메뉴 건너뛰기




Volumn 12, Issue 4, 2008, Pages 1331-1346

Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-α-induced regulation of myosin light chain kinase gene activity

Author keywords

Intestinal permeability; Myosin light chain kinase; NF B subunit; Tight junction; Tumour necrosis factor

Indexed keywords

MYOSIN LIGHT CHAIN KINASE; PROTEIN P53; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 49549104243     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00302.x     Document Type: Article
Times cited : (105)

References (66)
  • 1
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohn's disease and their relatives. a possible etiologic factor
    • Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty T, Rotter JI. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann Intern Med. 1986 105 : 883 5.
    • (1986) Ann Intern Med. , vol.105 , pp. 883-5
    • Hollander, D.1    Vadheim, C.M.2    Brettholz, E.3    Petersen, G.M.4    Delahunty, T.5    Rotter, J.I.6
  • 3
    • 0027293439 scopus 로고
    • Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
    • May GR, Sutherland LR, Meddings JB. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology. 1993 104 : 1627 32.
    • (1993) Gastroenterology. , vol.104 , pp. 1627-32
    • May, G.R.1    Sutherland, L.R.2    Meddings, J.B.3
  • 4
    • 0020643629 scopus 로고
    • Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon
    • Ukabam SO, Clamp JR, Cooper BT. Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon. Digestion. 1989 27 : 70 4.
    • (1989) Digestion. , vol.27 , pp. 70-4
    • Ukabam, S.O.1    Clamp, J.R.2    Cooper, B.T.3
  • 5
    • 0020644991 scopus 로고
    • Absorption of 51chromium-labeled ethylened aminetetraacetate in inflammatory bowel disease
    • Bjarnason I, O'Morain C, Levi AJ, Peters TJ. Absorption of 51chromium-labeled ethylened aminetetraacetate in inflammatory bowel disease. Gastroenterology. 1983 85 : 318 22.
    • (1983) Gastroenterology. , vol.85 , pp. 318-22
    • Bjarnason, I.1    O'Morain, C.2    Levi, A.J.3    Peters, T.J.4
  • 6
    • 0024746822 scopus 로고
    • Intestinal permeability of 51Cr-labelled ethylenedi-aminetetraacetic acid in patients with Crohn's disease and their healthy relatives
    • Ainsworth M, Eriksen J, Rasmussen JW, Schaffalitzky de Muckadell OB. Intestinal permeability of 51Cr-labelled ethylenedi-aminetetraacetic acid in patients with Crohn's disease and their healthy relatives. Scand J Gastroenterol. 1989 24 : 993 8.
    • (1989) Scand J Gastroenterol. , vol.24 , pp. 993-8
    • Ainsworth, M.1    Eriksen, J.2    Rasmussen, J.W.3    Schaffalitzky De Muckadell, O.B.4
  • 7
    • 0025329497 scopus 로고
    • Relationship between intestinal permeability to [51Cr]EDTA and inflammatory activity in asymptomatic patients with Crohn's disease
    • Pironi L, Miglioli M, Ruggeri E, Levorato M, Dallasta MA, Corbelli C, Nibali MG, Barbara L. Relationship between intestinal permeability to [51Cr]EDTA and inflammatory activity in asymptomatic patients with Crohn's disease. Dig Dis Sci. 1990 35 : 582 8.
    • (1990) Dig Dis Sci. , vol.35 , pp. 582-8
    • Pironi, L.1    Miglioli, M.2    Ruggeri, E.3    Levorato, M.4    Dallasta, M.A.5    Corbelli, C.6    Nibali, M.G.7    Barbara, L.8
  • 8
    • 0028103683 scopus 로고
    • Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives
    • Munkholm P, Langholz E, Hollander D, Thornberg K, Orholm M, Katz KD, Binder V. Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives. Gut. 1994 35 : 68 72.
    • (1994) Gut. , vol.35 , pp. 68-72
    • Munkholm, P.1    Langholz, E.2    Hollander, D.3    Thornberg, K.4    Orholm, M.5    Katz, K.D.6    Binder, V.7
  • 10
    • 0030958528 scopus 로고    scopus 로고
    • Intestinal epithelial barrier dysfunction in Crohn's disease
    • Ma TY. Intestinal epithelial barrier dysfunction in Crohn's disease. Proc Soc Exp Biol Med. 1997 214 : 318 27.
    • (1997) Proc Soc Exp Biol Med. , vol.214 , pp. 318-27
    • Ma, T.Y.1
  • 11
    • 0026630075 scopus 로고
    • The intestinal permeability barrier. a hypothesis as to its regulation and involvement in Crohn's disease
    • Hollander D. The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand J Gastroenterol. 1992 27 : 721 6.
    • (1992) Scand J Gastroenterol. , vol.27 , pp. 721-6
    • Hollander, D.1
  • 12
    • 0024267211 scopus 로고
    • Crohn's disease - A permeability disorder of the tight junction?
    • Hollander D. Crohn's disease - a permeability disorder of the tight junction? Gut. 1988 29 : 1621 4.
    • (1988) Gut. , vol.29 , pp. 1621-4
    • Hollander, D.1
  • 14
    • 0022977470 scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine
    • Bjarnason I, Williams P, Smethurst P, Peters TJ, Levi AJ. Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine. Gut. 1986 27 : 1292 7.
    • (1986) Gut. , vol.27 , pp. 1292-7
    • Bjarnason, I.1    Williams, P.2    Smethurst, P.3    Peters, T.J.4    Levi, A.J.5
  • 16
    • 0028961732 scopus 로고
    • Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function
    • Spitz J, Yuhan R, Koutsouris A, Blatt C, Alverdy J, Hecht G. Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function. Am J Physiol. 1995 268 : G374 9.
    • (1995) Am J Physiol. , vol.268
    • Spitz, J.1    Yuhan, R.2    Koutsouris, A.3    Blatt, C.4    Alverdy, J.5    Hecht, G.6
  • 18
    • 0024204607 scopus 로고
    • Clostridium difficile toxin a perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
    • Hecht G, Pothoulakis C, LaMont JT, Madara JL. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J Clin Invest. 1988 82 : 1516 24.
    • (1988) J Clin Invest. , vol.82 , pp. 1516-24
    • Hecht, G.1    Pothoulakis, C.2    Lamont, J.T.3    Madara, J.L.4
  • 19
    • 0024577594 scopus 로고
    • Loosening tight junctions. Lessons from the intestine
    • Madara JL. Loosening tight junctions. Lessons from the intestine. J Clin Invest. 1989 83 : 1089 94.
    • (1989) J Clin Invest. , vol.83 , pp. 1089-94
    • Madara, J.L.1
  • 21
    • 0030981088 scopus 로고    scopus 로고
    • Tumour necrosis factor and Crohn's disease
    • Van Deventer SJ. Tumour necrosis factor and Crohn's disease. Gut. 1997 40 : 443 8.
    • (1997) Gut. , vol.40 , pp. 443-8
    • Van Deventer, S.J.1
  • 24
    • 1342289293 scopus 로고    scopus 로고
    • Closing fistulas in Crohn's dis-ease- should the accent be on maintenance or safety?
    • Fiocchi C. Closing fistulas in Crohn's dis-ease- should the accent be on maintenance or safety? N Engl J Med. 2004 350 : 934 6.
    • (2004) N Engl J Med. , vol.350 , pp. 934-6
    • Fiocchi, C.1
  • 26
    • 5044235159 scopus 로고    scopus 로고
    • Long-term treatment of recto-vaginal fistulas in Crohn's disease: Response to infliximab in the ACCENT II Study
    • Sands BE, Blank MA, Patel K, van Deventer SJ. Long-term treatment of recto-vaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol. 2004 2 : 912 20.
    • (2004) Clin Gastroenterol Hepatol. , vol.2 , pp. 912-20
    • Sands, B.E.1    Blank, M.A.2    Patel, K.3    Van Deventer, S.J.4
  • 28
    • 33749428028 scopus 로고    scopus 로고
    • Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
    • Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest. 2006 116 : 2682 94.
    • (2006) J Clin Invest. , vol.116 , pp. 2682-94
    • Clayburgh, D.R.1    Musch, M.W.2    Leitges, M.3    Fu, Y.X.4    Turner, J.R.5
  • 30
    • 26244450671 scopus 로고    scopus 로고
    • Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats
    • Moriez R, Salvador-Cartier C, Theodorou V, Fioramonti J, Eutamene H, Bueno L. Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats. Am J Pathol. 2005 167 : 1071 9.
    • (2005) Am J Pathol. , vol.167 , pp. 1071-9
    • Moriez, R.1    Salvador-Cartier, C.2    Theodorou, V.3    Fioramonti, J.4    Eutamene, H.5    Bueno, L.6
  • 33
  • 36
    • 0036677473 scopus 로고    scopus 로고
    • Crohn's disease, TNF-alpha, and the leaky gut. the chicken or the egg?
    • Hollander D. Crohn's disease, TNF-alpha, and the leaky gut. The chicken or the egg? Am J Gastroenterol. 2002 97 : 1867 8.
    • (2002) Am J Gastroenterol. , vol.97 , pp. 1867-8
    • Hollander, D.1
  • 37
    • 0032005048 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line
    • Marano CW, Lewis SA, Garulacan LA, Soler AP, Mullin JM. Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line. J Membr Biol. 1998 161 : 263 74.
    • (1998) J Membr Biol. , vol.161 , pp. 263-74
    • Marano, C.W.1    Lewis, S.A.2    Garulacan, L.A.3    Soler, A.P.4    Mullin, J.M.5
  • 38
    • 0031227976 scopus 로고    scopus 로고
    • Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: Inhibition of increased permeability, but not diminished secretory responses by TGF-beta2
    • McKay DM, Singh PK. Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: inhibition of increased permeability, but not diminished secretory responses by TGF-beta2. J Immunol. 1997 159 : 2382 90.
    • (1997) J Immunol. , vol.159 , pp. 2382-90
    • McKay, D.M.1    Singh, P.K.2
  • 39
    • 0028998062 scopus 로고
    • Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers
    • Rodriguez P, Heyman M, Candalh C, Blaton MA, Bouchaud C. Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers. Cytokine. 1995 7 : 441 8.
    • (1995) Cytokine. , vol.7 , pp. 441-8
    • Rodriguez, P.1    Heyman, M.2    Candalh, C.3    Blaton, M.A.4    Bouchaud, C.5
  • 40
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol. 2005 166 : 409 19.
    • (2005) Am J Pathol. , vol.166 , pp. 409-19
    • Wang, F.1    Graham, W.V.2    Wang, Y.3    Witkowski, E.D.4    Schwarz, B.T.5    Turner, J.R.6
  • 41
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma TY, Boivin MA, Ye D, Pedram A, Said HM. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol. 2005 288 : G422 30.
    • (2005) Am J Physiol Gastrointest Liver Physiol. , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3    Pedram, A.4    Said, H.M.5
  • 42
    • 34250190636 scopus 로고    scopus 로고
    • LIGHT signals directly to intestinal epithe-lia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms
    • Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithe-lia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007 132 : 2383 94.
    • (2007) Gastroenterology. , vol.132 , pp. 2383-94
    • Schwarz, B.T.1    Wang, F.2    Shen, L.3    Clayburgh, D.R.4    Su, L.5    Wang, Y.6    Fu, Y.X.7    Turner, J.R.8
  • 43
    • 28444489667 scopus 로고    scopus 로고
    • Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability
    • Fedwick JP, Lapointe TK, Meddings JB, Sherman PM, Buret AG. Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect Immun. 2005 73 : 7844 52.
    • (2005) Infect Immun. , vol.73 , pp. 7844-52
    • Fedwick, J.P.1    Lapointe, T.K.2    Meddings, J.B.3    Sherman, P.M.4    Buret, A.G.5
  • 44
    • 0036789132 scopus 로고    scopus 로고
    • Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion
    • Scott KG, Meddings JB, Kirk DR, Lees-Miller SP, Buret AG. Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology. 2002 123 : 1179 90.
    • (2002) Gastroenterology. , vol.123 , pp. 1179-90
    • Scott, K.G.1    Meddings, J.B.2    Kirk, D.R.3    Lees-Miller, S.P.4    Buret, A.G.5
  • 45
    • 30944443377 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    • Blair SA, Kane SV, Clayburgh DR, Turner JR. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest. 2006 86 : 191 201.
    • (2006) Lab Invest. , vol.86 , pp. 191-201
    • Blair, S.A.1    Kane, S.V.2    Clayburgh, D.R.3    Turner, J.R.4
  • 46
    • 33644981348 scopus 로고    scopus 로고
    • Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
    • Ye D, Ma I, Ma TY. Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2006 290 : G496 504.
    • (2006) Am J Physiol Gastrointest Liver Physiol. , vol.290
    • Ye, D.1    Ma, I.2    Ma, T.Y.3
  • 48
    • 0034081817 scopus 로고    scopus 로고
    • The downstream promoter element DPE appears to be as widely used as the TATA box in Drosophila core promoters
    • Kutach AK, Kadonaga JT. The downstream promoter element DPE appears to be as widely used as the TATA box in Drosophila core promoters. Mol Cell Biol. 2000 20 : 4754 64.
    • (2000) Mol Cell Biol. , vol.20 , pp. 4754-64
    • Kutach, A.K.1    Kadonaga, J.T.2
  • 49
    • 0025943986 scopus 로고
    • The p65 sub-unit is responsible for the strong transcription activating potential of NF-kappa B
    • Schmitz ML, Baeuerle PA. The p65 sub-unit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J. 1991 10 : 3805 17.
    • (1991) EMBO J. , vol.10 , pp. 3805-17
    • Schmitz, M.L.1    Baeuerle, P.A.2
  • 50
    • 0027190466 scopus 로고
    • KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells
    • Plaksin D, Baeuerle PA, Eisenbach L. KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells. J Exp Med. 1993 177 : 1651 62.
    • (1993) J Exp Med. , vol.177 , pp. 1651-62
    • Plaksin, D.1    Baeuerle, P.A.2    Eisenbach, L.3
  • 52
    • 1542319174 scopus 로고    scopus 로고
    • Bcl-3 and NFkappaB p50-p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells
    • Grundstrom S, Anderson P, Scheipers P, Sundstedt A. Bcl-3 and NFkappaB p50-p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells. J Biol Chem. 2004 279 : 8460 8.
    • (2004) J Biol Chem. , vol.279 , pp. 8460-8
    • Grundstrom, S.1    Anderson, P.2    Scheipers, P.3    Sundstedt, A.4
  • 54
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NFkappaB
    • Hayden MS, Ghosh S. Signaling to NFkappaB. Genes Dev. 2004 18 : 2195 224.
    • (2004) Genes Dev. , vol.18 , pp. 2195-224
    • Hayden, M.S.1    Ghosh, S.2
  • 55
    • 0025078530 scopus 로고
    • Cloning of the p50 DNA binding subunit of NF-kappa B: Homology to rel and dorsal
    • Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D. Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell. 1990 62 : 1019 29.
    • (1990) Cell. , vol.62 , pp. 1019-29
    • Ghosh, S.1    Gifford, A.M.2    Riviere, L.R.3    Tempst, P.4    Nolan, G.P.5    Baltimore, D.6
  • 57
    • 0025975795 scopus 로고
    • DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide
    • Nolan GP, Ghosh S, Liou HC, Tempst P, Baltimore D. DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell. 1991 64 : 961 9.
    • (1991) Cell. , vol.64 , pp. 961-9
    • Nolan, G.P.1    Ghosh, S.2    Liou, H.C.3    Tempst, P.4    Baltimore, D.5
  • 61
    • 0037927519 scopus 로고    scopus 로고
    • The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homod-imers while enhancing the binding of p50 homodimers
    • Ma XY, Wang H, Ding B, Zhong H, Ghosh S, Lengyel P. The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homod-imers while enhancing the binding of p50 homodimers. J Biol Chem. 2003 278 : 23008 19.
    • (2003) J Biol Chem. , vol.278 , pp. 23008-19
    • Ma, X.Y.1    Wang, H.2    Ding, B.3    Zhong, H.4    Ghosh, S.5    Lengyel, P.6
  • 62
    • 0242664264 scopus 로고    scopus 로고
    • Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding
    • Hou S, Guan H, Ricciardi RP. Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding. J Biol Chem. 2003 278 : 45994 8.
    • (2003) J Biol Chem. , vol.278 , pp. 45994-8
    • Hou, S.1    Guan, H.2    Ricciardi, R.P.3
  • 63
    • 0031126702 scopus 로고    scopus 로고
    • Rel/NF-kappa B and I kappa B proteins: An overview
    • May MJ, Ghosh S. Rel/NF-kappa B and I kappa B proteins: an overview. Semin Cancer Biol. 1997 8 : 63 73.
    • (1997) Semin Cancer Biol. , vol.8 , pp. 63-73
    • May, M.J.1    Ghosh, S.2
  • 64
    • 0031114133 scopus 로고    scopus 로고
    • Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression
    • Iwamoto GK, Konicek SA. Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression. J Investig Med. 1997 45 : 175 82.
    • (1997) J Investig Med. , vol.45 , pp. 175-82
    • Iwamoto, G.K.1    Konicek, S.A.2
  • 65
    • 0027493436 scopus 로고
    • Autoradiographic determination of permeation pathway of permeability probes across intestinal and tracheal epithelia
    • Ma TY, Hollander D, Riga R, Bhalla D. Autoradiographic determination of permeation pathway of permeability probes across intestinal and tracheal epithelia. J Lab Clin Med. 1993 122 : 590 600.
    • (1993) J Lab Clin Med. , vol.122 , pp. 590-600
    • Ma, T.Y.1    Hollander, D.2    Riga, R.3    Bhalla, D.4
  • 66
    • 0029089328 scopus 로고
    • Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability
    • Ma TY, Hollander D, Tran LT, Nguyen D, Hoa N, Bhalla D. Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability. J Cell Physiol. 1995 164 : 533 45.
    • (1995) J Cell Physiol. , vol.164 , pp. 533-45
    • Ma, T.Y.1    Hollander, D.2    Tran, L.T.3    Nguyen, D.4    Hoa, N.5    Bhalla, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.