메뉴 건너뛰기




Volumn 65, Issue 2, 2015, Pages 320-327

Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study

Author keywords

blood pressure; nitrate; nitric oxide; nitrites

Indexed keywords

ALDOSTERONE ANTAGONIST; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CYCLIC GMP; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHEMOGLOBIN; NITRATE; PLACEBO; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRITE; PLANT EXTRACT;

EID: 84921543574     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04675     Document Type: Article
Times cited : (359)

References (48)
  • 1
    • 84871055775 scopus 로고    scopus 로고
    • A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224-2260.
    • (2012) Lancet. , vol.380 , pp. 2224-2260
    • Lim, S.S.1    Vos, T.2    Flaxman, A.D.3
  • 4
    • 84864863840 scopus 로고    scopus 로고
    • New drugs, procedures, and devices for hypertension
    • Laurent S, Schlaich M, Esler M. New drugs, procedures, and devices for hypertension. Lancet. 2012;380:591-600.
    • (2012) Lancet. , vol.380 , pp. 591-600
    • Laurent, S.1    Schlaich, M.2    Esler, M.3
  • 5
    • 77952750659 scopus 로고    scopus 로고
    • US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008
    • Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA. 2010;303:2043-2050.
    • (2010) JAMA. , vol.303 , pp. 2043-2050
    • Egan, B.M.1    Zhao, Y.2    Axon, R.N.3
  • 6
    • 84901754304 scopus 로고    scopus 로고
    • Hypertension management in England: A serial cross-sectional study from 1994 to 2011
    • Falaschetti E, Mindell J, Knott C, Poulter N. Hypertension management in England: a serial cross-sectional study from 1994 to 2011. Lancet. 2014;383:1912-1919.
    • (2014) Lancet. , vol.383 , pp. 1912-1919
    • Falaschetti, E.1    Mindell, J.2    Knott, C.3    Poulter, N.4
  • 8
    • 0025300333 scopus 로고
    • Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension
    • Linder L, Kiowski W, Bühler FR, Lüscher TF. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation. 1990;81:1762-1767.
    • (1990) Circulation. , vol.81 , pp. 1762-1767
    • Linder, L.1    Kiowski, W.2    Bühler, F.R.3    Lüscher, T.F.4
  • 10
    • 0034805427 scopus 로고    scopus 로고
    • Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans
    • Gori T, Mak SS, Kelly S, Parker JD. Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans. J Am Coll Cardiol. 2001;38:1096-1101.
    • (2001) J Am Coll Cardiol. , vol.38 , pp. 1096-1101
    • Gori, T.1    Mak, S.S.2    Kelly, S.3    Parker, J.D.4
  • 11
    • 0023183110 scopus 로고
    • Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure
    • Elkayam U, Kulick D, McIntosh N, Roth A, Hsueh W, Rahimtoola SH. Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure. Circulation. 1987;76:577-584.
    • (1987) Circulation. , vol.76 , pp. 577-584
    • Elkayam, U.1    Kulick, D.2    McIntosh, N.3    Roth, A.4    Hsueh, W.5    Rahimtoola, S.H.6
  • 12
    • 0028932732 scopus 로고
    • ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction
    • ISIS-4 Collaborative Group
    • ISIS-4 Collaborative Group. ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995;345:669-685.
    • (1995) Lancet. , vol.345 , pp. 669-685
  • 14
    • 0028143644 scopus 로고
    • Intragastric nitric oxide production in humans: Measurements in expelled air
    • Lundberg JO, Weitzberg E, Lundberg JM, Alving K. Intragastric nitric oxide production in humans: measurements in expelled air. Gut. 1994;35:1543-1546.
    • (1994) Gut. , vol.35 , pp. 1543-1546
    • Lundberg, J.O.1    Weitzberg, E.2    Lundberg, J.M.3    Alving, K.4
  • 15
    • 0029114339 scopus 로고
    • Enzyme-independent formation of nitric oxide in biological tissues
    • Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med. 1995;1:804-809.
    • (1995) Nat Med. , vol.1 , pp. 804-809
    • Zweier, J.L.1    Wang, P.2    Samouilov, A.3    Kuppusamy, P.4
  • 18
    • 0017036773 scopus 로고
    • The effect of nitrate intake on nitrite formation in human saliva
    • Tannenbaum SR, Weisman M, Fett D. The effect of nitrate intake on nitrite formation in human saliva. Food Cosmet Toxicol. 1976;14:549-552.
    • (1976) Food Cosmet Toxicol. , vol.14 , pp. 549-552
    • Tannenbaum, S.R.1    Weisman, M.2    Fett, D.3
  • 20
    • 10744220361 scopus 로고    scopus 로고
    • Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    • Cosby K, Partovi KS, Crawford JH, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003;9:1498-1505.
    • (2003) Nat Med. , vol.9 , pp. 1498-1505
    • Cosby, K.1    Partovi, K.S.2    Crawford, J.H.3
  • 24
    • 1542614346 scopus 로고    scopus 로고
    • British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): Summary
    • BHS Guidelines Working Party, for the British Hypertension Society
    • Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, Sever PS, Thom SM; BHS Guidelines Working Party, for the British Hypertension Society. British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ. 2004;328:634-640.
    • (2004) BMJ. , vol.328 , pp. 634-640
    • Williams, B.1    Poulter, N.R.2    Brown, M.J.3    Davis, M.4    McInnes, G.T.5    Potter, J.F.6    Sever, P.S.7    Thom, S.M.8
  • 25
    • 84902687710 scopus 로고    scopus 로고
    • Dietary nitrate supplementation improves reaction time in type 2 diabetes: Development and application of a novel nitrate-depleted beetroot juice placebo
    • Gilchrist M, Winyard PG, Fulford J, Anning C, Shore AC, Benjamin N. Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo. Nitric Oxide. 2014;40:67-74.
    • (2014) Nitric Oxide. , vol.40 , pp. 67-74
    • Gilchrist, M.1    Winyard, P.G.2    Fulford, J.3    Anning, C.4    Shore, A.C.5    Benjamin, N.6
  • 26
    • 38849162730 scopus 로고    scopus 로고
    • The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    • Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7:156-167.
    • (2008) Nat Rev Drug Discov. , vol.7 , pp. 156-167
    • Lundberg, J.O.1    Weitzberg, E.2    Gladwin, M.T.3
  • 28
    • 84861314928 scopus 로고    scopus 로고
    • Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers
    • Bahra M, Kapil V, Pearl V, Ghosh S, Ahluwalia A. Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. Nitric Oxide. 2012;26:197-202.
    • (2012) Nitric Oxide. , vol.26 , pp. 197-202
    • Bahra, M.1    Kapil, V.2    Pearl, V.3    Ghosh, S.4    Ahluwalia, A.5
  • 32
    • 73349121330 scopus 로고    scopus 로고
    • Nitrate and nitrite in biology, nutrition and therapeutics
    • Lundberg JO, Gladwin MT, Ahluwalia A, et al. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 2009;5:865-869.
    • (2009) Nat Chem Biol. , vol.5 , pp. 865-869
    • Lundberg, J.O.1    Gladwin, M.T.2    Ahluwalia, A.3
  • 33
    • 84893754765 scopus 로고    scopus 로고
    • Risk stratification by self-measured home blood pressure across categories of conventional blood pressure: A participant-level metaanalysis
    • International Database of Home Blood Pressure in Relation to Cardiovascular Outcome (IDHOCO) Investigators
    • Asayama K, Thijs L, Brguljan-Hitij J, et al; International Database of Home Blood Pressure in Relation to Cardiovascular Outcome (IDHOCO) Investigators. Risk stratification by self-measured home blood pressure across categories of conventional blood pressure: a participant-level metaanalysis. PLoS Med. 2014;11:e1001591.
    • (2014) PLoS Med. , vol.11 , pp. e1001591
    • Asayama, K.1    Thijs, L.2    Brguljan-Hitij, J.3
  • 34
    • 17144375670 scopus 로고    scopus 로고
    • Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: Follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study
    • Sega R, Facchetti R, Bombelli M, Cesana G, Corrao G, Grassi G, Mancia G. Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. Circulation. 2005;111:1777-1783.
    • (2005) Circulation. , vol.111 , pp. 1777-1783
    • Sega, R.1    Facchetti, R.2    Bombelli, M.3    Cesana, G.4    Corrao, G.5    Grassi, G.6    Mancia, G.7
  • 35
    • 67650082354 scopus 로고    scopus 로고
    • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    • Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665.
    • (2009) BMJ. , vol.338 , pp. b1665
    • Law, M.R.1    Morris, J.K.2    Wald, N.J.3
  • 37
    • 84890100176 scopus 로고    scopus 로고
    • More answers to the still unresolved question of nitrate tolerance
    • Münzel T, Daiber A, Gori T. More answers to the still unresolved question of nitrate tolerance. Eur Heart J. 2013;34:2666-2673.
    • (2013) Eur Heart J. , vol.34 , pp. 2666-2673
    • Münzel, T.1    Daiber, A.2    Gori, T.3
  • 38
    • 84896709653 scopus 로고    scopus 로고
    • Aortic pulse wave velocity improves cardiovascular event prediction: An individual participant metaanalysis of prospective observational data from 17,635 subjects
    • Ben-Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant metaanalysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63:636-646.
    • (2014) J Am Coll Cardiol. , vol.63 , pp. 636-646
    • Ben-Shlomo, Y.1    Spears, M.2    Boustred, C.3
  • 39
    • 84863113703 scopus 로고    scopus 로고
    • Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products
    • Fleenor BS, Sindler AL, Eng JS, Nair DP, Dodson RB, Seals DR. Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp Gerontol. 2012;47:588-594.
    • (2012) Exp Gerontol. , vol.47 , pp. 588-594
    • Fleenor, B.S.1    Sindler, A.L.2    Eng, J.S.3    Nair, D.P.4    Dodson, R.B.5    Seals, D.R.6
  • 40
    • 84902081240 scopus 로고    scopus 로고
    • Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk
    • Rammos C, Hendgen-Cotta UB, Sobierajski J, Bernard A, Kelm M, Rassaf T. Dietary nitrate reverses vascular dysfunction in older adults with moderately increased cardiovascular risk. J Am Coll Cardiol. 2014;63:1584-1585.
    • (2014) J Am Coll Cardiol. , vol.63 , pp. 1584-1585
    • Rammos, C.1    Hendgen-Cotta, U.B.2    Sobierajski, J.3    Bernard, A.4    Kelm, M.5    Rassaf, T.6
  • 41
    • 55549114493 scopus 로고    scopus 로고
    • Nitrate in vegetables: Scientific opinion of the panel on contaminants in the food chain
    • European Food Standards Agency
    • European Food Standards Agency. Nitrate in vegetables: Scientific opinion of the panel on contaminants in the food chain. EFSA J. 2008;689:1-79.
    • (2008) EFSA J. , vol.689 , pp. 1-79
  • 42
    • 29244472852 scopus 로고    scopus 로고
    • Food and Agriculture Organization of the United Nations, World Health Organization Geneva: WHO Press
    • Food and Agriculture Organization of the United Nations, World Health Organization. Nitrate (and Potential Endogenous Formation Of N-Nitroso Compounds). Geneva: WHO Press; 2003.
    • (2003) Nitrate (And Potential Endogenous Formation of N-Nitroso Compounds)
  • 44
    • 0019457427 scopus 로고
    • Animal Species in which N-nitroso compounds induce cancer
    • Bogovski P, Bogovski S. Animal Species in which N-nitroso compounds induce cancer. Int J Cancer. 1981;27:471-474.
    • (1981) Int J Cancer. , vol.27 , pp. 471-474
    • Bogovski, P.1    Bogovski, S.2
  • 46
    • 77951633863 scopus 로고    scopus 로고
    • Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • Boffetta P, Couto E, Wichmann J, et al. Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2010;102:529-537.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 529-537
    • Boffetta, P.1    Couto, E.2    Wichmann, J.3
  • 47
    • 0037079309 scopus 로고    scopus 로고
    • Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies
    • Lewington S, Clarke R, Qizilbash N, Peto R, Collins R; Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-1913.
    • (2002) Lancet. , vol.360 , pp. 1903-1913
    • Lewington, S.1    Clarke, R.2    Qizilbash, N.3    Peto, R.4    Collins, R.5
  • 48
    • 80053907554 scopus 로고    scopus 로고
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
    • International Consortium for Blood Pressure Genome-Wide Association Studies
    • International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-109.
    • (2011) Nature. , vol.478 , pp. 103-109


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.