Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers

Nitric Oxide - Biology and Chemistry

Volumn 26, Issue 4, 2012, Pages 197-202

  Bahra, M ^a   Kapil, V ^a   Pearl, V ^a   Ghosh, S ^a   Ahluwalia, A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Blood flow; Endothelium; Human; Nitrite

Indexed keywords

NITRATE; NITRITE; PLACEBO; POTASSIUM CHLORIDE;

ADULT; ARTERY DILATATION; BLOOD FLOW; BLOOD SAMPLING; BLOOD VESSEL COMPLIANCE; BRACHIAL ARTERY; CHEMOLUMINESCENCE; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; FEMALE; FLOW MEDIATED DILATATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; SALIVA ANALYSIS; SUPPLEMENTATION; SYSTOLIC BLOOD PRESSURE; URINALYSIS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRATES; NITRITES; POTASSIUM CHLORIDE; POTASSIUM COMPOUNDS; SALIVA; VASCULAR STIFFNESS;

EID: 84861314928     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2012.01.004     Document Type: Conference Paper

References (50)

1. S. Moncada, and E.A. Higgs Nitric oxide and the vascular endothelium Handb. Exp. Pharmacol. 2006 213 254
2. I.C. Villar, A.J. Hobbs, and A. Ahluwalia Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor J. Endocrinol. 197 2008 447 462
3. R.M. Palmer, D.S. Ashton, and S. Moncada Vascular endothelial cells synthesize nitric oxide from l-arginine Nature 333 1988 664 666
4. S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol. Rev. 43 1991 109 142
5. D.S. Celermajer, K.E. Sorensen, C. Bull, J. Robinson, and J.E. Deanfield Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction J. Am. Coll. Cardiol. 24 1994 1468 1474
6. J.A. Panza, P.R. Casino, C.M. Kilcoyne, and A.A. Quyyumi Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension Circulation 87 1993 1468 1474
7. P. Vallance, and N. Chan Endothelial function and nitric oxide: clinical relevance Heart (Brit. Cardiac Soc.) 85 2001 342 350
8. J. Deanfield, A. Donald, C. Ferri, C. Giannattasio, J. Halcox, S. Halligan, A. Lerman, G. Mancia, J.J. Oliver, A.C. Pessina, D. Rizzoni, G.P. Rossi, A. Salvetti, E.L. Schiffrin, S. Taddei, and D.J. Webb Endothelial function and dysfunction. Part I: methodological issues for assessment in the different vascular beds: a statement by the working group on endothelin and endothelial factors of the European Society of Hypertension J. Hypertens. 23 2005 7 17
9. R. Joannides, W.E. Haefeli, L. Linder, V. Richard, E.H. Bakkali, C. Thuillez, and T.F. Lüscher Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo Circulation 91 1995 1314 1319
10. H. Brunner, J.R. Cockcroft, J. Deanfield, A. Donald, E. Ferrannini, J. Halcox, W. Kiowski, T.F. Lüscher, G. Mancia, A. Natali, J.J. Oliver, A.C. Pessina, D. Rizzoni, G.P. Rossi, A. Salvetti, L.E. Spieker, S. Taddei, and D.J. Webb Endothelial function and dysfunction. Part II: association with cardiovascular risk factors and diseases. A statement by the working group on endothelins and endothelial factors of the European Society of Hypertension J. Hypertens. 23 2005 233 246
11. M.E. Widlansky, N. Gokce, J.F. Keaney, and J.A. Vita The clinical implications of endothelial dysfunction J. Am. Coll. Cardiol. 42 2003 1149 1160
12. M.G. Modena, L. Bonetti, F. Coppi, F. Bursi, and R. Rossi Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women J. Am. Coll. Cardiol. 40 2002 505 510
13. D.R. Witte, J. Westerink, E.J. de Koning, Y. van der Graaf, D.E. Grobbee, and M.L. Bots Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations? J. Am. Coll. Cardiol. 45 2005 1987 1993
14. D. Shimbo, C. Grahame-Clarke, Y. Miyake, C. Rodriguez, R. Sciacca, M. Di Tullio, B. Boden-Albala, R. Sacco, and S. Homma The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort Atherosclerosis 192 2007 197 203
15. T. Neunteufl, R. Katzenschlager, A. Hassan, U. Klaar, S. Schwarzacher, D. Glogar, P. Bauer, and F. Weidinger Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease Atherosclerosis 129 1997 111 118
16. L. Ghiadoni, Y. Huang, A. Magagna, S. Buralli, S. Taddei, and A. Salvetti Effect of acute blood pressure reduction on endothelial function in the brachial artery of patients with essential hypertension J. Hypertens 19 2001 547 551
17. L.J. Ignarro, J.M. Fukuto, J.M. Griscavage, N.E. Rogers, and R.E. Byrns Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from l-arginine Proc. Nat. Acad. Sci. USA 90 1993 8103 8107
18. N.G. Hord, Y. Tang, and N.S. Bryan Food sources of nitrates and nitrites: the physiologic context for potential health benefits Am. J. Clin. Nutr. 90 2009 1 10
19. J.O. Lundberg, M.T. Gladwin, A. Ahluwalia, N. Benjamin, N.S. Bryan, A. Butler, P. Cabrales, A. Fago, M. Feelisch, P.C. Ford, B.A. Freeman, M. Frenneaux, J. Friedman, M. Kelm, C.G. Kevil, D.B. Kim-Shapiro, A.V. Kozlov, J.R. Lancaster, D.J. Lefer, K. McColl, K. McCurry, R.P. Patel, J. Petersson, T. Rassaf, V.P. Reutov, G.B. Richter-Addo, A. Schechter, S. Shiva, K. Tsuchiya, E.E. van Faassen, A.J. Webb, B.S. Zuckerbraun, J.L. Zweier, and E. Weitzberg Nitrate and nitrite in biology, nutrition and therapeutics Nat. Chem. Biol. 5 2009 865 869
20. V. Kapil, A.J. Webb, and A. Ahluwalia Inorganic nitrate and the cardiovascular system Heart (Brit. Cardiac Soc.) 96 2010 1703 1709
21. B. Spiegelhalder, G. Eisenbrand, and R. Preussmann Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds Food Cosmet. Toxicol. 14 1976 545 548
22. J.J. Doel, N. Benjamin, M.P. Hector, M. Rogers, and R.P. Allaker Evaluation of bacterial nitrate reduction in the human oral cavity Eur. J. Oral. Sci. 113 2005 14 19
23. A.J. Webb, N. Patel, S. Loukogeorgakis, M. Okorie, Z. Aboud, S. Misra, R. Rashid, P. Miall, J. Deanfield, N. Benjamin, R. MacAllister, A.J. Hobbs, and A. Ahluwalia Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite Hypertension 51 2008 784 790
24. V. Kapil, A.B. Milsom, M. Okorie, S. Maleki-Toyserkani, F. Akram, F. Rehman, S. Arghandawi, V. Pearl, N. Benjamin, S. Loukogeorgakis, R. MacAllister, A.J. Hobbs, A.J. Webb, and A. Ahluwalia Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO Hypertension 56 2010 274 281
25. F.J. Larsen, B. Ekblom, K. Sahlin, J.O. Lundberg, and E. Weitzberg Effects of dietary nitrate on blood pressure in healthy volunteers N. Engl. J. Med. 355 2006 2792 2793
26. E.E. van Faassen, S. Bahrami, M. Feelisch, N. Hogg, M. Kelm, D.B. Kim-Shapiro, A.V. Kozlov, H. Li, J.O. Lundberg, R. Mason, H. Nohl, T. Rassaf, A. Samouilov, A. Slama-Schwok, S. Shiva, A.F. Vanin, E. Weitzberg, J. Zweier, and M.T. Gladwin Nitrite as regulator of hypoxic signaling in mammalian physiology Med. Res. Rev. 29 2009 683 741
27. A.J. Hobbs Soluble guanylate cyclase: the forgotten sibling Trends Pharmacol. Sci. 18 1997 484 491
28. M.B. Engler, M.M. Engler, C.Y. Chen, M.J. Malloy, A. Browne, E.Y. Chiu, H.K. Kwak, P. Milbury, S.M. Paul, J. Blumberg, and M.L. Mietus-Snyder Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults J. Am. Coll. Nutr. 23 2004 197 204
29. N. Alexopoulos, C. Vlachopoulos, K. Aznaouridis, K. Baou, C. Vasiliadou, P. Pietri, P. Xaplanteris, E. Stefanadi, and C. Stefanadis The acute effect of green tea consumption on endothelial function in healthy individuals Eur. J. Cardiovasc. Prev. Rehabil. 15 2008 300 305
30. B. Williams, N.R. Poulter, M.J. Brown, M. Davis, G.T. McInnes, J.F. Potter, P.S. Sever, and S.M. Thom The BHS guidelines working party, British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary BMJ 328 2004 634 640
31. M.C. Corretti, T.J. Anderson, E.J. Benjamin, D. Celermajer, F. Charbonneau, M.A. Creager, J. Deanfield, H. Drexler, M. Gerhard-Herman, D. Herrington, P. Vallance, J. Vita, and R. Vogel Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force J. Am. Coll. Cardiol. 39 2002 257 265
32. S.S. Hickson, M. Butlin, J. Broad, A.P. Avolio, I.B. Wilkinson, and C.M. McEniery Validity and repeatability of the Vicorder apparatus: a comparison with the SphygmoCor device Hypertens. Res. 32 2009 1079 1085
33. K.J. Joshipura, A. Ascherio, J.E. Manson, M.J. Stampfer, E.B. Rimm, F.E. Speizer, C.H. Hennekens, D. Spiegelman, and W.C. Willett Fruit and vegetable intake in relation to risk of ischemic stroke JAMA 282 1999 1233 1239
34. K.J. Joshipura, F.B. Hu, J.E. Manson, M.J. Stampfer, E.B. Rimm, F.E. Speizer, G. Colditz, A. Ascherio, B. Rosner, D. Spiegelman, and W.C. Willett The effect of fruit and vegetable intake on risk for coronary heart disease Ann. Intern. Med. 134 2001 1106 1114
35. D.P. Vivekananthan, M.S. Penn, S.K. Sapp, A. Hsu, and E.J. Topol Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials Lancet 361 2003 2017 2023
36. G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857
37. G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, C. Gluud, Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases, Cochrane Database Syst. Rev. (2008) CD007176.
38. J.O. Lundberg, M. Feelisch, H. Björne, E.A. Jansson, and E. Weitzberg Cardioprotective effects of vegetables: is nitrate the answer? Nitric Oxide 15 2006 359 362
39. A. Suessenbacher, M. Frick, H.F. Alber, V. Barbieri, O. Pachinger, and F. Weidinger Association of improvement of brachial artery flow-mediated vasodilation with cardiovascular events Vasc. Med. 11 2006 239 244
40. M. Galleano, P.I. Oteiza, and C.G. Fraga Cocoa, chocolate, and cardiovascular disease J. Cardiovasc. Pharmacol. 54 2009 483 490
41. J.M. Hodgson, and K.D. Croft Tea flavonoids and cardiovascular health Mol. Aspects Med. 31 2010 495 502
42. N.D. Fisher, M. Hughes, M. Gerhard-Herman, and N.K. Hollenberg Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans J. hypertens. 21 2003 2281 2286
43. W.M. Loke, J.M. Hodgson, J.M. Proudfoot, A.J. McKinley, I.B. Puddey, and K.D. Croft Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men Am. J. Clin. Nutr. 88 2008 1018 1025
44. M.R. Adams, C.J. Forsyth, W. Jessup, J. Robinson, and D.S. Celermajer Oral l-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men J. Am. Coll. Cardiol. 26 1995 1054 1061
45. S.Y. Chung, J.S. Kim, M. Kim, M.K. Hong, J.O. Lee, C.M. Kim, and I.S. Song Survey of nitrate and nitrite contents of vegetables grown in Korea Food. Addit. Contam. 20 2003 621 628
46. S. Laurent, J.R. Cockcroft, L.M. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I.B. Wilkinson, and H. Struijker-Boudier Expert consensus document on arterial stiffness: methodological issues and clinical applications Eur. Heart J. 27 2006 2588 2605
47. A.D. Stewart, B. Jiang, S.C. Millasseau, J.M. Ritter, and P.J. Chowienczyk Acute reduction of blood pressure by nitroglycerin does not normalize large artery stiffness in essential hypertension Hypertension 48 2006 404 410
48. I.B. Wilkinson, A. Qasem, C.M. McEniery, D.J. Webb, A.P. Avolio, and J.R. Cockcroft Nitric oxide regulates local arterial distensibility in vivo Circulation 105 2002 213 217
49. S. Laurent, P. Boutouyrie, R. Asmar, I. Gautier, B. Laloux, L. Guize, P. Ducimetiere, and A. Benetos Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients Hypertension 37 2001 1236 1241
50. G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R.H. Fagard, G. Germano, G. Grassi, A.M. Heagerty, S.E. Kjeldsen, S. Laurent, K. Narkiewicz, L. Ruilope, A. Rynkiewicz, R.E. Schmieder, H.A. Struijker Boudier, A. Zanchetti, A. Vahanian, J. Camm, R. De Caterina, V. Dean, K. Dickstein, G. Filippatos, C. Funck-Brentano, I. Hellemans, S.D. Kristensen, K. Mcgregor, U. Sechtem, S. Silber, M. Tendera, P. Widimsky, J.L. Zamorano, S.E. Kjeldsen, S. Erdine, K. Narkiewicz, W. Kiowski, E. Agabiti-Rosei, E. Ambrosioni, R. Cifkova, A. Dominiczak, R.H. Fagard, A.M. Heagerty, S. Laurent, L.H. Lindholm, G. Mancia, A. Manolis, P.M. Nilsson, J. Redon, R.E. Schmieder, H.A. Struijker-Boudier, M. Viigimaa, G. Filippatos, S. Adamopoulos, E. Agabiti-Rosei, E. Ambrosioni, V. Bertomeu, D. Clement, S. Erdine, C. Farsang, D. Gaita, W. Kiowski, G. Lip, J.M. Mallion, A.J. Manolis, P.M. Nilsson, E. O'Brien, P. Ponikowski, J. Redon, F. Ruschitzka, J. Tamargo, P. van Zwieten, M. Viigimaa, B. Waeber, B. Williams, and J.L. Zamorano Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) Eur. Heart J. 28 2007 1462 1536