Plasma nitrate and nitrite are increased by a high-nitrate supplement but not by high-nitrate foods in older adults

Nutrition Research

Volumn 32, Issue 3, 2012, Pages 160-168

  Miller, Gary D ^a   Marsh, Anthony P ^a   Dove, Robin W ^a   Beavers, Daniel ^a,b   Presley, Tennille ^a,c   Helms, Christine ^a   Bechtold, Erika ^a   King, S Bruce ^a   Kim Shapiro, Daniel ^a  

^a WAKE FOREST UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c WINSTON SALEM STATE UNIVERSITY   (United States)

Author keywords

Beetroot juice; Blood pressure; Crossover controlled; Nitric oxide; Older adult

Indexed keywords

BEETROOT JUICE; HERBACEOUS AGENT; NITRATE; NITRITE; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; AGED; ARTICLE; BEET; BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG MECHANISM; DRUG METABOLISM; FEMALE; FOLLOW UP; HUMAN; MALE; NITRATE METABOLISM; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE;

AGED; BETA VULGARIS; BLOOD PRESSURE; CROSS-OVER STUDIES; DIET; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; NITRATES; NITRIC OXIDE; NITRITES; PLANT PREPARATIONS; PLANT ROOTS; REFERENCE VALUES;

EID: 84859117987     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2012.02.002     Document Type: Article

References (29)

1. Trends in aging-United States and worldwide. MMWR Morb Mortal Wkly Rep 2003;52(6):101-104, 106.
2. Newman A.B., Arnold A.M., Naydeck B.L., Fried L.P., Burke G.L., Enright P., Gottdiener J., Hirsch C., O'Leary D., Tracy R. "Successful aging": effect of subclinical cardiovascular disease. Arch Intern Med 2003, 163(19):2315-2322.
3. Kunz J. Initial lesions of vascular aging disease (arteriosclerosis). Gerontology 2000, 46(6):295-299.
4. Larsen F.J., Schiffer T.A., Borniquel S., Sahlin K., Ekblom B., Lundberg J.O., Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab 2011, 13(2):149-159.
5. Lauer T., Preik M., Rassaf T., Strauer B.E., Deussen A., Feelisch M., Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 2001, 98(22):12814-12819.
6. Cosby K., Partovi K.S., Crawford J.H., Patel R.P., Reiter C.D., Martyr S., Yang B.K., Waclawiw M.A., Zalos G., Xu X., Huang K.T., Shields H., Kim-Shapiro D.B., Schechter A.N., Cannon R.O., Gladwin M.T. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003, 9(12):1498-1505.
7. Lundberg J.O., Weitzberg E., Gladwin M.T. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 2008, 7(2):156-167.
8. Lundberg J.O., Gladwin M.T., Ahluwalia A., Benjamin N., Bryan N.S., Butler A., Cabrales P., Fago A., Feelisch M., Ford P.C., Freeman B.A., Frenneaux M., Friedman J., Kelm M., Kevil C.G., Kim-Shapiro D.B., Kozlov A.V., Lancaster J.R., Lefer D.J., McColl K., McCurry K., Patel R.P., Petersson J., Rassaf T., Reutov V.P., Richter-Addo G.B., Schechter A., Shiva S., Tsuchiya K., van Faassen E.E., Webb A.J., Zuckerbraun B.S., Zweier J.L., Weitzberg .E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol 2009, 5(12):865-869.
9. Gangolli S.D., van den Brandt P.A., Feron V.J., Janzowsky C., Koeman J.H., Speijers G.J., Spiegelhalder B., Walker R., Wisnok J.S. Nitrate, nitrite and N-nitroso compounds. Eur J Pharmacol 1994, 292(1):1-38.
10. Hord N.G., Tang Y., Bryan N.S. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr 2009, 90(1):1-10.
11. Larsen F.J., Ekblom B., Sahlin K., Lundberg J.O., Weitzberg E. Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med 2006, 355(26):2792-2793.
12. Kapil V., Milsom A.B., Okorie M., Maleki-Toyserkani S., Akram F., Rehman F., Arghandawi S., Pearl V., Benjamin N., Loukogeorgakis S., MacAllister R., Hobbs A.J., Webb A.J., Ahluwalia A. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 2010, 56(2):274-281.
13. Lansley K.E., Winyard P.G., Bailey S.J., Vanhatalo A., Wilkerson D.P., Blackwell J.R., Gilchrist M., Benjamin N., Jones A.M. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc 2011, 43(6):1125-1131.
14. Presley T.D., Morgan A.R., Bechtold E., Clodfelter W., Dove R.W., Jennings J.M., Kraft R.A., King S.B., Laurienti P.J., Rejeski W.J., Burdette J.H., Kim-Shapiro D.B., Miller G.D. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide 2011, 24(1):34-42.
15. Williams E.J. Experimental designs balanced for the estimation of residual effects of treatments. Aust J Sci Res 1949, (Ser. A2):149-168.
16. Webb A.J., Patel N., Loukogeorgakis S., Okorie M., Aboud Z., Misra S., Rashid R., Miall P., Deanfield J., Benjamin N., MacAllister R., Hobbs A.J., Ahluwalia A. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 2008, 51(3):784-790.
17. Green L.C., Ruiz de L.K., Wagner D.A., Rand W., Istfan N., Young V.R., Tannenbaum S.R. Nitrate biosynthesis in man. Proc Natl Acad Sci USA 1981, 78(12):7764-7768.
18. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12(3):189-198.
19. Kenjale A.A., Ham K.L., Stabler T., Robbins J.L., Johnson J.L., Vanbruggen M., Privette G., Yim E., Kraus W.E., Allen J.D. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol 2011, 110(6):1582-1591.
20. Vanhatalo A., Bailey S.J., Blackwell J.R., Dimenna F.J., Pavey T.G., Wilkerson D.P., Benjamin N., Winyard P.G., Jones A.M. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol 2010, 299(4):R1121-R1131.
21. Ferreira P.G., Lima M.A., Bernedo-Navarro R.A., Conceicao R.A., Linhares E., Sawaya A.C., Yano T., Salgado I. Stimulation of acidic reduction of nitrite to nitric oxide by soybean phenolics: possible relevance to gastrointestinal host defense. J Agric Food Chem 2011, 59(10):5609-5616.
22. Bailey S.J., Fulford J., Vanhatalo A., Winyard P.G., Blackwell J.R., Dimenna F.J., Wilkerson D.P., Benjamin N., Jones A.M. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol 2010, 109(1):135-148.
23. Bloomer R.J., Farney T.M., Trepanowski J.F., McCarthy C.G., Canale R.E., Schilling B.K. Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men. J Int Soc Sports Nutr 2010, 7:16.
24. Larsen F.J., Weitzberg E., Lundberg J.O., Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol (Oxf) 2007, 191(1):59-66.
25. Sobko T., Marcus C., Govoni M., Kamiya S. Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. Nitric Oxide 2010, 22(2):136-140.
26. van Velzen A.G., Sips A.J., Schothorst R.C., Lambers A.C., Meulenbelt J. The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett 2008, 181(3):177-181.
27. Bailey S.J., Winyard P., Vanhatalo A., Blackwell J.R., Dimenna F.J., Wilkerson D.P., Tarr J., Benjamin N., Jones A.M. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 2009, 107(4):1144-1155.
28. Larsen F.J., Weitzberg E., Lundberg J.O., Ekblom B. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med 2010, 48(2):342-347.
29. Lundberg J.O., Feelisch M., Bjorne H., Jansson E.A., Weitzberg E. Cardioprotective effects of vegetables: is nitrate the answer?. Nitric Oxide 2006, 15(4):359-362.