The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide

American Journal of Clinical Nutrition

Volumn 72, Issue 5, 2000, Pages 1150-1155

  Pignatelli, Pasquale ^a   Pulcinelli, Fabio M ^a   Celestini, Andrea ^a   Lenti, Luisa ^a   Ghiselli, Andrea ^a   Gazzaniga, Pier Paolo ^a   Violi, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cardiovascular disease; Catechin; Flavonoids; Hydrogen peroxide; Phospholipase C; Platelet adhesion; Platelet aggregation; Quercetin; Red wine

Indexed keywords

CATECHIN; FLAVONOID; HYDROGEN PEROXIDE; PHOSPHOLIPASE C; QUERCETIN;

ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIETARY INTAKE; HUMAN; HUMAN CELL; NORMAL HUMAN; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; WINE;

EID: 0033753482     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/72.5.1150     Document Type: Article

References (23)

1. Moderate alcohol consumption and coronary artery disease
2. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction
3. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries
4. Platelet inhibition in stenosed canine arteries by quercetin and rutin, polyphenolic flavonoids found in red wine
5. Effect of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: Results from an in vitro and dietary supplement study
6. The red wine phenolics trans-resveretrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease
7. Wines and grape juices as modulators of platelet aggregation in healthy human subjects
8. Flavonoids as antioxidant: Determination of radical-scavenging efficiencies
9. Platelet sequestration in man. I. Methods
10. The aggregation of blood platelets by adenosine diphosphate and its reversal
11. 2+ indicators with greatly improved fluorescence properties
12. 32p-labelled inositol phosphates
13. Determination of platelet adhesion to collagen and the associated formation of phosphatidic acid and calcium mobilization
14. Flow-cytometric characterization of stimulation, free radical formation, peroxidase activity and phagocytosis of human granulocytes with 2,7-dichlorofluorescein (DCF)
15. Hydrogen peroxide is an intermediate in platelet activation cascade triggered by collagen, but not by thrombin
16. Generation of hydrogen peroxide in resting and activated platelets
17. Oxidative metabolism of human platelets
18. Mechanism of platelet shape change, aggregation and release induced by collagen, thrombin or A23187
19. Hydrogen peroxide is involved in collagen-induced platelet activation
20. Vitamin E inhibits collagen-induced platelet activation by blunting hydrogen peroxide
21. Application of a new high-performance liquid chromatographic method for measuring selected polyphenols in human plasma
22. Absorption and disposition kinetics of the dietary antioxidant quercetin in man
23. Increased platelet deposition on atherosclerotic coronary arteries