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Volumn 44, Issue 10, 2009, Pages 1226-1235

Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines

Author keywords

Barrier function; Claudins; Colon; Crypts; Cytokines; Interferon ; Large intestine; Mucosal structure; Occludin; Permeability; Tight junctions; Transepithelial resistance; Tumor necrosis factor

Indexed keywords

CLAUDIN 1; CLAUDIN 2; CLAUDIN 5; CLAUDIN 7; GAMMA INTERFERON; HORSERADISH PEROXIDASE; MANNITOL; OCCLUDIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 70350648021     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520903131973     Document Type: Article
Times cited : (106)

References (58)
  • 1
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998;/141:/1539-50.
    • (1998) J Cell Biol , vol.141 , pp. 1539-50
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 5
    • 0000418018 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6
    • Schmitz H, Fromm M, Bentzel CJ, Scholz P, Detjen K, Mankertz J, et al. Tumor necrosis factor-alpha (TNF-alpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 1999;/112:/137-6.
    • (1999) J Cell Sci , vol.112 , pp. 137-6
    • Schmitz, H.1    Fromm, M.2    Bentzel, C.J.3    Scholz, P.4    Detjen, K.5    Mankertz, J.6
  • 7
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factoralpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR. Interferon-gamma and tumor necrosis factoralpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 2005;/166:/409-9.
    • (2005) Am J Pathol , vol.166 , pp. 409-9
    • Wang, F.1    Graham, W.V.2    Wang, Y.3    Witkowski, E.D.4    Schwarz, B.T.5    Turner, J.R.6
  • 9
    • 0031937067 scopus 로고    scopus 로고
    • Small bowel enteropathy: Role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal
    • Guy-Grand D, DiSanto JP, Henchoz P, Malassis-Séris M, Vassalli P. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal. Eur J Immunol 1998;/8:/730-4.
    • (1998) Eur J Immunol , vol.8 , pp. 730-4
    • Guy-Grand, D.1    Disanto, J.P.2    Henchoz, P.3    Malassis-Séris, M.4    Vassalli, P.5
  • 10
    • 0033818743 scopus 로고    scopus 로고
    • Leaks in the epithelial barrier caused by spontaneous and TNFalpha- induced single-cell apoptosis
    • Gitter AH, Bendfeldt K, Schulzke JD, Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNFalpha- induced single-cell apoptosis. Faseb J 2000;/4:/1749-3.
    • (2000) Faseb J , vol.4 , pp. 1749-3
    • Gitter, A.H.1    Bendfeldt, K.2    Schulzke, J.D.3    Fromm, M.4
  • 11
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma
    • Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, et al. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 2000;/13:/2085-90.
    • (2000) J Cell Sci , vol.13 , pp. 2085-90
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3    Mankertz, A.4    Riecken, E.O.5    Fromm, M.6
  • 12
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
    • Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 2003;/71:/6164-2.
    • (2003) J Immunol , vol.71 , pp. 6164-2
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3    Parkos, C.A.4    Madara, J.L.5    Hopkins, A.M.6
  • 13
    • 27744551342 scopus 로고    scopus 로고
    • Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    • Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, et al. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest 2005;/85:/1139-62.
    • (2005) Lab Invest , vol.85 , pp. 1139-62
    • Prasad, S.1    Mingrino, R.2    Kaukinen, K.3    Hayes, K.L.4    Powell, R.M.5    MacDonald, T.T.6
  • 14
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • Utech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, et al. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 2005;/16:/5040-52.
    • (2005) Mol Biol Cell , vol.16 , pp. 5040-52
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6
  • 15
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma TY, Boivin MA, Ye D, Pedram A, Said HM. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 2005;/288:/G422-30.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3    Pedram, A.4    Said, H.M.5
  • 16
    • 33644981348 scopus 로고    scopus 로고
    • Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
    • Ye D, Ma I, Ma TY.Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 2006;/290:/ G496-504.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Ye, D.1    Ma, I.2    Ma, T.Y.3
  • 17
    • 33749466490 scopus 로고    scopus 로고
    • IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
    • Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, et al. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 2006;/131:/1153-63.
    • (2006) Gastroenterology , vol.131 , pp. 1153-63
    • Wang, F.1    Schwarz, B.T.2    Graham, W.V.3    Wang, Y.4    Su, L.5    Clayburgh, D.R.6
  • 18
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging
    • Gitter AH, Wullstein F, Fromm M, Schulzke JD. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 2001;/121:/1320-8.
    • (2001) Gastroenterology , vol.121 , pp. 1320-8
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 20
    • 4344700784 scopus 로고    scopus 로고
    • Down-regulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment
    • Zeissig S, Bojarski C, Buergel N, Mankertz J, Zeitz M, Fromm M. Down-regulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 2004;/53:/1295-302.
    • (2004) Gut , vol.53 , pp. 1295-302
    • Zeissig, S.1    Bojarski, C.2    Buergel, N.3    Mankertz, J.4    Zeitz, M.5    Fromm, M.6
  • 21
    • 0025898866 scopus 로고
    • Immune-related intestinal chloride secretion. III. Acute and chronic effects of mast cell mediators on chloride secretion by a human colonic epithelial cell line
    • Barrett KE. Immune-related intestinal chloride secretion. III. Acute and chronic effects of mast cell mediators on chloride secretion by a human colonic epithelial cell line. J Immunol 1991;/147:/959-64.
    • (1991) J Immunol , vol.147 , pp. 959-64
    • Barrett, K.E.1
  • 22
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F, Florian P, Bojarski C, Richter J, Christ M, Hillenbrand B, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005;/129:/550-64.
    • (2005) Gastroenterology , vol.129 , pp. 550-64
    • Heller, F.1    Florian, P.2    Bojarski, C.3    Richter, J.4    Christ, M.5    Hillenbrand, B.6
  • 23
    • 0028005748 scopus 로고
    • Neuroimmune signaling in regulation of intestinal ion transport
    • Cooke HJ. Neuroimmune signaling in regulation of intestinal ion transport. Am J Physiol 1994;/266:/G167-78.
    • (1994) Am J Physiol , vol.266
    • Cooke, H.J.1
  • 25
    • 0032963813 scopus 로고    scopus 로고
    • Electrogenic Na- transport in rat late distal colon by natural and synthetic glucocorticosteroids
    • Grotjohann I, Schulzke JD, Fromm M. Electrogenic Na- transport in rat late distal colon by natural and synthetic glucocorticosteroids. Am J Physiol 1999;/276:/G491-8.
    • (1999) Am J Physiol , vol.276
    • Grotjohann, I.1    Schulzke, J.D.2    Fromm, M.3
  • 26
    • 0027398441 scopus 로고
    • Control of electrogenic Na- absorption in rat late distal colon by nanomolar aldosterone added in vitro
    • Fromm M, Schulzke JD, Hegel U. Control of electrogenic Na- absorption in rat late distal colon by nanomolar aldosterone added in vitro. Am J Physiol 1993;/264:/E68-73.
    • (1993) Am J Physiol , vol.264
    • Fromm, M.1    Schulzke, J.D.2    Hegel, U.3
  • 28
    • 0019403643 scopus 로고
    • The conventional short-circuiting technique under-short-circuits most epithelia
    • Tai YH, Tai CY. The conventional short-circuiting technique under-short-circuits most epithelia. J Membr Biol 1981;/59:/ 173-7.
    • (1981) J Membr Biol , vol.59 , pp. 173-7
    • Tai, Y.H.1    Tai, C.Y.2
  • 29
    • 0023116774 scopus 로고
    • Impaired intestinal sodium and chloride transport in the blind loop syndrome of the rat
    • Schulzke JD, Fromm M, Menge H, Riecken EO. Impaired intestinal sodium and chloride transport in the blind loop syndrome of the rat. Gastroenterology 1987;/92:/693-8.
    • (1987) Gastroenterology , vol.92 , pp. 693-8
    • Schulzke, J.D.1    Fromm, M.2    Menge, H.3    Riecken, E.O.4
  • 30
    • 0035038535 scopus 로고    scopus 로고
    • Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
    • Santos J, Yang PC, Söderholm JD, Benjamin M, Perdue MH. Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat. Gut 2001;/48:/630-6.
    • (2001) Gut , vol.48 , pp. 630-6
    • Santos, J.1    Yang, P.C.2    Söderholm, J.D.3    Benjamin, M.4    Perdue, M.H.5
  • 31
    • 0017758863 scopus 로고
    • Na and Cl transport across the isolated turtle colon: Parallel pathways for transmural ion movement
    • Dawson DC. Na and Cl transport across the isolated turtle colon: parallel pathways for transmural ion movement. J Membr Biol 1977;/37:/213-33.
    • (1977) J Membr Biol , vol.37 , pp. 213-33
    • Dawson, D.C.1
  • 32
    • 0035129369 scopus 로고    scopus 로고
    • Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut
    • Rahner C, Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 2001;/120:/411-22.
    • (2001) Gastroenterology , vol.120 , pp. 411-22
    • Rahner, C.1    Mitic, L.L.2    Anderson, J.M.3
  • 34
    • 0032958705 scopus 로고    scopus 로고
    • Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
    • Schmitz H, Barmeyer C, Fromm M, Runkel N, Foss HD, Bentzel CJ, et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 1999;/116:/301-9.
    • (1999) Gastroenterology , vol.116 , pp. 301-9
    • Schmitz, H.1    Barmeyer, C.2    Fromm, M.3    Runkel, N.4    Foss, H.D.5    Bentzel, C.J.6
  • 35
    • 20444464523 scopus 로고    scopus 로고
    • Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease
    • Sanders DS. Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease. J Clin Pathol 2005;/58:/568-72.
    • (2005) J Clin Pathol , vol.58 , pp. 568-72
    • Sanders, D.S.1
  • 36
    • 0024553788 scopus 로고
    • Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers
    • Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989;/83:/724-7.
    • (1989) J Clin Invest , vol.83 , pp. 724-7
    • Madara, J.L.1    Stafford, J.2
  • 38
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells
    • Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 2000;/ 279:/G851-7.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 39
    • 22144441209 scopus 로고    scopus 로고
    • Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells
    • Amasheh S, Schmidt T, Mahn M, Florian P, Mankertz J, Tavalali S, et al. Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell Tissue Res 2005;/321:/89-96.
    • (2005) Cell Tissue Res , vol.321 , pp. 89-96
    • Amasheh, S.1    Schmidt, T.2    Mahn, M.3    Florian, P.4    Mankertz, J.5    Tavalali, S.6
  • 40
    • 0037128938 scopus 로고    scopus 로고
    • Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin- 1-deficient mice
    • Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin- 1-deficient mice. J Cell Biol 2002;/156:/1099-111.
    • (2002) J Cell Biol , vol.156 , pp. 1099-111
    • Furuse, M.1    Hata, M.2    Furuse, K.3    Yoshida, Y.4    Haratake, A.5    Sugitani, Y.6
  • 41
    • 0037115724 scopus 로고    scopus 로고
    • Claudin-2 expression induces cationselective channels in tight junctions of epithelial cells
    • Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, et al. Claudin-2 expression induces cationselective channels in tight junctions of epithelial cells. J Cell Sci 2002;/115:/4969-76.
    • (2002) J Cell Sci , vol.115 , pp. 4969-76
    • Amasheh, S.1    Meiri, N.2    Gitter, A.H.3    Schöneberg, T.4    Mankertz, J.5    Schulzke, J.D.6
  • 42
    • 21644461890 scopus 로고    scopus 로고
    • Overexpression of claudin- 7 decreases the paracellular Cl- conductance and increases the paracellular Na- conductance in LLC-PK1 cells
    • Alexandre MD, Lu Q, Chen YH. Overexpression of claudin- 7 decreases the paracellular Cl- conductance and increases the paracellular Na- conductance in LLC-PK1 cells. J Cell Sci 2005;/118:/2683-93.
    • (2005) J Cell Sci , vol.118 , pp. 2683-93
    • Alexandre, M.D.1    Lu, Q.2    Chen, Y.H.3
  • 43
    • 0347721125 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha disrupts tight junction assembly
    • Poritz LS, Garver KI, Tilberg AF, Koltun WA. Tumor necrosis factor alpha disrupts tight junction assembly. J Surg Res 2004;/116:/14-8.
    • (2004) J Surg Res , vol.116 , pp. 14-8
    • Poritz, L.S.1    Garver, K.I.2    Tilberg, A.F.3    Koltun, W.A.4
  • 44
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. Faseb J 2005;/19:/923-33.
    • (2005) Faseb J , vol.19 , pp. 923-33
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 45
    • 17844397159 scopus 로고    scopus 로고
    • Endocytosis of the apical junctional complex: Mechanisms and possible roles in regulation of epithelial barriers
    • Ivanov AI, Nusrat A, Parkos CA. Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers. Bioessays 2005;/27:/356-65.
    • (2005) Bioessays , vol.27 , pp. 356-65
    • Ivanov, A.I.1    Nusrat, A.2    Parkos, C.A.3
  • 46
    • 13844312631 scopus 로고    scopus 로고
    • The epithelium in inflammatory bowel disease: Potential role of endocytosis of junctional proteins in barrier disruption
    • Ivanov AI, Nusrat A, Parkos CA. The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption. Novartis Found Symp 2004;/263:/115-24.
    • (2004) Novartis Found Symp , vol.263 , pp. 115-24
    • Ivanov, A.I.1    Nusrat, A.2    Parkos, C.A.3
  • 48
    • 0024267211 scopus 로고
    • Crohn's disease: A permeability disorder of the tight junction?
    • Hollander D. Crohn's disease: a permeability disorder of the tight junction? Gut 1988;/29:/1621-4.
    • (1988) Gut , vol.29 , pp. 1621-4
    • Hollander, D.1
  • 50
    • 3242813596 scopus 로고    scopus 로고
    • Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases
    • Kersting S, Bruewer M, Schuermann G, Klotz A, Utech M, Hansmerten M, et al. Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases. Am J Physiol 2004;/165:/425-37.
    • (2004) Am J Physiol , vol.165 , pp. 425-37
    • Kersting, S.1    Bruewer, M.2    Schuermann, G.3    Klotz, A.4    Utech, M.5    Hansmerten, M.6
  • 53
    • 9344264671 scopus 로고    scopus 로고
    • Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor a
    • Söderholm JD, Streutker C, Yang PC, Paterson C, Singh PK, McKay DM, et al. Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor a. Gut 2004;/53:/1817-24.
    • (2004) Gut , vol.53 , pp. 1817-24
    • Söderholm, J.D.1    Streutker, C.2    Yang, P.C.3    Paterson, C.4    Singh, P.K.5    McKay, D.M.6
  • 54
    • 0026531017 scopus 로고
    • Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
    • Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992;/339:/89-91.
    • (1992) Lancet , vol.339 , pp. 89-91
    • Braegger, C.P.1    Nicholls, S.2    Murch, S.H.3    Stephens, S.4    MacDonald, T.T.5
  • 55
    • 0030981088 scopus 로고    scopus 로고
    • Tumour necrosis factor and Crohn's disease
    • Van Deventer SJ. Tumour necrosis factor and Crohn's disease. Gut 1997;/40:/443-8.
    • (1997) Gut , vol.40 , pp. 443-8
    • Van Deventer, S.J.1
  • 56
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • Van Dullemen HM, de Jong E, Slors F, Tytgat GN, van Deventer SJ. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 1995;/109:/129-35.
    • (1995) Gastroenterology , vol.109 , pp. 129-35
    • Van Dullemen, H.M.1    De Jong, E.2    Slors, F.3    Tytgat, G.N.4    Van Deventer, S.J.5
  • 57
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin-2 -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S, Bü rgel N, Gü nzel D, Richter J, Mankertz J, Wahnschaffe U, et al. Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007;/ 56:/61-72.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Bü Rgel, N.2    Gü Nzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6


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