Bioavailability of sodium nitrite from an aqueous solution in healthy adults

Toxicology Letters

Volumn 190, Issue 1, 2009, Pages 48-53

  Hunault, Claudine C ^a   van Velzen, Agnes G ^a   Sips, Adrienne J A M ^a   Schothorst, Ronald C ^a   Meulenbelt, Jan ^a,b,c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Bioavailability; Human; Methaemoglobinemia; Nitrate; Nitrite; Pharmacokinetics

Indexed keywords

METHEMOGLOBIN; SODIUM NITRITE;

ADSORPTION KINETICS; ADULT; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; FIRST PASS EFFECT; GASTROINTESTINAL ABSORPTION; HUMAN; MALE; NORMAL HUMAN; OXIDATION KINETICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; CROSS-OVER STUDIES; DIET; FEMALE; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; METHEMOGLOBIN; NITRATES; SODIUM NITRITE; SOLUTIONS; YOUNG ADULT;

LACTUCA; SPINACIA OLERACEA;

EID: 68349130367     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.06.865     Document Type: Article

References (29)

1. Bartholomew B., and Hill M.J. The pharmacology of dietary nitrate and the origin of urinary nitrate. Food Chem. Toxicol. 22 (1984) 789-795
2. Cosby K., Partovi K.S., Crawford J.H., Patel R.P., Reiter C.D., Martyr S., Yang B.K., Waclawiw M.A., Zalos G., Xu X., Huang K.T., Shields H., Kim-Shapiro D.B., Schechter A.N., Cannon III R.O., and Gladwin M.T. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat. Med. 9 (2003) 1498-1505
3. Fine D.H., Ross R., Rounbehler D.P., Silvergleid A., and Song L. Formation in vivo of volatile N-nitrosamines in man after ingestion of cooked bacon and spinach. Nature 265 (1977) 753-755
4. Gangolli S.D., van den Brandt P.A., Feron V.J., Janzowsky C., Koeman J.H., Speijers G.J., Spiegelhalder B., Walker R., and Wisnok J.S. Nitrate, nitrite and N-nitroso compounds. Eur. J. Pharmacol. 292 (1994) 1-38
5. Guadagnin S.G., Rath S., and Reyes F.G. Evaluation of the nitrate content in leaf vegetables produced through different agricultural systems. Food Addit. Contam. 22 (2005) 1203-1208
6. Kortboyer J.M., Schothorst R.C., Zeilmaker M.J., and Meulenbelt J. Intravenous Administration of Sodium Nitrite to Healthy Volunteers: A Single Ascending Dose Study (1998), National Institute of Public Health and Environment, Bilthoven, The Netherlands
7. Lundberg J.O., Weitzberg E., and Gladwin M.T. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat. Rev. Drug Discov. 7 (2008) 156-167
8. Lundberg J.O., Weitzberg E., Lundberg J.M., and Alving K. Intragastric nitric oxide production in humans: measurements in expelled air. Gut 35 (1994) 1543-1546
9. Manassaram D.M., Backer L.C., and Moll D.M. A review of nitrates in drinking water: maternal exposure and adverse reproductive and developmental outcomes. Cien. Saude Colet. 12 (2007) 153-163
10. Meah M.N., Harrison N., and Davies A. Nitrate and nitrite in foods and the diet. Food Addit. Contam. 11 (1994) 519-532
11. Mirvish S.S. Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence. Toxicol. Appl. Pharmacol. 31 (1975) 325-351
12. Petersen A., and Stoltze S. Nitrate and nitrite in vegetables on the Danish market: content and intake. Food Addit. Contam. 16 (1999) 291-299
13. Powlson D.S., Addiscott T.M., Benjamin N., Cassman K.G., de Kok T.M., van Grinsven H., L'Hirondel J.L., Avery A.A., and van Kessel C. When does nitrate become a risk for humans?. J. Environ. Qual. 37 (2008) 291-295
14. Seifert S.A. In: Dart R.C. (Ed). Nitrates and Nitrites (2004), Lippincott, Williams and Wilkins, Baltimore 1174-1180
15. Spiegelhalder B., Eisenbrand G., and Preussmann R. Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food Cosmet. Toxicol. 14 (1976) 545-548
16. Stephany R.W., and Schuller P.L. Daily dietary intakes of nitrate, nitrite and volative N-nitrosamines in the Netherlands using the duplicate portion sampling technique. Oncology 37 (1980) 203-210
17. Tannenbaum S.R., Sinskey A.J., Weisman M., and Bishop W. Nitrite in human saliva. Its possible relationship to nitrosamine formation. J. Natl. Cancer Inst. 53 (1974) 79-84
18. Tannenbaum S.R., Weisman M., and Fett D. The effect of nitrate intake on nitrite formation in human saliva. Food Cosmet. Toxicol. 14 (1976) 549-552
19. Vaessen H.A.M., van de Kamp C.G., and van de Vliet J.J.H. Nitraat en nitriet in urine, maagsap, speeksel en bloedplasma. Bepaling met hoge prestatie ion chromatografie (HPIC) en UV-detectie (1994), National Institute of Public Health and Environment, Bilthoven, The Netherlands
20. van Grinsven H.J., Ward M.H., Benjamin N., and de Kok T.M. Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water?. Environ. Health 5 (2006) 26
21. van Loon A.J.M., and van Klaveren J.D. Nitraatinname van de Nederlandse bevolking. Voeding 52 (1991) 96-100
22. van Maanen J.M., Welle I.J., Hageman G., Dallinga J.W., Mertens P.L., and Kleinjans J.C. Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines. Environ. Health Perspect. 104 (1996) 522-528
23. Vleeming W., van de K.A., te Biesebeek J.D., Meulenbelt J., and Boink A.B. Effect of nitrite on blood pressure in anaesthetized and free-moving rats. Food Chem. Toxicol. 35 (1997) 615-619
24. Ward M.H., deKok T.M., Levallois P., Brender J., Gulis G., Nolan B.T., and VanDerslice J. Workgroup report: drinking-water nitrate and health-recent findings and research needs. Environ. Health Perspect. 113 (2005) 1607-1614
25. Webb A.J., Patel N., Loukogeorgakis S., Okorie M., Aboud Z., Misra S., Rashid R., Miall P., Deanfield J., Benjamin N., MacAllister R., Hobbs A.J., and Ahluwalia A. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 51 (2008) 784-790
26. White J.W. Relative significance of dietary sources of nitrate and nitrite. J. Agric. Food Chem. 23 (1975) 886-891
27. WHO. Health Hazards from Nitrates in Drinking Water (1985), World Health Organization, Copenhagen
28. WHO. Evaluation of Certain Food Additives and Contaminants. Forty-fourth Report of the Joint FAO/WHO Experts Committee on Food Additives (1995), World Health Organization, Geneva
29. - in germfree and conventional-flora rats. Appl. Environ. Microbiol. 38 (1979) 861-869