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Volumn 135, Issue 10, 2005, Pages 2299-2304

Quercetin decreases oxidative stress, NF-κB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats

Author keywords

Diabetes; Nitric oxide; Nuclear factor B; Oxidative stress; Quercetin

Indexed keywords

BIOLOGICAL MARKER; CATALASE; GLUCOSE; GLUTATHIONE PEROXIDASE; HYDROPEROXIDE; I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; QUERCETIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

EID: 26444581298     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.10.2299     Document Type: Article
Times cited : (277)

References (64)
  • 1
    • 0033980885 scopus 로고    scopus 로고
    • Oxidative stress and glycemic regulation
    • Ceriello A. Oxidative stress and glycemic regulation. Metabolism. 2000;49:27-9.
    • (2000) Metabolism , vol.49 , pp. 27-29
    • Ceriello, A.1
  • 2
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-20.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 3
    • 0142029557 scopus 로고    scopus 로고
    • Chemical modification of protein by lipids in diabetes
    • Baynes W. Chemical modification of protein by lipids in diabetes. Clin Chem Lab Med. 2003;41:1159-65.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1159-1165
    • Baynes, W.1
  • 4
    • 0023259759 scopus 로고
    • Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes
    • Wolff SP, Dean RT. Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes. Biochem J. 1987;245:243-50.
    • (1987) Biochem J , vol.245 , pp. 243-250
    • Wolff, S.P.1    Dean, R.T.2
  • 5
    • 0025853670 scopus 로고
    • Protein glycation and oxidative stress in diabetes mellitus and ageing
    • Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med. 1991;10:339-52.
    • (1991) Free Radic Biol Med , vol.10 , pp. 339-352
    • Wolff, S.P.1    Jiang, Z.Y.2    Hunt, J.V.3
  • 6
    • 0027384310 scopus 로고
    • Effect of fatty acids on energy coupling processes in mitochondria
    • Wojtczak L, Schonfeld P. Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta. 1993;1183:41-57.
    • (1993) Biochim Biophys Acta , vol.1183 , pp. 41-57
    • Wojtczak, L.1    Schonfeld, P.2
  • 7
    • 8644267972 scopus 로고    scopus 로고
    • Hyperglycemia-induced oxidative stress in diabetic complications
    • King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol. 2004;122:333-8.
    • (2004) Histochem Cell Biol , vol.122 , pp. 333-338
    • King, G.L.1    Loeken, M.R.2
  • 8
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress-activated signaling pathways: A unifying hypothesis type 2 diabetes
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress-activated signaling pathways: a unifying hypothesis type 2 diabetes. Endocr Rev. 2002;23:599-622.
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 9
    • 0035988181 scopus 로고    scopus 로고
    • Vascular targets off redox signaling in diabetes mellitus
    • Spitaler MM, Graier WF. Vascular targets off redox signaling in diabetes mellitus. Diabetologia. 2002;45:476-94.
    • (2002) Diabetologia , vol.45 , pp. 476-494
    • Spitaler, M.M.1    Graier, W.F.2
  • 10
    • 0142055950 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular injury. I. Basic mechanisms and in vivo monitoring of ROS
    • Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury. I. Basic mechanisms and in vivo monitoring of ROS. Circulation. 2003;108:1912-6.
    • (2003) Circulation , vol.108 , pp. 1912-1916
    • Griendling, K.K.1    FitzGerald, G.A.2
  • 11
    • 3242738667 scopus 로고    scopus 로고
    • Role of free radicals and reactive nitrogen species in the late complications of diabetes mellitus in rats
    • Stadler K, Jenei V, von Bolcshazy G, Somogyi A, Jakus J. Role of free radicals and reactive nitrogen species in the late complications of diabetes mellitus in rats. Orv Hetil. 2004;145:1135-40.
    • (2004) Orv Hetil , vol.145 , pp. 1135-1140
    • Stadler, K.1    Jenei, V.2    Von Bolcshazy, G.3    Somogyi, A.4    Jakus, J.5
  • 12
    • 0035702761 scopus 로고    scopus 로고
    • Antioxidant vitamins and prevention of cardiovascular disease: Epidemiological and clinical trial data
    • Marchioli R, Scweiger C, Levantesi G, Gavazzi L, Valagussa F. Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids. 2001;36:S53-65.
    • (2001) Lipids , vol.36
    • Marchioli, R.1    Scweiger, C.2    Levantesi, G.3    Gavazzi, L.4    Valagussa, F.5
  • 13
    • 0034619027 scopus 로고    scopus 로고
    • Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE) randomized placebo-controlled trial
    • Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Iaina A, Knecht A, Weissgarten Y, Brunner D, et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE) randomized placebo-controlled trial. Lancet. 2000;356:1213-8.
    • (2000) Lancet , vol.356 , pp. 1213-1218
    • Boaz, M.1    Smetana, S.2    Weinstein, T.3    Matas, Z.4    Gafter, U.5    Iaina, A.6    Knecht, A.7    Weissgarten, Y.8    Brunner, D.9
  • 14
    • 0034792627 scopus 로고    scopus 로고
    • Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in type 2 diabetic patients
    • Gaede P, Poulsen HE, Parving HH, Pedersen O. Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in type 2 diabetic patients. Diabet Med. 2001;18:756-60.
    • (2001) Diabet Med , vol.18 , pp. 756-760
    • Gaede, P.1    Poulsen, H.E.2    Parving, H.H.3    Pedersen, O.4
  • 15
    • 0036834582 scopus 로고    scopus 로고
    • Effects of vitamin E on cardiovascular and microvascular outcomes in high risk patients with diabetes: Results of the HOPE study and MICRO-HOPE substudy
    • Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zimman B, Bosch J, Dagenais G, Mann J, Gerstein H. C. Effects of vitamin E on cardiovascular and microvascular outcomes in high risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care. 2002;25:1919-27.
    • (2002) Diabetes Care , vol.25 , pp. 1919-1927
    • Lonn, E.1    Yusuf, S.2    Hoogwerf, B.3    Pogue, J.4    Yi, Q.5    Zimman, B.6    Bosch, J.7    Dagenais, G.8    Mann, J.9    Gerstein, H.C.10
  • 16
    • 0030021661 scopus 로고    scopus 로고
    • Potential health effects of the dietary flavonol quercetin
    • Hertog MGL, Hollman PCH. Potential health effects of the dietary flavonol quercetin. Eur J Clin Nutr. 1996;50:63-71.
    • (1996) Eur J Clin Nutr , vol.50 , pp. 63-71
    • Hertog, M.G.L.1    Hollman, P.C.H.2
  • 18
    • 0031876672 scopus 로고    scopus 로고
    • Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: An experimental study
    • Huk I, Brovkovich V, Nanobash V, Weigel G, Neumayer C, Partyka L. Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia-reperfusion injury: an experimental study. Br J Surg. 1998;85:1080-5.
    • (1998) Br J Surg , vol.85 , pp. 1080-1085
    • Huk, I.1    Brovkovich, V.2    Nanobash, V.3    Weigel, G.4    Neumayer, C.5    Partyka, L.6
  • 19
    • 0034706914 scopus 로고    scopus 로고
    • The protective effect of flavonol quercetin against ultraviolet A induced oxidative stress in rats
    • Erden Inal M, Kahraman A. The protective effect of flavonol quercetin against ultraviolet A induced oxidative stress in rats. Toxicology. 2000;54:21-9.
    • (2000) Toxicology , vol.54 , pp. 21-29
    • Erden Inal, M.1    Kahraman, A.2
  • 22
    • 0035979306 scopus 로고    scopus 로고
    • Effects of Gingko biloba extract (Egb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide
    • Wadsworth TL, Koop DR. Effects of Gingko biloba extract (Egb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem Biol Interact. 2001;137:43-58.
    • (2001) Chem Biol Interact , vol.137 , pp. 43-58
    • Wadsworth, T.L.1    Koop, D.R.2
  • 23
    • 0035964450 scopus 로고    scopus 로고
    • Resvetatrol and quercetin inhibit angiogenesis in vitro
    • Igura K, Ohta T, Kuroda Y, Kaji K. Resvetatrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001;171:11-6.
    • (2001) Cancer Lett , vol.171 , pp. 11-16
    • Igura, K.1    Ohta, T.2    Kuroda, Y.3    Kaji, K.4
  • 24
    • 0033862118 scopus 로고    scopus 로고
    • Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon
    • Yang K, Lamprecht SA, Liu Y, Shinozaki H, Fan K, Leung D. Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon. Carcinogenesis 2000;21:1655-60.
    • (2000) Carcinogenesis , vol.21 , pp. 1655-1660
    • Yang, K.1    Lamprecht, S.A.2    Liu, Y.3    Shinozaki, H.4    Fan, K.5    Leung, D.6
  • 27
    • 1642323567 scopus 로고    scopus 로고
    • Quercetin alleviates oxidative stress in streptozotocin-induced diabetic rats
    • Mahesh T, Menom VP. Quercetin alleviates oxidative stress in streptozotocin-induced diabetic rats. Phytother Res. 2004;18:123-7.
    • (2004) Phytother Res , vol.18 , pp. 123-127
    • Mahesh, T.1    Menom, V.P.2
  • 28
    • 11144328863 scopus 로고    scopus 로고
    • Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas
    • Coskum O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res. 2005;51:117-23.
    • (2005) Pharmacol Res , vol.51 , pp. 117-123
    • Coskum, O.1    Kanter, M.2    Korkmaz, A.3    Oter, S.4
  • 29
    • 0242352418 scopus 로고    scopus 로고
    • Increased nitric oxide levels as an early sign of premature aging in diabetes
    • Stadler K, Jenei V, Bolcshazy G, Somogyi A, Jakus J. Increased nitric oxide levels as an early sign of premature aging in diabetes. Free Radic Biol Med. 2003;35:1240-51.
    • (2003) Free Radic Biol Med , vol.35 , pp. 1240-1251
    • Stadler, K.1    Jenei, V.2    Bolcshazy, G.3    Somogyi, A.4    Jakus, J.5
  • 30
    • 4644305395 scopus 로고    scopus 로고
    • Effect of vitamin E supplementation on oxidative stress in streptozotocin induced diabetic rats: Investigation of liver and plasma
    • Seven A, Guzel S, Seymen O, Civelek S, Bolayirh M, Uncu M, Burcak G. Effect of vitamin E supplementation on oxidative stress in streptozotocin induced diabetic rats: investigation of liver and plasma. Yonsei Med J. 2004;45:703-10.
    • (2004) Yonsei Med J , vol.45 , pp. 703-710
    • Seven, A.1    Guzel, S.2    Seymen, O.3    Civelek, S.4    Bolayirh, M.5    Uncu, M.6    Burcak, G.7
  • 32
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95;351-8.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 33
    • 0026064054 scopus 로고
    • Hydroperoxide-initiated chemiluminescence: An assay for oxidative stress in biopsies of liver, heart, and muscle
    • González-Flecha B, Llesuy S, Boveris A. Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of liver, heart, and muscle. Free Radic Biol Med. 1991;10:41-7.
    • (1991) Free Radic Biol Med , vol.10 , pp. 41-47
    • González-Flecha, B.1    Llesuy, S.2    Boveris, A.3
  • 34
    • 77957006400 scopus 로고
    • Assays of catalases and peroxidases
    • Chance B, Machley AL. Assays of catalases and peroxidases. Methods Enzymol. 1995;2:764-75.
    • (1995) Methods Enzymol , vol.2 , pp. 764-775
    • Chance, B.1    Machley, A.L.2
  • 36
    • 0015523099 scopus 로고
    • The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase
    • 1972
    • Misra HP, Fridovich I. (1972) The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170-5.
    • (1972) J Biol Chem , vol.247 , pp. 3170-3175
    • Misra, H.P.1    Fridovich, I.2
  • 37
    • 0030584781 scopus 로고    scopus 로고
    • Endotoxin-induced activation of the nuclear transcription factor NF-κB in hepatocytes, Kupffer cells and endothelial cells in vivo
    • Essani NA, McGuire GM, Manning AM, Jaeschke H. Endotoxin-induced activation of the nuclear transcription factor NF-κB in hepatocytes, Kupffer cells and endothelial cells in vivo. J Immunol. 1996;156:2956-63.
    • (1996) J Immunol , vol.156 , pp. 2956-2963
    • Essani, N.A.1    McGuire, G.M.2    Manning, A.M.3    Jaeschke, H.4
  • 38
    • 0031771998 scopus 로고    scopus 로고
    • Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: Effect of DL-α-lipoic acid
    • Obrosova I, Cao X, Greene DA, Stevens MJ. Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-α-lipoic acid. Diabetologia. 1998;41:1442-50.
    • (1998) Diabetologia , vol.41 , pp. 1442-1450
    • Obrosova, I.1    Cao, X.2    Greene, D.A.3    Stevens, M.J.4
  • 39
    • 0037707713 scopus 로고    scopus 로고
    • Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetics rats
    • Maritim AC, Sanders RA, Watkins III JB. Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetics rats. J Nutr Biochem. 2003;14:288-94.
    • (2003) J Nutr Biochem , vol.14 , pp. 288-294
    • Maritim, A.C.1    Sanders, R.A.2    Watkins III, J.B.3
  • 40
    • 5044245855 scopus 로고    scopus 로고
    • Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver
    • Yilmaz HR, Uz E, Yucel N, Altuntas I, Ozcelik N. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxicol. 2004;18:234-8.
    • (2004) J Biochem Mol Toxicol , vol.18 , pp. 234-238
    • Yilmaz, H.R.1    Uz, E.2    Yucel, N.3    Altuntas, I.4    Ozcelik, N.5
  • 41
    • 0036155267 scopus 로고    scopus 로고
    • Alteration of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract
    • Cho SY, Park JY, Park EM, Choi MS, Lee MK, Jeon SM, Jang MK, Kim MJ, Park YB. Alteration of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract. Clin Chim Acta. 2002;317:109-17.
    • (2002) Clin Chim Acta , vol.317 , pp. 109-117
    • Cho, S.Y.1    Park, J.Y.2    Park, E.M.3    Choi, M.S.4    Lee, M.K.5    Jeon, S.M.6    Jang, M.K.7    Kim, M.J.8    Park, Y.B.9
  • 43
    • 0023576328 scopus 로고
    • Alterations in free radical tissue-defense mechanisms in streptozotocin-induced diabetes in rat. Effects of insulin treatment
    • Wahaieb SA, Godin DV. Alterations in free radical tissue-defense mechanisms in streptozotocin-induced diabetes in rat. Effects of insulin treatment. Diabetes. 1987;36:1014-8.
    • (1987) Diabetes , vol.36 , pp. 1014-1018
    • Wahaieb, S.A.1    Godin, D.V.2
  • 44
    • 0034477316 scopus 로고    scopus 로고
    • The effect of dietary treatment on erythrocyte lipid peroxidation, superoxide dismutase and glutathione peroxidase, and serum lipid peroxidation in patients with type 2 diabetes mellitus
    • Sekeroglu MR, Sahin H, Dulger H, Algun E. The effect of dietary treatment on erythrocyte lipid peroxidation, superoxide dismutase and glutathione peroxidase, and serum lipid peroxidation in patients with type 2 diabetes mellitus. Clin Biochem. 2000;33:669-74.
    • (2000) Clin Biochem , vol.33 , pp. 669-674
    • Sekeroglu, M.R.1    Sahin, H.2    Dulger, H.3    Algun, E.4
  • 45
    • 0141921796 scopus 로고    scopus 로고
    • Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats
    • Aliciguzel Y, Ozen I, Asian M, Karayalcin U. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. J Lab Clin Med. 2003;142:172-7.
    • (2003) J Lab Clin Med , vol.142 , pp. 172-177
    • Aliciguzel, Y.1    Ozen, I.2    Asian, M.3    Karayalcin, U.4
  • 46
    • 0032878014 scopus 로고    scopus 로고
    • Changes of superoxide dismutase gene expression and activity in the brain of streptozotocin induced diabetic rats
    • Huang WC, Juang SW, Liu IM, Chi TC, Cheng JT. Changes of superoxide dismutase gene expression and activity in the brain of streptozotocin induced diabetic rats. Neurosci Lett. 1999;275:25-8.
    • (1999) Neurosci Lett , vol.275 , pp. 25-28
    • Huang, W.C.1    Juang, S.W.2    Liu, I.M.3    Chi, T.C.4    Cheng, J.T.5
  • 47
    • 0034993878 scopus 로고    scopus 로고
    • Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats
    • Sanders RA, Rauscher FM, Watkins JB. Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2001;15:143-9.
    • (2001) J Biochem Mol Toxicol , vol.15 , pp. 143-149
    • Sanders, R.A.1    Rauscher, F.M.2    Watkins, J.B.3
  • 48
    • 0019833539 scopus 로고
    • Changes in peroxisomal fatty acid oxidation in the diabetic rat liver
    • Horie S, Ishii H, Suga T. Changes in peroxisomal fatty acid oxidation in the diabetic rat liver. J Biochem. 1981;90:1691-6.
    • (1981) J Biochem , vol.90 , pp. 1691-1696
    • Horie, S.1    Ishii, H.2    Suga, T.3
  • 49
    • 0003319715 scopus 로고
    • Effect of plant and animal lesions on superoxide dismutase activities
    • McCord G, Michelson AM, Fridovich I, editors , New York: Academic Press
    • Matkovics B. Effect of plant and animal lesions on superoxide dismutase activities. In: McCord G, Michelson AM, Fridovich I, editors. Superoxide and superoxide dismutase, New York: Academic Press; 1977. p. 501-15.
    • (1977) Superoxide and Superoxide Dismutase , pp. 501-515
    • Matkovics, B.1
  • 51
    • 0032897751 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative stress-sensitive transcription factor NF-κB
    • Hofmann MA, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, et al. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative stress-sensitive transcription factor NF-κB. Diabetologia. 1999;42:222-32.
    • (1999) Diabetologia , vol.42 , pp. 222-232
    • Hofmann, M.A.1    Schiekofer, S.2    Isermann, B.3    Kanitz, M.4    Henkels, M.5    Joswig, M.6    Treusch, A.7    Morcos, M.8    Weiss, T.9
  • 52
    • 0034652424 scopus 로고    scopus 로고
    • A-Phenyl-tert-butylnitroen (PBN) inhibits NF-κB activation offering protection against chemically induced diabetes
    • Ho E, Chen G, Bray TM. A-Phenyl-tert-butylnitroen (PBN) inhibits NF-κB activation offering protection against chemically induced diabetes. Free Radic Biol Med. 2000;28:604-14.
    • (2000) Free Radic Biol Med , vol.28 , pp. 604-614
    • Ho, E.1    Chen, G.2    Bray, T.M.3
  • 53
    • 0142180047 scopus 로고    scopus 로고
    • Diabetes-induced activation of nuclear transcriptional factor in the retin, and its inhibition by antioxidants
    • Kowluru RA, Koppolu P, Chakrabarti S, Chen S. Diabetes-induced activation of nuclear transcriptional factor in the retin, and its inhibition by antioxidants. Free Radic Res. 2003;37:1169-80.
    • (2003) Free Radic Res , vol.37 , pp. 1169-1180
    • Kowluru, R.A.1    Koppolu, P.2    Chakrabarti, S.3    Chen, S.4
  • 54
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
    • Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell. 1997;91:243-52.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 55
    • 0025677250 scopus 로고
    • Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus
    • Staal FJT, Roederer M, Herzenberg LA, Herzeneberg LA. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus. Proc Natl Acad Sci U S A. 1990;87:9943-7.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 9943-9947
    • Staal, F.J.T.1    Roederer, M.2    Herzenberg, L.A.3    Herzeneberg, L.A.4
  • 56
    • 4043109947 scopus 로고    scopus 로고
    • Diverse regulation of NF-κB and peroxisome proliferators-activated receptors in murine non-alcoholic fatty liver
    • Romics L, Kodys K, Dolganiuc A, Graham L, Velayudham A, Mandrekar P, Szabo G. Diverse regulation of NF-κB and peroxisome proliferators- activated receptors in murine non-alcoholic fatty liver. Hepatology. 2004;40:376-85.
    • (2004) Hepatology , vol.40 , pp. 376-385
    • Romics, L.1    Kodys, K.2    Dolganiuc, A.3    Graham, L.4    Velayudham, A.5    Mandrekar, P.6    Szabo, G.7
  • 57
    • 0028035106 scopus 로고
    • The high-output nitric oxide pathway: Role and regulation
    • Xie Q, Nathan C. The high-output nitric oxide pathway: role and regulation. J Leukoc Biol. 1994;56:576-82.
    • (1994) J Leukoc Biol , vol.56 , pp. 576-582
    • Xie, Q.1    Nathan, C.2
  • 58
    • 0032585932 scopus 로고    scopus 로고
    • IKappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporin and quercetin
    • Peet GW, Li J. IKappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporin and quercetin. J Biol Chem. 1999;274:32655-61.
    • (1999) J Biol Chem , vol.274 , pp. 32655-32661
    • Peet, G.W.1    Li, J.2
  • 59
    • 3142564598 scopus 로고    scopus 로고
    • Role of nitric oxide in diabetic nephropathy
    • Prabhakar SS. Role of nitric oxide in diabetic nephropathy. Semin Nephrol. 2004;24:333-44.
    • (2004) Semin Nephrol , vol.24 , pp. 333-344
    • Prabhakar, S.S.1
  • 60
    • 11444256883 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase activity and expression in liver and hepatocytes of diabetic rats
    • Madar Z, Kalet-Litman S, Stark AH. Inducible nitric oxide synthase activity and expression in liver and hepatocytes of diabetic rats. Pharmacology. 2004;73:106-12.
    • (2004) Pharmacology , vol.73 , pp. 106-112
    • Madar, Z.1    Kalet-Litman, S.2    Stark, A.H.3
  • 61
    • 16244394743 scopus 로고    scopus 로고
    • Cardiovascular diseases and the nitric oxide pathway
    • Llorens S, Nava E. Cardiovascular diseases and the nitric oxide pathway. Curr Vasc Pharmacol. 2003;1:335-46.
    • (2003) Curr Vasc Pharmacol , vol.1 , pp. 335-346
    • Llorens, S.1    Nava, E.2
  • 64
    • 84866013013 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005;81:2435-55.
    • (2005) Am J Clin Nutr , vol.81 , pp. 2435-2455
    • Williamson, G.1    Manach, C.2


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