Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease

Alimentary Pharmacology and Therapeutics

Volumn 23, Issue 10, 2006, Pages 1455-1461

  D'Inca R ^a,c   Annese, V ^b   Di Leo, V ^a   Latiano, A ^b   Quaino, V ^c   Abazia, C ^a   Vettorato, M G ^a   Sturniolo, G C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; LACTULOSE; MANNITOL;

ADULT; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; FEMALE; FRAMESHIFT MUTATION; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HUMAN; INTESTINE MUCOSA PERMEABILITY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CROHN DISEASE; FAMILY HEALTH; FEMALE; FRAMESHIFT MUTATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTULOSE; MALE; MANNITOL; MIDDLE AGED; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; PERMEABILITY;

EID: 33646246756     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2006.02916.x     Document Type: Article

References (31)

1. Hollander D Vadheim CM Brettholz E Petersen GM Delahunty TJ Rotter JI Increased intestinal permeability in patients with Crohn's disease and their healthy relatives Ann Intern Med 1986 105 883 5
2. D'Incà R Sturniolo GC Martines D et al. Functional and morphological changes in small bowel of Crohn's disease patients. Influence of site of disease Dig Dis Sci 1995 40 1388 93
3. Miki K Moore DJ Buther RN et al. The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease J Pediatr 1998 133 750 4
4. Wyatt J Vogelsang H Hubl W et al. Intestinal permeability and the prediction of relapse in Crohn's disease Lancet 1993 341 1437 9
5. D'Incà R Di Leo V Corrao G et al. Intestinal permeability test as a predictor of clinical course in Crohn's disease Am J Gastroenterol 1999 94 2956 60
6. Sanderson IR Boulton P Menzies I et al. Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet Gut 1987 28 1073 6
7. Teahon K Smethurst P Pearson M et al. The effect of elemental diet on intestinal permeability and inflammation in Crohn's disease Gastroenterology 1991 101 84 9
8. Marin ML Grenstein AJ Geller SA Gordon RE Aufses AH A freeze fracture study of Crohn's disease of the terminal ileum: changes in epithelial tight junction organisation Am J Gastroenterol 1983 78 537 47
9. Peeters M Ghoos Y Maes B et al. Increased permeability of macroscopically normal small bowel in Crohn's disease Dig Dis Sci 1994 39 2170 6
10. Soderholm JD Streutker C Yang PC et al. Increased epitheilal uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha Gut 2004 53 1817 24
11. May GR Sutherland LR Meddings JB Is small intestinal permeability really increased in relatives of patients with Crohn's disease Gastroenterology 1993 104 1627 32
12. Munkholm P Langholz E Hollander D et al. Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first-degree relatives Gut 1994 35 1675 6
13. Peeters M Geypens B Claus D et al. Clustering of increased small intestinal permeability in families with Crohn's disease Gastroenterology 1997 113 802 7
14. Tysk C Lindberg E Jarnerot G Floderus-Myrhed B Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking Gut 1988 29 990 6
15. Bennett RA Rubin PH Present DH Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease Gastroenterology 1991 100 1638 43
16. Hugot JP Chamaillard M Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 2001 411 599 603
17. Hampe J Cuthbert A Croucher PJ et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations Lancet 2001 357 1925 8
18. Annese V Latiano A Andriulli A Genetics of inflammatory bowel disease. The beginning of the end or the end of the beginning Dig Liver Dis 2003 35 442 9
19. Buhner S Buning C Genschel J et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation Gut 2006 55 324 47
20. Corcoran A A method for determination of mannitol in plasma urine J Biol Chem 1947 170 165 71
21. Beherens RH Docherty H Elia M et al. A simple enzymatic method for the assay of urinary lactulose Clin Chim Acta 1984 137 361 7
22. Palmieri O Toth S Ferraris A et al. CARD15 genotyping in inflammatory bowel disease patients by multiplex pyrosequencing Clin Chem 2003 49 1675 9
23. Annese V Latiano A Palmieri O et al. Linkage of ulcerative colitis to the pericentromeric region of chromosome 16 in Italian inflammatory bowel disease families is independent of the presence of common CARD15 mutations J Med Genet 2003 40 837 41
24. Soderholm JD Olaison G Lindberg E et al. Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence Gut 1999 44 96 100
25. Breslin NP Nash C Hildsen RJ et al. Intestinal permeability is increased in a proportion of spouses of patients with Crohn's disease Am J Gastroenterol 2001 96 2934 8
26. Irvine EJ Marshall JK Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk Gastroenterology 2000 119 1740 4
27. Thjodleifsson B Sighthorsson G Cariglia N et al. Subclinical intestinal inflammation; an inherited abnormality in Crohn's disease relatives Gastroenterology 2003 124 1728 37
28. Orholm M Munkholm P Langholz E et al. Familial occurrence of inflammatory bowel disease N Engl J Med 1991 324 84 8
29. Annese V Palmieri O Latiano A et al. Frequency of NOD2/CARD15 variants in both sporadic and familial cases of Crohn's disease across Italy. An Italian Group for Inflammatory Bowel Disease study Dig Liver Dis 2004 36 121 4
30. Kobayashi KS Chamaillard M Ogura Y et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract Science 2005 307 731 4
31. Wehkamp J Harder J Weichenthal M et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal γ-defensin expression Gut 2004 53 1658 64