Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers

Journal of the American College of Cardiology

Volumn 46, Issue 7, 2005, Pages 1276-1283

  Heiss, Christian ^a,c   Kleinbongard, Petra ^a   Dejam, Andrè ^a   Perré, Sandra ^a   Schroeter, Hagen ^b   Sies, Helmut ^a   Kelm, Malte ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVANOL DERIVATIVE; NITRIC OXIDE;

ADULT; ARTICLE; CACAO; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET; DRUG EFFECT; ENDOTHELIUM CELL; ENDOTHELIUM LESION; FEMALE; HUMAN; INGESTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING;

ADULT; BEVERAGES; CACAO; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FLAVONOIDS; HUMANS; MALE; NITRIC OXIDE; SMOKING;

EID: 27744449813     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2005.06.055     Document Type: Article

References (45)

1. D.S. Celermajer, K.E. Sorensen, D. Georgakopoulos Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults Circulation 88 1993 2149 2155
2. J.A. Ambrose, R.S. Barua The pathophysiology of cigarette smoking and cardiovascular disease an update J Am Coll Cardiol 43 2004 1731 1737
3. M. Tsuchiya, A. Asada, E. Kasahara, E.F. Sato, M. Shindo, M. Inoue Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma Circulation 105 2002 1155 1157
4. R. Ross Atherosclerosis - an inflammatory disease N Engl J Med 340 1999 115 126
5. R.F. Furchgott, P.M. Vanhoutte Endothelium-derived relaxing and contracting factors FASEB J 3 1989 2007 2018
6. J.C. Liao, T.W. Hein, M.W. Vaughn, K.T. Huang, L. Kuo Intravascular flow decreases erythrocyte consumption of nitric oxide Proc Natl Acad Sci USA 96 1999 8757 8761
7. T. Rassaf, N.S. Bryan, M. Kelm, M. Feelisch Concomitant presence of N-nitroso and S-nitroso proteins in human plasma Free Radic Biol Med 33 2002 1590 1596
8. J.S. Stamler, O. Jaraki, J. Osborne Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin Proc Natl Acad Sci USA 89 1992 7674 7677
9. X. Wang, J.E. Tanus-Santos, C.D. Reiter Biological activity of nitric oxide in the plasmatic compartment Proc Natl Acad Sci USA 101 2004 11477 11482
10. R.O. Cannon, A.N. Schechter, J.A. Panza Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery J Clin Invest 108 2001 279 287
11. T. Rassaf, P. Kleinbongard, M. Preik Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO experimental and clinical study on the fate of NO in human blood Circ Res 91 2002 470 477
12. K.J. Joshipura, F.B. Hu, J.E. Manson The effect of fruit and vegetable intake on risk for coronary heart disease Ann Intern Med 134 2001 1106 1114
13. S.J. Duffy, J.F. Keaney Jr., M. Holbrook Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease Circulation 104 2001 151 156
14. C. Papamichael, E. Karatzis, K. Karatzi Red wine's antioxidants counteract acute endothelial dysfunction caused by cigarette smoking in healthy nonsmokers Am Heart J 147 2004 E5
15. D. Grassi, C. Lippi, S. Necozione, G. Desideri, C. Ferri Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons Am J Clin Nutr 81 2005 611 614
16. J.F. Leikert, T.R. Rathel, P. Wohlfart, V. Cheynier, A.M. Vollmar, V.M. Dirsch Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells Circulation 106 2002 1614 1617
17. N.D. Fisher, M. Hughes, M. Gerhard-Herman, N.K. Hollenberg Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans J Hypertens 21 2003 2281 2286
18. M. Karim, K. McCormick, C.T. Kappagoda Effects of cocoa extracts on endothelium-dependent relaxation J Nutr 130 2000 2105S 2108S
19. C. Heiss, A. Dejam, P. Kleinbongard, T. Schewe, H. Sies, M. Kelm Vascular effects of cocoa rich in flavan-3-ols JAMA 290 2003 1030 1031
20. R.R. Holt, S.A. Lazarus, M.C. Sullards Procyanidin dimer B2 (epicatechin-[4beta-8]-epicatechin)] in human plasma after the consumption of a flavanol-rich cocoa Am J Clin Nutr 76 2002 798 804
21. M. Richelle, I. Tavazzi, M. Enslen, E.A. Offord Plasma kinetics in man of epicatechin from black chocolate Eur J Clin Nutr 53 1999 22 26
22. D. Rein, S. Lotito, R.R. Holt, C.L. Keen, H.H. Schmitz, C.G. Fraga Epicatechin in human plasma in vivo determination and effect of chocolate consumption on plasma oxidation status J Nutr 130 2000 2109S 2114S
23. T. Heitzer, C. Brockhoff, B. Mayer Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers evidence for a dysfunctional nitric oxide synthase Circ Res 86 2000 E36 E41
24. M. Preik, T. Lauer, C. Heiss, S. Tabery, B.E. Strauer, M. Kelm Automated ultrasonic measurement of human arteries for the determination of endothelial function Ultraschall Med 21 2000 195 198
25. M.C. Corretti, T.J. Anderson, E.J. Benjamin Guidelines for the ultrasound assessment of endothelial-dependent flow- mediated vasodilation of the brachial artery a report of the International Brachial Artery Reactivity Task Force J Am Coll Cardiol 39 2002 257 265
26. C. Heiss, S. Keymel, U. Niesler, J. Ziemann, M. Kelm, C. Kalka Impaired progenitor cell activity in age-related endothelial dysfunction J Am Coll Cardiol 45 2005 1441 1448
27. T. Rassaf, M. Preik, P. Kleinbongard Evidence for in vivo transport of bioactive nitric oxide in human plasma J Clin Invest 109 2002 1241 1248
28. M.M. Abd El Mohsen, G. Kuhnle, A.R. Rechner Uptake and metabolism of epicatechin and its access to the brain after oral ingestion Free Radic Biol Med 33 2002 1683 1702
29. H. Schroeter, R.R. Holt, T.J. Orozco, H.H. Schmitz, C.L. Keen Nutrition milk and absorption of dietary flavanols Nature 426 2003 787 788
30. H. Sies, W. Stahl, A. Sevanian Nutritional, dietary and postprandial oxidative stress J Nutr 135 2005 969 972
31. R. Rossi, D. Giustarini, A. Milzani, R. Colombo, I. Dalle-Donne, P. Di Simplicio Physiological levels of S-nitrosothiols in human plasma Circ Res 89 2001 E47
32. A.J. de Belder, R. MacAllister, M.W. Radomski, S. Moncada, P.J. Vallance Effects of S-nitroso-glutathione in the human forearm circulation evidence for selective inhibition of platelet activation Cardiovasc Res 28 1994 691 694
33. Z. Kaposzta, P.A. Baskerville, D. Madge, S. Fraser, J.F. Martin, H.S. Markus L-arginine and S-nitrosoglutathione reduce embolization in humans Circulation 103 2001 2371 2375
34. R. Joannides, W.E. Haefeli, L. Lindner Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo Circulation 91 1995 1314 1319
35. J.C. Yugar-Toledo, J.E. Tanus-Santos, M. Sabha Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction Chest 125 2004 823 830
36. D. Taubert, R. Berkels, R. Roesen, W. Klaus Chocolate and blood pressure in elderly individuals with isolated systolic hypertension JAMA 290 2003 1029 1030
37. A.J. Innes, G. Kennedy, M. McLaren, A.J. Bancroft, J.J. Belch Dark chocolate inhibits platelet aggregation in healthy volunteers Platelets 14 2003 325 327
38. M.B. Engler, M.M. Engler, C.Y. Chen Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults J Am Coll Nutr 23 2004 197 204
39. B.R. Clapp, G.M. Hirschfield, C. Storry Inflammation and endothelial function direct vascular effects of human C-reactive protein on nitric oxide bioavailability Circulation 111 2005 1530 1536
40. R.S. Barua, J.A. Ambrose, S. Srivastava, M.C. DeVoe, L.J. Eales-Reynolds Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase an in vitro demonstration in human coronary artery endothelial cells Circulation 107 2003 2342 2347
41. T. Motoyama, H. Kawano, K. Kugiyama Endothelium-dependent vasodilation in the brachial artery is impaired in smokers effect of vitamin C Am J Physiol 273 1997 H1644 H1650
42. R. Heller, A. Unbehaun, B. Schellenberg, B. Mayer, G. Werner-Felmayer, E.R. Werner L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin J Biol Chem 276 2001 40 47
43. S. Baba, N. Osakabe, A. Yasuda Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers Free Radic Res 33 2000 635 641
44. J.P. Spencer, H. Schroeter, A.R. Rechner, C. Rice-Evans Bioavailability of flavan-3-ols and procyanidins gastrointestinal tract influences and their relevance to bioactive forms in vivo Antioxid Redox Signal 3 2001 1023 1039
45. X. Meng, S. Sang, N. Zhu Identification and characterization of methylated and ring-fission metabolites of tea catechins formed in humans, mice, and rats Chem Res Toxicol 15 2002 1042 1050