Potential role of polyphenols in the prevention of cardiovascular diseases: Molecular bases

Current Medicinal Chemistry

Volumn 23, Issue 2, 2016, Pages 115-128

  Gormaz, Juan Guillermo ^a   Valls, Nicolas ^a   Sotomayor, Camilo ^a   Turner, Thomas ^b   Rodrigo, Ramón ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b J Crayton Pruitt Family Department of Biomedical Engineering   (United States)

Author keywords

Atherogenesis; Cardiovascular diseases prevention; Inflammation; Polyphenols; Thrombosis; Vasodilatation

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTICOAGULANT AGENT; ANTIINFLAMMATORY AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPHENOL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; VASODILATOR AGENT; POLYPHENOL;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG MECHANISM; DRUG METABOLISM; DRUG TISSUE LEVEL; ENDOTHELIAL DYSFUNCTION; HUMAN; HYPERTENSION; INTRACELLULAR SIGNALING; NONHUMAN; PROPHYLAXIS; STOMACH PH; URINARY EXCRETION; VASODILATATION; ANIMAL; CARDIOVASCULAR DISEASES; CHEMICAL STRUCTURE; CHEMISTRY;

ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; MOLECULAR STRUCTURE; POLYPHENOLS;

EID: 84958183857     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867323666151127201732     Document Type: Article

References (106)

1. World Health Organization: Global status report on noncommunicable diseases 2010; c2011. http://www.who.int/ nmh/publications/ncd-report2010/en/l. (Accessed February 24, 2015).
2. Dickson, V.V.; Nocella, J.; Yoon, H.W.; Hammer, M.; Melkus, G.D.; Chyun D.l. Cardiovascular disease self-care interventions. Nurs. Res. Pract., 2013, 2013, 407608.
3. Poljsak, B.; Šuput, D.; Milisav I. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid. Med. Cell. Longev., 2013, 2013, 956792.
4. Santhakumar, A.B.; Bulmer, A.C.; Singh I. A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk. J. Hum. Nutr. Diet., 2014, 27, 1-21.
5. Iriti, M. Editorial: introduction to polyphenols, plant chemicals for human health. Mini Rev Med Chem., 2011, 11, 1183-5.
6. Bravo, L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev., 1998, 56, 317-33.
7. Tsao, R. Chemistry and biochemistry of dietary polyphenols. Nutrients., 2010, 2, 1231-46.
8. Manach, C.; Scalbert, A.; Morand, C.; R YC L.; Jim Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr., 2004, 79, 727-747.
9. Scheepens, A.; Tan, K.; Paxton, J.W. Improving the oral bioavailability of beneficial polyphenols through designed synergies. Genes Nutr., 2010, 5, 75-87.
10. Fang J. Bioavailability of anthocyanins. Drug Metab. Rev., 2014, 46, 508-20.
11. Robbins, R.J. Phenolic acids in foods: an overview of analytical methodology. J. Agric. Food Chem., 2003, 51, 2866-87.
12. Bavaresco, L.; Fregoni, C.; Cant? E.; Trevisan, M. Stilbene compounds: from the grapevine to wine. Drugs Exp. Clin. Res., 1999, 25, 57-63.
13. Reinisalo, M.; K?lund, A.; Koskela, A.; Kaarniranta, K.; Karjalainen, R.O. Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging- Related Diseases. Oxid Med Cell Longev., 2015, 2015, 340520.
14. Mignet, N.; Seguin, J.; Chabot, G.G. Bioavailability of polyphenol liposomes: a challenge ahead. Pharmaceutics, 2013, 5, 457-471.
15. Varoni, E.M.; Lodi, G.; Iriti, M. Efficacy behind activity- phytotherapeutics are not different from pharmaceuticals. Pharm Biol. 2015, 53, 404-406.
16. Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Ry, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr., 2005, 81, 230-42.
17. Mallery, S.R.; Budendorf, D.E.; Larsen, M.P.; Pei, P.; Tong, M.; Holpuch, A.S.; Larsen, P.E.; Stoner, G.D.; Fields, H.W.; Chan, K.K.; Ling, Y.; Liu, Z. Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. Cancer Prev. Res. (Phila)., 2011, 4, 1209-21.
18. Lewandowska, U.; Szewczyk, K.; Hrabec, E.; Janecka, A.; Gorlach, S. Overview of metabolism and bioavailability enhancement of polyphenols. J. Agric. Food. Chem., 2013, 61, 12183-12199.
19. Tagliazucchi, D.; Verzelloni, E.; Bertolini, D.; Conte, A. In vitro bio.accessibility and antioxidant activity of grape polyphenols. Food. Chem., 2010, 120, 599-606.
20. Boyer, J; Brown, D.; Liu, R.H. In vitro digestion and lactase treatment influence uptake of quercetin and quercetinglucoside by the Caco-2 cell monolayer. Nutr. J., 2005, 4, 1.
21. Record, I.R.; Lane, J.M. Simulated intestinal digestion of green and black teas. Food Chem., 2001, 73, 481-486.
22. Gormaz, J.G.; Valle, J. Polyphenols in Cardiovascular Diseases: Mechanism of Action. In: Polyphenols: Food Sources,Bioactive Properties and Antioxidant Effects; Cobb, T., Ed.; Nova Science Publishers Inc.: New York, 2014, pp. 189-216..
23. Van de Wetering, K.; Burkon, A.; Feddema, W.; Bot; A.; de Jonge, H.; Somoza, V.; Borst,; P. Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Mol. Pharmacol., 2009, 75, 876-885.
24. Ma , L.; Miguez, E.M.; Villar, C.J.; Lomb F. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed. Res. Int., 2015, 2015, 905215.
25. Bang, S.H.; Hyun, Y.J.; Shim, J.; Hong, S.W.; Kim, D.H. Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing ?-Lrhamnosidase from Bifidobacterium dentium. J. Microbiol. Biotechnol., 2015, 25, 18-25.
26. Borges, G.; Lean, M.E.; Roberts, S.A.; Crozier, A. Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine. Food Funct., 2013, 4, 754-62.
27. Hodek, P.; Trefil, P.; Stiborov? M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem. Biol. Interact., 2002, 139, 1-21.
28. Ciolino, H.P.; Yeh, G.C. The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. Br. J. Cancer, 1999, 79, 1340-1346.
29. Canivenc-Lavier, M.C.; Bentejac, M.; Miller, M.L.; Leclerc, J.; Siess, M.H. Latruffe, N.; Suschetet, M. Differential effects of nonhydroxylated flavonoids as inducers of cytochrome P450 1A and 2B isozymes in rat liver. Toxicol. Appl. Pharmacol., 1996,136, 348-353.
30. Lambert, J.D.; Sang, S.M.; Yang, C.S. Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol. Pharmaceutics., 2007, 4, 819-825.
31. Maier-Salamon, A.; B?mdorfer, M; Riha, J.; Thalhammer, T.; Szekeres, T.; Jaeger, W. Interplay between metabolism and transport of resveratrol. Ann. N.Y. Acad. Sci., 2013, 1290, 98-106.
32. Herath, W.; Khan, S.I.; Khan, I.A. Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol. Nat. Prod. Res., 2013, 27, 1437-1444.
33. Rodrigo, R.; Gil, D.; Miranda-Merchak, A.;, Kalantzidis, G. Antihypertensive role of polyphenols. Adv. Clin. Chem., 2012, 58, 225-54.
34. Tangney, C.C.; Rasmussen, H.E. Polyphenols, inflammation, and cardiovascular disease. Curr. Atheroscler. Rep., 2013, 15, 324.
35. Triggle, C.R.; Samuel, S.M.; Ravishankar, S. The endothelium: influencing vascular smooth muscle in many ways. Can. J. Physiol. Pharmacol., 2012, 90, 713-738.
36. Griendling, K.K.; FitzGerald, G.A. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation, 2003, 108, 1912-1916.
37. Griendling, K.K.; FitzGerald, G.A. Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation, 2003, 108, 2034-2040.
38. Fitzpatrick, D.F.; Hirschfield, S.L.; Coffey, R.G. Endothelium- dependent vasorelaxing activity of wine and other grape products. Am. J. Physiol., 1993, 265, 774-778.
39. Schini-Kerth, V.B.; Auger, C.; Kim, J.H.; Etienne-Selloum, N.; Chataigneau, T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch., 2010, 459, 853-862.
40. Andriambeloson, E.; Kleschyov, A.L.; Muller, B.; Beretz, A.; Stoclet, J.C.; Andriantsitohaina, R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br. J. Pharmacol., 1997, 120, 1053-1058.
41. Ndiaye, M.; Chataigneau, M.; Lobysheva, I.; Chataigneau, T.; Schini-Kerth, V.B. Red wine polyphenol-induced, endothelium- dependent NO-mediated relaxation is due to the redox- sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J., 2005, 19, 455-457.
42. Chalopin, M.; Tesse, A.; Martinez, M.C; Rognan, D.; Arnal, J.F.; Andriantsitohaina, R. Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium. PLoS One, 2015, 5, e8554.
43. Reiter, C.E.; Kim, J.A; Quon, M.J. Green tea polyphenol epigallocatechingallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMPactivated protein kinase, Akt, and FOXO1. Endocrinology, 2010, 151, 103-114.
44. Steffen, Y.; Gruber, C.; Schewe, T.; Sies, H. Mono-Omethylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch. Biochem. Biophys., 2008, 469, 209-219.
45. Li, Y.; Cao, Z.; Zhu, H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol. Res., 2006, 53, 6-15.
46. Bucova, M.; Bernadic, M.; Buckingham, T. C-reactive protein, cytokines and inflammation in cardiovascular diseases. Bratisl. Lek. Listy., 2008, 109, 333-340.
47. Baeuerle, P.A.; Henkel, T. Function and activation of NFkappa B in the immune system. Ann. Rev. Immunol., 1994, 12, 141-179.
48. May, M.J.; Ghosh, S. Signal transduction through NFkappa B. Immunol. Today., 1998, 19, 80-88.
49. Calabriso, N.; Scoditti, E.; Massaro, M.; Pellegrino, M.; Storelli, C.; Ingrosso, I.; Giovinazzo, G.; Carluccio, M.A. Multiple anti-inflammatory and anti-atherosclerotic properties of red wine polyphenolic extracts: differential role of hydroxycinnamic acids, flavonols and stilbenes on endothelial inflammatory gene expression. Eur. J. Nutr., 2015, Epub ahead of print].
50. Gormaz, J.G.; Erazo, M. Dietary Fat and its Impact on Health: Analysis of Basic, Clinical and Epidemiological Evidence. In: Low and High-Fat Diets: Myths vs. Reality, Health Effects and Risks; Ferreira, J.E.; Muniz, N., Eds.; Nova Science Publishers Inc.: New York, 2012, pp. 223- 256.
51. Chu. A.J. Antagonism by bioactive polyphenols against inflammation: a systematic view. Inflamm. Allergy Drug Targets, 2014, 13, 34-64.
52. Karlsen, A.; Retterstol, L.; Laake, P.; Paur, I.; B?n, S.K.; Sandvik, L.; Blomhoff, R. Anthocyanins inhibit nuclear factor- kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J. Nutr., 2007, 137, 1951-1954.
53. Rodrigo, R.; Libuy, M.; Feliu, F.; Hasson, D. Polyphenols in disease: from diet to supplements. Curr. Pharm. Biotechnol., 2014, 15, 304-17.
54. Pan, M.H.; Lin-Shiau, S.Y.; Ho, C.T.; Lin, J.H.; Lin, J.K. Suppression of lipopolysaccharide-induced nuclear factorkappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem. Pharmacol., 2000, 59, 357-367.
55. Karlsen, A.; Paur, I.; Bohn, S.K.; Sakhi, A.K.; Borge, G.I.; Serafini, M.; Erlund, I.; Laake, P.; Tonstad, S.; Blomhoff, R. Bilberry juice modulates plasma concentration of NFkappaB related inflammatory markers in subjects at increased risk of CVD. Eur. J. Nutr., 2010, 49, 345-355.
56. Kaspar, K.L.; Park, J.S.; Brown, C.R.; Mathison, B.D; Navarre, D.A; Chew, B.P. Pigmented potato consumption alters oxidative stress and inflammatory damage in men. J. Nutr., 2011, 141, 108-111.
57. Natsume, M.; Baba, S. Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipoprotein E-deficient mice. Subcell. Biochem., 2014, 77, 189-98.
58. Zapolska-Downar, D.; Bryk, D.; Ma?ecki, M.; Hajdukiewicz, K.; Sitkiewicz, D. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur. J. Nutr., 2012, 51, 563-72.
59. Wu, K.K. Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators. Prostaglandins Leukot. Essent. Fatty Acids, 2005, 72, 89-93.
60. Scoditti, E.; Calabriso, N.; Massaro, M.; Pellegrino, M.; Storelli, C.; Martines, G.; De Caterina, R.; Carluccio, M.A. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch. Biochem. Biophys., 2012, 15, 527, 81-89.
61. Fuentes, E.; Palomo, I. Relationship between platelet PPARs, cAMP levels, and p-selectin expression: antiplatelet activity of natural products. Evid. Based Complement. Alternat. Med., 2013, 2013, 861786.
62. Badimon, L.; Vilahur, G. Thrombosis formation on atherosclerotic lesions and plaque rupture. J. Intern. Med., 2014, 276, 618-32.
63. Nakahata, N. Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol. Ther., 2008, 118, 18-35.
64. Wang, S.B.; Jang, J.Y.; Chae, Y.H.; Min, J.H.; Baek, J.Y.; Kim, M.; Park, Y.; Hwang, G.S.; Ryu, J.S.; Chang, T.S. Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. Free. Radic. Biol. Med., 2015, 83, 41-53.
65. Jang, J.Y.; Min, J.H.; Chae, Y.H.; Baek, J.Y.; Wang, S.B.; Park, S.J.; Oh, G.T.; Lee, S.H.; Ho, Y.S.; Chang, T.S. Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation. Antioxid. Redox Signal., 2013, 20, 2528-2540.
66. Nardini, M.; Natella, F.; Scaccini, C. Role of dietary polyphenols in platelet aggregation. A review of the supplementation studies. Platelets, 2007, 18, 224-243.
67. De Gaetano, G.; De Curtis, A.; di Castelnuovo, A.; Donat, M.B.; Iacoviello, L.; Rotondo, S. Antithrombotic effect of polyphenols in experimental models: a mechanism of reduced vascular risk by moderate wine consumption. Ann. N.Y. Acad. Sci., 2002, 957, 174-88.
68. Pignatelli, P.; Pulcinelli, F.M.; Celestini, A.; Lenti, L.; Ghiselli, A.; Gazzaniga, P.P.; Violi, F. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am. J. Clin. Nutr., 2000, 72, 1150-1155.
69. Pignatelli, P.; Di Santo, S.; Buchetti, B.; Sanguigni, V.; Brunelli, A.; Violi, F. Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment. FASEB J., 2006, 20, 1082-1089.
70. Cathcart, M.K. Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2004, 24, 23-28.
71. Dav G.; Patrono, C. Platelet Activation and Atherothrombosis. N. Engl. J. Med., 2007, 357, 2482-2494.
72. Ruggeri, Z.M. Platelets in atherothrombosis. Nat. Med., 2002, 8, 1227-1234.
73. B?k, M.; Hansson, G.K. Anti-inflammatory therapies for atherosclerosis. Nat. Rev. Cardiol., 2015, 12, 199-211.
74. Massaro, M.; Scoditti, E.; Carluccio, M.A.; De Caterina, R. Nutraceuticals and prevention of atherosclerosis: focus on omega-3 polyunsaturated fatty acids and Mediterranean diet polyphenols. Cardiovasc. Ther., 2010, 28, 13-19.
75. Donato, A.J.; Morgan, R.G.; Walker, A.E.; Lesniewski, L.A. Cellular and molecular biology of aging endothelial cells. J. Mol. Cell. Cardiol., 2015, 89, 122-135.
76. Mulvihill, E.E.; Huff, M.W. Antiatherogenic properties of flavonoids: implications for cardiovascular health. Can. J. Cardiol., 2010, 26, 17-21.
77. Sanchez, M.; Lodi, F.; Vera, R.; Villar, I.C.; Cogolludo, A.; Jimenez, R.; Moreno, L.; Romero, M.; Tamargo, J.; Perez- Vizcaino, F.; Duarte, J. Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. J. Nutr., 2007, 137, 910-915.
78. Jochmann, N.; Lorenz, M.; von Krosigk, A,; Martus, P.; Bohm, V.; Baumann, G.; Stangl, K.; Stangl, V. The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Br. J. Nutr., 2008, 99, 863-868.
79. Do, G.M.; Kwon, E.Y.; Kim, H.J.; Jeon. S.M.; Ha, TY.; Park, T.; Choi, M.S. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem. Biophys. Res. Commun., 2008, 374, 55-59.
80. Kurosawa, T.; Itoh, F.; Nozaki, A.; Nakano, Y.; Katsuda, S.; Osakabe, N.; Tsubone, H.; Kondo, K.; Itakura, H. Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. J. Atheroscler. Thromb., 2005, 12, 20-28.
81. Breen, D.M.; Dolinsky, V.W.; Zhang, H.; Ghanim, H.; Guo, J.; Mroziewicz, M.; Tsiani, E.L.; Bendeck, M.P.; Dandona, P.; Dyck, J.R.; Heximer, S.P.; Giacca, A. Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism. Atherosclerosis., 2012, 222, 375-381.
82. Khandelwal, A.R.; Hebert, V.Y.; Kleinedler, J.J.; Rogers, L.K.; Ullevig, S.L.; Asmis, R.; Shi, R.; Dugas, T.R. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J. Nutr., 2012, 142, 1487-1494.
83. Daleprane, J.B.; FreitasVda, S.; Pacheco, A.; Rudnicki, M.; Faine, L.A.; D?r, F.A.; Ikegaki, M.; Salazar, L.A.; Ong, T.P.; Abdalla, D.S. Anti-atherogenic and anti-angiogenic activities of polyphenols from propolis. J. Nutr. Biochem., 2012, 23, 557-566.
84. Zhai, X.; Chi, J.; Tang, W.; Ji, Z.; Zhao, F.; Jiang, C.; Lv, H.; Guo, H. Yellow wine polyphenolic compounds inhibit matrix metalloproteinase-2, -9 expression and improve atherosclerotic plaque in LDL-receptor-knockout mice. J. Pharmacol. Sci., 2014, 125, 132-141.
85. Schueller K1, Pignitter M1, Somoza V1. Sulfated and glucuronated trans-resveratrol metabolites regulate chemokines and sirtuin-1 expression in U-937 macrophages. J. Agric. Food Chem., 2015, 63, 6535-6545.
86. Wenzel, E.; Somoza, V. Metabolism and bioavailability of trans-resveratrol. Mo. Nutr. Food Res. 2005, 49, 472-481.
87. Sesso, H.D.; Gaziano, J.M.; Liu, S.; Buring, J.E. Flavonoid intake and the risk of cardiovascular disease in women. Am. J. Clin. Nutr. 2003, 77, 1400-8.
88. Lin, J.; Rexrode, K.M.; Hu, F.; Albert, C.M.; Chae, C.U.; Rimm, E.B.; Stampfer, M.J.; Manson, J.E. Dietary intakes of flavonols and flavones and coronary heart disease in US women. Am. J. Epidemiol., 2007, 165, 1305-1313.
89. Hashimoto, M.; Kim, S.; Eto, M.; Iijima, K.; Ako, J.; Yoshizumi, M.; Akishita, M.; Kondo, K.; Itakura, H.; Hosoda, K.; Toba, K.; Ouchi, Y. Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery. Am. J. Cardiol., 2001, 88, 1457-60, A9.
90. Heiss, C.; Kleinbongard, P.; Dejam, A.; Perre, S.; Schroeter, H.; Sies, H.; Kelm, M. Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J. Am. Coll. Cardiol., 2005, 46, 1276-1283.
91. Faridi, Z.; Njike, V.Y.; Dutta, S.; Ali, A.; Katz, D.L. Acute dark chocolate and cocoa ingestion and endothelial function: A randomized controlled crossover trial. Am. J. Clin. Nutr., 2008, 88, 58-63.
92. Andriantsitohaina, R.; Auger, C.; Chataigneau, T.; Tienne- Selloum, N.; Li H.; Martez, M.C; Schini-Kerth, V.B.; Laher I.; Molecular mechanisms of the cardiovascular protective effects of polyphenols. Br. J. Nutr., 2012, 108, 1532-1549.
93. Duthie, G.G.; Pedersen, M.W.; Gardner, P.T.; Morrice, P.C.; Jenkinson, A.M.; McPhail, D.B.; Steele, G.M. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur. J. Clin. Nutr., 1998, 52, 733-736.
94. Huang, P.H.; Chen, Y.H.; Tsai, H.Y.; Chen, J.S.; Wu, T.C.; Lin, F.Y.; Sata, M.; Chen, J.W.; Lin, S.J. Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells byenhancing nitric oxide bioavailability. Arterioscler. Thromb. Vasc. Biol., 2010, 30, 869-77.
95. Matsuo, S.1.; Nakamura, Y.; Takahashi, M.; Ouchi, Y.; Hosoda, K.; Nozawa, M.; Kinoshita, M. Effect of red wine and ethanol on production of nitric oxide in healthy subjects. Am J Cardiol., 2001, 87, 1029-31.
96. Stewart, L.K.; Soileau, J.L.; Ribnicky, D.; Wang, Z.Q.; Raskin, I.; Poulev, A.; Majewski, M.; Cefalu, W.T.; Gettys, T.W. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism, 2008, 57, S39-46.
97. Dias, A.S.; Porawski, M.; Alonso, M.; Marroni, N.; Collado, P.S.; Gonz?ez-Gallego, J. Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J. Nutr., 2005, 135, 2299-2304.
98. Atteritano, M.; Marini, H.; Minutoli, L.; Polito, F.; Bitto, A.; Altavilla, D.; Mazzaferro, S.; D'Anna, R.; Cannata, M.L.; Gaudio, A.; Frisina, A.; Frisina, N.; Corrado, F.; Cancellieri, F.; Lubrano, C.; Bonaiuto, M.; Adamo, E.B.; Squadrito, F. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J. Clin. Endocrinol. Metab., 2007, 92, 3068-3075.
99. Basu, A.; Fu, D.X.; Wilkinson, M.; Simmons, B.; Wu, M.; Betts, N.M.; Du, M.; Lyons, T.J. Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome. Nutr. Res., 2010, 30, 462-469.
100. Rosa, F.T.; Zulet, M.?.; Marchini, J.S.; Mart?ez, J.A. Bioactive compounds with effects on inflammation markers in humans. Int. J. Food Sci. Nutr., 2012, 63, 749-765.
101. Gresele, P.; Pignatelli, P.; Guglielmini, G. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. J Nutr., 2008, 138, 1602-1608.
102. Casta?r, O.; Covas, M.I.; Khymenets, O.; Nyyssonen, K.; Konstantinidou, V.; Zunft, H.F.; de la Torre, R.; Mu?z- Aguayo, D.; Vila, J.; Fit? M. Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans. Am. J. Clin. Nutr., 2012, 95, 1238-1244.
103. Luomala, M.; Laaksonen, R.; Janatuinen, T.; Vesalainen, R.; Nuutila, P.; Saarela, M.; Mattila, K.; Kalij?vi, M.; Solakivi, T.; Knuuti, J.; Hurme, M.; Lehtim?i, T. High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men. Scand. J. Clin. Lab. Invest., 2007, 67, 115-122.
104. Botden, I.P.; Draijer, R.; Westerhof, B.E.; Rutten, J.H.; Langendonk, J.G.; Sijbrands, E.J.; Danser, A.H.; Zock, P.L.; van den Meiracker, A.H. Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension. Am. J. Hypertens., 2012, 25, 718-723.
105. Ras, R.T.; Zock, P.L.; Zebregs, Y.E.; Johnston, N.R.; Webb, D.J.; Draijer, R. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br. J. Nutr., 2013, 110, 2234-2241.
106. Hodgson, J.M.; Croft, K.D.; Woodman, R.J.; Puddey, I.B.; Bondonno, C.P.; Wu, J.H.; Beilin, L.J.; Lukoshkova, E.V.; Head, G.A.; Ward, N.C. Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised controlled trials. Br. J. Nutr., 2014, 112, 1551-1561.