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Volumn 79, Issue 9-10, 1999, Pages 1340-1346

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

Author keywords

CYP1A1; DMBA; EROD; Flavonoid; Galangin

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; DIMETHYLBENZ[A]ANTHRACENE; ETHOXYRESORUFIN DEETHYLASE; FLAVONOID; GALANGIN;

EID: 0033014568     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690216     Document Type: Article
Times cited : (138)

References (44)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 2
    • 0019364430 scopus 로고
    • Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids
    • Buening M, Chan R, Huang M, Fortner J, Wood A and Conney A (1981) Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids. Cancer Res 41: 67-72
    • (1981) Cancer Res , vol.41 , pp. 67-72
    • Buening, M.1    Chan, R.2    Huang, M.3    Fortner, J.4    Wood, A.5    Conney, A.6
  • 3
    • 0030589078 scopus 로고    scopus 로고
    • Comparative effects of flavonoids and model inducers on drug metabolizing enzymes in rat liver
    • Canivene-Lavier M, Vernevaut M, Totis M, Siess M, Magdalou J and Suschetet M (1996) Comparative effects of flavonoids and model inducers on drug metabolizing enzymes in rat liver. Toxicology 114: 19-27
    • (1996) Toxicology , vol.114 , pp. 19-27
    • Canivene-Lavier, M.1    Vernevaut, M.2    Totis, M.3    Siess, M.4    Magdalou, J.5    Suschetet, M.6
  • 4
    • 0028328463 scopus 로고
    • 450-EF in response to 2,3,7,8-cells, tetrachkmxlibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cell
    • 450-EF in response to 2,3,7,8-cells, tetrachkmxlibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cell. Carcinogenesis 15: 725-732
    • (1994) Carcinogenesis , vol.15 , pp. 725-732
    • Christou, M.1    Savas, U.2    Spink, D.3    Gierthy, J.4    Jefcoate, C.5
  • 6
    • 0028172728 scopus 로고
    • Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism
    • Critchfield J, Welsh C, Phang J and Yeh G (1994) Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism. Biochem Pharmacol 48: 1437-1445
    • (1994) Biochem Pharmacol , vol.48 , pp. 1437-1445
    • Critchfield, J.1    Welsh, C.2    Phang, J.3    Yeh, G.4
  • 7
    • 0030945675 scopus 로고    scopus 로고
    • Molecular mechanisms in the antiproliferative action of quercetin
    • Csokay B, Prajda N, Weber G and Olah E (1997) Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 60: 2157-2163
    • (1997) Life Sci , vol.60 , pp. 2157-2163
    • Csokay, B.1    Prajda, N.2    Weber, G.3    Olah, E.4
  • 8
    • 0028946536 scopus 로고
    • DNA adducts of chemical carcinogens
    • Dipple A (1995) DNA adducts of chemical carcinogens. Carcinogenesis 16: 437-441
    • (1995) Carcinogenesis , vol.16 , pp. 437-441
    • Dipple, A.1
  • 9
    • 0028978209 scopus 로고
    • Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells
    • Dohr O, Vogel C and Abel J (1995) Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells. Arch Biochem Biophys 321: 405-412
    • (1995) Arch Biochem Biophys , vol.321 , pp. 405-412
    • Dohr, O.1    Vogel, C.2    Abel, J.3
  • 10
    • 0030022005 scopus 로고    scopus 로고
    • Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention
    • Eaton E, Walle U, Lewis A, Hudson T, Wilson A and Walle T (1996) Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention. Drug Metab Dispo 24: 232-237
    • (1996) Drug Metab Dispo , vol.24 , pp. 232-237
    • Eaton, E.1    Walle, U.2    Lewis, A.3    Hudson, T.4    Wilson, A.5    Walle, T.6
  • 11
    • 0029610477 scopus 로고
    • Review of the biology of quercetin and related bioflavonoids
    • Formica J and Regelson W (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33: 1061-1080
    • (1995) Food Chem Toxicol , vol.33 , pp. 1061-1080
    • Formica, J.1    Regelson, W.2
  • 12
    • 0030775534 scopus 로고    scopus 로고
    • Absorption, metabolism and health effects of dietary flavonoids in man
    • Hollman P and Katan M (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 51: 305-310
    • (1997) Biomed Pharmacother , vol.51 , pp. 305-310
    • Hollman, P.1    Katan, M.2
  • 13
    • 0031613667 scopus 로고    scopus 로고
    • Bioavailability and health effects of dietary flavonols in man
    • Hollman P and Katan M (1998) Bioavailability and health effects of dietary flavonols in man. Arch Toxicol Suppl 20: 237-249
    • (1998) Arch Toxicol Suppl , vol.20 , pp. 237-249
    • Hollman, P.1    Katan, M.2
  • 14
    • 0030891773 scopus 로고    scopus 로고
    • Bioavailability of the dietary antioxidant flavonol quercetin in man
    • Hollman P, van Trijp J. Mengelers M, de Vries J and Katan M (1997) Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett 114: 139-140
    • (1997) Cancer Lett , vol.114 , pp. 139-140
    • Hollman, P.1    Van Trijp, J.2    Mengelers, M.3    De Vries, J.4    Katan, M.5
  • 15
    • 0000468691 scopus 로고
    • Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression
    • Huggins C, Grand L and Brillantes F (1961) Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression. Nature 189: 204-207
    • (1961) Nature , vol.189 , pp. 204-207
    • Huggins, C.1    Grand, L.2    Brillantes, F.3
  • 16
    • 0027457434 scopus 로고
    • Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation
    • Jellinck P, Forkert P, Riddick D, Okey A, Michnovicz J and Bradlow H (1993) Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol 45: 1129-1136
    • (1993) Biochem Pharmacol , vol.45 , pp. 1129-1136
    • Jellinck, P.1    Forkert, P.2    Riddick, D.3    Okey, A.4    Michnovicz, J.5    Bradlow, H.6
  • 17
    • 0031915796 scopus 로고    scopus 로고
    • Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study
    • Kao Y, Zhou C, Sherman M, Laughton C and Chen S (1998) Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: a site-directed mutagenesis study. Environ Health Perspect 106: 85-92
    • (1998) Environ Health Perspect , vol.106 , pp. 85-92
    • Kao, Y.1    Zhou, C.2    Sherman, M.3    Laughton, C.4    Chen, S.5
  • 18
    • 0027943307 scopus 로고
    • 450 1A catalytic activity and total protein concentration with a fluorescence plate reader
    • 450 1A catalytic activity and total protein concentration with a fluorescence plate reader. Anal Biochem 222: 217-223
    • (1994) Anal Biochem , vol.222 , pp. 217-223
    • Kennedy, S.1    Jones, S.2
  • 19
    • 0030918880 scopus 로고    scopus 로고
    • Antioxidant activity of polyphenolics in diets. Rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen
    • Kono Y, Kobayashi K, Tagawa S, Adachi K, Ueda A, Sawa Y and Shibata H (1997) Antioxidant activity of polyphenolics in diets. Rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen. Biochim Biophys Acta 1335: 335-342
    • (1997) Biochim Biophys Acta , vol.1335 , pp. 335-342
    • Kono, Y.1    Kobayashi, K.2    Tagawa, S.3    Adachi, K.4    Ueda, A.5    Sawa, Y.6    Shibata, H.7
  • 20
    • 0016906546 scopus 로고
    • The flavonoids. A class of semi-essential food components: Their role in human nutrition
    • Kuhnau J (1976) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 24: 117-191
    • (1976) World Rev Nutr Diet , vol.24 , pp. 117-191
    • Kuhnau, J.1
  • 22
    • 0032100577 scopus 로고    scopus 로고
    • Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: Role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism
    • Larsen MC, Angus WG, Brake PB, Eltom SE, Sukow KA and Jefcoate CR (1998) Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Cancer Res 58: 2366-2374
    • (1998) Cancer Res , vol.58 , pp. 2366-2374
    • Larsen, M.C.1    Angus, W.G.2    Brake, P.B.3    Eltom, S.E.4    Sukow, K.A.5    Jefcoate, C.R.6
  • 23
    • 0028068634 scopus 로고
    • 450-dependent activity (pentoxyresorufin-O-deethylase and ethoxyresorufin-O-deethylase)
    • 450-dependent activity (pentoxyresorufin-O-deethylase and ethoxyresorufin-O-deethylase). In Vitro Toxicol 7: 13-23
    • (1994) In Vitro Toxicol , vol.7 , pp. 13-23
    • Luhinski, J.1    Flint, O.2    Durham, S.3
  • 25
    • 0024284028 scopus 로고
    • A simple salting out procedure for extracting DNA from human nucleated cells
    • Miller S, Dykes D and Polesky H (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215
    • (1988) Nucleic Acids Res , vol.16 , pp. 1215
    • Miller, S.1    Dykes, D.2    Polesky, H.3
  • 26
    • 0030457644 scopus 로고    scopus 로고
    • The effect of propolis and its components on eicosanoid production during the inflammatory response
    • Mirzoeva O and Calder P (1996) The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids 55: 441-449
    • (1996) Prostaglandins Leukot Essent Fatty Acids , vol.55 , pp. 441-449
    • Mirzoeva, O.1    Calder, P.2
  • 27
    • 0031913738 scopus 로고    scopus 로고
    • Inhibition of 7-ethoxycoumarin O-deethylase activity in rat liver microsomes by naturally occurring flavonoids: Structure-activity relationships
    • Moon JY, Lee DW and Park KH (1998) Inhibition of 7-ethoxycoumarin O-deethylase activity in rat liver microsomes by naturally occurring flavonoids: structure-activity relationships. Xenabiotica 28: 117-126
    • (1998) Xenabiotica , vol.28 , pp. 117-126
    • Moon, J.Y.1    Lee, D.W.2    Park, K.H.3
  • 28
    • 0028180131 scopus 로고
    • Benzolalpyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone
    • Moore M, Wang X, Lu Y, Wormke M, Craig A, Gerlach J, Burghardt R, Barhoumi R and Safe S (1994) Benzolalpyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone. J Biol Chem 269: 11751-11759
    • (1994) J Biol Chem , vol.269 , pp. 11751-11759
    • Moore, M.1    Wang, X.2    Lu, Y.3    Wormke, M.4    Craig, A.5    Gerlach, J.6    Burghardt, R.7    Barhoumi, R.8    Safe, S.9
  • 30
    • 0031284745 scopus 로고    scopus 로고
    • Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system
    • Noda Y, Anzai K, Mori A, Kohno M, Shinmei M and Packer (1997) Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system. Biochem Mol Biol Int 42: 35-44
    • (1997) Biochem Mol Biol Int , vol.42 , pp. 35-44
    • Noda, Y.1    Anzai, K.2    Mori, A.3    Kohno, M.4    Shinmei, M.5    Packer, L.6
  • 31
    • 0023078285 scopus 로고
    • Identification of regulatory elements of cloned genes with functional assays
    • Rosenthal N (1987) Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol 152: 704
    • (1987) Methods Enzymol , vol.152 , pp. 704
    • Rosenthal, N.1
  • 32
    • 0030888748 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated signal transduction
    • Rowlands J and Gustafsson J (1997) Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 27: 109-134
    • (1997) Crit Rev Toxicol , vol.27 , pp. 109-134
    • Rowlands, J.1    Gustafsson, J.2
  • 33
    • 0025367455 scopus 로고
    • Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
    • Rubinstein L, Shoemaker R, Paull K, Simon R, Tosin S, Skehan P, Scudiero D, Monks A and Boyd M (1990) Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 82: 113-118
    • (1990) J Natl Cancer Inst , vol.82 , pp. 113-118
    • Rubinstein, L.1    Shoemaker, R.2    Paull, K.3    Simon, R.4    Tosin, S.5    Skehan, P.6    Scudiero, D.7    Monks, A.8    Boyd, M.9
  • 35
    • 0028842375 scopus 로고
    • Heterogenous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes
    • Siess M, Leclerc J, Canivenc-Lavier M, Rat P and Suschetet M (1995) Heterogenous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes. Toxicol Appl Pharmacol 130: 73-78
    • (1995) Toxicol Appl Pharmacol , vol.130 , pp. 73-78
    • Siess, M.1    Leclerc, J.2    Canivenc-Lavier, M.3    Rat, P.4    Suschetet, M.5
  • 36
    • 0029781370 scopus 로고    scopus 로고
    • Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices
    • So F, Guthrie N, Chambers A, Moussa M and Carroll K (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 26: 167-181
    • (1996) Nutr Cancer , vol.26 , pp. 167-181
    • So, F.1    Guthrie, N.2    Chambers, A.3    Moussa, M.4    Carroll, K.5
  • 37
    • 0031590969 scopus 로고    scopus 로고
    • Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen
    • So F, Guthrie N, Chambers A and Carroll K (1997) Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Lett 127-133
    • (1997) Cancer Lett , pp. 127-133
    • So, F.1    Guthrie, N.2    Chambers, A.3    Carroll, K.4
  • 39
    • 0021813176 scopus 로고
    • 450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin
    • 450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin. Arch Biochem Biophys 240: 345-357
    • (1985) Arch Biochem Biophys , vol.240 , pp. 345-357
    • Sousa, R.1    Marletta, M.2
  • 40
    • 0030411296 scopus 로고    scopus 로고
    • Vegetables, fruit, and cancer prevention: A review
    • Steinmetz K and Potler (1996) Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96: 1027-1039
    • (1996) J Am Diet Assoc , vol.96 , pp. 1027-1039
    • Steinmetz, K.1    Potler, J.2
  • 42
    • 0023681264 scopus 로고    scopus 로고
    • Inhibition of 7,12-dimethylbenz-[a]-anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin
    • Verma A, Johnson J, Gould M and Tanner M (1998) Inhibition of 7,12-dimethylbenz-[a]-anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Rev 49: 5754-5758
    • (1998) Cancer Rev , vol.49 , pp. 5754-5758
    • Verma, A.1    Johnson, J.2    Gould, M.3    Tanner, M.4
  • 43
    • 58149209724 scopus 로고
    • Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines
    • Wang X, Thomsen J, Santostefano M, Rosengren R, Safe S and Perdew G (1995) Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines. Eur J Pharmacol 293: 191-205
    • (1995) Eur J Pharmacol , vol.293 , pp. 191-205
    • Wang, X.1    Thomsen, J.2    Santostefano, M.3    Rosengren, R.4    Safe, S.5    Perdew, G.6
  • 44
    • 0021934758 scopus 로고
    • Chemoprevention of cancer
    • Wattenberg L (1985) Chemoprevention of cancer. Cancer Res 45: 1-8
    • (1985) Cancer Res , vol.45 , pp. 1-8
    • Wattenberg, L.1


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