Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control

Journal of Clinical Investigation

Volumn 115, Issue 8, 2005, Pages 2099-2107

  Huang, Zhi ^a,b   Shiva, Sruti ^a   Kim Shapiro, Daniel B ^c,d   Patel, Rakesh P ^e   Ringwood, Lorna A ^a   Irby, Cynthia E ^f   Huang, Kris T ^c,d   Ho, Chien ^g   Hogg, Neil ^h   Schechter, Alan N ^b   Gladwin, Mark T ^a,f  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c WAKE FOREST UNIVERSITY   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e University of Alabama at Birmingham   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g CARNEGIE MELLON UNIVERSITY   (United States)

^h FREE RADICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYHEMOGLOBIN; HEME; HEMOGLOBIN; NITRIC OXIDE; NITRITE REDUCTASE; OXYHEMOGLOBIN;

ADULT; ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; HUMAN; HYPOXIA; KINETICS; NORMAL HUMAN; OXIMETRY; OXYGEN AFFINITY; PH; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; REDUCTION; VASODILATATION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; ANOXIA; HEMOGLOBINS; HORSES; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; NITRIC OXIDE; NITRITE REDUCTASES; NITRITES; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; VASODILATION;

EID: 23644460670     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI24650     Document Type: Article

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