Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats

Free Radical Biology and Medicine

Volumn 53, Issue 4, 2012, Pages 701-709

  Pinheiro, Lucas C ^a   Montenegro, Marcelo F ^b   Amaral, Jefferson H ^b   Ferreira, Graziele C ^b   Oliveira, Alisson M ^b   Tanus Santos, Jose E ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Free radicals; Hypertension; L NAME; Nitrite; Omeprazole

Indexed keywords

N(G) NITROARGININE METHYL ESTER; OMEPRAZOLE; S NITROSOTHIOL; SODIUM NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; HYPERTENSION; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROOM TEMPERATURE; STOMACH PH; THERAPY EFFECT; VASODILATATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ULCER AGENTS; ANTIHYPERTENSIVE AGENTS; AORTA; BENZOATES; BLOOD PRESSURE; FREE RADICAL SCAVENGERS; GASTRIC JUICE; HYDROGEN-ION CONCENTRATION; HYPERTENSION; IMIDAZOLES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OMEPRAZOLE; RATS; RATS, WISTAR; S-NITROSOTHIOLS; SODIUM NITRITE; VASODILATION;

RATTUS;

EID: 84864412442     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.06.001     Document Type: Article

References (43)

1. P.J. Andrew, and B. Mayer Enzymatic function of nitric oxide synthases Cardiovasc. Res. 43 1999 521 531
2. S. Moncada, R. Palmer, and E. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol. Rev. 43 1991 109
3. A. Dejam, C.J. Hunter, A.N. Schechter, and M.T. Gladwin Emerging role of nitrite in human biology Blood Cells Mol. Dis. 32 2004 423 429
4. I.F. Metzger, J.T. Sertorio, and J.E. Tanus-Santos Relationship between systemic nitric oxide metabolites and cyclic GMP in healthy male volunteers Acta Physiol. (Oxford) 188 2006 123 127
5. P. Kleinbongard, A. Dejam, T. Lauer, T. Jax, S. Kerber, P. Gharini, J. Balzer, R.B. Zotz, R.E. Scharf, R. Willers, A.N. Schechter, M. Feelisch, and M. Kelm Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans Free Radic. Biol. Med. 40 2006 295 302
6. P. Kleinbongard, A. Dejam, T. Lauer, T. Rassaf, A. Schindler, O. Picker, T. Scheeren, A. Godecke, J. Schrader, R. Schulz, G. Heusch, G.A. Schaub, N.S. Bryan, M. Feelisch, and M. Kelm Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals Free Radic. Biol. Med. 35 2003 790 796
7. J.O. Lundberg Nitric oxide metabolites and cardiovascular disease markers, mediators, or both? J. Am. Coll. Cardiol. 47 2006 580 581
8. M.T. Gladwin, A.N. Schechter, D.B. Kim-Shapiro, R.P. Patel, N. Hogg, S. Shiva, R.O. Cannon 3rd, M. Kelm, D.A. Wink, M.G. Espey, E.H. Oldfield, R.M. Pluta, B.A. Freeman, J.R. Lancaster Jr, M. Feelisch, and J.O. Lundberg The emerging biology of the nitrite anion Nat. Chem. Biol. 1 2005 308 314
9. J.O. Lundberg, M.T. Gladwin, A. Ahluwalia, N. Benjamin, N.S. Bryan, A. Butler, P. Cabrales, A. Fago, M. Feelisch, P.C. Ford, B.A. Freeman, M. Frenneaux, J. Friedman, M. Kelm, C.G. Kevil, D.B. Kim-Shapiro, A.V. Kozlov, J.R. Lancaster Jr, D.J. Lefer, K. McColl, K. McCurry, R.P. Patel, J. Petersson, T. Rassaf, V.P. Reutov, G.B. Richter-Addo, A. Schechter, S. Shiva, K. Tsuchiya, E.E. van Faassen, A.J. Webb, B.S. Zuckerbraun, J.L. Zweier, and E. Weitzberg Nitrate and nitrite in biology, nutrition and therapeutics Nat. Chem. Biol. 5 2009 865 869
10. J.O. Lundberg, E. Weitzberg, and M.T. Gladwin The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics Nat. Rev. Drug Discovery 7 2008 156 167
11. K. Cosby, K.S. Partovi, J.H. Crawford, R.P. Patel, C.D. Reiter, S. Martyr, B.K. Yang, M.A. Waclawiw, G. Zalos, X. Xu, K.T. Huang, H. Shields, D.B. Kim-Shapiro, A.N. Schechter, R.O. Cannon 3rd, and M.T. Gladwin Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation Nat. Med 9 2003 1498 1505
12. S. Shiva, Z. Huang, R. Grubina, J. Sun, L.A. Ringwood, P.H. MacArthur, X. Xu, E. Murphy, V.M. Darley-Usmar, and M.T. Gladwin Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration Circ. Res. 100 2007 654 661
13. T. Rassaf, U. Flogel, C. Drexhage, U. Hendgen-Cotta, M. Kelm, and J. Schrader Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function Circ. Res. 100 2007 1749 1754
14. P. Tripatara, N.S. Patel, A. Webb, K. Rathod, F.M. Lecomte, E. Mazzon, S. Cuzzocrea, M.M. Yaqoob, A. Ahluwalia, and C. Thiemermann Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase J. Am. Soc. Nephrol. 18 2007 570 580
15. A. Webb, R. Bond, P. McLean, R. Uppal, N. Benjamin, and A. Ahluwalia Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage Proc. Natl. Acad. Sci. USA 101 2004 13683 13688
16. H. Li, H. Cui, T.K. Kundu, W. Alzawahra, and J.L. Zweier Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase J. Biol. Chem. 283 2008 17855 17863
17. C. Gautier, E. van Faassen, I. Mikula, P. Martasek, and A. Slama-Schwok Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia Biochem. Biophys. Res. Commun. 341 2006 816 821
18. A.V. Kozlov, K. Staniek, and H. Nohl Nitrite reductase activity is a novel function of mammalian mitochondria FEBS Lett 454 1999 127 130
19. N. Benjamin, F. O'Driscoll, H. Dougall, C. Duncan, L. Smith, and M. Golden Stomach NO synthesis Nature 368 1994 502
20. G.M. McKnight, L.M. Smith, R.S. Drummond, C.W. Duncan, M. Golden, and N. Benjamin Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans Gut 40 1997 211 214
21. J.O. Lundberg, E. Weitzberg, J.M. Lundberg, and K. Alving Intragastric nitric oxide production in humans: measurements in expelled air Gut 35 1994 1543 1546
22. M.F. Montenegro, J.H. Amaral, L.C. Pinheiro, E.K. Sakamoto, G.C. Ferreira, R.I. Reis, D.M.O. Marçal, R.P. Pereira, and J.E. Tanus-Santos Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension Free Radic. Biol. Med. 51 2011 144 152
23. C.A. Campbell, P.J. Gaskin, J. Darton, P. Chiu, K. Lee, and P.G. McLean Validation of a conscious rat model for the discovery of novel agents that inhibit gastric acid secretion Eur. J. Pharmacol. 589 2008 260 263
24. S. Kimura, G.X. Zhang, Y. Nagai, K. Miyata, A. Nishiyama, T. Shokoji, L. Yao, Y.Y. Fan, M. Rahman, Y. Fujisawa, A. Miyatake, and Y. Abe Time-dependent transition of tempol-sensitive reduction of blood pressure in angiotensin II-induced hypertension J. Hypertens. 22 2004 2161 2168
25. M. Feelisch, T. Rassaf, S. Mnaimneh, N. Singh, N.S. Bryan, D. Jourd'Heuil, and M. Kelm Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo FASEB J 16 2002 1775 1785
26. M.F. Montenegro, E.M. Neto-Neves, C.A. Dias-Junior, C.S. Ceron, M.M. Castro, V.A. Gomes, A. Kanashiro, and J.E. Tanus-Santos Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension Naunyn Schmiedebergs Arch. Pharmacol. 382 2010 293 301
27. X. Wang, J.E. Tanus-Santos, C.D. Reiter, A. Dejam, S. Shiva, R.D. Smith, N. Hogg, and M.T. Gladwin Biological activity of nitric oxide in the plasmatic compartment Proc. Natl. Acad. Sci. USA 101 2004 11477 11482
28. M.F. Montenegro, L.R. Pessa, V.A. Gomes, Z. Desta, D.A. Flockhart, and J.E. Tanus-Santos Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarters vascular bed Basic Clin. Pharmacol. Toxicol. 104 2009 400 407
29. J. Petersson, M. Phillipson, E.A. Jansson, A. Patzak, J.O. Lundberg, and L. Holm Dietary nitrate increases gastric mucosal blood flow and mucosal defense Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 G718 724
30. M.M. Castro, E. Rizzi, G.J. Rodrigues, C.S. Ceron, L.M. Bendhack, R.F. Gerlach, and J.E. Tanus-Santos Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension Free Radic. Biol. Med. 46 2009 1298 1307
31. M. Carlström, A.E.G. Persson, E. Larsson, M. Hezel, P.G. Scheffer, T. Teerlink, E. Weitzberg, and J.O. Lundberg Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension Cardiovasc. Res. 89 2011 574 585
32. J.O. Lundberg, and E. Weitzberg Nitrite reduction to nitric oxide in the vasculature Am. J. Physiol. Heart Circ. Physiol 295 2008 H477 478
33. A.J. Webb, N. Patel, S. Loukogeorgakis, M. Okorie, Z. Aboud, S. Misra, R. Rashid, P. Miall, J. Deanfield, N. Benjamin, R. MacAllister, A.J. Hobbs, and A. Ahluwalia Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite Hypertension 51 2008 784 790
34. V. Kapil, A.B. Milsom, M. Okorie, S. Maleki-Toyserkani, F. Akram, F. Rehman, S. Arghandawi, V. Pearl, N. Benjamin, S. Loukogeorgakis, R. Macallister, A.J. Hobbs, A.J. Webb, and A. Ahluwalia Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO Hypertension 56 2010 274 281
35. E.A. Jansson, L. Huang, R. Malkey, M. Govoni, C. Nihlen, A. Olsson, M. Stensdotter, J. Petersson, L. Holm, E. Weitzberg, and J.O. Lundberg A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis Nat. Chem. Biol. 4 2008 411 417
36. S. Beier, H.G. Classen, K. Loeffler, E. Schumacher, and H. Thoni Antihypertensive effect of oral nitrite uptake in the spontaneously hypertensive rat Arzneimittelforschung 45 1995 258 261
37. M. Haas, H.G. Classen, H. Thoni, U.G. Classen, and B. Drescher Persistent antihypertensive effect of oral nitrite supplied up to one year via the drinking water in spontaneously hypertensive rats Arzneimittelforschung 49 1999 318 323
38. Y. Kanematsu, K. Yamaguchi, H. Ohnishi, Y. Motobayashi, K. Ishizawa, Y. Izawa, K. Kawazoe, S. Kondo, S. Kagami, S. Tomita, K. Tsuchiya, and T. Tamaki Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats Am. J. Physiol. Renal Physiol 295 2008 F1457 1462
39. K. Tsuchiya, Y. Kanematsu, M. Yoshizumi, H. Ohnishi, K. Kirima, Y. Izawa, M. Shikishima, T. Ishida, S. Kondo, S. Kagami, Y. Takiguchi, and T. Tamaki Nitrite is an alternative source of NO in vivo Am. J. Physiol. Heart Circ. Physiol 288 2005 H2163 2170
40. B.S. Rocha, B. Gago, R.M. Barbosa, and J. Laranjinha Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: physiological impact Nitric Oxide 22 2010 235 241
41. M. Carlstrom, F.J. Larsen, T. Nystrom, M. Hezel, S. Borniquel, E. Weitzberg, and J.O. Lundberg Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice Proc. Natl. Acad. Sci. USA 107 2010 17716 17720
42. A.V. Kozlov, G. Costantino, B. Sobhian, L. Szalay, F. Umar, H. Nohl, S. Bahrami, and H. Redl Mechanisms of vasodilatation induced by nitrite instillation in intestinal lumen: possible role of hemoglobin Antioxid. Redox Signaling 7 2005 515 521
43. M.F. Montenegro, L.C. Pinheiro, J.H. Amaral, D.M. Marcal, A.C. Palei, A.J. Costa-Filho, and J.E. Tanus-Santos Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension Naunyn Schmiedebergs Arch. Pharmacol. 385 2012 509 517