Ohno S. aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci. 115:2002;3565-3573
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, pp. 3565-3573
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Suzuki, A.1
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32
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0036832157
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Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1
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Fanning A.S., Ma T.Y., Anderson J.M. Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1. FASEB J. 16:2002;1835-1837
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Fanning, A.S.1
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33
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0037416129
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Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability
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Benais-Pont G., Punn A., Flores-Maldonado C., Eckert J., Raposo G., Fleming T.P., Cereijido M., Balda M.S., Matter K. Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. J Cell Biol. 160:2003;729-740
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J Cell Biol
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Benais-Pont, G.1
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Flores-Maldonado, C.3
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Fleming, T.P.6
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Balda, M.S.8
Matter, K.9
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34
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The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
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Balda M.S., Garrett M.D., Matter K. The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol. 160:2003;423-432
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Balda, M.S.1
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Cadherins, catenins and APC protein: Interplay between cytoskeletal complexes and signaling pathways
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Barth, A.I.1
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36
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Regulation of tight junctions during the epithelium-mesenchyme transition: Direct repression of the gene expression of claudins/occludin by Snail
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Ikenouchi J., Matsuda M., Furuse M., Tsukita S. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci. 116:2003;1959-1967
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Ikenouchi, J.1
Matsuda, M.2
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37
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0037129361
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Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells
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Al Moustafa A.E., Alaoui-Jamali M.A., Batist G., Hernandez-Perez M., Serruya C., Alpert L., Black M.J., Sladek R., Foulkes W.D. Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells. Oncogene. 21:2002;2634-2640
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Oncogene
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Al Moustafa, A.E.1
Alaoui-Jamali, M.A.2
Batist, G.3
Hernandez-Perez, M.4
Serruya, C.5
Alpert, L.6
Black, M.J.7
Sladek, R.8
Foulkes, W.D.9
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38
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12444330869
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Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas
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Rangel L.B., Agarwal R., D'Souza T., Pizer E.S., Alo P.L., Lancaster W.D., Gregoire L., Schwartz D.R., Cho K.R., Morin P.J. Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res. 9:2003;2567-2575
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Clin Cancer Res
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, pp. 2567-2575
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Rangel, L.B.1
Agarwal, R.2
D'Souza, T.3
Pizer, E.S.4
Alo, P.L.5
Lancaster, W.D.6
Gregoire, L.7
Schwartz, D.R.8
Cho, K.R.9
Morin, P.J.10
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39
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0141885097
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Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer
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These findings identify claudin-4 as a potent inhibitor of the invasiveness and metastatic phenotype of pancreatic cancer cells. Restoring claudin-4 to an invasive pancreatic cell line reduces metastasis when injected into nude mice and reverses the transformed phenotype in in vitro assays. The mechanism is not clear but raises the suspicion that claudins are not only barrier proteins but also serve in cell differentiation.
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Michl P., Barth C., Buchholz M., Lerch M.M., Rolke M., Holzmann K.H., Menke A., Fensterer H., Giehl K., Lohr M., et al. Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res. 63:2003;6265-6271 These findings identify claudin-4 as a potent inhibitor of the invasiveness and metastatic phenotype of pancreatic cancer cells. Restoring claudin-4 to an invasive pancreatic cell line reduces metastasis when injected into nude mice and reverses the transformed phenotype in in vitro assays. The mechanism is not clear but raises the suspicion that claudins are not only barrier proteins but also serve in cell differentiation.
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(2003)
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