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Volumn 13, Issue 1, 2016, Pages 47-59

The Nitrate-Nitrite-NO Pathway and Its Implications for Heart Failure and Preserved Ejection Fraction

Author keywords

Afterload; Heart failure with preserved ejection fraction; Inorganic nitrate; Mitochondria; Therapy; Wave reflections

Indexed keywords

NITRATE; NITRIC OXIDE; NITRITE; NITRIC ACID DERIVATIVE;

EID: 84958056835     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-016-0277-9     Document Type: Review
Times cited : (49)

References (154)
  • 1
    • 78650397086 scopus 로고    scopus 로고
    • Epidemiology and clinical course of heart failure with preserved ejection fraction
    • PID: 20685685
    • Lam CS, Donal E, Kraigher-Krainer E, Vasan RS. Epidemiology and clinical course of heart failure with preserved ejection fraction. Eur J Heart Fail. 2011;13:18–28.
    • (2011) Eur J Heart Fail , vol.13 , pp. 18-28
    • Lam, C.S.1    Donal, E.2    Kraigher-Krainer, E.3    Vasan, R.S.4
  • 2
    • 0028839751 scopus 로고
    • Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective
    • COI: 1:STN:280:DyaK28%2FotlGhtA%3D%3D, PID: 7594087
    • Vasan RS, Benjamin EJ, Levy D. Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective. J Am Coll Cardiol. 1995;26:1565–74.
    • (1995) J Am Coll Cardiol , vol.26 , pp. 1565-1574
    • Vasan, R.S.1    Benjamin, E.J.2    Levy, D.3
  • 3
    • 0037425535 scopus 로고    scopus 로고
    • Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    • Redfield MM, Jacobsen SJ, Burnett Jr JC, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA J Am Med Assoc. 2003;289:194–202.
    • (2003) JAMA J Am Med Assoc , vol.289 , pp. 194-202
    • Redfield, M.M.1    Jacobsen, S.J.2    Burnett, J.C.3    Mahoney, D.W.4    Bailey, K.R.5    Rodeheffer, R.J.6
  • 4
    • 0035865536 scopus 로고    scopus 로고
    • Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study
    • COI: 1:STN:280:DC%2BD3M3gsV2msw%3D%3D, PID: 11179524
    • Kitzman DW, Gardin JM, Gottdiener JS, Arnold A, Boineau R, Aurigemma G, et al. Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study. Am J Cardiol. 2001;87:413–9.
    • (2001) Am J Cardiol , vol.87 , pp. 413-419
    • Kitzman, D.W.1    Gardin, J.M.2    Gottdiener, J.S.3    Arnold, A.4    Boineau, R.5    Aurigemma, G.6
  • 5
    • 0034670140 scopus 로고    scopus 로고
    • Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the Strong Heart Study
    • COI: 1:STN:280:DC%2BD3M%2FmtFOgsQ%3D%3D, PID: 11074205
    • Devereux RB, Roman MJ, Liu JE, Welty TK, Lee ET, Rodeheffer R, et al. Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the Strong Heart Study. Am J Cardiol. 2000;86:1090–6.
    • (2000) Am J Cardiol , vol.86 , pp. 1090-1096
    • Devereux, R.B.1    Roman, M.J.2    Liu, J.E.3    Welty, T.K.4    Lee, E.T.5    Rodeheffer, R.6
  • 6
    • 0036674339 scopus 로고    scopus 로고
    • Prevalence of chronic heart failure in Southwestern Europe: the EPICA study
    • PID: 12167394
    • Ceia F, Fonseca C, Mota T, Morais H, Matias F, de Sousa A, et al. Prevalence of chronic heart failure in Southwestern Europe: the EPICA study. Eur J Heart Fail. 2002;4:531–9.
    • (2002) Eur J Heart Fail , vol.4 , pp. 531-539
    • Ceia, F.1    Fonseca, C.2    Mota, T.3    Morais, H.4    Matias, F.5    de Sousa, A.6
  • 7
    • 0032972473 scopus 로고    scopus 로고
    • Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study
    • COI: 1:STN:280:DyaK1M3ivVelsA%3D%3D, PID: 10213348
    • Mosterd A, Hoes AW, de Bruyne MC, Deckers JW, Linker DT, Hofman A, et al. Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study. Eur Heart J. 1999;20:447–55.
    • (1999) Eur Heart J , vol.20 , pp. 447-455
    • Mosterd, A.1    Hoes, A.W.2    de Bruyne, M.C.3    Deckers, J.W.4    Linker, D.T.5    Hofman, A.6
  • 8
    • 0033528260 scopus 로고    scopus 로고
    • Prevalence and clinical characteristics of left ventricular dysfunction among elderly patients in general practice setting: cross sectional survey
    • COI: 1:STN:280:DyaK1M7jt1Sqtg%3D%3D, PID: 9933201
    • Morgan S, Smith H, Simpson I, Liddiard GS, Raphael H, Pickering RM, et al. Prevalence and clinical characteristics of left ventricular dysfunction among elderly patients in general practice setting: cross sectional survey. BMJ. 1999;318:368–72.
    • (1999) BMJ , vol.318 , pp. 368-372
    • Morgan, S.1    Smith, H.2    Simpson, I.3    Liddiard, G.S.4    Raphael, H.5    Pickering, R.M.6
  • 9
    • 0035876895 scopus 로고    scopus 로고
    • Prevalence of heart failure in Asturias (a region in the north of Spain)
    • COI: 1:STN:280:DC%2BD3MzivFCrsg%3D%3D, PID: 11397369
    • Cortina A, Reguero J, Segovia E, Rodriguez Lambert JL, Cortina R, Arias JC, et al. Prevalence of heart failure in Asturias (a region in the north of Spain). Am J Cardiol. 2001;87:1417–9.
    • (2001) Am J Cardiol , vol.87 , pp. 1417-1419
    • Cortina, A.1    Reguero, J.2    Segovia, E.3    Rodriguez Lambert, J.L.4    Cortina, R.5    Arias, J.C.6
  • 10
    • 0031010013 scopus 로고    scopus 로고
    • Congestive heart failure in old age: prevalence, mechanisms and 4-year prognosis in the Helsinki Ageing Study
    • COI: 1:STN:280:DyaK2szis1Crtw%3D%3D, PID: 9183306
    • Kupari M, Lindroos M, Iivanainen AM, Heikkila J, Tilvis R. Congestive heart failure in old age: prevalence, mechanisms and 4-year prognosis in the Helsinki Ageing Study. J Intern Med. 1997;241:387–94.
    • (1997) J Intern Med , vol.241 , pp. 387-394
    • Kupari, M.1    Lindroos, M.2    Iivanainen, A.M.3    Heikkila, J.4    Tilvis, R.5
  • 11
    • 34547837711 scopus 로고    scopus 로고
    • Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry
    • PID: 17707182
    • Fonarow GC, Stough WG, Abraham WT, Albert NM, Gheorghiade M, Greenberg BH, et al. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry. J Am Coll Cardiol. 2007;50:768–77.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 768-777
    • Fonarow, G.C.1    Stough, W.G.2    Abraham, W.T.3    Albert, N.M.4    Gheorghiade, M.5    Greenberg, B.H.6
  • 12
    • 29344440492 scopus 로고    scopus 로고
    • Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database
    • PID: 16386668
    • Yancy CW, Lopatin M, Stevenson LW, De Marco T, Fonarow GC. Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database. J Am Coll Cardiol. 2006;47:76–84.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 76-84
    • Yancy, C.W.1    Lopatin, M.2    Stevenson, L.W.3    De Marco, T.4    Fonarow, G.C.5
  • 13
    • 3042715684 scopus 로고    scopus 로고
    • Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey
    • COI: 1:STN:280:DC%2BD2czktlSnsw%3D%3D, PID: 15246639
    • Lenzen MJ, op Reimer WJ S, Boersma E, Vantrimpont PJ, Follath F, Swedberg K, et al. Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. Eur Heart J. 2004;25:1214–20.
    • (2004) Eur Heart J , vol.25 , pp. 1214-1220
    • Lenzen, M.J.1    op Reimer WJ, S.2    Boersma, E.3    Vantrimpont, P.J.4    Follath, F.5    Swedberg, K.6
  • 14
    • 84884294190 scopus 로고    scopus 로고
    • American College of Cardiology F and American Heart Association Task Force on Practice G. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • PID: 23747642
    • Yancy CW, Jessup M, Bozkurt B, Butler J, Casey Jr DE, Drazner MH, et al. American College of Cardiology F and American Heart Association Task Force on Practice G. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62:e147–239.
    • (2013) J Am Coll Cardiol , vol.62 , pp. e147-e239
    • Yancy, C.W.1    Jessup, M.2    Bozkurt, B.3    Butler, J.4    Casey, D.E.5    Drazner, M.H.6
  • 15
    • 79957777288 scopus 로고    scopus 로고
    • Treatment of heart failure with preserved ejection fraction: have we been pursuing the wrong paradigm?
    • PID: 21576513
    • Oghlakian GO, Sipahi I, Fang JC. Treatment of heart failure with preserved ejection fraction: have we been pursuing the wrong paradigm? Mayo Clin Proc. 2011;86:531–9.
    • (2011) Mayo Clin Proc , vol.86 , pp. 531-539
    • Oghlakian, G.O.1    Sipahi, I.2    Fang, J.C.3
  • 16
    • 84947866951 scopus 로고    scopus 로고
    • Heart failure with preserved ejection fraction: uncertainties and dilemmas
    • COI: 1:CAS:528:DC%2BC2MXhtFCru7nJ, PID: 26079097
    • Ferrari R, Bohm M, Cleland JG, Paulus WJ, Pieske B, Rapezzi C, et al. Heart failure with preserved ejection fraction: uncertainties and dilemmas. Eur J Heart Fail. 2015;17:665–71.
    • (2015) Eur J Heart Fail , vol.17 , pp. 665-671
    • Ferrari, R.1    Bohm, M.2    Cleland, J.G.3    Paulus, W.J.4    Pieske, B.5    Rapezzi, C.6
  • 17
    • 84879748718 scopus 로고    scopus 로고
    • A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation
    • PID: 23684677
    • Paulus WJ, Tschope C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62:263–71.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 263-271
    • Paulus, W.J.1    Tschope, C.2
  • 18
    • 84875531214 scopus 로고    scopus 로고
    • Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
    • COI: 1:CAS:528:DC%2BC3sXlvFSgs7Y%3D, PID: 23478662
    • Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2013;309:1268–77.
    • (2013) JAMA , vol.309 , pp. 1268-1277
    • Redfield, M.M.1    Chen, H.H.2    Borlaug, B.A.3    Semigran, M.J.4    Lee, K.L.5    Lewis, G.6
  • 19
    • 80051970563 scopus 로고    scopus 로고
    • Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction
    • PID: 21712287
    • Hoekstra T, Lesman-Leegte I, van Veldhuisen DJ, Sanderman R, Jaarsma T. Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. Eur J Heart Fail. 2011;13:1013–8.
    • (2011) Eur J Heart Fail , vol.13 , pp. 1013-1018
    • Hoekstra, T.1    Lesman-Leegte, I.2    van Veldhuisen, D.J.3    Sanderman, R.4    Jaarsma, T.5
  • 20
    • 33846087698 scopus 로고    scopus 로고
    • Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM
    • PID: 17188020
    • Lewis EF, Lamas GA, O'Meara E, Granger CB, Dunlap ME, McKelvie RS, et al. Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM. Eur J Heart Fail. 2007;9:83–91.
    • (2007) Eur J Heart Fail , vol.9 , pp. 83-91
    • Lewis, E.F.1    Lamas, G.A.2    O'Meara, E.3    Granger, C.B.4    Dunlap, M.E.5    McKelvie, R.S.6
  • 21
    • 0037032384 scopus 로고    scopus 로고
    • Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure
    • PID: 12413374
    • Kitzman DW, Little WC, Brubaker PH, Anderson RT, Hundley WG, Marburger CT, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA. 2002;288:2144–50.
    • (2002) JAMA , vol.288 , pp. 2144-2150
    • Kitzman, D.W.1    Little, W.C.2    Brubaker, P.H.3    Anderson, R.T.4    Hundley, W.G.5    Marburger, C.T.6
  • 22
    • 84863633337 scopus 로고    scopus 로고
    • The pathophysiology of heart failure with preserved ejection fraction: from molecular mechanisms to exercise haemodynamics
    • PID: 21794933
    • Phan TT, Shivu GN, Abozguia K, Sanderson JE, Frenneaux M. The pathophysiology of heart failure with preserved ejection fraction: from molecular mechanisms to exercise haemodynamics. Int J Cardiol. 2012;158:337–43.
    • (2012) Int J Cardiol , vol.158 , pp. 337-343
    • Phan, T.T.1    Shivu, G.N.2    Abozguia, K.3    Sanderson, J.E.4    Frenneaux, M.5
  • 23
    • 0025727274 scopus 로고
    • Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism
    • COI: 1:STN:280:DyaK3M7nvVWltw%3D%3D, PID: 2007704
    • Kitzman DW, Higginbotham MB, Cobb FR, Sheikh KH, Sullivan MJ. Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism. J Am Coll Cardiol. 1991;17:1065–72.
    • (1991) J Am Coll Cardiol , vol.17 , pp. 1065-1072
    • Kitzman, D.W.1    Higginbotham, M.B.2    Cobb, F.R.3    Sheikh, K.H.4    Sullivan, M.J.5
  • 24
    • 3843094224 scopus 로고    scopus 로고
    • Diastolic heart failure—abnormalities in active relaxation and passive stiffness of the left ventricle
    • COI: 1:CAS:528:DC%2BD2cXjslehs7o%3D, PID: 15128895
    • Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure—abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004;350:1953–9.
    • (2004) N Engl J Med , vol.350 , pp. 1953-1959
    • Zile, M.R.1    Baicu, C.F.2    Gaasch, W.H.3
  • 25
    • 77956324154 scopus 로고    scopus 로고
    • Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction
    • PID: 20813283
    • Maeder MT, Thompson BR, Brunner-La Rocca HP, Kaye DM. Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction. J Am Coll Cardiol. 2010;56:855–63.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 855-863
    • Maeder, M.T.1    Thompson, B.R.2    Brunner-La Rocca, H.P.3    Kaye, D.M.4
  • 26
  • 27
    • 33750995868 scopus 로고    scopus 로고
    • Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction
    • PID: 17088459
    • Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, et al. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006;114:2138–47.
    • (2006) Circulation , vol.114 , pp. 2138-2147
    • Borlaug, B.A.1    Melenovsky, V.2    Russell, S.D.3    Kessler, K.4    Pacak, K.5    Becker, L.C.6
  • 28
    • 48049092842 scopus 로고    scopus 로고
    • Left ventricular abnormal response during dynamic exercise in patients with heart failure and preserved left ventricular ejection fraction at rest
    • PID: 18672195
    • Ennezat PV, Lefetz Y, Marechaux S, Six-Carpentier M, Deklunder G, Montaigne D, et al. Left ventricular abnormal response during dynamic exercise in patients with heart failure and preserved left ventricular ejection fraction at rest. J Card Fail. 2008;14:475–80.
    • (2008) J Card Fail , vol.14 , pp. 475-480
    • Ennezat, P.V.1    Lefetz, Y.2    Marechaux, S.3    Six-Carpentier, M.4    Deklunder, G.5    Montaigne, D.6
  • 29
    • 84908006935 scopus 로고    scopus 로고
    • Causes of exercise intolerance in heart failure with preserved ejection fraction: searching for consensus
    • PID: 25108084, Excellent review article discussing the mechanisms of exertional intolerance in HFpEF
    • Houstis NE, Lewis GD. Causes of exercise intolerance in heart failure with preserved ejection fraction: searching for consensus. J Card Fail. 2014;20:762–78. Excellent review article discussing the mechanisms of exertional intolerance in HFpEF.
    • (2014) J Card Fail , vol.20 , pp. 762-778
    • Houstis, N.E.1    Lewis, G.D.2
  • 30
    • 84876967191 scopus 로고    scopus 로고
    • Pulsatile hemodynamics in patients with exertional dyspnea: potentially of value in the diagnostic evaluation of suspected heart failure with preserved ejection fraction
    • PID: 23500307
    • Weber T, Wassertheurer S, O'Rourke MF, Haiden A, Zweiker R, Rammer M, et al. Pulsatile hemodynamics in patients with exertional dyspnea: potentially of value in the diagnostic evaluation of suspected heart failure with preserved ejection fraction. J Am Coll Cardiol. 2013;61:1874–83.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 1874-1883
    • Weber, T.1    Wassertheurer, S.2    O'Rourke, M.F.3    Haiden, A.4    Zweiker, R.5    Rammer, M.6
  • 31
    • 79960039049 scopus 로고    scopus 로고
    • Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction
    • PID: 21737017
    • Haykowsky MJ, Brubaker PH, John JM, Stewart KP, Morgan TM, Kitzman DW. Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol. 2011;58:265–74.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 265-274
    • Haykowsky, M.J.1    Brubaker, P.H.2    John, J.M.3    Stewart, K.P.4    Morgan, T.M.5    Kitzman, D.W.6
  • 32
    • 84900559283 scopus 로고    scopus 로고
    • Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction
    • COI: 1:CAS:528:DC%2BC2cXptVChsLw%3D, PID: 24658015, This study demonstrates important structural abnormalities within the peripheral skeletal muscles of HFpEF patients including reduced Type I fibers and reduced capillary to fiber ratios, both of which correlated with impaired peak aerobic capacity
    • Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, et al. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306:H1364–70. This study demonstrates important structural abnormalities within the peripheral skeletal muscles of HFpEF patients including reduced Type I fibers and reduced capillary to fiber ratios, both of which correlated with impaired peak aerobic capacity.
    • (2014) Am J Physiol Heart Circ Physiol , vol.306 , pp. H1364-H1370
    • Kitzman, D.W.1    Nicklas, B.2    Kraus, W.E.3    Lyles, M.F.4    Eggebeen, J.5    Morgan, T.M.6
  • 33
    • 77956330748 scopus 로고    scopus 로고
    • Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction
    • PID: 20813282, Important article demonstrating key hemodynamic limitations identified in HFpEF patients
    • Borlaug BA, Olson TP, Lam CS, Flood KS, Lerman A, Johnson BD, et al. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2010;56:845–54. Important article demonstrating key hemodynamic limitations identified in HFpEF patients.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 845-854
    • Borlaug, B.A.1    Olson, T.P.2    Lam, C.S.3    Flood, K.S.4    Lerman, A.5    Johnson, B.D.6
  • 34
    • 84857275034 scopus 로고    scopus 로고
    • Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance
    • COI: 1:CAS:528:DC%2BC38XkslCisrw%3D, PID: 22101528, Excellent review article describing impairments in oxygen transport found in heart failure and their implications for exercise intolerance
    • Poole DC, Hirai DM, Copp SW, Musch TI. Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance. Am J Physiol Heart Circ Physiol. 2012;302:H1050–63. Excellent review article describing impairments in oxygen transport found in heart failure and their implications for exercise intolerance.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302 , pp. H1050-H1063
    • Poole, D.C.1    Hirai, D.M.2    Copp, S.W.3    Musch, T.I.4
  • 35
    • 84887100487 scopus 로고    scopus 로고
    • The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply–demand matching
    • Umbrello M, Dyson A, Feelisch M and Singer M. The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply–demand matching. Antioxid Redox Signal. 2013.
    • (2013) Antioxid Redox Signal
    • Umbrello, M.1    Dyson, A.2    Feelisch, M.3    Singer, M.4
  • 36
    • 84863927306 scopus 로고    scopus 로고
    • Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    • COI: 1:CAS:528:DC%2BC38XhtVCrsrnE, PID: 22685116
    • Totzeck M, Hendgen-Cotta UB, Luedike P, Berenbrink M, Klare JP, Steinhoff HJ, et al. Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation. Circulation. 2012;126:325–34.
    • (2012) Circulation , vol.126 , pp. 325-334
    • Totzeck, M.1    Hendgen-Cotta, U.B.2    Luedike, P.3    Berenbrink, M.4    Klare, J.P.5    Steinhoff, H.J.6
  • 37
    • 78649754097 scopus 로고    scopus 로고
    • Erythrocyte-dependent regulation of human skeletal muscle blood flow: role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin, and ATP
    • COI: 1:CAS:528:DC%2BC3cXhs1elsL3I, PID: 20852046
    • Dufour SP, Patel RP, Brandon A, Teng X, Pearson J, Barker H, et al. Erythrocyte-dependent regulation of human skeletal muscle blood flow: role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin, and ATP. Am J Physiol Heart Circ Physiol. 2010;299:H1936–46.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H1936-H1946
    • Dufour, S.P.1    Patel, R.P.2    Brandon, A.3    Teng, X.4    Pearson, J.5    Barker, H.6
  • 38
    • 70350094707 scopus 로고    scopus 로고
    • Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans
    • COI: 1:CAS:528:DC%2BD1MXhtlGnsLzK, PID: 19661447
    • Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol. 2009;107:1144–55.
    • (2009) J Appl Physiol , vol.107 , pp. 1144-1155
    • Bailey, S.J.1    Winyard, P.2    Vanhatalo, A.3    Blackwell, J.R.4    Dimenna, F.J.5    Wilkerson, D.P.6
  • 39
    • 10744220361 scopus 로고    scopus 로고
    • Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    • COI: 1:CAS:528:DC%2BD3sXpt1Gksr0%3D, PID: 14595407, Important article demonstrating increased conversion of nitrite to NO in the context of exercise
    • Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003;9:1498–505. Important article demonstrating increased conversion of nitrite to NO in the context of exercise.
    • (2003) Nat Med , vol.9 , pp. 1498-1505
    • Cosby, K.1    Partovi, K.S.2    Crawford, J.H.3    Patel, R.P.4    Reiter, C.D.5    Martyr, S.6
  • 40
    • 0030482536 scopus 로고    scopus 로고
    • Influence of aortic impedance on the development of pressure-overload left ventricular hypertrophy in rats
    • COI: 1:STN:280:DyaK2s7ktlWnsw%3D%3D, PID: 8989152, This study demonstrates the adverse effects of wave reflections arriving during late-systole and shows greater degrees of hypertrophy and fibrosis associated with late-systolic load
    • Kobayashi S, Yano M, Kohno M, Obayashi M, Hisamatsu Y, Ryoke T, et al. Influence of aortic impedance on the development of pressure-overload left ventricular hypertrophy in rats. Circulation. 1996;94:3362–8. This study demonstrates the adverse effects of wave reflections arriving during late-systole and shows greater degrees of hypertrophy and fibrosis associated with late-systolic load.
    • (1996) Circulation , vol.94 , pp. 3362-3368
    • Kobayashi, S.1    Yano, M.2    Kohno, M.3    Obayashi, M.4    Hisamatsu, Y.5    Ryoke, T.6
  • 41
    • 0026072757 scopus 로고
    • Influence of systolic pressure profile on rate of left ventricular pressure fall
    • COI: 1:STN:280:DyaK3Mzmt1Srug%3D%3D, PID: 1887926, this study demonstrates that, for any given increase in pressure, late systolic load leads to a much greater impairement in ventricular relaxation, compared to early systolic load
    • Gillebert TC, Lew WY. Influence of systolic pressure profile on rate of left ventricular pressure fall. Am J Physiol. 1991;261:H805–13. this study demonstrates that, for any given increase in pressure, late systolic load leads to a much greater impairement in ventricular relaxation, compared to early systolic load.
    • (1991) Am J Physiol , vol.261 , pp. H805-H813
    • Gillebert, T.C.1    Lew, W.Y.2
  • 42
    • 84911480835 scopus 로고    scopus 로고
    • Vlachopoulos C. McDonald’s blood flow in arteries. Theoretical, Experimental and Clinical Principles
    • Nichols WW ORM, Vlachopoulos C. McDonald’s blood flow in arteries. Theoretical, Experimental and Clinical Principles. 6 ed: Hodder Arnold; 2011.
    • (2011) 6 ed: Hodder Arnold
    • Nichols, W.W.O.R.M.1
  • 43
    • 77957238761 scopus 로고    scopus 로고
    • Noninvasive evaluation of left ventricular afterload: part 1: pressure and flow measurements and basic principles of wave conduction and reflection
    • COI: 1:CAS:528:DC%2BC3cXhtFKls7vM, PID: 20733089
    • Chirinos JA, Segers P. Noninvasive evaluation of left ventricular afterload: part 1: pressure and flow measurements and basic principles of wave conduction and reflection. Hypertension. 2010;56:555–62.
    • (2010) Hypertension , vol.56 , pp. 555-562
    • Chirinos, J.A.1    Segers, P.2
  • 44
    • 77957226007 scopus 로고    scopus 로고
    • Noninvasive evaluation of left ventricular afterload: part 2: arterial pressure-flow and pressure-volume relations in humans
    • COI: 1:CAS:528:DC%2BC3cXhtFKls7vN, PID: 20733088
    • Chirinos JA, Segers P. Noninvasive evaluation of left ventricular afterload: part 2: arterial pressure-flow and pressure-volume relations in humans. Hypertension. 2010;56:563–70.
    • (2010) Hypertension , vol.56 , pp. 563-570
    • Chirinos, J.A.1    Segers, P.2
  • 45
    • 77957226007 scopus 로고    scopus 로고
    • Noninvasive evaluation of left ventricular afterload: part 2: arterial pressure-flow and pressure-volume relations in humans
    • Chirinos JA and Segers P. Noninvasive evaluation of left ventricular afterload: part 2: arterial pressure-flow and pressure-volume relations in humans. Hypertension. 56:563–70.
    • Hypertension , vol.56 , pp. 563-570
    • Chirinos, J.A.1    Segers, P.2
  • 46
    • 84873057096 scopus 로고    scopus 로고
    • Chirinos JA, Segers P, Rietzschel ER, De Buyzere ML, Raja MW, Claessens T, De Bacquer D, St John Sutton M and Gillebert T. Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults. The Asklepios study. Hypertension. 2013;In press
    • Chirinos JA, Segers P, Rietzschel ER, De Buyzere ML, Raja MW, Claessens T, De Bacquer D, St John Sutton M and Gillebert T. Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults. The Asklepios study. Hypertension. 2013;In press.
  • 47
    • 84865811389 scopus 로고    scopus 로고
    • Arterial properties as determinants of time-varying myocardial stress in humans
    • COI: 1:CAS:528:DC%2BC38XhtVerur%2FI, PID: 22665121
    • Chirinos JA, Segers P, Gillebert TC, Gupta AK, De Buyzere ML, De Bacquer D, et al. Arterial properties as determinants of time-varying myocardial stress in humans. Hypertension. 2012;60:64–70.
    • (2012) Hypertension , vol.60 , pp. 64-70
    • Chirinos, J.A.1    Segers, P.2    Gillebert, T.C.3    Gupta, A.K.4    De Buyzere, M.L.5    De Bacquer, D.6
  • 48
    • 84869091777 scopus 로고    scopus 로고
    • Increased arterial wave reflection magnitude: a novel form of stage B heart failure?
    • PID: 23103043
    • Shah SJ, Wasserstrom JA. Increased arterial wave reflection magnitude: a novel form of stage B heart failure? J Am Coll Cardiol. 2012;60:2178–81.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2178-2181
    • Shah, S.J.1    Wasserstrom, J.A.2
  • 49
    • 84919436418 scopus 로고    scopus 로고
    • Resistive and pulsatile arterial load as predictors of left ventricular mass and geometry: the multi-ethnic study of atherosclerosis
    • COI: 1:CAS:528:DC%2BC2cXitVGmsLnK, PID: 25287396
    • Zamani P, Bluemke DA, Jacobs Jr DR, Duprez DA, Kronmal R, Lilly SM, et al. Resistive and pulsatile arterial load as predictors of left ventricular mass and geometry: the multi-ethnic study of atherosclerosis. Hypertension. 2015;65:85–92.
    • (2015) Hypertension , vol.65 , pp. 85-92
    • Zamani, P.1    Bluemke, D.A.2    Jacobs, D.R.3    Duprez, D.A.4    Kronmal, R.5    Lilly, S.M.6
  • 50
    • 42049085072 scopus 로고    scopus 로고
    • Different role of wave reflection magnitude and timing on left ventricular mass reduction during antihypertensive treatment
    • COI: 1:CAS:528:DC%2BD1cXktl2rtbY%3D, PID: 18398345
    • Hashimoto J, Westerhof BE, Westerhof N, Imai Y, O'Rourke MF. Different role of wave reflection magnitude and timing on left ventricular mass reduction during antihypertensive treatment. J Hypertens. 2008;26:1017–24.
    • (2008) J Hypertens , vol.26 , pp. 1017-1024
    • Hashimoto, J.1    Westerhof, B.E.2    Westerhof, N.3    Imai, Y.4    O'Rourke, M.F.5
  • 51
    • 77956102500 scopus 로고    scopus 로고
    • Impact of arterial load on left ventricular diastolic function in patients undergoing cardiac catheterization for coronary artery disease
    • Fukuta H, Ohte N, Wakami K, Asada K, Goto T, Mukai S, et al. Impact of arterial load on left ventricular diastolic function in patients undergoing cardiac catheterization for coronary artery disease. Circ J Off J Jpn Circ Soc. 2010;74:1900–5.
    • (2010) Circ J Off J Jpn Circ Soc , vol.74 , pp. 1900-1905
    • Fukuta, H.1    Ohte, N.2    Wakami, K.3    Asada, K.4    Goto, T.5    Mukai, S.6
  • 52
    • 54249106692 scopus 로고    scopus 로고
    • Arterial stiffness and arterial wave reflections are associated with systolic and diastolic function in patients with normal ejection fraction
    • PID: 18787521
    • Weber T, O'Rourke MF, Ammer M, Kvas E, Punzengruber C, Eber B. Arterial stiffness and arterial wave reflections are associated with systolic and diastolic function in patients with normal ejection fraction. Am J Hypertens. 2008;21:1194–202.
    • (2008) Am J Hypertens , vol.21 , pp. 1194-1202
    • Weber, T.1    O'Rourke, M.F.2    Ammer, M.3    Kvas, E.4    Punzengruber, C.5    Eber, B.6
  • 53
    • 84873057096 scopus 로고    scopus 로고
    • Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the Asklepios study
    • COI: 1:CAS:528:DC%2BC3sXhtFymt70%3D, PID: 23283359, This study demonstrates the relationship between late systolic load (wall stress) and abnormal myocardial relaxation
    • Chirinos JA, Segers P, Rietzschel ER, De Buyzere ML, Raja MW, Claessens T, et al. Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the Asklepios study. Hypertension. 2013;61:296–303. This study demonstrates the relationship between late systolic load (wall stress) and abnormal myocardial relaxation.
    • (2013) Hypertension , vol.61 , pp. 296-303
    • Chirinos, J.A.1    Segers, P.2    Rietzschel, E.R.3    De Buyzere, M.L.4    Raja, M.W.5    Claessens, T.6
  • 54
    • 84869087378 scopus 로고    scopus 로고
    • Arterial wave reflections and incident cardiovascular events and heart failure: MESA (Multiethnic Study of Atherosclerosis)
    • PID: 23103044, This study demonstrates the strong association between wave reflections, which cause late systolic load, and incident heart failure over ~8 years in the MESA cohort
    • Chirinos JA, Kips JG, Jacobs Jr DR, Brumback L, Duprez DA, Kronmal R, et al. Arterial wave reflections and incident cardiovascular events and heart failure: MESA (Multiethnic Study of Atherosclerosis). J Am Coll Cardiol. 2012;60:2170–7. This study demonstrates the strong association between wave reflections, which cause late systolic load, and incident heart failure over ~8 years in the MESA cohort.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2170-2177
    • Chirinos, J.A.1    Kips, J.G.2    Jacobs, D.R.3    Brumback, L.4    Duprez, D.A.5    Kronmal, R.6
  • 55
    • 84922349670 scopus 로고    scopus 로고
    • Paradoxical normoxia-dependent selective actions of inorganic nitrite in human muscular conduit arteries and related selective actions on central blood pressures
    • COI: 1:CAS:528:DC%2BC2MXhvVOisLg%3D, PID: 25533964, discussion 389. this article demonstrates the reduction in augmentation index, a metric of wave reflections, in conduit arteries with nitrite infusion
    • Omar SA, Fok H, Tilgner KD, Nair A, Hunt J, Jiang B, et al. Paradoxical normoxia-dependent selective actions of inorganic nitrite in human muscular conduit arteries and related selective actions on central blood pressures. Circulation. 2015;131:381–9. discussion 389. this article demonstrates the reduction in augmentation index, a metric of wave reflections, in conduit arteries with nitrite infusion.
    • (2015) Circulation , vol.131 , pp. 381-389
    • Omar, S.A.1    Fok, H.2    Tilgner, K.D.3    Nair, A.4    Hunt, J.5    Jiang, B.6
  • 56
    • 84922367928 scopus 로고    scopus 로고
    • The Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure with Preserved Ejection Fraction
    • COI: 1:CAS:528:DC%2BC2MXhvVOisLw%3D, PID: 25533966, This study provides the first evidence that targetting the inorganic nitrate-nitrite-NO pathway in HFpEF leads to improvements in aerobic capacity, mediated by improved vasodilatory and cardiac output reserves
    • Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, et al. The Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure with Preserved Ejection Fraction. Circulation. 2015;131:371–80. This study provides the first evidence that targetting the inorganic nitrate-nitrite-NO pathway in HFpEF leads to improvements in aerobic capacity, mediated by improved vasodilatory and cardiac output reserves.
    • (2015) Circulation , vol.131 , pp. 371-380
    • Zamani, P.1    Rawat, D.2    Shiva-Kumar, P.3    Geraci, S.4    Bhuva, R.5    Konda, P.6
  • 57
    • 38849162730 scopus 로고    scopus 로고
    • The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    • COI: 1:CAS:528:DC%2BD1cXhs1Khsrw%3D, PID: 18167491
    • Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7:156–67.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 156-167
    • Lundberg, J.O.1    Weitzberg, E.2    Gladwin, M.T.3
  • 58
    • 84861696311 scopus 로고    scopus 로고
    • Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables?
    • PID: 22646129
    • Machha A, Schechter AN. Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables? Nutr Rev. 2012;70:367–72.
    • (2012) Nutr Rev , vol.70 , pp. 367-372
    • Machha, A.1    Schechter, A.N.2
  • 59
    • 78751615379 scopus 로고    scopus 로고
    • Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect
    • COI: 1:CAS:528:DC%2BC3MXlsFWrsA%3D%3D, PID: 21102328
    • Tang Y, Jiang H, Bryan NS. Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect. Curr Opin Lipidol. 2011;22:11–5.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 11-15
    • Tang, Y.1    Jiang, H.2    Bryan, N.S.3
  • 60
    • 78650170793 scopus 로고    scopus 로고
    • Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    • COI: 1:CAS:528:DC%2BC3cXhsV2gu7rJ, PID: 21045638
    • Weitzberg E, Hezel M, Lundberg JO. Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care. Anesthesiology. 2010;113:1460–75.
    • (2010) Anesthesiology , vol.113 , pp. 1460-1475
    • Weitzberg, E.1    Hezel, M.2    Lundberg, J.O.3
  • 61
    • 79551500803 scopus 로고    scopus 로고
    • Roles of dietary inorganic nitrate in cardiovascular health and disease
    • COI: 1:CAS:528:DC%2BC3MXhsVSmu7s%3D, PID: 20937740
    • Lundberg JO, Carlstrom M, Larsen FJ, Weitzberg E. Roles of dietary inorganic nitrate in cardiovascular health and disease. Cardiovasc Res. 2011;89:525–32.
    • (2011) Cardiovasc Res , vol.89 , pp. 525-532
    • Lundberg, J.O.1    Carlstrom, M.2    Larsen, F.J.3    Weitzberg, E.4
  • 62
    • 80051520193 scopus 로고    scopus 로고
    • Regional left ventricular systolic function and the right ventricle: the multi-ethnic study of atherosclerosis right ventricle study
    • PID: 21330384
    • Dibble CT, Lima JA, Bluemke DA, Chirinos JA, Chahal H, Bristow MR, et al. Regional left ventricular systolic function and the right ventricle: the multi-ethnic study of atherosclerosis right ventricle study. Chest. 2011;140:310–6.
    • (2011) Chest , vol.140 , pp. 310-316
    • Dibble, C.T.1    Lima, J.A.2    Bluemke, D.A.3    Chirinos, J.A.4    Chahal, H.5    Bristow, M.R.6
  • 63
    • 79951772306 scopus 로고    scopus 로고
    • Surrogate markers of cardiovascular disease in CKD: what's under the hood?
    • PID: 21168944
    • Rubin MF, Rosas SE, Chirinos JA, Townsend RR. Surrogate markers of cardiovascular disease in CKD: what's under the hood? Am J Kidney Dis. 2011;57:488–97.
    • (2011) Am J Kidney Dis , vol.57 , pp. 488-497
    • Rubin, M.F.1    Rosas, S.E.2    Chirinos, J.A.3    Townsend, R.R.4
  • 64
    • 78249288750 scopus 로고    scopus 로고
    • Hormonal evaluation and midcycle detection of intrauterine glycodelin in women treated with levonorgestrel as in emergency contraception
    • COI: 1:CAS:528:DC%2BC3cXhsVWqt7bI, PID: 21074015
    • Durand M, Koistinen R, Chirinos M, Rodriguez JL, Zambrano E, Seppala M, et al. Hormonal evaluation and midcycle detection of intrauterine glycodelin in women treated with levonorgestrel as in emergency contraception. Contraception. 2010;82:526–33.
    • (2010) Contraception , vol.82 , pp. 526-533
    • Durand, M.1    Koistinen, R.2    Chirinos, M.3    Rodriguez, J.L.4    Zambrano, E.5    Seppala, M.6
  • 65
    • 84878232230 scopus 로고    scopus 로고
    • Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXos1Kgsrs%3D, PID: 23596162
    • Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr. 2013;143:818–26.
    • (2013) J Nutr , vol.143 , pp. 818-826
    • Siervo, M.1    Lara, J.2    Ogbonmwan, I.3    Mathers, J.C.4
  • 66
    • 68349130367 scopus 로고    scopus 로고
    • Bioavailability of sodium nitrite from an aqueous solution in healthy adults
    • COI: 1:CAS:528:DC%2BD1MXhtVSgtbnE, PID: 19576277
    • Hunault CC, van Velzen AG, Sips AJ, Schothorst RC, Meulenbelt J. Bioavailability of sodium nitrite from an aqueous solution in healthy adults. Toxicol Lett. 2009;190:48–53.
    • (2009) Toxicol Lett , vol.190 , pp. 48-53
    • Hunault, C.C.1    van Velzen, A.G.2    Sips, A.J.3    Schothorst, R.C.4    Meulenbelt, J.5
  • 67
    • 36248995976 scopus 로고    scopus 로고
    • Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation
    • COI: 1:CAS:528:DC%2BD2sXhtFersLnK, PID: 17893272
    • Dejam A, Hunter CJ, Tremonti C, Pluta RM, Hon YY, Grimes G, et al. Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation. 2007;116:1821–31.
    • (2007) Circulation , vol.116 , pp. 1821-1831
    • Dejam, A.1    Hunter, C.J.2    Tremonti, C.3    Pluta, R.M.4    Hon, Y.Y.5    Grimes, G.6
  • 68
    • 79251547703 scopus 로고    scopus 로고
    • Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers
    • COI: 1:CAS:528:DC%2BC3MXhtVSis7c%3D, PID: 21249218
    • Pluta RM, Oldfield EH, Bakhtian KD, Fathi AR, Smith RK, Devroom HL, et al. Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers. PLoS One. 2011;6:e14504.
    • (2011) PLoS One , vol.6 , pp. e14504
    • Pluta, R.M.1    Oldfield, E.H.2    Bakhtian, K.D.3    Fathi, A.R.4    Smith, R.K.5    Devroom, H.L.6
  • 69
    • 84901819805 scopus 로고    scopus 로고
    • Nitrite reduction and cardiovascular protection
    • COI: 1:CAS:528:DC%2BC2cXislCgsrs%3D, PID: 24486197
    • Omar SA, Webb AJ. Nitrite reduction and cardiovascular protection. J Mol Cell Cardiol. 2014;73:57–69.
    • (2014) J Mol Cell Cardiol , vol.73 , pp. 57-69
    • Omar, S.A.1    Webb, A.J.2
  • 71
    • 33947728687 scopus 로고    scopus 로고
    • Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
    • COI: 1:CAS:528:DC%2BD2sXisFyntLg%3D, PID: 17293481
    • Shiva S, Huang Z, Grubina R, Sun J, Ringwood LA, MacArthur PH, et al. Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res. 2007;100:654–61.
    • (2007) Circ Res , vol.100 , pp. 654-661
    • Shiva, S.1    Huang, Z.2    Grubina, R.3    Sun, J.4    Ringwood, L.A.5    MacArthur, P.H.6
  • 72
    • 34250877421 scopus 로고    scopus 로고
    • Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function
    • COI: 1:CAS:528:DC%2BD2sXmslygtL8%3D, PID: 17495223
    • Rassaf T, Flogel U, Drexhage C, Hendgen-Cotta U, Kelm M, Schrader J. Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function. Circ Res. 2007;100:1749–54.
    • (2007) Circ Res , vol.100 , pp. 1749-1754
    • Rassaf, T.1    Flogel, U.2    Drexhage, C.3    Hendgen-Cotta, U.4    Kelm, M.5    Schrader, J.6
  • 73
    • 48249110926 scopus 로고    scopus 로고
    • Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury
    • COI: 1:CAS:528:DC%2BD1cXpt1Sju70%3D, PID: 18632562
    • Hendgen-Cotta UB, Merx MW, Shiva S, Schmitz J, Becher S, Klare JP, et al. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2008;105:10256–61.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10256-10261
    • Hendgen-Cotta, U.B.1    Merx, M.W.2    Shiva, S.3    Schmitz, J.4    Becher, S.5    Klare, J.P.6
  • 74
    • 53449085187 scopus 로고    scopus 로고
    • The functional nitrite reductase activity of the heme-globins
    • COI: 1:CAS:528:DC%2BD1cXht1SrtLfO, PID: 18596228
    • Gladwin MT, Kim-Shapiro DB. The functional nitrite reductase activity of the heme-globins. Blood. 2008;112:2636–47.
    • (2008) Blood , vol.112 , pp. 2636-2647
    • Gladwin, M.T.1    Kim-Shapiro, D.B.2
  • 75
    • 4544378255 scopus 로고    scopus 로고
    • Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    • COI: 1:CAS:528:DC%2BD2cXnvFehsL0%3D, PID: 15347817
    • Webb A, Bond R, McLean P, Uppal R, Benjamin N, Ahluwalia A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci U S A. 2004;101:13683–8.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13683-13688
    • Webb, A.1    Bond, R.2    McLean, P.3    Uppal, R.4    Benjamin, N.5    Ahluwalia, A.6
  • 76
    • 0033035767 scopus 로고    scopus 로고
    • Nitrite reductase activity is a novel function of mammalian mitochondria
    • COI: 1:CAS:528:DyaK1MXks1Crtbk%3D, PID: 10413109
    • Kozlov AV, Staniek K, Nohl H. Nitrite reductase activity is a novel function of mammalian mitochondria. FEBS Lett. 1999;454:127–30.
    • (1999) FEBS Lett , vol.454 , pp. 127-130
    • Kozlov, A.V.1    Staniek, K.2    Nohl, H.3
  • 77
    • 75149193813 scopus 로고    scopus 로고
    • Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall
    • COI: 1:CAS:528:DC%2BC3cXht12lur0%3D
    • Zweier JL, Li H, Samouilov A, Liu X. Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall. Nitric Oxide Biol Chem Off J Nitric Oxide Soc. 2010;22:83–90.
    • (2010) Nitric Oxide Biol Chem Off J Nitric Oxide Soc , vol.22 , pp. 83-90
    • Zweier, J.L.1    Li, H.2    Samouilov, A.3    Liu, X.4
  • 78
    • 72249108763 scopus 로고    scopus 로고
    • Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation
    • COI: 1:CAS:528:DC%2BD1MXhsFOltLnN, PID: 19820197
    • Aamand R, Dalsgaard T, Jensen FB, Simonsen U, Roepstorff A, Fago A. Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation. Am J Physiol Heart Circ Physiol. 2009;297:H2068–74.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , pp. H2068-H2074
    • Aamand, R.1    Dalsgaard, T.2    Jensen, F.B.3    Simonsen, U.4    Roepstorff, A.5    Fago, A.6
  • 80
    • 34548743996 scopus 로고    scopus 로고
    • Red wine-dependent reduction of nitrite to nitric oxide in the stomach
    • COI: 1:CAS:528:DC%2BD2sXhtVOis7nL, PID: 17893036
    • Gago B, Lundberg JO, Barbosa RM, Laranjinha J. Red wine-dependent reduction of nitrite to nitric oxide in the stomach. Free Radic Biol Med. 2007;43:1233–42.
    • (2007) Free Radic Biol Med , vol.43 , pp. 1233-1242
    • Gago, B.1    Lundberg, J.O.2    Barbosa, R.M.3    Laranjinha, J.4
  • 81
    • 46649116908 scopus 로고    scopus 로고
    • The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions
    • COI: 1:CAS:528:DC%2BD1cXosFWnt7Y%3D, PID: 18482590
    • Gago B, Nystrom T, Cavaleiro C, Rocha BS, Barbosa RM, Laranjinha J, et al. The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. Free Radic Biol Med. 2008;45:404–12.
    • (2008) Free Radic Biol Med , vol.45 , pp. 404-412
    • Gago, B.1    Nystrom, T.2    Cavaleiro, C.3    Rocha, B.S.4    Barbosa, R.M.5    Laranjinha, J.6
  • 82
    • 31744451494 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia
    • COI: 1:CAS:528:DC%2BD28XhtFaktbc%3D, PID: 16442076
    • Gautier C, van Faassen E, Mikula I, Martasek P, Slama-Schwok A. Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia. Biochem Biophys Res Commun. 2006;341:816–21.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 816-821
    • Gautier, C.1    van Faassen, E.2    Mikula, I.3    Martasek, P.4    Slama-Schwok, A.5
  • 83
    • 33846545594 scopus 로고    scopus 로고
    • Nitric oxide synthase reduces nitrite to NO under anoxia
    • COI: 1:CAS:528:DC%2BD2sXhs1aju74%3D, PID: 17160351
    • Vanin AF, Bevers LM, Slama-Schwok A, van Faassen EE. Nitric oxide synthase reduces nitrite to NO under anoxia. Cell Mol Life Sci. 2007;64:96–103.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 96-103
    • Vanin, A.F.1    Bevers, L.M.2    Slama-Schwok, A.3    van Faassen, E.E.4
  • 84
    • 40149087392 scopus 로고    scopus 로고
    • Hypoxic modulation of exogenous nitrite-induced vasodilation in humans
    • COI: 1:CAS:528:DC%2BD1cXhtVKju7s%3D, PID: 18212289, Important article demonstrating the increased conversion of nitrite to NO in the context of hypoxia
    • Maher AR, Milsom AB, Gunaruwan P, Abozguia K, Ahmed I, Weaver RA, et al. Hypoxic modulation of exogenous nitrite-induced vasodilation in humans. Circulation. 2008;117:670–7. Important article demonstrating the increased conversion of nitrite to NO in the context of hypoxia.
    • (2008) Circulation , vol.117 , pp. 670-677
    • Maher, A.R.1    Milsom, A.B.2    Gunaruwan, P.3    Abozguia, K.4    Ahmed, I.5    Weaver, R.A.6
  • 85
    • 0035054644 scopus 로고    scopus 로고
    • Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation
    • COI: 1:CAS:528:DC%2BD3MXivVKisbY%3D, PID: 11350258, Important article demonstrating the increased conversion of nitrite to NO in the context of acidemia
    • Modin A, Bjorne H, Herulf M, Alving K, Weitzberg E, Lundberg JO. Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation. Acta Physiol Scand. 2001;171:9–16. Important article demonstrating the increased conversion of nitrite to NO in the context of acidemia.
    • (2001) Acta Physiol Scand , vol.171 , pp. 9-16
    • Modin, A.1    Bjorne, H.2    Herulf, M.3    Alving, K.4    Weitzberg, E.5    Lundberg, J.O.6
  • 86
    • 84920901715 scopus 로고    scopus 로고
    • Mechanisms of human erythrocytic bioactivation of nitrite
    • COI: 1:CAS:528:DC%2BC2MXpvFSisA%3D%3D, PID: 25471374, Important article demonstrating the importance of deoxyhemoglobin in catalyzing the reduction of nitrite to nitric oxide
    • Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, et al. Mechanisms of human erythrocytic bioactivation of nitrite. J Biol Chem. 2015;290:1281–94. Important article demonstrating the importance of deoxyhemoglobin in catalyzing the reduction of nitrite to nitric oxide.
    • (2015) J Biol Chem , vol.290 , pp. 1281-1294
    • Liu, C.1    Wajih, N.2    Liu, X.3    Basu, S.4    Janes, J.5    Marvel, M.6
  • 87
    • 23644460670 scopus 로고    scopus 로고
    • Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
    • COI: 1:CAS:528:DC%2BD2MXntFCmtLo%3D, PID: 16041407
    • Huang Z, Shiva S, Kim-Shapiro DB, Patel RP, Ringwood LA, Irby CE, et al. Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest. 2005;115:2099–107.
    • (2005) J Clin Invest , vol.115 , pp. 2099-2107
    • Huang, Z.1    Shiva, S.2    Kim-Shapiro, D.B.3    Patel, R.P.4    Ringwood, L.A.5    Irby, C.E.6
  • 88
    • 33751198519 scopus 로고    scopus 로고
    • Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    • COI: 1:CAS:528:DC%2BD28Xht1GnsLjP, PID: 16798825
    • Gladwin MT, Raat NJ, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, et al. Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. Am J Physiol Heart Circ Physiol. 2006;291:H2026–35.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. H2026-H2035
    • Gladwin, M.T.1    Raat, N.J.2    Shiva, S.3    Dezfulian, C.4    Hogg, N.5    Kim-Shapiro, D.B.6
  • 89
    • 84876688013 scopus 로고    scopus 로고
    • Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential
    • COI: 1:CAS:528:DC%2BC3sXmtF2qsb8%3D, PID: 23589565
    • Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, et al. Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension. 2013;61:1091–102.
    • (2013) Hypertension , vol.61 , pp. 1091-1102
    • Ghosh, S.M.1    Kapil, V.2    Fuentes-Calvo, I.3    Bubb, K.J.4    Pearl, V.5    Milsom, A.B.6
  • 90
    • 77957907689 scopus 로고    scopus 로고
    • Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction
    • PID: 20543134
    • Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010;3:588–95.
    • (2010) Circ Heart Fail , vol.3 , pp. 588-595
    • Borlaug, B.A.1    Nishimura, R.A.2    Sorajja, P.3    Lam, C.S.4    Redfield, M.M.5
  • 91
    • 84918258075 scopus 로고
    • Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs
    • COI: 1:CAS:528:DyaG3sXlvFCruw%3D%3D, PID: 13062084
    • Furchgott RF, Bhadrakom S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther. 1953;108:129–43.
    • (1953) J Pharmacol Exp Ther , vol.108 , pp. 129-143
    • Furchgott, R.F.1    Bhadrakom, S.2
  • 92
    • 0035940415 scopus 로고    scopus 로고
    • Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
    • COI: 1:CAS:528:DC%2BD3MXotFahsLw%3D, PID: 11606734
    • Lauer T, Preik M, Rassaf T, Strauer BE, Deussen A, Feelisch M, et al. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci U S A. 2001;98:12814–9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12814-12819
    • Lauer, T.1    Preik, M.2    Rassaf, T.3    Strauer, B.E.4    Deussen, A.5    Feelisch, M.6
  • 93
    • 0030010035 scopus 로고    scopus 로고
    • Beneficial actions of nitrates in cardiovascular disease
    • COI: 1:CAS:528:DyaK28Xkt1Kiu7Y%3D, PID: 8638524
    • Abrams J. Beneficial actions of nitrates in cardiovascular disease. Am J Cardiol. 1996;77:31C–7.
    • (1996) Am J Cardiol , vol.77 , pp. 31-37
    • Abrams, J.1
  • 94
    • 84879244665 scopus 로고    scopus 로고
    • Low-dose sodium nitrite attenuates myocardial ischemia and vascular ischemia-reperfusion injury in human models
    • COI: 1:CAS:528:DC%2BC3sXpvVyktbc%3D, PID: 23623914
    • Ingram TE, Fraser AG, Bleasdale RA, Ellins EA, Margulescu AD, Halcox JP, et al. Low-dose sodium nitrite attenuates myocardial ischemia and vascular ischemia-reperfusion injury in human models. J Am Coll Cardiol. 2013;61:2534–41.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2534-2541
    • Ingram, T.E.1    Fraser, A.G.2    Bleasdale, R.A.3    Ellins, E.A.4    Margulescu, A.D.5    Halcox, J.P.6
  • 95
    • 84881453227 scopus 로고    scopus 로고
    • Beetroot juice and exercise: pharmacodynamic and dose–response relationships
    • COI: 1:CAS:528:DC%2BC3sXhsVCisrzJ, PID: 23640589
    • Wylie LJ, Kelly J, Bailey SJ, Blackwell JR, Skiba PF, Winyard PG, et al. Beetroot juice and exercise: pharmacodynamic and dose–response relationships. J Appl Physiol. 2013;115:325–36.
    • (2013) J Appl Physiol , vol.115 , pp. 325-336
    • Wylie, L.J.1    Kelly, J.2    Bailey, S.J.3    Blackwell, J.R.4    Skiba, P.F.5    Winyard, P.G.6
  • 96
    • 55549095980 scopus 로고    scopus 로고
    • The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash
    • COI: 1:CAS:528:DC%2BD1cXhtlGhu7jM
    • Govoni M, Jansson EA, Weitzberg E, Lundberg JO. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide Biol Chem Off J Nitric Oxide Soc. 2008;19:333–7.
    • (2008) Nitric Oxide Biol Chem Off J Nitric Oxide Soc , vol.19 , pp. 333-337
    • Govoni, M.1    Jansson, E.A.2    Weitzberg, E.3    Lundberg, J.O.4
  • 97
    • 3042667643 scopus 로고    scopus 로고
    • Inorganic nitrate is a possible source for systemic generation of nitric oxide
    • COI: 1:CAS:528:DC%2BD2cXltF2rtrk%3D, PID: 15223073
    • Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004;37:395–400.
    • (2004) Free Radic Biol Med , vol.37 , pp. 395-400
    • Lundberg, J.O.1    Govoni, M.2
  • 98
    • 63049130956 scopus 로고    scopus 로고
    • Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash
    • COI: 1:CAS:528:DC%2BD1MXkt1ShtL0%3D, PID: 19439233
    • Petersson J, Carlstrom M, Schreiber O, Phillipson M, Christoffersson G, Jagare A, et al. Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash. Free Radic Biol Med. 2009;46:1068–75.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1068-1075
    • Petersson, J.1    Carlstrom, M.2    Schreiber, O.3    Phillipson, M.4    Christoffersson, G.5    Jagare, A.6
  • 99
    • 84871394316 scopus 로고    scopus 로고
    • Physiological role for nitrate-reducing oral bacteria in blood pressure control
    • COI: 1:CAS:528:DC%2BC3sXhvFWju78%3D, PID: 23183324
    • Kapil V, Haydar SM, Pearl V, Lundberg JO, Weitzberg E, Ahluwalia A. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med. 2013;55:93–100.
    • (2013) Free Radic Biol Med , vol.55 , pp. 93-100
    • Kapil, V.1    Haydar, S.M.2    Pearl, V.3    Lundberg, J.O.4    Weitzberg, E.5    Ahluwalia, A.6
  • 100
    • 39749182795 scopus 로고    scopus 로고
    • Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
    • COI: 1:CAS:528:DC%2BD1cXhvVemsLc%3D, PID: 18250365
    • Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008;51:784–90.
    • (2008) Hypertension , vol.51 , pp. 784-790
    • Webb, A.J.1    Patel, N.2    Loukogeorgakis, S.3    Okorie, M.4    Aboud, Z.5    Misra, S.6
  • 101
    • 0029074273 scopus 로고
    • Pharmacokinetics of isosorbide-5-mononitrate after oral administration of an extended-release mononitrate formulation versus a standard dinitrate formulation
    • COI: 1:STN:280:DyaK2MzjvFektw%3D%3D, PID: 7614524
    • Kosoglou T, Patrick JE, Cohen A, Radwanski E, Christopher D, Affrime MB. Pharmacokinetics of isosorbide-5-mononitrate after oral administration of an extended-release mononitrate formulation versus a standard dinitrate formulation. Clin Ther. 1995;17:241–51.
    • (1995) Clin Ther , vol.17 , pp. 241-251
    • Kosoglou, T.1    Patrick, J.E.2    Cohen, A.3    Radwanski, E.4    Christopher, D.5    Affrime, M.B.6
  • 102
    • 0026716853 scopus 로고
    • Pharmacokinetics of isosorbide mononitrate
    • COI: 1:STN:280:DyaK3s%2FotVWgsA%3D%3D, PID: 1449102
    • Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992;70:61G–6.
    • (1992) Am J Cardiol , vol.70 , pp. 61-66
    • Abshagen, U.W.1
  • 103
    • 0037062518 scopus 로고    scopus 로고
    • Identification of the enzymatic mechanism of nitroglycerin bioactivation
    • COI: 1:CAS:528:DC%2BD38XkvVGgsb0%3D, PID: 12048254
    • Chen Z, Zhang J, Stamler JS. Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci U S A. 2002;99:8306–11.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8306-8311
    • Chen, Z.1    Zhang, J.2    Stamler, J.S.3
  • 104
    • 0023183110 scopus 로고
    • Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure
    • COI: 1:STN:280:DyaL2szgt1Wmsg%3D%3D, PID: 3113764
    • Elkayam U, Kulick D, McIntosh N, Roth A, Hsueh W, Rahimtoola SH. Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure. Circulation. 1987;76:577–84.
    • (1987) Circulation , vol.76 , pp. 577-584
    • Elkayam, U.1    Kulick, D.2    McIntosh, N.3    Roth, A.4    Hsueh, W.5    Rahimtoola, S.H.6
  • 105
    • 0032887045 scopus 로고    scopus 로고
    • Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate
    • COI: 1:CAS:528:DyaK1MXlvFCgtLg%3D, PID: 10499557, discussion S29-31
    • Waller DG. Optimal nitrate therapy with a once-daily sustained-release formulation of isosorbide mononitrate. J Cardiovasc Pharmacol. 1999;34 Suppl 2:S21–7. discussion S29-31.
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. S21-S27
    • Waller, D.G.1
  • 106
    • 26244465889 scopus 로고    scopus 로고
    • Explaining the phenomenon of nitrate tolerance
    • PID: 16195486
    • Munzel T, Daiber A, Mulsch A. Explaining the phenomenon of nitrate tolerance. Circ Res. 2005;97:618–28.
    • (2005) Circ Res , vol.97 , pp. 618-628
    • Munzel, T.1    Daiber, A.2    Mulsch, A.3
  • 107
    • 79551495798 scopus 로고    scopus 로고
    • Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension
    • PID: 21097806
    • Carlstrom M, Persson AE, Larsson E, Hezel M, Scheffer PG, Teerlink T, et al. Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res. 2011;89:574–85.
    • (2011) Cardiovasc Res , vol.89 , pp. 574-585
    • Carlstrom, M.1    Persson, A.E.2    Larsson, E.3    Hezel, M.4    Scheffer, P.G.5    Teerlink, T.6
  • 108
    • 84921543574 scopus 로고    scopus 로고
    • Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study
    • COI: 1:CAS:528:DC%2BC2MXktFWktw%3D%3D, PID: 25421976
    • Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 2015;65:320–7.
    • (2015) Hypertension , vol.65 , pp. 320-327
    • Kapil, V.1    Khambata, R.S.2    Robertson, A.3    Caulfield, M.J.4    Ahluwalia, A.5
  • 109
    • 77954371337 scopus 로고    scopus 로고
    • Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans
    • COI: 1:CAS:528:DC%2BC3cXhtVSksLbP, PID: 20466802
    • Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, et al. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol. 2010;109:135–48.
    • (2010) J Appl Physiol , vol.109 , pp. 135-148
    • Bailey, S.J.1    Fulford, J.2    Vanhatalo, A.3    Winyard, P.G.4    Blackwell, J.R.5    DiMenna, F.J.6
  • 110
    • 80052964796 scopus 로고    scopus 로고
    • Acute administration of inorganic nitrate reduces VO(2peak) in endurance athletes
    • COI: 1:CAS:528:DC%2BC3MXhtF2jtrzI, PID: 21407132
    • Bescos R, Rodriguez FA, Iglesias X, Ferrer MD, Iborra E, Pons A. Acute administration of inorganic nitrate reduces VO(2peak) in endurance athletes. Med Sci Sports Exerc. 2011;43:1979–86.
    • (2011) Med Sci Sports Exerc , vol.43 , pp. 1979-1986
    • Bescos, R.1    Rodriguez, F.A.2    Iglesias, X.3    Ferrer, M.D.4    Iborra, E.5    Pons, A.6
  • 111
    • 84893382348 scopus 로고    scopus 로고
    • Cardiorespiratory function associated with dietary nitrate supplementation
    • COI: 1:CAS:528:DC%2BC3sXhvVGru7fN, PID: 24476472
    • Bond Jr V, Curry BH, Adams RG, Millis RM, Haddad GE. Cardiorespiratory function associated with dietary nitrate supplementation. Appl Physiol Nutr Metab. 2014;39:168–72.
    • (2014) Appl Physiol Nutr Metab , vol.39 , pp. 168-172
    • Bond, V.1    Curry, B.H.2    Adams, R.G.3    Millis, R.M.4    Haddad, G.E.5
  • 112
    • 79954597313 scopus 로고    scopus 로고
    • Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study
    • COI: 1:CAS:528:DC%2BC3MXktFagsL8%3D, PID: 21071588
    • Lansley KE, Winyard PG, Fulford J, Vanhatalo A, Bailey SJ, Blackwell JR, et al. Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Appl Physiol. 2011;110:591–600.
    • (2011) J Appl Physiol , vol.110 , pp. 591-600
    • Lansley, K.E.1    Winyard, P.G.2    Fulford, J.3    Vanhatalo, A.4    Bailey, S.J.5    Blackwell, J.R.6
  • 113
    • 79551510834 scopus 로고    scopus 로고
    • Dietary inorganic nitrate improves mitochondrial efficiency in humans
    • COI: 1:CAS:528:DC%2BC3MXhtlaju7c%3D, PID: 21284982
    • Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, et al. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011;13:149–59.
    • (2011) Cell Metab , vol.13 , pp. 149-159
    • Larsen, F.J.1    Schiffer, T.A.2    Borniquel, S.3    Sahlin, K.4    Ekblom, B.5    Lundberg, J.O.6
  • 114
    • 72649101329 scopus 로고    scopus 로고
    • Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise
    • COI: 1:CAS:528:DC%2BC3cXps1Cn, PID: 19913611
    • Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med. 2010;48:342–7.
    • (2010) Free Radic Biol Med , vol.48 , pp. 342-347
    • Larsen, F.J.1    Weitzberg, E.2    Lundberg, J.O.3    Ekblom, B.4
  • 115
    • 34547660516 scopus 로고    scopus 로고
    • Effects of dietary nitrate on oxygen cost during exercise
    • COI: 1:CAS:528:DC%2BD2sXhtVSmtr%2FO
    • Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol. 2007;191:59–66.
    • (2007) Acta Physiol , vol.191 , pp. 59-66
    • Larsen, F.J.1    Weitzberg, E.2    Lundberg, J.O.3    Ekblom, B.4
  • 117
    • 77957600797 scopus 로고    scopus 로고
    • Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise
    • COI: 1:CAS:528:DC%2BC3cXhtlKlur3J, PID: 20702806
    • Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1121–31.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , pp. R1121-R1131
    • Vanhatalo, A.1    Bailey, S.J.2    Blackwell, J.R.3    DiMenna, F.J.4    Pavey, T.G.5    Wilkerson, D.P.6
  • 118
    • 84940661609 scopus 로고    scopus 로고
    • Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise
    • PID: 26084693
    • Lee JS, Stebbins CL, Jung E, Nho H, Kim JK, Chang MJ, et al. Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 2015;309:R459–66.
    • (2015) Am J Physiol Regul Integr Comp Physiol , vol.309 , pp. R459-R466
    • Lee, J.S.1    Stebbins, C.L.2    Jung, E.3    Nho, H.4    Kim, J.K.5    Chang, M.J.6
  • 119
    • 79957956569 scopus 로고    scopus 로고
    • Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension
    • COI: 1:CAS:528:DC%2BC3MXntFSktLY%3D, PID: 21530643
    • Montenegro MF, Amaral JH, Pinheiro LC, Sakamoto EK, Ferreira GC, Reis RI, et al. Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension. Free Radic Biol Med. 2011;51:144–52.
    • (2011) Free Radic Biol Med , vol.51 , pp. 144-152
    • Montenegro, M.F.1    Amaral, J.H.2    Pinheiro, L.C.3    Sakamoto, E.K.4    Ferreira, G.C.5    Reis, R.I.6
  • 120
    • 0032897642 scopus 로고    scopus 로고
    • Persistent antihypertensive effect of oral nitrite supplied up to one year via the drinking water in spontaneously hypertensive rats
    • COI: 1:CAS:528:DyaK1MXivVWhs7k%3D, PID: 10337450
    • Haas M, Classen HG, Thoni H, Classen UG, Drescher B. Persistent antihypertensive effect of oral nitrite supplied up to one year via the drinking water in spontaneously hypertensive rats. Arzneimittelforschung. 1999;49:318–23.
    • (1999) Arzneimittelforschung , vol.49 , pp. 318-323
    • Haas, M.1    Classen, H.G.2    Thoni, H.3    Classen, U.G.4    Drescher, B.5
  • 121
    • 33947501974 scopus 로고    scopus 로고
    • Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism
    • COI: 1:CAS:528:DC%2BD2sXjslGktrs%3D, PID: 17394960
    • Thomas GR, DiFabio JM, Gori T, Parker JD. Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism. J Am Coll Cardiol. 2007;49:1289–95.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1289-1295
    • Thomas, G.R.1    DiFabio, J.M.2    Gori, T.3    Parker, J.D.4
  • 122
    • 0034805427 scopus 로고    scopus 로고
    • Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans
    • COI: 1:CAS:528:DC%2BD3MXotVektr0%3D, PID: 11583888
    • Gori T, Mak SS, Kelly S, Parker JD. Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans. J Am Coll Cardiol. 2001;38:1096–101.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1096-1101
    • Gori, T.1    Mak, S.S.2    Kelly, S.3    Parker, J.D.4
  • 123
    • 0031931799 scopus 로고    scopus 로고
    • Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril
    • COI: 1:CAS:528:DyaK1cXjslKitg%3D%3D, PID: 9426022
    • Heitzer T, Just H, Brockhoff C, Meinertz T, Olschewski M, Munzel T. Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril. J Am Coll Cardiol. 1998;31:83–8.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 83-88
    • Heitzer, T.1    Just, H.2    Brockhoff, C.3    Meinertz, T.4    Olschewski, M.5    Munzel, T.6
  • 124
    • 0032420985 scopus 로고    scopus 로고
    • Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine
    • COI: 1:CAS:528:DyaK1MXht1Sj, PID: 9857880
    • Caramori PR, Adelman AG, Azevedo ER, Newton GE, Parker AB, Parker JD. Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine. J Am Coll Cardiol. 1998;32:1969–74.
    • (1998) J Am Coll Cardiol , vol.32 , pp. 1969-1974
    • Caramori, P.R.1    Adelman, A.G.2    Azevedo, E.R.3    Newton, G.E.4    Parker, A.B.5    Parker, J.D.6
  • 125
    • 84861314928 scopus 로고    scopus 로고
    • Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers
    • COI: 1:CAS:528:DC%2BC38Xis1Oqsb0%3D
    • Bahra M, Kapil V, Pearl V, Ghosh S, Ahluwalia A. Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. Nitric Oxide Biol Chem Off J Nitric Oxide Soc. 2012;26:197–202.
    • (2012) Nitric Oxide Biol Chem Off J Nitric Oxide Soc , vol.26 , pp. 197-202
    • Bahra, M.1    Kapil, V.2    Pearl, V.3    Ghosh, S.4    Ahluwalia, A.5
  • 126
    • 84874936090 scopus 로고    scopus 로고
    • Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXnsFWiu74%3D, PID: 23395779
    • Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N. Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Free Radic Biol Med. 2013;60:89–97.
    • (2013) Free Radic Biol Med , vol.60 , pp. 89-97
    • Gilchrist, M.1    Winyard, P.G.2    Aizawa, K.3    Anning, C.4    Shore, A.5    Benjamin, N.6
  • 127
    • 84902081240 scopus 로고    scopus 로고
    • Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk
    • COI: 1:CAS:528:DC%2BC2cXmtlaiu70%3D, PID: 23994403
    • Rammos C, Hendgen-Cotta UB, Sobierajski J, Bernard A, Kelm M, Rassaf T. Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk. J Am Coll Cardiol. 2014;63:1584–5.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 1584-1585
    • Rammos, C.1    Hendgen-Cotta, U.B.2    Sobierajski, J.3    Bernard, A.4    Kelm, M.5    Rassaf, T.6
  • 128
    • 77955476126 scopus 로고    scopus 로고
    • Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO
    • COI: 1:CAS:528:DC%2BC3cXovVyqtrc%3D, PID: 20585108
    • Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, et al. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010;56:274–81.
    • (2010) Hypertension , vol.56 , pp. 274-281
    • Kapil, V.1    Milsom, A.B.2    Okorie, M.3    Maleki-Toyserkani, S.4    Akram, F.5    Rehman, F.6
  • 129
    • 19644400578 scopus 로고    scopus 로고
    • African-American Heart Failure Trial I. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure
    • COI: 1:CAS:528:DC%2BD2cXpslegsrs%3D, PID: 15533851
    • Taylor AL. African-American Heart Failure Trial I. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351:2049–57.
    • (2004) N Engl J Med , vol.351 , pp. 2049-2057
    • Taylor, A.L.1
  • 130
    • 84929318500 scopus 로고    scopus 로고
    • Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: an individual participant meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXnvFCjtrs%3D
    • Siervo M, Lara J, Jajja A, Sutyarjoko A, Ashor AW, Brandt K, et al. Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: an individual participant meta-analysis. Nitric Oxide Biol Chem Off J Nitric Oxide Soc. 2015;47:97–105.
    • (2015) Nitric Oxide Biol Chem Off J Nitric Oxide Soc , vol.47 , pp. 97-105
    • Siervo, M.1    Lara, J.2    Jajja, A.3    Sutyarjoko, A.4    Ashor, A.W.5    Brandt, K.6
  • 131
    • 84859117987 scopus 로고    scopus 로고
    • Plasma nitrate and nitrite are increased by a high-nitrate supplement but not by high-nitrate foods in older adults
    • COI: 1:CAS:528:DC%2BC38XltVKltbs%3D, PID: 22464802
    • Miller GD, Marsh AP, Dove RW, Beavers D, Presley T, Helms C, et al. Plasma nitrate and nitrite are increased by a high-nitrate supplement but not by high-nitrate foods in older adults. Nutr Res. 2012;32:160–8.
    • (2012) Nutr Res , vol.32 , pp. 160-168
    • Miller, G.D.1    Marsh, A.P.2    Dove, R.W.3    Beavers, D.4    Presley, T.5    Helms, C.6
  • 132
    • 84894500990 scopus 로고    scopus 로고
    • Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: safety, walking distance and endothelial function
    • COI: 1:CAS:528:DC%2BC2cXhslCntr7N, PID: 24363302
    • Mohler 3rd ER, Hiatt WR, Gornik HL, Kevil CG, Quyyumi A, Haynes WG, et al. Sodium nitrite in patients with peripheral artery disease and diabetes mellitus: safety, walking distance and endothelial function. Vasc Med. 2014;19:9–17.
    • (2014) Vasc Med , vol.19 , pp. 9-17
    • Mohler, E.R.1    Hiatt, W.R.2    Gornik, H.L.3    Kevil, C.G.4    Quyyumi, A.5    Haynes, W.G.6
  • 133
    • 84863807391 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients
    • COI: 1:CAS:528:DC%2BC38XpvVOgt7o%3D, PID: 22468627
    • Greenway FL, Predmore BL, Flanagan DR, Giordano T, Qiu Y, Brandon A, et al. Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients. Diabetes Technol Ther. 2012;14:552–60.
    • (2012) Diabetes Technol Ther , vol.14 , pp. 552-560
    • Greenway, F.L.1    Predmore, B.L.2    Flanagan, D.R.3    Giordano, T.4    Qiu, Y.5    Brandon, A.6
  • 135
    • 84877820465 scopus 로고    scopus 로고
    • Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite
    • COI: 1:CAS:528:DC%2BC3sXptlOhtr8%3D, PID: 23472879
    • Maher AR, Arif S, Madhani M, Abozguia K, Ahmed I, Fernandez BO, et al. Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite. Br J Pharmacol. 2013;169:659–70.
    • (2013) Br J Pharmacol , vol.169 , pp. 659-670
    • Maher, A.R.1    Arif, S.2    Madhani, M.3    Abozguia, K.4    Ahmed, I.5    Fernandez, B.O.6
  • 136
    • 0032710821 scopus 로고    scopus 로고
    • Methemoglobinemia: etiology, pharmacology, and clinical management
    • COI: 1:STN:280:DC%2BD3c%2FgsVGhtg%3D%3D, PID: 10533013
    • Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med. 1999;34:646–56.
    • (1999) Ann Emerg Med , vol.34 , pp. 646-656
    • Wright, R.O.1    Lewander, W.J.2    Woolf, A.D.3
  • 137
    • 0022001043 scopus 로고
    • Nitrates, nitrites and gastric cancer in Great Britain
    • COI: 1:STN:280:DyaL2M7jslymsg%3D%3D, PID: 3974695
    • Forman D, Al-Dabbagh S, Doll R. Nitrates, nitrites and gastric cancer in Great Britain. Nature. 1985;313:620–5.
    • (1985) Nature , vol.313 , pp. 620-625
    • Forman, D.1    Al-Dabbagh, S.2    Doll, R.3
  • 138
    • 84861320026 scopus 로고    scopus 로고
    • Human safety controversies surrounding nitrate and nitrite in the diet
    • COI: 1:CAS:528:DC%2BC38XlvVSnt78%3D
    • Sindelar JJ, Milkowski AL. Human safety controversies surrounding nitrate and nitrite in the diet. Nitric Oxide Biol Chem Off J Nitric Oxide Soc. 2012;26:259–66.
    • (2012) Nitric Oxide Biol Chem Off J Nitric Oxide Soc , vol.26 , pp. 259-266
    • Sindelar, J.J.1    Milkowski, A.L.2
  • 139
    • 84880686365 scopus 로고    scopus 로고
    • Novel aspects of dietary nitrate and human health
    • COI: 1:CAS:528:DC%2BC3sXhsVSqtLvK, PID: 23642194
    • Weitzberg E, Lundberg JO. Novel aspects of dietary nitrate and human health. Annu Rev Nutr. 2013;33:129–59.
    • (2013) Annu Rev Nutr , vol.33 , pp. 129-159
    • Weitzberg, E.1    Lundberg, J.O.2
  • 140
    • 0031959619 scopus 로고    scopus 로고
    • Dietary nitrates, nitrites, and N-nitroso compounds and cancer risk: a review of the epidemiologic evidence
    • COI: 1:STN:280:DyaK1c3ksFCksQ%3D%3D, PID: 9584494
    • Eichholzer M, Gutzwiller F. Dietary nitrates, nitrites, and N-nitroso compounds and cancer risk: a review of the epidemiologic evidence. Nutr Rev. 1998;56:95–105.
    • (1998) Nutr Rev , vol.56 , pp. 95-105
    • Eichholzer, M.1    Gutzwiller, F.2
  • 143
    • 0027288485 scopus 로고
    • Incidence of cancer among workers in a Norwegian nitrate fertiliser plant
    • COI: 1:CAS:528:DyaK2cXhtFGls74%3D, PID: 8393697
    • Fandrem SI, Kjuus H, Andersen A, Amlie E. Incidence of cancer among workers in a Norwegian nitrate fertiliser plant. Br J Ind Med. 1993;50:647–52.
    • (1993) Br J Ind Med , vol.50 , pp. 647-652
    • Fandrem, S.I.1    Kjuus, H.2    Andersen, A.3    Amlie, E.4
  • 146
    • 0033007278 scopus 로고    scopus 로고
    • Dietary nitrate in man: friend or foe?
    • COI: 1:CAS:528:DyaK1MXjvFGgur4%3D, PID: 10615207
    • McKnight GM, Duncan CW, Leifert C, Golden MH. Dietary nitrate in man: friend or foe? Br J Nutr. 1999;81:349–58.
    • (1999) Br J Nutr , vol.81 , pp. 349-358
    • McKnight, G.M.1    Duncan, C.W.2    Leifert, C.3    Golden, M.H.4
  • 147
    • 0142088894 scopus 로고    scopus 로고
    • Health implications of exposure to environmental nitrogenous compounds
    • COI: 1:CAS:528:DC%2BD3sXoslyht7g%3D, PID: 14579546
    • Mensinga TT, Speijers GJ, Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev. 2003;22:41–51.
    • (2003) Toxicol Rev , vol.22 , pp. 41-51
    • Mensinga, T.T.1    Speijers, G.J.2    Meulenbelt, J.3
  • 148
    • 29244472852 scopus 로고    scopus 로고
    • Food Additives Series Geneva: Joint FAO/WHO Expert Committee on Food Additives
    • Speijers G BP. Nitrate. Food Additives Series Geneva: Joint FAO/WHO Expert Committee on Food Additives. 2003.
    • (2003) Nitrate
    • Speijers, G.B.P.1
  • 149
    • 49549097364 scopus 로고    scopus 로고
    • The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective
    • PID: 18452640
    • Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67:253–6.
    • (2008) Proc Nutr Soc , vol.67 , pp. 253-256
    • Wiseman, M.1
  • 150
    • 33845877743 scopus 로고    scopus 로고
    • Effects of dietary nitrate on blood pressure in healthy volunteers
    • COI: 1:CAS:528:DC%2BD2sXhslGjtA%3D%3D, PID: 17192551
    • Larsen FJ, Ekblom B, Sahlin K, Lundberg JO, Weitzberg E. Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med. 2006;355:2792–3.
    • (2006) N Engl J Med , vol.355 , pp. 2792-2793
    • Larsen, F.J.1    Ekblom, B.2    Sahlin, K.3    Lundberg, J.O.4    Weitzberg, E.5
  • 152
    • 34249894415 scopus 로고    scopus 로고
    • Nitric oxide increases oxidative phosphorylation efficiency
    • COI: 1:CAS:528:DC%2BD2sXntlChs7w%3D, PID: 17447126
    • Clerc P, Rigoulet M, Leverve X, Fontaine E. Nitric oxide increases oxidative phosphorylation efficiency. J Bioenerg Biomembr. 2007;39:158–66.
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 158-166
    • Clerc, P.1    Rigoulet, M.2    Leverve, X.3    Fontaine, E.4
  • 154
    • 84927712448 scopus 로고    scopus 로고
    • Nitrate's effect on activity tolerance in heart failure with preserved ejection fraction trial: rationale and design
    • PID: 25605640
    • Zakeri R, Levine JA, Koepp GA, Borlaug BA, Chirinos JA, LeWinter M, et al. Nitrate's effect on activity tolerance in heart failure with preserved ejection fraction trial: rationale and design. Circ Heart Fail. 2015;8:221–8.
    • (2015) Circ Heart Fail , vol.8 , pp. 221-228
    • Zakeri, R.1    Levine, J.A.2    Koepp, G.A.3    Borlaug, B.A.4    Chirinos, J.A.5    LeWinter, M.6


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